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A low-cost digital filing system for echocardiography data with MPEG4 compression and its application to remote diagnosis.

The high cost of digital echocardiographs and the large size of data files hinder the adoption of remote diagnosis of digitized echocardiography data. We have developed a low-cost digital filing system for echocardiography data. In this system, data from a conventional analog echocardiograph are captured using a personal computer (PC) equipped with an analog-to-digital converter board. Motion picture data are promptly compressed using a moving pictures expert group (MPEG) 4 codec. The digitized data with preliminary reports obtained in a rural hospital are then sent to cardiologists at distant urban general hospitals via the internet. The cardiologists can evaluate the data using widely available movie-viewing software (Windows Media Player). The diagnostic accuracy of this double-check system was confirmed by comparison with ordinary super-VHS videotapes. We have demonstrated that digitization of echocardiography data from a conventional analog echocardiograph and MPEG 4 compression can be performed using an ordinary PC-based system, and that this system enables highly efficient digital storage and remote diagnosis at low cost.

Analog-Digital Conversion↗

High level processing scope in spoken sentence production.

Five experiments investigate the scope of conceptual and grammatical encoding during spoken sentence production. An online picture description task is employed in which participants generate a variety of sentences in response to an array of moving pictured objects. Experiment 1, demonstrates longer onset latencies for single clause sentences beginning with a complex phrase (e.g. The dog and the kite move above the house) than for matched single clause sentences beginning with a simple phrase (e.g. The dog moves above the kite and the house). This finding suggests that more time is dedicated to the processing of the first phrase of an utterance than the remainder prior to speech onset. Experiments 2 and 3, compare the production of single and double clause sentences. The main effect of Experiment 1 is replicated. However, the data also suggest that some time is dedicated to the processing of elements within the second clause prior to speech onset. In Experiment 4, when participants are allowed to preview pictures prior to movement and timer onset the effect of initial phrase complexity is significantly reduced indicating that the latency effects observed previously primarily reflect lemma access. Finally, Experiment 5 demonstrates that this reduction is greater for nouns within the first phrase than for nouns beyond it. We conclude from these experiments that, prior to speech onset, lemma access is completed for the first phrase of an utterance and that high level processing is initiated but not completed for the remainder of a sentence beyond the first phrase.

Adult↗

Lateral neural model of binocular rivalry.

This article introduces a two-dimensionally extended, neuron-based model for binocular rivalry. The basic block of the model is a certain type of astable multivibrator comprising excitatory and inhibitory neurons. Many of these blocks are laterally coupled on a medium range to provide a two-dimensional layer. Our model, like others, needs noise to reproduce typical stochastic oscillations. Due to its spatial extension, the noise has to be laterally correlated. When the contrast ratio of the pictures varies, their share of the perception time changes in a way that is known from comparable experimental data (Levelt, 1965; Mueller & Blake, 1989). This is a result of the lateral coupling and not a property of the single model block. The presentation of simple and suitable inhomogeneous stimuli leads to an easily describable perception of periodically moving pictures like propagating fronts or breathing spots. This suggests new experiments. Under certain conditions, a bifurcation from static to moving perceptions is predicted and may be checked and employed by future experiments. Recent "paradox" (Logothetis, 1999) observations of two different neuron classes in cortical areas MT (Logothetis & Schall, 1989) and V4 (Leopold & Logothetis, 1996), one that behaves alike under rivaling and nonrivaling conditions and another that drastically changes its behavior, are interpreted as being related to separate inhibitor neurons.

Action Potentials↗

Cineradiographic study of football helmets and the cervical spine.

A total of 16 men (4 professional football players, 5 high school athletes, and 7 hospital personnel) was studied by cineradiography to evaluate the possible roles of the posterior rim of the football helmet in causing neck injuries. The men ranged from tall elongated neck individuals to short chunky neck individuals. Moving picture (16-mm) films were produced from a series of lateral view cineradiograms that were taken to document the path and position of the posterior rim of the helmet relative to the spinal column as the subject moved his head from the fully flexed to the fully extended positions under several loading conditions. Five different helmets, all from different companies, were used in the studies. No contact existed at any time between the posterior rim of any of the five helmets worn and the fourth cervical vertebral spinous process; in fact, it did not come close to the spinous process of vertebrae C1 through C6. The notion of the posterior rim of the helmet being capable of striking the cervical spine about the C4 to C5 level is without foundation.

Athletic Injuries↗

Chimpanzee (Pan troglodytes) spatial problem solving with the use of mirrors and televised equivalents of mirrors.

Two adult male chimpanzees reached through a hole in the wall of their home cage and, by tracking the images of their hands and of an otherwise hidden target object in a mirror or closed-circuit television picture, moved their hands in whichever direction was necessary to make contact with the target object. They discriminated between live video images and tapes and performed effectively when the target objects were presented in novel locations and when the video picture was presented at random in different orientations. There was thus no consistent relation between the location of images on the monitor and the location of their real-world counterparts. Comparable performances in monkeys and nonprimates seem unlikely.

Animals↗

Visualization of near-optimal sequence alignments.

MOTIVATION: Mathematically optimal alignments do not always properly align active site residues or well-recognized structural elements. Most near-optimal sequence alignment algorithms display alternative alignment paths, rather than the conventional residue-by-residue pairwise alignment. Typically, these methods do not provide mechanisms for finding effectively the most biologically meaningful alignment in the potentially large set of options. RESULTS: We have developed Web-based software that displays near optimal or alternative alignments of two protein or DNA sequences as a continuous moving picture. A WWW interface to a C++ program generates near optimal alignments, which are sent to a Java Applet, which displays them in a series of alignment frames. The Applet aligns residues so that consistently aligned regions remain at a fixed position on the display, while variable regions move. The display can be stopped to examine alignment details.

Algorithms↗

Hysterical chorea: Report of an outbreak and movie documentation by Arthur Van Gehuchten (1861-1914).

Psychogenic movement disorders remain a frequent and important clinical problem. First described in the Middle Ages, the dancing mania is considered to be one form of mass hysteria characterized by outbreaks of collective movement disorders. Patients may exhibit a wide variety of movement and gait disturbances, including tremulousness, jerks, or convulsions, usually with a sudden onset. Arthur Van Gehuchten (1861-1914), a distinguished Belgian neuroanatomist and neurologist, reported an outbreak of sudden involuntary movements in 13 adolescent girls residing in an orphanage. The description is to be found in his book Les Maladies nerveuses, completed before 1914 and published posthumously in 1920. The chapter is illustrated with sequential photographs of a girl exhibiting a peculiar gait, which is descriptively referred to as "chorée salutatoire" (saluting chorea). The original film with these pictures has been retrieved and is presented here together with a very similar film excerpt also found in Van Gehuchten's film collection. Van Gehuchten's movie documentation of a psychogenic movement disorder--labeled chorea but which should probably be considered as dystonia according to contemporary classification--appears to be unique. This report illustrates the tremendous value of moving pictures in recording and analyzing movement disorders.

Belgium↗

Arthur van Gehuchten takes neurology to the movies.

OBJECTIVE: To present the cinematographic production of Arthur Van Gehuchten (1861-1914) and to put this collection into its medical and sociocultural context. BACKGROUND: The arrival of Edison's Kinetoscope (1891) and Lumière's Cinématographe (1895) provoked the immediate interest of neurologists who foresaw the potential of motion pictures for illustration, research, and teaching. RESULTS: Arthur Van Gehuchten, professor of anatomy and neurology at the Catholic University of Louvain, was trained as a microscopist and a cytologist. From neuroanatomy, he progressively broadened his interest to neurology. Van Gehuchten was an avant-garde teacher, eager to adopt new visual aids. In 1895, he attended the first cinematographic screenings. Medical cinematography was soon brought into disrepute in European academic circles, when films made by the French surgeon Doyen were copied and shown on fairgrounds. Nevertheless, in 1905, Van Gehuchten began to film neurologic patients. He used this technique extensively to demonstrate clinical signs, to illustrate neurologic diseases, and to document functional evolution following surgery. For decades, these films were screened for medical students by Van Gehuchten's successors to the chair of neurology. The original nitrate films (more than 2 hours) have been recently rediscovered. They have been restored by the Royal Belgian Film Archive, where they are the oldest Belgian films. CONCLUSIONS: At the beginning of the 20th century, Van Gehuchten built up a collection of moving pictures for teaching purposes. This was one of the first such undertakings. This unique set of films has miraculously survived, and serves as an important archive of nervous diseases and their manifestations prior to the advent of modern therapies.

Audiovisual Aids↗

A new computer-analyzing system for clinical use with a strobo-videoscope.

We introduce a new method for using the computer-analyzing system that deals with a display on a television screen of moving picture frames of the vibrations of vocal folds taken by a stroboscopic videoscope in various voice disorders. The principle of the analyzing system is based on discrimination between the first and second videoscopic images by means of the different intensities of colors. We describe the usefulness of this system in measuring the excursion of the right and left vocal folds, where the glottal transverse diameter and the glottal area are computed and displayed as a function of time.

Computers↗

Magnetic field exposure and behavioral monitoring system.

To maximize the availability and usefulness of a small magnetic field exposure laboratory, we designed a magnetic field exposure system that has been used to test human subjects, caged or confined animals, and cell cultures. The magnetic field exposure system consists of three orthogonal pairs of coils 2 m square x 1 m separation, 1.751 m x 0.875 m separation, and 1.5 m x 0.75 m separation. Each coil consisted of ten turns of insulated 8 gauge stranded copper conductor. Each of the pairs were driven by a constant-current amplifier via digital to analog (D/A) converter. A 9 pole zero-gain active Bessel low-pass filter (1 kHz corner frequency) before the amplifier input attenuated the expected high frequencies generated by the D/A conversion. The magnetic field was monitored with a 3D fluxgate magnetometer (0-3 kHz, +/- 1 mT) through an analog to digital converter. Behavioral monitoring utilized two monochrome video cameras (viewing the coil center vertically and horizontally), both of which could be video recorded and real-time digitally Moving Picture Experts Group (MPEG) encoded to CD-ROM. Human postural sway (standing balance) was monitored with a 3D forceplate mounted on the floor, connected to an analog to digital converter. Lighting was provided by 12 offset overhead dimmable fluorescent track lights and monitored using a digitally connected spectroradiometer. The dc resistance, inductance of each coil pair connected in series were 1.5 m coil (0.27 Omega, 1.2 mH), 1.75 m coil (0.32 Omega, 1.4 mH), and 2 m coil (0.38 Omega, 1.6 mH). The frequency response of the 1.5 m coil set was 500 Hz at +/- 463 microT, 1 kHz at +/- 232 microT, 150 micros rise time from -200 microT(pk) to + 200 microT(pk) (square wave) and is limited by the maximum voltage ( +/- 146 V) of the amplifier (Bessel filter bypassed).

Animals↗

Time course of frequency effects in spoken-word recognition: evidence from eye movements.

In two experiments, eye movements were monitored as participants followed spoken instructions to click on and move pictures with a computer mouse. In Experiment 1, a referent picture (e.g., the picture of a bench) was presented along with three pictures, two of which had names that shared the same initial phonemes as the name of the referent (e.g., bed and bell). Participants were more likely to fixate the picture with the higher frequency name (bed) than the picture with the lower frequency name (bell). In Experiment 2, referent pictures were presented with three unrelated distractors. Fixation latencies to referents with high-frequency names were shorter than those to referents with low-frequency names. The proportion of fixations to the referents and distractors were analyzed in 33-ms time slices to provide fine-grained information about the time course of frequency effects. These analyses established that frequency affects the earliest moments of lexical access and rule out a late-acting, decision-bias locus for frequency. Simulations using models in which frequency operates on resting-activation levels, on connection strengths, and as a postactivation decision bias provided further constraints on the locus of frequency effects.

Eye Movements↗

The structure of mitochondrial DNA from the liverwort, Marchantia polymorpha.

The structure of mitochondrial DNA (mtDNA) from cultured cells of the liverwort, Marchantia polymorpha, was analyzed by pulsed-field gel electrophoresis (PFGE) and moving pictures of the fluorescently labeled molecules. Previous electron microscopic analysis with this liverwort revealed a unique property among land plants: mtDNA circles of only one size, that of the 186 kb genome, with no subgenomic circles. Most of the mtDNA was immobile in PFGE and contained complex structures, larger than the genome size with a bright fluorescent node and multiple attached fibers. The mobile mtDNA was mostly linear molecules in monomeric to pentameric lengths of the unit genome that increased following mung bean nuclease digestion, with a corresponding decrease in the immobile fraction. From 0 to 5% of the mtDNA was found as circular molecules the size of the genome and its oligomers; no subgenome-sized circles were present. Radiolabeling revealed that mtDNA synthesis began soon after transfer of cells to fresh medium and most newly replicated mtDNA was immobile; the circular form of the genome was not rapidly labeled.

DNA Replication↗

A pair of monozygotic twins discordant for homosexuality: sex-dimorphic behavior and penile volume responses.

In reports of identical twins discordant for homosexuality, the homosexual twins showed the effeminacy syndrome in childhood. This has been considered evidence that the homosexuality comes from the twin himself. The possibility that the heterosexual twin was denying homosexuality has never been excluded. A pair of identical male twins discordant for homosexuality are reported. They showed significant differences in their penile volume responses to moving pictures of male and female nudes indicative of sexual orientations consistent with their statements. The homosexual twin showed the effeminacy syndrome. Aspects of the syndrome can be induced in mammals by altering their hormonal environment during some critical period in their intrauterine development. Discordance for homosexuality in identical twins could be due to one's being exposed to a different hormonal level during such a critical period.

Adult↗

Rewarding properties of visual stimuli.

The behavioral functions of rewards comprise the induction of learning and approach behavior. Rewards are not only related to vegetative states of hunger, thirst and reproduction but may also consist of visual stimuli. The present experiment tested the reward potential of different types of still and moving pictures in three operant tasks involving key press, touch of computer monitor and choice behavior in a laboratory environment. We found that all tested visual stimuli induced approach behavior in all three tasks, and that action movies sustained consistently higher rates of responding compared to changing still pictures, which were more effective than constant still pictures. These results demonstrate that visual stimuli can serve as positive reinforcers for operant reactions of animals in controlled laboratory settings. In particular, the coherently animated visual stimuli of movies have considerable reward potential. These observations would allow similar forms of visual rewards to be used for neurophysiological investigations of mechanisms related to non-vegetative rewards.

Animals↗

The evaluation of dysphagia following radical surgery for oral and pharyngeal carcinomas by cine-magnetic resonance imaging (Cine-MRI).

Cine-magnetic resonance imaging (cine-MRI) creates moving pictures by a video system and turbo-flash method that allow for high-speed MRI. This report describes our experience using this new technique for dynamic imaging using the fast spoiled GRASS (SPGR) sequence to study swallowing in patients with dysphagia following radical surgery for oral cancer. We defined two new parameters, laryngeal elevation and the angle of the epiglottis, to quantify swallowing ability by cine-MRI. These variables were markedly different in patients with dysphagia than they were in healthy controls. Cine-MRI not only provides dynamic images of swallowing but can generate objective measures of swallowing ability as well.

Adult↗

Development of a System to Provide Full, Real-time Remote Control of a Scanning Electron Microscope across the Second Generation Internet: The Teaching SEM.

The development and makeup of a real-time full remote control system for the University of Michigan, Department of Materials Science and Engineering Teaching SEM is described. The instrument was initially controlled via the campus local area Ethernet network and cable TV network. The latest implementation employs Fast Ethernet, Asynchronous Transfer Mode (ATM) networks, and moving picture experts group (MPEG) video encoding to effect the remote control via the computer network alone. Remote control demonstrations from Washington, DC, Dearborn, MI, and Emerson School, Ann Arbor, MI are described.

Journal Article↗

Downlink power control in multi-code CDMA for mobile medicine.

In this paper, we propose a downlink power-control mechanism to be applied in a multi-code code division multiple access (CDMA) mobile medicine system. The mobile medicine system can provide (i) measured blood pressure and body temperature, (ii) medical signals measured by the electrocardiogram (ECG) device, (iii) mobile patient's history, (iv) G.729 audio signals, (v) Joint Photographic Experts Group 2000 Medical images and Moving Picture Experts Group 4 charge-coupled device sensor video signals. By utilizing a multi-code CDMA spread spectrum communication system with downlink power-control strategy, it is possible for this system to meet the quality of service requirements of a mobile medicine network. In addition, such a system can maximize the resource utilization. For different messages to be sent, the power is controlled according to the requisite bit error rate (BER). Higher transmission power is given to the media with lower BER requirement. Numerical analysis shows that the ratios of transmission power for voice, video, and data virtual channels is approximately 1:2:13 when the BERs for voice, video, and data are 10(wedge)(- 3), 10(wedge)(- 4), and 10(wedge)(- 7), respectively. This power ratio is similar to the ratio of signal-to-noise plus interference power ratio for voice, video, and data during transmission. For the purpose of verifying the proposed argument, a simulation has been done and the results match the derivation very well.

Blood Pressure Determination↗

Mesial temporal neurons in the macaque monkey with responses selective for aspects of social stimuli.

Primates possess a sophisticated cognitive ability to interpret and respond to the social actions of conspecifics. Neurons in the temporal lobes of macaque monkeys which are selective for the appearance and motions of conspecifics have been described previously; the results reported here indicate that pathways which integrate such information converge in mesial temporal regions. Single neuron data from an alert macaque viewing moving pictures of other monkeys engaged in a variety of behaviors are presented. Neurons in medial nuclei of the amygdala and adjacent mesial temporal cortex are sensitive to identity, movement, and high-level aspects of depicted scenes.

Amygdala↗