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[Prevalent disease characteristics in the ambulatory sector--need for social medicine competence with reference to hard-to-define and undefined disease pictures].

Poorly defined or undefined disease patterns occur sporadically in the physician's daily routine. They appear as uncharacteristic, early and compensated stages of disease. Sociomedical competence can contribute to cope with illness, where physician and patient are unable to cope on the basis of diagnostic and clinical categories alone. It allows to understand the individual concept of illness as a construct, answering several purposes and dependent on the acting individuals and on the particular situation. The search for better solutions within the system opens many ways to redefine, reframe, behavioural change and structures beyond the limits of a clinical concept of disease. This requires theoretical knowledge about the complex effects an intervention may have. In medical training it is necessary to emphasise problem-orientated learning strategies to promote systemic understanding of the context of health and disease in the perspective of the individual and also from a social point of view.

Adaptation, Psychological↗

Esophagogastrectomy.

The diagnosis of esophageal cancer continues to stimulate much research to find the most effective methods of treatment. Combined radiotherapy and chemotherapy may produce results as good as if not better than those with operation plus radiotherapy and chemotherapy. Esophagogastrectomy is performed using any one of several surgical approaches. The individual status of the patient is an important determinant when selecting the surgical approach. There is no clear evidence that one approach is superior to another. Patients should be evaluated appropriately and prepared for operation so that they have the best chance for having a benign postoperative course. Postoperative nursing management requires complex assessment and intervention skills. The optimal approach to the management of esophageal cancer has yet to be defined. Esophagogastrectomy remains primarily a palliative, not curative, approach to patient management. The prevention of postoperative complications through astute assessment and intervention will improve the quality of patient outcomes.

Critical Illness↗

Nutrient intake amongst adolescent girls belonging to poor socioeconomic group of rural area of Rajasthan.

OBJECTIVE: To assess the nutrient intake of adolescent girls belonging to low socio-economic group of rural Rajasthan. DESIGN: Cross-sectional, using probability proportionate to size, cluster sampling method. SETTING: 18 villages of Jaipur district. SUBJECTS: 941 adolescent girls of age 10-18 yr. METHODS: Anthropometric measurements for height, weight, mid-upper arm circumference, triceps skin fold and chest circumference; 24 h recall method to assess nutrient intake. Nutrient intake was compared with Indian Council of Medical Research recommended dietary allowances. RESULTS: The diets were deficient in calories by 26 to 36%, and in proteins by 23 to 32%. Nutritional status as assessed by body mass index revealed that 8.1% of adolescent girls suffered from chronic energy deficiency (CED) grade I, 6.6% grade II CED, and 78.8% grade III CED. About 73.7% of subjects suffered from anemia and 43.6% had signs of vitamin B complex deficiency. CONCLUSIONS: Intervention strategies are needed to improve the dietary intake of adolescent girls so that their requirements of energy, protein, vitamins and minerals are met.

Adolescent↗

Survey of current practice patterns for percutaneous transluminal coronary angioplasty. SANDBAG Nursing Coordinators.

BACKGROUND: The increasing complexity of coronary intervention has led to variations in current patterns of nursing practice for patients undergoing routine percutaneous transluminal coronary angioplasty. In preparation for a large study examining the effects of specific nursing practices on complications at the site of vascular access, we surveyed institutions participating in a randomized phase III trial involving 4010 patients to determine current patterns of practice. OBJECTIVE: The purpose of this study was to determine the current patterns of nursing practice for patients undergoing percutaneous transluminal coronary angioplasty. METHODS: An eight-page questionnaire was completed by 70 hospitals participating in the study titled Integrelin to Manage Platelet Aggregation to Prevent Coronary Thrombosis (IMPACT II). RESULTS: The hospitals participating in this study have an average of 500 beds; 34% of the institutions do 500 to 1000 angioplasty procedures annually. At many sites (39%), heparin is infused for 12 to 18 hours after the intervention, but heparin is not infused at all in 31% of the hospitals studied. At 27% of the hospitals, arterial sheaths are removed 12 to 18 hours after angioplasty, and at 15% of the hospitals, sheaths are removed more than 18 hours after the procedure. Typically after angioplasty (36%), patients are transferred to an ICU, with a nurse-patient ratio of 1:2. Eighty-three percent of the hospitals use CareMAPs or care plans for standardization of care. Most hospitals (83%) require complete bed rest for patients who have had angioplasty, with the affected leg restrained to prevent mobility. Ninety-one percent of the hospitals reported continuing to treat the patient with bed rest for an additional 6 hours after the sheath is removed. CONCLUSION: Comprehensive nursing standards of care based on well-designed clinical trials for patients after angioplasty are not available. In the second phase of our study, we hope to correlate nursing practices with clinical outcome data to improve further the care of patients who have had angioplasty.

Angioplasty, Balloon, Coronary↗

The particular and the general. Issues of specificity and verticality in the history of malaria control.

Several ideas have currency through long periods of malaria control history and important issues in controlling many communicable diseases have often been fought out over malaria. Health administrators view complex problems of malaria control through these apparently simple ideas. The most important concepts concern the need for specific methods to combat particular features of the spread of malaria and how far this is reflected by the development of specific health services. This paper follows these ideas through the last century and argues that the dead hand of history has played too large a role in determining malaria control generally, and especially over the last two decades, while the whole period provides an illuminating commentary on conceptualization in tropical health and its evolution. The two decades following discovery of the mosquito transmission of malaria saw increasingly specific knowledge about the vectors and approaches to preventing breeding. This required "odd" health workers who poured oil on water and did fresh-water biology and later special engineers who could design reservoirs and irrigation systems hostile to anopheline breeding and apply "species sanitation". The expertise required lay outside the health sector. Later, the DDT phase focused on a single highly specialized control technique, total coverage house spraying, and led on to attempted eradication, whose activities were vertically grouped. Malaria eradication became autonomous within the health department. It became the archetypal vertical programme whose funding levels and early successes made it a model to be emulated. But the need for active case surveillance to be integrated with general health services was a major reason for failure in some countries. The subsequent reaction to failed eradication emphasized horizontal or general health services, and these are very relevant to current pre-occupations with morbidity and mortality reduction by early diagnosis and prompt treatment. The future needs a complex mixture of interventions that cut across traditional views of either specificity or of the horizontal/vertical split in programmes, and development of effective control with imperfect tools requires a more sophisticated analysis of control methods and organizations than is provided by a simple vertical/horizontal debate.

Africa↗

Critical thinking and clinical decision making in critical care nursing: a pilot study.

OBJECTIVE: This pilot study examined the relationship of education level, years of critical care nursing experience, and critical thinking (CT) ability (skills and dispositions) to consistency in clinical decision making among critical care nurses. Consistency was defined as the degree to which intuitive and analytical decision processes resulted in similar selection of interventions in tasks of low and high complexity. DESIGN: The study was nonexperimental and correlational. SAMPLE: Critical care nurses (n = 54) from adult critical care units in 3 private teaching hospitals. The majority of nurses held a BSN or MSN and had an average of 9 years of direct clinical experience in the care of the critically ill. RESULTS: Decision-making consistency decreased significantly between low-complexity and high-complexity tasks. Both intuitive and analytical decision processes produced clear intervention selections in the low-complexity task, although the analytical process resulted in a more complete specification of interventions. In the high-complexity task, however, only the intuitive process resulted in a clear, plausible, and safe specification of interventions. Education and experience were not related to CT ability, nor was CT ability related to decision-making consistency. Only greater years of critical care nursing experience increased the likelihood of decision-making consistency. CONCLUSIONS: Overall, intuitive decision processes resulted in more clinically consistent selection of interventions across tasks. More investigation is needed to examine the influence of decision heuristics, and the conceptualization and measurement of CT abilities among practicing nurses.

Adult↗

Viral-specific immunization in AIDS-related complex by photopheresis.

The potential for therapeutic intervention in 7 patients with AIDS-related complex (ARC) was evaluated through the use of photopheresis. The rationale for the study was based on: 1. the demonstration that psoralen and UVA could inactivate HIV/virus in vitro; 2. CD4 cells are the primary target population effected by HIV and photopheresis; and 3. reinfusion of inactivated virus and cell-associated virus might serve to engender an immune response. Preliminary results in 7 patients with ARC over 6 to 18 months revealed a virus-specific response with an elevation of HIV antibodies, while EBV and CMV titers remained unchanged. The immunologic results revealed an increase in the CD8 lymphocyte population, stable activation markers (B2 microglobulin neopterin), a decrease in p24 antigen titers and inability to culture HIV virus in 3 patients. All of these results were in the context of a stable or increasing CD4+ percent. Six patients did not reveal a generalized inhibition of other immune responses as demonstrated by recovery of DTH. In addition, the resolution of lymphadenopathy, night sweats, fever and weight loss, paralleled the immunologic response.

AIDS-Related Complex↗

Three-dimensional imaging, surgical planning, and image-guided therapy.

Three-dimensional imaging is now widely available and used often to aid in the comprehension and application of volumetric data to diagnosis, planning, and therapy. CAS comprises visualization of complex anatomy, planning of interventions, image-based guidance for diagnosis and therapy, evaluation of results, and follow up. CAS-networked workstations have interactive pointing devices and specialized software that support simulation, navigation, and follow-up functions. Volumetric and real time digital imaging are used to plan procedures, for intra-operative guidance, and to monitor progress. Monitoring with real time ultrasound, fluoroscopy, and MR imaging is performed to assess local effects of specific therapeutic modalities. Normative data bases, especially digital stereotactic atlases, allow incorporation of a priori anatomic knowledge in CAS. Computer-assisted planning and simulation of complex craniofacial surgery is feasible with commercially available software and hardware using CT scan and MR images. This can be performed by an operator with low-level computer skills on a graphics workstation. The outcome of computer-simulated surgery can be validated quantitatively. Computer-simulated surgery does affect the choice of intervention for patients with complex craniofacial anomalies. Further evaluation of the process is needed to determine the influence of surgical simulation and planning on outcome.

Computer Simulation↗

Bridging the research-practice gap: exploring the research cultures of practitioners and managers.

To ensure effective utilization of research in nursing more evidence is needed which illuminates the way nurses think about research, the value which they put on it, and how they envisage that it may help or hinder them in their everyday work. This English study aimed to meet these objectives by describing the research culture of practising nurses, health visitors and midwives, and their managers. It rests on two assumptions. Firstly that the reasons why practitioners do, or do not, base their practice on research are complex, and secondly, that interventions to increase research utilization must be grounded in an appreciation of this complex 'whole'. Thus the study took a qualitative approach to exploring: what participants thought and felt about research; the current status of research based practice; and the opportunities and constraints to increasing research based practice. The results confirm the hypothesis that many factors, both individual and organizational affect research utilization. Furthermore, practitioners and managers hold differing perceptions regarding the nature of research, its role, and the opportunities and constraints which effect its dissemination and utilization. The implications of the results for education, policy and practice are discussed.

Diffusion of Innovation↗

Developing and refining interventions in persons with health disparities: the use of qualitative description.

Eliminating health disparities by the year 2010 has become a clear priority for nursing and health sciences research. To date, much of the research has relied on traditional analytic methods to identify the disparities and develop clinical interventions. However, health disparities are typically embedded in complex, cultural and contextual issues. Interventions to improve access, quality and care among vulnerable populations need to be developed with these factors in mind. This article illustrates the benefits of using Qualitative Description as one method for assessing, developing and refining interventions with vulnerable populations. Qualitative Description study results have tremendous potential to translate directly to pressing health care situations and provide clear information about ways to improve care.

Attitude to Health↗

Effect of alteration in triglyceride levels on factor VII-phospholipid complexes in plasma.

Clotting Factor VII activity emerges as a highly significant predictive factor for development of cardiovascular disease (CVD) in prospective trials. We have previously shown that in hypertriglyceridemic individuals a fraction of their clotting Factor VII molecules is present in an activated state in phospholipase C-sensitive complexes in plasma. These complexes may explain the increased Factor VII activity observed to be a predictive factor for CVD. We demonstrate here that the level of such complexes is amenable to dietary intervention and that the alteration in Factor VII complex levels correlates closely with the corresponding alteration in triglycerides.

Cardiovascular Diseases↗

Complex causal process diagrams for analyzing the health impacts of policy interventions.

Causal diagrams are rigorous tools for controlling confounding. They also can be used to describe complex causal systems, which is done routinely in communicable disease epidemiology. The use of change diagrams has advantages over static diagrams, because change diagrams are more tractable, relate better to interventions, and have clearer interpretations. Causal diagrams are a useful basis for modeling. They make assumptions explicit, provide a framework for analysis, generate testable predictions, explore the effects of interventions, and identify data gaps. Causal diagrams can be used to integrate different types of information and to facilitate communication both among public health experts and between public health experts and experts in other fields. Causal diagrams allow the use of instrumental variables, which can help control confounding and reverse causation.

Audiovisual Aids↗

Diarrhoeal disease--epidemiology and intervention.

The causes of the complex triad of gastro-enteritis, other related infections and malnutrition have at their roots poverty, lack of political will, overpopulation and destruction of the environment. Intervention involves multiple sectors of the economy and not only the health services of a country, and should take place as early as possible during the natural history of the disease.

Birth Intervals↗

Responsiveness of goal attainment scaling in a randomized controlled trial of comprehensive geriatric assessment.

BACKGROUND AND OBJECTIVE: Frail elderly patients have complex problems that require a multidimensional assessment and a range of treatment goals. Goal Attainment Scaling (GAS) measures multiple, individualized goals, but its responsiveness in comparative clinical trials has not been established. METHODS: We assessed the responsiveness of GAS in a randomized, controlled trial of an interdisciplinary Mobile Geriatric Assessment Team (MGAT) in 265 rural frail older adults. Sensitivity to change was compared with standard measures; clinical meaningfulness was assessed in relation to a patient and a blinded physician global measure. RESULTS: At 3 months follow-up, GAS was the most responsive measure (standardized response mean 1.22, Norman's responsiveness statistic 0.58) compared with the Barthel Index (1.13, 0.46), Physical Self-Maintenance Scale (0.10, 0.16, 0.02), Instrumental Activities of Daily Living (0.23, 0.00), and modified Spitzer Quality of Life Index (-0.04, 0.00). CONCLUSIONS: Only GAS detected clinically important change associated with the MGAT intervention in these frail elderly patients. Clinometric measures can offer a responsive means of evaluating complex interventions.

Aged↗

Deterministic effects in interventional radiology.

Since the development of interventional radiology, the number and complexity of procedures has increased significantly and continues to grow. Interventional radiology procedures offer substantial health care benefits. However, associated with the increasing complexity as well as a lack of quality control programmes and specific training in radiation protection, there is an increase in the occurrence of deterministic effects in both patients and staff. There is a growing literature of case reports describing deterministic effects. A review of some case reports and the response of various international organisations is presented. It is important that workers in interventional radiology are aware of the potential for deterministic effects and the dose threshold for their onset, so that patients can be followed up appropriately.

Adolescent↗

A lignan complex isolated from flaxseed does not affect plasma lipid concentrations or antioxidant capacity in healthy postmenopausal women.

A lignan complex rich in the plant lignan secoisolariciresinol diglucoside (SDG) was isolated from flaxseed. SDG is metabolized by the colonic microflora to the mammalian lignans enterodiol (END) and enterolactone (ENL), and was hypothesized to reduce plasma lipid concentrations and improve antioxidant capacity. The aim of this study was to investigate the effects of a lignan complex, providing 500 mg/d of SDG, on serum concentration and urinary excretion of ENL, plasma lipids, serum lipoprotein oxidation resistance, and markers of antioxidant capacity. Healthy postmenopausal women (n = 22) completed a randomized, double-blind, placebo-controlled, crossover study. Women consumed daily a low-fat muffin, with or without a lignan complex, for 6 wk, separated by a 6-wk washout period. Serum ENL concentration, urinary ENL excretion, plasma concentrations of total cholesterol (TC), LDL cholesterol (LDL-C), HDL cholesterol (HDL-C), triacylglycerol (TAG), serum lipoprotein oxidation lag time, plasma Trolox-equivalent antioxidant capacity (TEAC), and ferric reducing ability of plasma (FRAP) were measured at the beginning and end of each intervention period. ENL concentrations in serum (P < 0.001) and ENL urinary excretion (P < 0.001) were significantly higher after the lignan complex intervention period compared with placebo. Plasma concentrations of TC, LDL-C, HDL-C, TAG, lipoprotein oxidation lag time, TEAC and FRAP were not affected. Daily consumption for 6 wk of a low-fat muffin enriched with a lignan complex significantly increased serum ENL concentrations and urinary ENL excretion in healthy postmenopausal women, but had no effect on plasma lipid concentrations, serum lipoprotein oxidation resistance, or plasma antioxidant capacity.

4-Butyrolactone↗

Criteria for evaluating evidence on public health interventions.

Public health interventions tend to be complex, programmatic, and context dependent. The evidence for their effectiveness must be sufficiently comprehensive to encompass that complexity. This paper asks whether and to what extent evaluative research on public health interventions can be adequately appraised by applying well established criteria for judging the quality of evidence in clinical practice. It is adduced that these criteria are useful in evaluating some aspects of evidence. However, there are other important aspects of evidence on public health interventions that are not covered by the established criteria. The evaluation of evidence must distinguish between the fidelity of the evaluation process in detecting the success or failure of an intervention, and the success or failure of the intervention itself. Moreover, if an intervention is unsuccessful, the evidence should help to determine whether the intervention was inherently faulty (that is, failure of intervention concept or theory), or just badly delivered (failure of implementation). Furthermore, proper interpretation of the evidence depends upon the availability of descriptive information on the intervention and its context, so that the transferability of the evidence can be determined. Study design alone is an inadequate marker of evidence quality in public health intervention evaluation.

Evidence-Based Medicine↗

Psychosocial factors for failure to adapt to dental prostheses.

Currently, the best approach to the care and treatment of the patient with phantom bite lies in the dentist's familiarity with the signs and symptoms of these syndromes. This is especially important for those dentists interested in the practice of prosthetic dentistry. The patient with phantom bite presents problems for which there are no conventional solutions. This situation is not an isolated phenomenon for dentistry. Rapid and major advances in dental technology and public health programs during the last few decades have radically changed the character of the patient population. Interventions have become more effective and thus more contributive to a larger chronic dental population. Fewer persons lose their teeth. Palliation has become an alternative to the edentate state. Prolongation of the dentition has created need for the more complex treatments. These resulting interventions have also increased the number of organic, psychogenic, sociogenic, and iatrogenic complaints. Many of these complaints are not curable but nor are they terminal with regard to the dentition. For these chronic patient groups, dentistry has become an illness maintenance system. Thus, treatment intervention must begin to be viewed within the context of the ever-increasing complexity of technologic advances. In many cases, prolonged dental intervention and palliation result in the emergence of symptoms secondary to treatment. These secondary symptoms or "side effects" are sometimes more destructive than the disease the treatment was intended to palliate. Treatment, although frequently helpful, can, under certain circumstances, harm the patient. Phantom bite may be a metaphor for such a circumstance, as virtually all treatments promote the illness. Nowhere in the practice of dentistry is the advice of Szasz more relevant: "Don't just do something, stand there!"

Adaptation, Psychological↗