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Moment and power generation during maximal knee extensions performed at low and high speeds.

In the present study a method was developed to determine knee joint moment and power generated at low to very high velocities of knee extension. A group of 21 male subjects performed maximal knee extensions at four levels of external loading provided by a flywheel system. Knee extension was performed with no restrictions on joint angular velocity and acceleration. An interpolation procedure was employed to obtain moment and power at standard velocities. During each single knee extension peak velocity, peak moment, peak power and moment and power at 50 degrees knee flexion were determined (0 degree = full extension). While maximal recorded angular velocity averaged 693 degrees.s-1 (range 479-1030), maximal recorded moment and power were 226 N.m (157-278) and 1140 W (573-1688), respectively, which were generated at velocities of 55 degrees.s-1 (12-148) and 523 degrees.s-1 (327-846). Isokinetic moment and power were obtained for comparison. The velocity range applied was larger using the flywheel method (21-1030 degrees.s-1 individual range) than that achieved isokinetically (30-240 degrees.s-1). Significant differences were observed between flywheel and isokinetic measurements. These discrepancies may be ascribed to differences in the time course of muscle length change and contractile force generation imposed by the two measuring methods. However, by the nonisokinetic measuring method presently employed, knee extension moment and power could be determined from low to very high angular extension velocity, at loading and contraction conditions comparable to those encountered during sport and exercise.

Adult↗

Effects of different strength training regimes on moment and power generation during dynamic knee extensions.

This study examined the effect of different training regimes on moment and power generation during maximal knee extensions at low to very high extension velocities (0-1000 degrees.s-1 individual range). A group of 24 soccer players performed 12 weeks of progressively adjusted strength training of the knee extensors at either high resistance (HR, n = 7), low resistance (LR, n = 6), loaded kicking movements (FU, n = 6), while one group served as controls (n = 5). Moment and power generation of the knee extensors were determined before and after the training period with a nonisokinetic measuring method recently described. Following HR training, knee extension moment increased 9%-10% at knee angular velocities 0 (isometric) and 30 degrees.s-1 (P < 0.05), peak moment increased 20% at 240-300 degrees.s-1 (P < 0.05), while power generation increased 5%-29% at 240-480 degrees.s-1 (P < 0.01). In addition, in the HR group maximal recorded power increased 45% (P < 0.01). After FU training a 7%-13% increase in moment and power was observed at 30-180 degrees.s-1 (P < 0.05). Following LR training, peak moment increased 9% at 120 degrees.s-1 (P < 0.05). Improvements in knee extension moment and power were generally related to the angular velocities employed during training. However, as evaluated using the present measuring method, moment and power increased not only at very low but also at high knee angular velocities following the high-resistance strength training.

Adult↗

Mechanical power test and fiber composition of human leg extensor muscles.

The present study was undertaken to assess the relationship between the mechanical power developed during new anaerobic power test and muscular fiber distribution. Ten track and field male athletes were used as subjects, whose muscle fiber composition (m. vastus lateralis) varied from 25 to 58 fast twitch (FT) fibers. The test consisted of measuring the flight time with a special timer during 60 s continuous jumping. A formula was derived to allow the calculation of mechanical power during a certain period of time (e.g., in the present study every 15 s during 60 s of jumping performance). The relationship between the mechanical power for the first 15 s period correlated best with fast twitch (FT) fiber distribution (r = 0.86, p less than 0.005). However, the power output during the successive 15 s periods demonstrated lower correlation with FT, and this relationship became statistically non-significant after 30 s of work. The sensitivity to fatigue of the test was supported by the relationship observed between the decrease of power during 60 s jumping performance and the percentage of FT fibers (r = 0.73, p less than 0.01). Thus, the present findings suggest that muscular performance, as determined by the new jumping test, is influenced by skeletal muscle fiber composition. The new test, which primarily evaluates maximal short term muscular power, also proved sensitive in assessing fatigue patterns during 60 s of strenuous work.

Adult↗

A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability.

The statistical test of hypothesis of no difference between the average bioavailabilities of two drug formulations, usually supplemented by an assessment of what the power of the statistical test would have been if the true averages had been inequivalent, continues to be used in the statistical analysis of bioavailability/bioequivalence studies. In the present article, this Power Approach (which in practice usually consists of testing the hypothesis of no difference at level 0.05 and requiring an estimated power of 0.80) is compared to another statistical approach, the Two One-Sided Tests Procedure, which leads to the same conclusion as the approach proposed by Westlake based on the usual (shortest) 1-2 alpha confidence interval for the true average difference. It is found that for the specific choice of alpha = 0.05 as the nominal level of the one-sided tests, the two one-sided tests procedure has uniformly superior properties to the power approach in most cases. The only cases where the power approach has superior properties when the true averages are equivalent correspond to cases where the chance of concluding equivalence with the power approach when the true averages are not equivalent exceeds 0.05. With appropriate choice of the nominal level of significance of the one-sided tests, the two one-sided tests procedure always has uniformly superior properties to the power approach. The two one-sided tests procedure is compared to the procedure proposed by Hauck and Anderson.

Biological Availability↗

Assessing the statistical power to detect linkage in a sample of 51 bipolar affective disorder pedigrees.

We used computer simulation method to address the question of power in an initial collaborative sample of 51 bipolar affective disorder pedigrees. Simulations were performed for all possible combinations using (1) two levels of diagnostic stringency, (2) three transmission models, (3) locus heterogeneity, and (4) different assumed phenocopy rates. Some of the factors affect the power to detect linkage are (1) the specification of the correct genetic model, (2) the degree of locus heterogeneity, and (3) the frequency of phenocopies. The first two assertions were supported by our simulation results, but varying the rates of phenocopy did not substantially alter the power of the sample until a critical point. However, it is important to point out that these results are dependent on the genetic models under study and on the use of the "correct" model (i.e., the one used to simulate the data). If we assume a dominant mode of inheritance and locus homogeneity, the power to detect linkage is 97.5% at a theta of .01. However, the power declines dramatically, to 60.5% and 14.7%, if only 75 and 50% of the families are linked, respectively. Locus heterogeneity has a similar effect on the power of the sample to exclude linkage. The relative lack of power in our data, in the presence of significant locus heterogeneity, and for an intermediate mode of inheritance, underscores the need for multicenter collaboration.

Adolescent↗

Power of in silico QTL mapping from phenotypic, pedigree, and marker data in a hybrid breeding program.

Most quantitative trait locus (QTL) mapping studies in plants have used designed mapping populations. As an alternative to traditional QTL mapping, in silico mapping via a mixed-model approach simultaneously exploits phenotypic, genotypic, and pedigree data already available in breeding programs. The statistical power of this in silico mapping method, however, remains unknown. Our objective was to evaluate the power of in silico mapping via a mixed-model approach in hybrid crops. We used maize (Zea mays L.) as a model species to study, by computer simulation, the influence of number of QTLs (20 or 80), heritability (0.40 or 0.70), number of markers (200 or 400), and sample size (600 or 2,400 hybrids). We found that the average power to detect QTLs ranged from 0.11 to 0.59 for a significance level of alpha=0.01, and from 0.01 to 0.47 for alpha=0.0001. The false discovery rate ranged from 0.22 to 0.74 for alpha=0.01, and from 0.05 to 0.46 for alpha=0.0001. As with designed mapping experiments, a large sample size, high marker density, high heritability, and small number of QTLs led to the highest power for in silico mapping via a mixed-model approach. The power to detect QTLs with large effects was greater than the power to detect QTL with small effects. We conclude that gene discovery in hybrid crops can be initiated by in silico mapping. Finding an acceptable compromise, however, between the power to detect QTL and the proportion of false QTL would be necessary.

Breeding↗

Power spectral analysis of vertebral trabecular bone structure from radiographs: orientation dependence and correlation with bone mineral density and mechanical properties.

Trabecular bone structure and bone density contribute to the strength of bone and are potentially important in the study of osteoporosis. Fourier transforms of the textural patterns in radiographs of trabecular bone have previously been used for the measurement of trabecular bone structure in subjects, however, the relationship between these measures and biomechanical properties of bone have not previously been established. In this study radiographs were acquired of 28 cubic specimens of spinal trabecular bone along each of the three anatomic axes: cranio-caudal or superior-inferior (SI), medial-lateral (ML), and anterior-posterior (AP). The radiographs were digitized, background corrected, and uniformly aligned. The Fast Fourier transform (FFT) was performed on a region comprised solely of trabecular bone for each image. The zero (DC), first (FMO), and second moments (SMO) of the Fourier power spectrum and the fractal dimension (FD) as determined from the Fourier power spectrum were correlated with stereology measures, with bone mineral density (BMD) as well as with measured biomechanical properties [Young's elastic modulus (YM) and ultimate strength] of the cubes. The results show that the power spectra-based measures, when compared with structural parameters determined using 3D stereology, show good correlations with bone volume fraction, trabecular spacing, thickness, and number. These power spectral measures showed fair to good correlations with BMD and the biomechanical properties. Moreover, the correlations between the power spectral measures of trabecular structure and the BMD, YM, and stereology measures of structure depend on the orientation of the radiographic image. Specifically, these were significant differences in the measured biomechanical properties and the power spectral measures of the trabecular structure between the SI and ML and the SI and AP directions. In addition, depending on the spatial frequency range for analysis, the fractal dimension showed opposite trends with changes in BMD and biomechanical properties. Multivariate regression models showed the correlation coefficients increasing with the inclusion of some of the power spectral measures, suggesting that FFT-based texture analysis may play a potential role in studies of osteoporosis.

Biomechanical Phenomena↗

Differential diagnosis of lymphadenopathy: power Doppler vs color Doppler sonography.

Our objective was to compare color and power Doppler sonography of superficial lymph nodes. One hundred ninety-three lymph nodes in 161 patients were assessed by color and power Doppler sonography using standardized settings. We tested which modality displayed more intranodal vessels and checked if these differences would have altered the diagnosis. Additional vessels were seen by color Doppler sonography in 18 nodes and by power Doppler sonography in 58 nodes. Amongst those nodes were 15 nodes which showed no vascularization in color Doppler sonography and 23 nodes with only few intranodal flow signals; however, the better sensitivity of power Doppler sonography had no impact on the diagnosis in 42 of 58 nodes. Diagnostic confidence was increased in 7 nodes which showed normal vessels only in power Doppler sonography, although missing flow signals were defined as a benign finding. Pathological vessels were displayed only by power Doppler sonography in 9 nodes, but 6 of these 9 results proved to be false positive. Power Doppler sonography displays more intranodal flow signals than color Doppler sonography, but the diagnostic impact is low because of an increased risk of false-positive results.

Adult↗

[Relationship between lens power in refraction].

BACKGROUND: To achieve emmetropia, several components such as the cornea and lens power, and axial length have to be coordinated. Until now, not much is known about the influence of these factors on each other. METHODS: A total of 66 healthy subjects were enrolled in this study. Ocular dimensions including anterior chamber depth, lens thickness, vitreous chamber depth, and axial length were measured by A-scan ultrasonography. Corneal radius and corneal refractive power were determined by ophthalmometry. The equivalent lens power was calculated by a method based on the Gullstrand schematic eye. RESULTS: As expected, a good correlation was found to exist between refraction and axial length. Lens power was independent of refraction, but in emmetropic eyes a good correlation between lens power and axial length could be found. Higher axial length was related to lower values of lens power and vice versa. CONCLUSION: In emmetropic eyes, deviation of axial length seems to be compensated by lens power and if this mechanism does not function, ametropia results.

Adult↗

Effects of long-term training specificity on maximal strength and power of the upper and lower extremities in athletes from different sports.

Maximal concentric one repetition maximum half-squat (1RM(HS)), bench-press (1RM(BP)), power-load curves during concentric actions with loads ranging from 30% to 100% of 1RM(HS) and 1RM(BP)were examined in 70 male subjects divided into five groups: weightlifters (WL, n=11), handball players (HP, n=19), amateur road cyclists (RC, n=18), middle-distance runners (MDR, n=10) and age-matched control subjects (C, n=12). The 1RM(HS)values in WL, HP and RC were 50%, 29% and 28% greater, respectively, ( P<0.001-0.01) than those recorded for MDR and C. The half-squat average power outputs at all loads examined (from 30% to 100%) in WL and HP ( P<0.001 at 45% and 60% with HP) were higher ( P<0.05-0.001) than those in MDR, RC and C. Average power output at the load of 30% of 1RM(HS) in RC was higher ( P<0.05) than that recorded in MDR and C. Maximal power output was produced at the load of 60% for HP, MDR and C, and at the load of 45% for WL and RC. The 1RM(BP) in WL was larger ( P<0.05) than those recorded in HP, RC, MDR and C. In the bench press, average muscle power outputs in WL and HP were higher ( P<0.05-0.001) than those in MDR, RC and C, and were maximized at a load of 30% of 1RM for WL and HP, and at 45% for RC, MDR and C. In addition, the velocities that elicited the maximal power in the lower extremities were lower ( approximately 0.75 m.s(-1)) than those occurring in the upper extremities ( approximately 1 m.s(-1)). The data suggest that the magnitude of the sport-related differences in strength and/or muscle power output may be explained in part by differences in muscle cross-sectional area, fibre type distribution and in the muscle mechanics of the upper and lower limbs as well as by training background.

Adult↗

Relationship in humans between spontaneously chosen crank rate and power output during upper body exercise at different levels of intensity.

The aim of this study was to assess the relationship between spontaneously chosen crank rate (SCCR) and power output during two upper body exercise tests: firstly, an incremental maximal aerobic power test (T1), with an initial intensity of 50 W followed by 15-W increases at each subsequent 90-s stage and secondly, a test (T2) with consecutive exercise periods set at 50%, 60%, 70%, 80%, 110% and 120% of maximal power (Pmax) separated by passive recovery periods. Eight nationally and internationally ranked kayakers, aged 20 (SD 2) years, performed the tests. During both T1 and T2, mean SCCR values were correlated (r = 1) and increased significantly (P < 0.05) in association with the increases in power output. The finding that the subjects consistently increased their crank rate as the power output increased in different tests, i.e. at submaximal, maximal and supramaximal intensities, strongly suggests that SCCR depended on power output and not on the type of exercise (incremental or rectangular exercise). Moreover, the equation relating crank rate and power output determined from T1 suggests that it may be used to predict the crank rate which will be chosen in upper body exercise, whatever the intensity. Finally, the results of testing at 110% and 120% of Pmax would suggest that a high crank rate (>90 rpm) should be used during the test procedure using supramaximal exercises where accumulated oxygen deficit is calculated, and more particularly when exercise is performed using the upper body.

Adult↗

The power to detect genetic linkage for quantitative traits in the Utah CEPH pedigrees.

Quantitative trait phenotypes and linked marker genotypes were simulated for a range of models with different sets of assumptions based on displacement, prevalence, and heritability of the trait in 30 Utah Centre d'Etude du Polymorphisme Humain (CEPH) families. The gain in power by the addition of 15 families was also estimated by extrapolation. Power was evaluated using both parametric single locus (PSL) models and variance components (VC) methods for two situations: (1) a single marker with 75% heterozygosity and a recombination fraction of 0.05, and (2) a fully informative marker as an approximation to multipoint analysis. When the simulation and analysis models were both dominant with the same prevalence, power > or =80% for lod >3 was estimated when quantitative trait locus variance was > or =40% with a displacement of 2.5 or 3. Power was 5-15% lower for recessive models compared to dominant models. With the addition of 15 families, an average increase in power of 17% and 22% was estimated for the dominant and recessive models, respectively. In PSL analyses, power was estimated at < or =20% when the dominance was misspecified. This investigation delineates parameter conditions under which this unique sample affords adequate power to detect linkage using both PSL and VC methods.

Genetic Linkage↗

Models of metabolic utilization predict limiting conditions for sustained power from conditioned skeletal muscle.

Application and development of muscle powered cardiac assist devices is limited by the ability to predict the sustainable power output of in situ conditioned muscle under the expected loading conditions and geometrical constraints. Empirical definition of the sustained power limits and representative models of the bounding conditions where continuous power can be obtained are needed for device design and optimization. The latissimus dorsi muscles of four goats were chronically conditioned for 11 weeks with an implanted myostimulator. The ability to sustain power under isotonic conditions was evaluated across a range of contraction durations (100-600 ms) and rates (10-120 contractions/min). Muscles were characterized both biomechanically and myothermically to develop and evaluate three increasingly complex empirically-based models of metabolic utilization per contraction based on (1) the duty cycle, (2) a linear function of activation time, and (3) a multivariate-derived function of contraction duration, muscle load, and shortening distance. A clearly defined boundary for sustainable stimulation conditions was observed and was best represented by the linear metabolic model. These data provide both an empirical measure of chronically sustainable muscle power and predictive metabolic models that may be used to optimize the power harnessed for skeletal muscle actuated devices.

Adaptation, Physiological↗

Downlink power control in multi-code CDMA for mobile medicine.

In this paper, we propose a downlink power-control mechanism to be applied in a multi-code code division multiple access (CDMA) mobile medicine system. The mobile medicine system can provide (i) measured blood pressure and body temperature, (ii) medical signals measured by the electrocardiogram (ECG) device, (iii) mobile patient's history, (iv) G.729 audio signals, (v) Joint Photographic Experts Group 2000 Medical images and Moving Picture Experts Group 4 charge-coupled device sensor video signals. By utilizing a multi-code CDMA spread spectrum communication system with downlink power-control strategy, it is possible for this system to meet the quality of service requirements of a mobile medicine network. In addition, such a system can maximize the resource utilization. For different messages to be sent, the power is controlled according to the requisite bit error rate (BER). Higher transmission power is given to the media with lower BER requirement. Numerical analysis shows that the ratios of transmission power for voice, video, and data virtual channels is approximately 1:2:13 when the BERs for voice, video, and data are 10(wedge)(- 3), 10(wedge)(- 4), and 10(wedge)(- 7), respectively. This power ratio is similar to the ratio of signal-to-noise plus interference power ratio for voice, video, and data during transmission. For the purpose of verifying the proposed argument, a simulation has been done and the results match the derivation very well.

Blood Pressure Determination↗

Ventricular performance in patients based upon rate of change of power during isovolumic contraction.

Energy is expended by the ventricle during isovolumic contraction as the blood within the ventricle is compressed. This isovolumic energy of compression, as well as the isovolumic rate of energy transfer (power) and acceleration of energy transfer (rate of change of power), was calculated in 17 patients with angina pectoris who underwent diagnostic cardiac catheterization. The peak isovolumic rate of change of power in patients with normal left ventricular performance (based upon the ejection fraction, mean velocity of circumferential fiber shortening and end-diastolic volume index) was 31,000 plus or minus 3,000 dynes cm sec-2 (mean plus or minus standard error), whereas in those with poor ventricular performance it was 18,000 plus or minus 2,000 dynes cm sec-2 (P less than 0.01). None of the patients with poor ventricular performance had a peak isovolumic rate of change of power that exceeded 25,000 dynes cm sec-2. Overlap between patients with normal performance and those with reduced performance was less with the peak rate of change of power than with peak power, peak rate of change of intraventricular pressure (dp/dt), maximal (dp/dt)/p or Vmax. The derivation of these isovolumic energy transfer rates requires no assumptions related to ventricular geometry or characteristics of muscle fibers. Peak isovolumic rate of change of power may be a useful and sensitive indicator of ventricular performance in patients with coronary artery disease.

Angina Pectoris↗

Critical power as an endurance index.

The relationship between exhaustion time (t(lim)) and the work performed at the end of constant-power exercises can be described by a linear relationship (Wlim = a + b t(lim)) for work involving the whole body (eg cycling) or part of the body (eg knee extensions). The slope b in the equation is termed the critical power and has been proposed as an index of the capacity to perform work over a long period of time. The first objective of the present study was to compare the values of slopes b calculated from whole-body work of short duration, ie maximal and supra-maximal cycling exercises (slope b1), with the values calculated from the same work, the durations of which were between 3.5 and 35 min (slope b3), as in the protocols used by Scherrer and Monod (1960) for body-part work. Slope b1 was significantly higher than slope b3 in 10 subjects who performed 5 cycling exhausting exercises (60, 73, 86, 100 and 120% of maximal aerobic power (MAP) in watts). Exhaustion times corresponding to power outputs equivalent to b1 and b3 were equal to 29.0 +/- 19.1 min and 48.6 +/- 9.8 min respectively. Moreover, the exhaustion times at 60 and 73%,MAP were significantly correlated with slope b3 (expressed in %MAP) but not with slope b1. Consequently, slope b3 should be considered as the critical power instead of slope b1 as in some studies in the literature (Moritani et al, 1981). The second objective was to study the physiological significance of the critical power (slope b3) of whole-body work (cycling). The workload that corresponded to a lactate steady state was not significantly different from b3 (68.8 +/- 6.0 vs 68.7 +/- 6.3% MAP). Nevertheless, slope b3 represents a workload corresponding to a slight but significant drift of heart rate or oxygen uptake. These results probably explain why b3 is a power which can be maintained for a long time but not beyond about l h in an average subject.

Journal Article↗

EEG power spectral changes secondary to L-DOPA treatment in parkinsonian patients: a pilot study.

Clinical EEG evaluation and power spectral analysis were performed on 12 parkinsonian patients before and during L-DOPA treatment. The EEG evaluation did not disclose any significant effects of L-DOPA treatment. Spectral analysis disclosed normal interlobar and interhemispheric power differences and an increase in delta and slow-theta power in the right temporal as compared to the right occipital lobe before L-DOPA treatment was initiated. L-DOPA treatment significantly increased alpha power in both occipital lobes, decreased theta power in the right temporal lobe, accentuated power differences in the theta and alpha bands between temporal and occipital lobes and attenuated beta power differences in those areas. This work is intended as a pilot study in the quantitative EEG evaluation of Parkinson's disease and L-DOPA treatment.

Electroencephalography↗

Effects of SWS deprivation on subsequent EEG power density and spontaneous sleep duration.

In order to test predictions of the 2-process model of sleep regulation, the effects of slow wave sleep (SWS) deprivation by acoustic stimulation during the first part of the sleep period on EEG power density and sleep duration were investigated in 2 experiments. In the first experiment, 8 subjects were deprived of SWS during the first 5 h of a baseline nocturnal sleep period without awakening. Compared to the same interval of undisturbed sleep, power densities in the delta frequencies were attenuated. In the hour following SWS deprivation, power densities in the delta and theta frequencies were considerably enhanced in comparison with the same interval of undisturbed sleep. No change in sleep duration was observed. In the second experiment, 8 subjects were sleep deprived for 1 night and recovery sleep was initiated at 11 a.m. on 2 occasions. In 1 condition subjects were deprived of SWS during the first 3 h of recovery sleep. In the other condition recovery sleep was not experimentally disturbed. During undisturbed recovery sleep, power densities in the delta and theta frequencies were higher than during baseline sleep. During SWS deprivation, power densities in this frequency range were lower than during undisturbed recovery sleep. In the hour following SWS deprivation, power densities were enhanced relative to the same interval of undisturbed recovery sleep. Again, SWS deprivation did not cause an increase of sleep duration. The observed changes in EEG power density support the hypothesis that this EEG parameter reflects the homeostatic process S.(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗