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PubMed1998

Analytic treatment of resolution precision in electronically collimated SPECT imaging involving multiple-interaction gamma rays.

The widely applied single-interaction analytic expression characterizing the energy resolution component of the angular resolution precision for an electronically collimated point source is extended to include multiple-interaction Compton scatter sequences as well as sequences terminated by photoelectric absorption. The analytic formulation is developed using the statistical variance of the mean for components comprising composite, multivariate resolution precision estimators. It is demonstrated that enhanced resolution precision in the incident interaction scatter angle is attained when use is made of information from multiple interactions. An improvement in the resolution precision of up to approximately 40% is observed for triple Compton scatter. Comparison of the analytic estimates with Monte Carlo/chi-square results shows good agreement.

Chi-Square Distribution↗

PubMed2002

Spatial resolution in fast time-resolved transillumination imaging: an indeterministic Monte Carlo approach.

The spatial resolution achievable in time-resolved optical transillumination imaging through a turbid (scattering and absorbing) medium has been reassessed theoretically. The temporal point spread function was constructed assuming a delta function input pulse, a approximately 50 mm thick medium and a small detector with zero risetime. Temporal profiles were derived from an indeterministic Monte Carlo simulation for different time scales. From the temporal point spread function (TPSF), an analytic edge response function from which the spatial resolution was determined was derived. Previous analytical methods for determining the spatial resolution are approximations for very short flight times (sub-100 ps time region). The results show that a spatial resolution of about two millimetres is possible under ideal signal-to-noise ratio conditions and with detector gate times of the order of ten picoseconds. If this predicted spatial resolution can be achieved in an imaging system, it may be possible to improve the diagnosis of breast tumours.

Algorithms↗

PubMed2003

Inter-crystal scatter in a dual layer, high resolution LSO-APD positron emission tomograph.

Improving system efficiency without jeopardizing spatial resolution is one of the main problems of small animal PET scanners. In pursuit of this goal, the future LSO-APD-PET prototype MADPET-II will combine highly granulated detector modules with a dual layer structure. The individual readout of the LSO crystals allows separately handling multiple signals related to those photons scattering between different crystal units (inter-crystal scatter, ICS). The contribution of ICS events can significantly increase the system efficiency. Such coincidences are not characterized by a unique LOR. However, in order to minimize resolution degradation, it would be desirable to identify the primary path of the ICS events. Since ICS is geometry dependent, this work was aimed at investigating the effects of ICS in the performance of the dual layer prototype. Different recovery algorithms to select the primary crystal were implemented and developed, and applied to Monte Carlo simulated data. Some of these algorithms were based on the properties of Compton kinematics. For a centred point source and a 100 keV lower energy threshold, the absolute system efficiency was found to increase by 35% when including ICS events: from 1.8% without ICS events to 2.8% with ICS. Similarly, for a threshold of 200 keV, the contribution of ICS coincidences still represented approximately 20% of the total detected coincidences, leading to an absolute system efficiency of almost 2%. The mispositioning introduced by processing ICS coincidences only led to a moderate broadening of the axial line spread function (LSF), especially at the tails of the profile (FWTM). This effect was also noticeable in the transaxial plane. In presence of scattering media (water-filled cylinder), the resolution degradation was dominated by the contribution of object scatter. The reconstructed images from a simulated homogeneous cylinder filled with activity with a non-active rod at its centre were employed to estimate the impact of ICS on the image quality. In general, the use of ICS coincidences increased the signal-to-noise ratio (SNR) but worsened contrast. The effects of ICS on resolution could be reduced by employing a new identification scheme based on the maximum signal and the Compton kinematics. This method yielded the highest identification rate for the correct photon trajectory, even for a finite energy resolution of 15% (511 keV). This technique also increased the SNR by 17% to 30% and preserved the image contrast. In conclusion, by combining individual crystal readout, a low energy threshold and an appropriate recovery scheme, the processing of ICS coincidences significantly increases the system efficiency without any substantial deterioration of the image quality.

Algorithms↗

PubMed2004

Lutetium oxyorthosilicate block detector readout by avalanche photodiode arrays for high resolution animal PET.

Avalanche photodiodes (APDs) have proven to be useful as light detectors for high resolution positron emission tomography (PET). Their compactness makes these devices excellent candidates for replacing bulky photomultiplier tubes (PMTs) in PET systems where space limitations are an issue. The readout of densely packed, 10 x 10 lutetium oxyorthosilicate (LSO) block detectors (crystal size 2.0 x 2.0 x 12 mm3) with custom-built monolithic 3 x 3 APD arrays was investigated. The APDs had a 5 x 5 mm2 active surface and were arranged on a 6.25 mm pitch. The dead space on the edges of the array was 1.25 mm. The APDs were operated at a bias voltage of approximately 380 V for a gain of 100 and a dark current of 10 nA per APD. The standard deviation in gain between the APDs in the array ranged from 1.8 to 6.5% as the gain was varied from 50 to 108. A fast, low-noise, multi-channel charge sensitive preamplifier application-specific integrated circuit (ASIC) was developed for the APD readout. The amplifier had a rise time of 8 ns, a noise floor of 515 e- rms and a 9 e- pF(-1) noise slope. An acquired flood image showed that all 100 crystals from the block detector could be resolved. Timing measurements with single-channel LSO-APD detectors, as well as with the array, against a plastic scintillator and PMT assembly showed a time resolution of 1.2 ns and 2.5 ns, respectively. The energy resolution measured with a single 4.0 x 4.0 x 10 mm3 LSO crystal, wrapped in four-layer polytetrafluoroethylene (PTFE) tape and coupled with optical grease on a single APD of the array, yielded 15% (full width at half maximum, FWHM) at 511 keV. Stability tests over 9 months of operation showed that the APD arrays do not degrade appreciably. These results demonstrate the ability to decode densely packed LSO scintillation blocks with compact APD arrays. The good timing and energy resolution makes these detectors suitable for high resolution PET.

Equipment Design↗

PubMed2006

High spatial resolution quantitative MR images: an experimental study of dedicated surface coils.

Measuring spin-spin relaxation times (T2) by quantitative MR imaging represents a potentially efficient tool to evaluate the physicochemical properties of various media. However, noise in MR images is responsible for uncertainties in the determination of T2 relaxation times, which limits the accuracy of parametric tissue analysis. The required signal-to-noise ratio (SNR) depends on the T2 relaxation behaviour specific to each tissue. Thus, we have previously shown that keeping the uncertainty in T2 measurements within a limit of 10% implies that SNR values be greater than 100 and 300 for mono- and biexponential T2 relaxation behaviours, respectively. Noise reduction can be obtained either by increasing the voxel size (i.e., at the expense of spatial resolution) or by using high sensitivity dedicated surface coils (which allows us to increase SNR without deteriorating spatial resolution in an excessive manner). However, surface coil sensitivity is heterogeneous, i.e., it--and hence SNR--decreases with increasing depth, and the more so as the coil radius is smaller. The use of surface coils is therefore limited to the analysis of superficial structure such as the hypodermic tissue analysed here. The aim of this work was to determine the maximum limits of spatial resolution and depth compatible with reliable in vivo T2 quantitative MR images using dedicated surface coils available on various clinical MR scanners. The average thickness of adipose tissue is around 15 mm, and the results obtained have shown that obtaining reliable biexponential relaxation analysis requires a minimum achievable voxel size of 13 mm3 for a conventional volume birdcage coil and only of 1.7 mm3 for the smallest available surface coil (23 mm in diameter). Further improvement in spatial resolution allowing us to detect low details in MR images without deteriorating parametric T2 images can be obtained by image filtering. By using the non-linear selective blurring filter described in a previous work, the voxel size was reduced to 0.8 mm3, allowing us to detect microstructures such as fibrous septae while preserving precision in T2 measurements. This paper provides practical information allowing us to perform reliable T2 quantitative MR micro images. High resolution imaging with dedicated surface coils, which is only well-suited to near surface organs, might lead to highly valuable results in this context, especially to analyse the hypodermis involved in the lipodystrophy seen in patients with human immuno-deficiency virus (HIV).

Artifacts↗

PubMed2006

Refraction-angle resolution of diffraction enhanced imaging.

As a new method, x-ray diffraction enhanced imaging (DEI) has extremely high sensitivity for weakly absorbing low-Z samples in medical and biological fields. Conventional performance parameters, such as spatial resolution and low-contrast resolution, are not enough to describe the characteristics of a DEI system. This paper focuses on refraction-angle resolution which describes the ability of a DEI system to differentiate the x-rays refracted by the sample. The analysis of refraction-angle resolution is composed of two parts: the analysis of the single DEI image measured in a certain position of the rocking curve and the analysis of the refraction-angle image calculated by extraction methods. A 2D computer simulation experiment is performed to prove the results of the analyses. The limitations and conclusions of refraction-angle resolution are described in the end.

Algorithms↗

PubMed1987

Theoretical limits to sensitivity and resolution in impedance imaging.

In any practical impedance imaging system it is important to be able to predict the image quality which can be expected from particular measurements. It is of interest both to establish the smallest object that can be detected for a certain noise level and to determine the maximum resolution for a certain number of electrodes. In impedance imaging this is not straightforward. The reason is that the resolution and the accuracy of an image which represents a conductive region are related to the number of electrodes and to the noise on the measurements. They also vary with position in the image and depend on the particular distribution of conductivity itself. It is therefore not possible, in general, to make quantitative statements about the resolution and accuracy. It is of course possible to make qualitative statements, but they are not of much use in any particular situation. Formulations are presented here which do allow quantitative assessment of the resolution and accuracy in a certain class of conductive regions. The regions to which they apply are two-dimensional and have a circular boundary shape. The details of the approach are included, both mathematically and descriptively. The quantitative improvement in image quality which can be obtained by reducing the noise, is shown both in terms of accuracy and resolution. The limit to the improvement in quality which can be obtained by taking unlimited independent measurements (i.e. using an unlimited number of electrodes) is calculated. It is shown how to predict the smallest sized object that can just be detected by measurements with a known level of noise.

Electric Conductivity↗

PubMed2006

ADP_EM: fast exhaustive multi-resolution docking for high-throughput coverage.

MOTIVATION: Efficient fitting tools are needed to take advantage of a fast growth of atomic models of protein domains from crystallography or comparative modeling, and low-resolution density maps of larger molecular assemblies. Here, we report a novel fitting algorithm for the exhaustive and fast overlay of partial high-resolution models into a low-resolution density map. The method incorporates a fast rotational search based on spherical harmonics (SH) combined with a simple translational scanning. RESULTS: This novel combination makes it possible to accurately dock atomic structures into low-resolution electron-density maps in times ranging from seconds to a few minutes. The high-efficiency achieved with simulated and experimental test cases preserves the exhaustiveness needed in these heterogeneous-resolution merging tools. The results demonstrate its efficiency, robustness and high-throughput coverage. AVAILABILITY: http://sbg.cib.csic.es/Software/ADP_EM. SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

Algorithms↗

PubMed2001

Post-mortem high-resolution MRI of the spinal cord in multiple sclerosis: a correlative study with conventional MRI, histopathology and clinical phenotype.

We used high-resolution MRI to study the post-mortem appearance of spinal cord multiple sclerosis in relation to histopathology and low-resolution images. Fifty-nine 3 cm long formalin-fixed spinal cord specimens from 19 multiple sclerosis patients and three controls were studied. Clinical characteristics of each patient were reviewed. High-field MRI consisted of proton-density weighted spin-echo imaging with an in-plane resolution of 80 microm. Specimens were also imaged at 1.0 T, with 1 mm pixel resolution. After MRI, the specimens were cut at 5 mm intervals and stained for myelin (Luxol fast blue/cresyl violet) and axons (Bodian method). Two observers scored the MRIs for abnormalities and divided them into (i) well-delineated areas of high signal intensity (SI) and (ii) poorly defined areas of mildly increased SI. Abnormalities were scored semiquantitatively, white matter and grey matter separately. In 81 sections the total area of abnormalities per section was measured on both histopathology sections and on matched high-field MRIs. Abnormalities ranged from just a few abnormal areas to complete involvement of the spinal cord specimen. Patients with an aggressive disease course had more abnormalities than patients with a mild or intermediate disease course. Areas of mildly increased SI were seen in all specimens, and were often found around focal high-SI lesions. However, in six patients, areas of mildly increased SI were the predominant finding on the MRIs, correlating with a primary progressive disease course. Histopathologically, high-SI areas correlated with complete demyelination, while mildly increased SI corresponded with partial demyelination. All areas scored as abnormal by the neuropathologist were also found on the MRIs, and sizes measured using both methods correlated well (r = 0.85, P<0.01). On conventional MRIs, abnormalities could be recognized fairly well. However, better differentiation could be made between high-SI and mildly increased SI abnormalities on the 4.7 T images. In conclusion, high-resolution MRI revealed a great range of abnormalities in spinal cord multiple sclerosis, which related to disease course during life. Furthermore, we found very good correlation between the extent of abnormalities shown by histopathology and the SI changes on proton-density MRIs, mainly relating to demyelination revealed histopathologically.

Adult↗

PubMed2006

Two distinct functional networks for successful resolution of proactive interference.

In proactive interference (PI) paradigms, previous learning impairs the acquisition of new, related information. In rats, efficient resolution of PI relies on cholinergic modulation from the basal forebrain (BF). To test whether humans resolve PI using a functional network dependent on the medial septum/diagonal band of Broca (MS/DB) nuclei of the BF, we analyzed functional magnetic resonance imaging signal recorded while human participants learned to respond to baseline color paired associates and then additional pairs that interfered with the baseline pairs. Multivariate, partial least-squares analysis supported a MS/DB-dependent functional network: MS/DB activity covaried with activity in areas important to selective attention, including intraparietal sulcus, and memory that are direct cholinergic efferents of the MS/DB, including the hippocampus, as well as the ventrolateral prefrontal cortex, implicated in PI resolution. This network was associated with effective PI-resolution behavior. A second network also correlated with PI resolution but appearing not to be driven by the MS/DB, included the lateral orbitofrontal cortex. Patients with compromised BF function did not engage the MS/DB-dependent network reliably; instead their PI-resolution behavior was well explained by the second network. Thus, 2 functional networks may underly a single cognitive function; when the MS/DB-dependent attention/memory integration network is compromised, an alternate network is available to maintain normal levels of performance.

Alcoholism↗

PubMed2000

Prophage lambda induces terminal recombination in Escherichia coli by inhibiting chromosome dimer resolution. An orientation-dependent cis-effect lending support to bipolarization of the terminus.

A prophage lambda inserted by homologous recombination near dif, the chromosome dimer resolution site of Escherichia coli, is excised at a frequency that depends on its orientation with respect to dif. In wild-type cells, terminal hyper- (TH) recombination is prophage specific and undetectable by a test involving deletion of chromosomal segments between repeats identical to those used for prophage insertion. TH recombination is, however, detected in both excision and deletion assays when Deltadif, xerC, or ftsK mutations inhibit dimer resolution: lack of specialized resolution apparently results in recombinogenic lesions near dif. We also observed that the presence near dif of the prophage, in the orientation causing TH recombination, inhibits dif resolution activity. By its recombinogenic effect, this inhibition explains the enhanced prophage excision in wild-type cells. The primary effect of the prophage is probably an alteration of the dimer resolution regional control, which requires that dif is flanked by suitably oriented (polarized) stretches of DNA. Our model postulates that the prophage inserted near dif in the deleterious orientation disturbs chromosome polarization on the side of the site where it is integrated, because lambda DNA, like the chromosome, is polarized by sequence elements. Candidate sequences are oligomers that display skewed distributions on each oriC-dif chromosome arm and on lambda DNA.

Bacteriophage lambda↗

PubMed2005

Influence of random noise on the contrast-to-gradient image resolution in scanning electron microscopy.

The contrast-to-gradient (CG) method has been proposed previously for the evaluation of image resolution in scanning electron microscopy (SEM). The CG resolution is based on the local resolution, which is defined as the distance to recognize the object's local surface at each pixel position. Then, the CG resolution R is inherently influenced by random noise contained in the image. The present study demonstrates the influence of random noise on the R-values using both personal computer-made dot patterns in various sizes and densities and SEM test micrographs. It is found that the R-values increase with increasing random noise intensity N and their increases are smaller for higher-density patterns, but the R-values are independent of their image sizes under constant pattern density. In addition, the standard CG algorithm is modified especially for straightly fabricated patterns along the x- (or y-) axis, resulting in an improvement in the measurement accuracy of y- (or x-) directional resolutions. The straightness as known information is utilized fully to recognize the local pattern in the random noise.

Journal Article↗

PubMed1987

Resolution of DNA molecules greater than 5 megabases by contour-clamped homogeneous electric fields.

Excellent resolution of chromosomal DNA molecules from Saccharomyces cerevisiae, Candida albicans and Schizosaccharomyces pombe has been obtained using alternating contour-clamped homogeneous electric field (CHEF) gel electrophoresis. The largest of these molecules is greater than 5 Mb in size and is resolved after 130 hours in a 0.6% agarose gel at a field strength of 1.3 V/cm and a switching interval of 1 hour. Separation of concatamers of phage lambda DNA reveals four regions of resolution in alternating CHEF gel electrophoresis. There are two regions of good resolution in which mobility approximates a linear function of molecular weight. These are separated by a region of lower resolution and bounded at high molecular weights by a region of little or no resolution. The four regions are of practical and possibly theoretical importance.

Bacteriophage lambda↗

PubMed1999

High spatial resolution functional magnetic resonance imaging at very-high-magnetic field.

Although neuroimaging methods have been used successfully to map large-scale neurocognitive networks distributed across the human cortex, functional mapping and differentiation of localized brain organization within a small structure has been limited by inadequate sensitivity for high spatial resolution imaging. Functional magnetic resonance imaging (fMRI) technique based on blood oxygenation level-dependent (BOLD) contrast has become one of the most useful neuroimaging techniques. It has been used extensively to study human brain function from sensory perception to cognitive performance. However, the majority of these studies used a relatively low spatial resolution (typically with a voxel size of 3.1 x 3.1 x 5.0 mm3), which is incapable of mapping on the millimeter and submillimeter spatial scale. In this article, we review the technical aspects of the high-resolution fMRI technique and the sensitivity and spatial specificity of BOLD-based fMRI. We demonstrate applications of high-resolution fMRI in studying the human visual pathway from the lateral geniculate nucleus in the thalamus to the ocular dominance columns in the primary visual cortex. Most results were obtained at very-high-magnetic fields (3.0 and 4.0 Tesla). They reveal that high-resolution fMRI at very-high-magnetic field is promising for functional mapping of brain organization from large cortical networks, small nuclei, and even to cellular layer structures.

Brain↗

PubMed1993

High spatial resolution imaging of bone mineral using computed microtomography. Comparison with microradiography and undecalcified histologic sections.

RATIONALE AND OBJECTIVES: The application of various high-resolution (< 100 microns) imaging techniques for in vitro bone mineral analysis is explored. METHODS: The techniques of contact microradiography and microtomography, using the x-ray spectrum filtered out of synchrotron radiation (SR) and conventional staining techniques, are compared to each other by presenting a variety of different samples. The relationship between radiation exposure and spatial resolution micro-computed tomography (CT) images of a finger bone is explored. The relevant properties of SR are explained. RESULTS: In CT images, a spatial resolution of 100 microns was obtained. New bone mineral induced by mechanical periosteal irritation in a rabbit tibia was quantified. In one case a microradiogram and a microtomogram of the same slice were taken for comparison. Histologic sections and microradiograms taken from a specimen of a human femur for comparison are presented. CONCLUSIONS: Microradiography and staining techniques require rather sophisticated sample preparation; quantitative image analysis is more difficult as the resulting image must be digitized. The CT technique requires almost no sample preparation and allows for accurate bone mineral quantification. However, CT images with a resolution of several microns limit the sample size to a few mm. Micro-CT and microradiography can be performed with conventional x-ray sources, but the use of SR is of particular interest in high resolution imaging, because its white spectrum allows for optimum x-ray energy selection and its high intensity for short scan times.

Absorptiometry, Photon↗

PubMed1993

Spatial resolution in digital mammography.

RATIONAL AND OBJECTIVES: Digital acquisition systems currently available limit spatial resolution in digital mammography to roughly 0.1 mm/pixel. The objective of this study is to determine if high-quality mammography is possible at this resolution. METHODS: The influence of spatial resolution on diagnostic quality was investigated by comparing observer performance on film to that on digitized film. A 0.1-mm sampling distance was used for digitization. Detection of mammographic details was studied by measuring threshold contrast as a function of detail size for small circular objects in the range of 0.12 to 2.5 mm. Characterization of microcalcifications was investigated in a receiver operating characteristic (ROC) study, in which 10 radiologists read 72 mammographic details with microcalcifications, both digitally and on film. RESULTS: Digitization improved the detectability of the larger, low contrast objects, whereas for small objects the detectability did not change. The authors found that even under the most optimal circumstances, isolated spherical calcifications with diameters smaller than 0.13 mm are not detectable with film-screen mammography, despite its resolution limit of 15 line patterns per mm (lp/mm). The ability to characterize microcalcification clusters did not change significantly with digitization. However, the results suggest that differentiation of benign from malignant cases decreases slightly, and that characterization of different types of malignancies somewhat improves by digitization. Mean differences between the two modalities were considerably smaller than the interobserver variability. CONCLUSION: A relatively low spatial resolution of 0.1 mm/pixel does not prohibit high-quality diagnostic performance in digital mammography.

Breast Diseases↗

PubMedDate not supplied

A BGO detector unit for a stationary high resolution positron emission tomograph.

A new encoding scheme was developed that is applicable to bismuth germanate (BGO) detector units for a high resolution positron emission tomograph. The detector unit is composed of eight equal-size, 3 mm wide BGO crystals coupled to a dual-module square photomultiplier tube (PMT) through a pair of light guides. The light guides divide the scintillation light between the two modules of the PMT, with a ratio dependent on the crystal of origin. Mean detector pair spatial resolution as measured by the point spread function was 3.9 mm full width at half maximum (FWHM) and reconstructed image spatial resolution was 4.8 mm FWHM at the center of the field of view. Timing resolution between two detector units was 6.0 ns FWHM. Energy resolution was 24% FWHM for 511 keV gamma rays. The finest spots of the Derenzo phantom were clearly resolved.

Bismuth↗

PubMedDate not supplied

Comparative study with a moving heart phantom of the impact of temporal resolution on image quality with two multidetector electrocardiography-gated computed tomography units.

OBJECTIVE: The objective of this study was to compare the temporal resolution-related image quality of electrocardiography-gated images acquired with two multidetector computed tomography (CT) units with a moving heart phantom, at similar fixed heart rates, using half-scan and multisector acquisition modes. METHODS: An adjustable moving heart phantom (Limbsandthings, Horfield, Bristol, UK) was used. Specific heart rates (47, 55, 64, 66, 69, and 73 beats per minute [bpm]) were chosen. On a General Electric CT unit (LightSpeed Plus; General Electric Medical Systems, Milwaukee, WI), retrospective half-scan and multisector mode protocols were performed. On a Siemens CT unit (Somatom Volume Zoom; Siemens, Forchheim, Germany), a retrospective half-scan mode was performed at 47, 55, and 64 bpm, and a two-sector mode was performed at 66, 69, and 73 bpm. Reformatted maximum intensity projection images were qualitatively compared and related to their temporal resolution. RESULTS: Half-scan mode protocols provided similar good results with both CT units up to 55 bpm. The two-sector mode improved image quality compared with the half-scan mode. High temporal resolution with the multisector mode provided the best results. CONCLUSION: For coronary artery imaging, acquisition protocols that provide the highest temporal resolution are mandatory. The multisector mode is one technique that allows high temporal resolution but may be clinically inappropriate at heart rates below 65 bpm or when heart rate variation is observed during scan time.

Coronary Angiography↗