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[Mediastinal form of cat-scratch disease].

The authors reported a case of Cat--Scratch Disease (CSD) in a 14-year-old boy; it was an unusual CSD by its mediastinal mass location. Histopathological lesions which appeared as pseudo-tubercular folliculi mislead us. Disease was finally diagnosed by biological exams: a strongly positive Hanger-Rose reaction and serological assays used for the diagnosis of psittacosis, ornithosis, lymphagranuloma venereum and trachoma. CSD is a common cause of chronic lymphadenopathy in children. In the majority of patients, CSD is a mild illness. Some unusual forms as Parinaud's oculoglandular syndrome, neurological lesions, osteomyelitis and exceptionaly mediastinal lymphadenopathy have been reported. 2 cases of the latest ones were already described.

Adolescent↗

Cat-scratch disease occurring in three siblings simultaneously.

We report for the first time three siblings with cat-scratch disease occurring simultaneously. Case 1 was an 8-year-old boy with enlarged supraclavicular lymph nodes and fever. Case 2 was the 11-year-old sister whose presentation was a prolonged febrile illness. Case 3 was a 13-year-old male adolescent with adenitis of the neck and thigh. All three patients were treated with rifampin with improvement of their symptoms.

Adolescent↗

[Problems diagnosing cat scratch disease].

The diagnosis of cat scratch disease is hampered by the fact the basic laboratory investigations fail to demonstrate characteristic changes of this disease, and the diagnosis is based usually on epidemiological history and the clinical symptom complex. The diagnosis is confirmed by the complement binging test with the antigen obtained from pathologically changed lymph nodes with values over 1.5 being pathognomonic for the disease, and by the cutaneous tests of Hanger-Rose and Mollaret. The authors present 2 cases treated for the disease stressing differences in its course.

Adult↗

Neck abscess secondary to cat-scratch disease.

A 7-year-old boy was referred to us for evaluation of an enlarging neck mass. The results of his primary care physician's initial clinical examination suggested lymphadenopathy secondary to lymphadenitis, and the patient was treated over a 4-week period with two rounds of antibiotics. However, the mass did not resolve, and it subsequently became fluctuant. The patient was referred to our institution, where we diagnosed cat-scratch disease.

Abscess↗

[Cat-scratch disease].

OBJECTIVE: To study the etiology, epidemiology, clinical and pathological features, diagnose and treatment of cat-scratch disease(CSD). METHOD: The clinical information of 1 case was reported and the literatures were also reviewed. RESULT: Bartonella henselae was the primary pathogen of CSD. Almost all patients with CSD were in contact with animals, especially cat or dog before the occurrence of the disease. All the patients had the self-limited swelling of local lymph nodes and commonly a fever. The pathological feature was necrotic granulation-like micro abscessation, and a pleomorphous argyrophil G- bacillus could be showed by Warthin-Starry or Brown-Hopp stainings in the swelling lymph nodes. CONCLUSION: CSD is a self-limited bacterial infectious disease. And its clinical features,biopsy and special stainings of swelling lymph nodes are helpful to the final diagnosis. Gentamicin, rifadin, ciprofloxacin, clarithromycin, bactrim, mitramycin, or resection of swelling lymph nodes had good effects on treating CSD.

Bartonella henselae↗

[A case of cat scratch disease in a patient with diabetes mellitus and chronic renal failure].

The article describes a case of cat scratch disease in a female patient with severe chronic pathology. This relatively rare disease was manifested by regional (in the site of microbial intrusion) lymphadenopathy, and general infectious syndrome. The presence of oncohematological process was excluded without biopsy; serologic examination with bartonella antibodies confirmed the diagnosis. Combined treatment with two antibiotics, rifampicin and doxycycline, was successful. The article stresses that general practitioners should be aware of this disease; timely diagnosis and specific treatment are of utter importance.

Anti-Bacterial Agents↗

[A case of hepatosplenic cat scratch disease].

A 43-year-old man was admitted with idiopathic fever. Abdominal ultrasonogram demonstrated multiple hypoechoic lesions in the spleen. Abdominal CT scan showed multiple hypodense lesions in the liver and spleen. The patient had a cat in his house, and the presence of a very high serous antibody titer for Bartonella henselae led to the diagnosis of hepatosplenic cat scratch disease. It is important to consider this disease in the differential diagnosis of idiopathic fever when multiple lesions are detected in the liver and spleen.

Adult↗

[Rash and purulent lymphadenitis in cat scratch disease].

We present a case of a cat-scratch disease (CSD) presenting with typical (primary lesion and regional lymphadenitis) and rare (purulent lymphadenitis and maculopapular rash) symptoms and positive epidemiological data. Laboratory blood test showed normal values for routine parameters, except for mild leukocytosis (L 12.4 x 10(9)), elevated erythrocyte sedimentation rate (SE 65/h) and moderately elevated asparta e-aminotransferase and alanine-aminotransferase values (AST/ALT 48/90), fibrinogen (5.3 g/L) and C-reactive protein (CRP 85 mg/L). Cytological analysis of lymph node content revealed granulomatous inflammation in the first sample, and purulent inflammation in the second sample. In paired serum samples, collected on the 15th and 29th day from the onset of disease, antibodies IgG (titre 4096/8192) and IgM (titre 80/40) to Bartonella henselae were detected by using an indirect immunofluorescence assay (IFA). Antibiotic therapy with azithromycin (1 x 500 mg per os/5 days) was administered. Purulent lymphadenitis and rash, although a rare clinical manifestation in CSD, are significant clinical findings in differentiating CSD from other febrile illnesses accompanied with rash and lymphadenitis.

Cat-Scratch Disease↗

[Cat scratch pneumonia: a case report].

Pasteurella multocida infections can be caused by scratches or bites of many animals including pets. An unrecognized infection can lead to severe complications such as arthritis, osteomyelitis, respiratory infections and even meningitis or endocarditis. We present the case of a woman affected by soft tissue infection caused by Pasteurella multocida complicated by bacteremia and pneumonia.

Aged↗

Cat-scratch disease.

Cat-scratch disease is a relatively common disorder that is the result of infection with a recently identified gram-negative bacillus. Although it is overwhelmingly a benign, self-limited illness requiring only supportive care, serious complications can occur and the disease may be life-threatening on occasion. Although randomized clinical trials of antibiotic therapy for CSD do not exist, CSD has demonstrated in vitro susceptibility to several antibiotics, and gentamicin has been reported beneficial in a few patients with systemic manifestations of the illness. Therefore, pending clinical trials, gentamicin may be worthy of consideration in CSD patients with serious manifestations of this illness. CSD is one of the most common causes of adenopathy and should be considered in all patients who present with unilateral or regional lymphadenopathy.

Cat-Scratch Disease↗

[Cat-scratch disease].

Cat-scratch disease is usually a self-limited illness characterized by regional lymphadenopathy and a skin inoculation lesion. These findings generally resolve spontaneously over a period of several weeks or months. The discovery of the causative organism, an intracellular gram-negative rod and the recognition of severe systemic courses in immuno-compromised patients have renewed the interest in this disease. We report a prolonged clinical course with lymph node suppuration in an immunocompetent patient. The diagnosis was confirmed by the detection of the organism in Warthin-Starry silver stained lymph node biopsy.

Adult↗

Cat scratch disease: no longer a diagnostic dilemma.

Cat scratch disease is a relatively common cause of localized lymphadenopathy with about 80% of cases occurring in children. This self-limited infection is caused by a small pleomorphic gram-negative bacillus that has been identified in ocular granulomas, skin and lymph node specimens. Unusual manifestations of the disease, such as the oculoglandular disease of Parinaud, encephalopathy, or severe systemic disease, occur in about 12% of patients. Management consists of symptomatic treatment, occasionally aspiration of a node or selected antibiotic therapy in moderate to severely ill patients. Persistence of adenopathy for several months in a generally healthy patient with gradual, spontaneous resolution of the enlarged node is the natural course.

Animals↗

Cat-scratch disease bacteria.

Cat-scratch disease is a benign inoculative lymphoreticulosis, related to the presence of a polymorph bacillus, Warthin-Stary silver stained, Gram negative as assessed by Brown-Hopp staining. It is found in the capillary walls and in macrophages bordering the lymph node sinusoids at the site of inoculation, in regional subacute adenopathy before softening, in internal organs and blood cultures of systemic infections, occurring more often in immuno-compromised patients. These bacteria have been demonstrated in subcutaneous vascular nodules, near to histiocytoid hemangioma in AIDS patients; these lesions are very similar to early stage Kaposi's sarcomas. This bacteria is provisionally listed as G 1492 by the Center for Disease Control.

Acquired Immunodeficiency Syndrome↗

[Splenic calcification following cat scratch disease].

In a 9-year-old girl presenting with symptoms of cat scratch disease, ultrasound of the spleen showed multiple round hypoechogenic nodules which turned into calcifications within a year. Two years later, splenic calcifications were unchanged.

Calcinosis↗

[Cat-scratch disease].

Cat scratch disease is a self-limited but chronic lymphadenitis which has acquired new interest by the description of a responsible pathogen, an intracellularly located gram-negative rod. Due to its low pathogenicity for laboratory animals, the definite proof for causality is still lacking. Severe systemic courses, mainly in immune suppressed patients, can however be identified more positively by detection of this pathogen. A routine diagnostic test is likely to be developed in the near future and therapeutic guidelines for the minority of severe, progressive forms may be drawn up.

Cat-Scratch Disease↗

[Cat-scratch disease associated with osteomyelitis].

A case of cat-scratch disease in an 8 year-old girl is reported. The inoculation injury followed by regional lymphadenopathy was typical of Parinaud syndrome. This patient also had vertebral lesions on scintigraphy, x-rays and CT scan. While the oculoglandular localization spontaneously improved within a few weeks, osteomyelitic lesions remained grossly unchanged after almost 2 years of follow-up.

Cat-Scratch Disease↗

Cat-scratch disease masquerading as a solitary tumor of the breast.

Cat-scratch disease in breast lymph node tissue may present as a mass lesion and require clinical investigation to rule out malignancy. Four cases involving prepectoral lymph nodes have been diagnosed at the Armed Forces Institute of Pathology, Washington, DC. Mammographic findings of a smooth-edged soft-tissue density without spiculation or calcification may suggest the diagnosis. Warthin-Starry silver impregnation of tissue sections is the preferred method of diagnosis, and should be added to the diagnostic workup of granulomatous lesions of the breast.

Adult↗

Disseminated cat-scratch disease in a patient with AIDS.

A patient with AIDS developed subcutaneous nodules and associated osteolytic lesions with negative stains and cultures for bacteria, fungi and parasites. Flucloxacillin was not effective but treatment with vancomycin was associated with improvement. Six months later the patient became severely ill, with fever, malaise and multiple skin and laryngeal papules. Cat-scratch disease was diagnosed from the typical epithelioid angiomatosis seen in skin biopsies with bacterium-like structures in the Warthin-Starry stain. Retrospectively these typical structures were also seen in earlier biopsies. All lesions improved after therapy with erythromycin had been instituted.

Acquired Immunodeficiency Syndrome↗