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At least 811 records · Page 45Linked to original sources

Non-linear Feature Extraction by Redundancy Reduction in an Unsupervised Stochastic Neural Network.

Unsupervised feature extraction by a stochastic neural network can be defined as a minimization of the redundancy between the elements of the output layer, given complete information transfer from input to output. Redundancy minimization can be achieved by minimization of the mutual information between the units of the output layer. Complete information transfer is enforced by maximizing the mutual information of the input and output. With these two conditions we define a novel learning algorithm for stochastic recurrent networks. The minimum of redundancy corresponds to the extraction of statistically independent features, leading to a factorial representation of the environment. The resulting learning rule includes Hebbian and anti-Hebbian learning terms. These two terms are weighted by the amount of information transmitted in the learning synapse minus the grade of redundant information in the corresponding output neuron, giving thus, an information-theoretic interpretation of the proportionality constant of Hebb's biological rule. Simulations demonstrate the performance of this method. When a retina is simulated, the learning algorithm forms decorrelated receptive fields. This represents the first experiment that extends the results of the linear principle component analysis to the nonlinear case by a direct implementation of Barlow's principle of redundancy reduction for unsupervised features extraction by receptive fields formation in a retina model. Copyright 1997 Elsevier Science Ltd.

Journal Article↗

The canadian health claim for calcium, vitamin d and osteoporosis.

To provide evidence for or against allowing a health claim for calcium in Canada, we undertook a review of the current U.S. health claim for calcium and osteoporosis, and also reviewed the scientific literature published since that health claim was first proposed and reviewed by the U.S. Food and Drug Administration in 1991 and adopted in 1993. Our objectives were 1) to determine if the science behind the claim was still valid, and if so, 2) to recommend any new wording to the claim, if warranted, prior to implementation in Canada. Based on a review of the evidence (to May 2000) related to the various claim elements, the following health claim for calcium has been established in Canada: A healthy diet with adequate calcium and vitamin D, and regular physical activity, help to achieve strong bones and may reduce the risk of osteoporosis. The compositional criteria for foods bearing this claim are that the food must provide at least 200 mg calcium per serving and that the phosphorus content (excluding that provided by phytate) must be less than the calcium content.

Calcium, Dietary↗

Concept paper: a virtual centralized IRB system.

CONTEXT: As the volume and complexity of research have increased, the amount of time spent on Institutional Review Board (IRB) review has decreased. The complexity of research has expanded, requiring increasingly specialized knowledge to review it. Dilemma: Under the current system, increasing numbers of research studies requiring expertise in ethics, new technologies or diverse study designs place a substantial burden upon local IRBs and often result in substantial variability among their reviews. This lack of uniformity in the review process creates uneven human subjects' protection thus undermining the intent of the Common Rule. OBJECTIVES: To outline a scenario for expert centralized IRB review via implementation of a national virtual IRB review system overseen by the Office for Human Research Protections (OHRP). CONCLUSIONS: The complicated ethical issues and science involved in much of current research warrant an expert review panel. Centralized review would enable expert review specific to the research at hand, ensure consistency in human subjects protection, reduce the burden on local IRBs, and may reduce time spent obtaining approval. A centralized virtual system would allow IRB members to remain at their institutions while providing unprecedented expert review through currently available technology, and make information regarding monitoring and adverse event reporting available online in real-time.

Clinical Trials as Topic↗

Senior partnership practicum.

Discussions between clinical nurse leaders and nurse faculty regarding changes in healthcare that affect the new Bachelor of Science in Nursing (BSN) graduate resulted in the creation of the Senior Partnership Practicum. This article describes the process that took place to implement this clinical partnership model at Johnson City Medical Center (JCMC).

Clinical Competence↗

Dietary reference intakes: implications for fiber labeling and consumption: a summary of the International Life Sciences Institute North America Fiber Workshop, June 1-2, 2004, Washington, DC.

Multiple definitions of dietary fiber have been developed and are in use around the world. The definitions vary as to which substances are considered to be fibers, the analytical methods utilized to identify and measure these fibers, and whether physiological criteria are part of the definition. A workshop entitled "Dietary Reference Intakes: Implications for Fiber Labeling and Consumption" was held by the International Life Sciences Institute North America Technical Committee on Carbohydrates to review the fiber definitions recently published by the Institute of Medicine (IOM) of the National Academies. Presentations and facilitated discussions reviewed the rationale for the IOM definitions of dietary fiber, functional fiber, and total fiber in light of evolving nutritional science. Also discussed were potential analytical, regulatory, and consumer issues involved if the US Food and Drug Administration and/or Health Canada were to implement the IOM's recommendations. Issues, concerns, and questions to be addressed are summarized here.

Dietary Fiber↗

Information management and informatics: need for a modern pathology service.

Requirements for information technology in pathology now extend well beyond the provision of purely analytical data. With the aim of achieving seamless integration of laboratory data into the total clinical pathway, "informatics"--the art and science of turning data into useful information--is becoming increasingly important in laboratory medicine. Informatics is a powerful tool in pathology--whether in implementing processes for pathology modernization, introducing new diagnostic modalities (e.g. proteomics, genomics), providing timely and evidence-based disease management, or enabling best use of limited and often costly resources. Providing appropriate information to empowered and interested patients--which requires critical assessment of the ever-increasing volume of information available--can also benefit greatly from appropriate use of informatics. General trends in medical informatics are reflected in current priorities for laboratory medicine, including the need for unified electronic records, computerized order entry, data security and recovery, and audit. The increasing demands placed on pathology information systems in the context of wider developmental change in healthcare delivery are explored in this paper.

Data Collection↗

Environmental health and African Americans.

As environmental health has taken on immensely increased significance in the prevention of disease, dysfunction, and premature death, its boundaries have been anything but stable. This instability, along with a multitude of demographic, social, and economic currents, have brought into stark relief the increasing demand for scientists who have the skills and knowledge to perform environmental risk assessment and implement effective risk management policies and services. Despite this demand far too few African Americans want, or are prepared, to pursue careers in sciences. This paper describes efforts to address this problem and suggests why such initiatives may not yield the desired results.

Black or African American↗

Report of the health care delivery work group: behavioral research related to the establishment of a chronic disease model for diabetes care.

As one of four work groups for the November 1999 conference on Behavioral Science Research in Diabetes, sponsored by the National Institute on Diabetes and Digestive and Kidney Diseases, the health care delivery work group evaluated the status of research on quality of care, patient-provider interactions, and health care systems' innovations related to improved diabetes outcomes. In addition, we made recommendations for future research. In this article, which was developed and modified at the November conference by experts in health care delivery, diabetes and behavioral science, we summarize the literature on patient-provider interactions, diabetes care and self-management support among underserved and minority populations, and implementation of chronic care management systems for diabetes. We conclude that, although the quality of care provided to the vast majority of diabetic patients is problematic, this is principally not the fault of either individual patients or health care professionals. Rather, it is a systems issue emanating from the acute illness model of care, which still predominates. Examples of proactive population-based chronic care management programs incorporating behavioral principles are discussed. The article concludes by identifying barriers to the establishment of a chronic care model (e.g., lack of supportive policies, understanding of population-based management, and information systems) and priorities for future research in this area needed to overcome these barriers.

Behavioral Medicine↗

An integrated curriculum for MBBS.

OBJECTIVE: To report the formulation and implementation of an organ system based integrated curriculum for MBBS students at Ziauddin Medical University (ZMU) Karachi. STEPS OF INTEGRATION: The Basic Medical Science Faculty (Anatomy, Physiology and Biochemistry) along with representatives from Medicine, Surgery and Community Health Sciences held joint meetings spread over weeks to design a system based integrated curriculum for the first two years of the MBBS class. Objectives of an integrated course were devised and the duties of term coordinator determined. CONCLUSION: Horizontal integration of Basic Science subjects can be achieved, with the subject specialists coordinating the teaching of a system based as opposed to subject based curriculum. The basic sciences can also be integrated with Community Health Sciences to achieve partial vertical integration.

Biological Science Disciplines↗

Structural proteomics: methods in deriving protein structural information and issues in data management.

Structural proteomics is an emerging paradigm that is gaining importance in the post-genomic era as a valuable discipline to process the protein target information being deciphered. The field plays a crucial role in assigning function to sequenced proteins, defining pathways in which the targets are involved, and understanding structure-function relationships of the protein targets. A key component of this research sector is accessing the three-dimensional structures of protein targets by both experimental and theoretical methods. This then leads to the question of how to store, retrieve, and manipulate vast amounts of sequence (1-D) and structural (3-D) information in a relational format so that extensive data analysis can be achieved. We at SBI have addressed both of these fundamental requirements of structural proteomics. We have developed an extensive collection of three-dimensional protein structures from sequence data and have implemented a relational architecture for data management. In this article we will discuss our approaches to structural proteomics and the tools that life science researchers can use in their discovery efforts.

Computational Biology↗

[Systemic and andragogic issues related to professional training of medical personnel in the sphere of hygiene of children and adolescents].

The continuous education concept presupposes that a person is educated during his or her entire conscious lifetime. The pedagogical education model is made use of at the higher-school stage; while at the postgraduate stage, the andragogic model must be involved. The andragogics is a branch of science, according to which the leading role belongs to the person who is educated. He or she contributes extensively to the planning, organization, implementation, assessment and amendment of the educational process. Such process is translated into reality at the chair for hygiene of children and teenagers in accordance with the State Standard of postgraduate professional training of experts with higher medical education in the sphere of "hygiene of children and teenagers". The defined educational levels as well as psycho-physiological and specific features of the educating staff are a basis for a individual approach to them. Not only hygienists but also pediatricians and attending doctors from the chair for family life are trained at the above-mentioned chair. The diversity of training appicable to medical personnel of different categories necessitates serious educational-and-methodolgical measures.

Adolescent↗

The role of mucus and its components in protection and repair within the alimentary tract mucosa: Polish experience.

The Gastroenterology Research Laboratory at New York Medical College, New York City, NY, directed by Prof. Dr. George B. Jerzy Glass and after his retirement by Prof. Dr. Bronislaw L. Slomiany and Prof. Dr. Amalia Slomiany served as a launching pad for successful careers in exploration of mucus for Dr. Andrzej Gindzienski and Dr. Krzysztof Zwierz and Janusz Badurski at the Medical School in Bialystok, Poland as well as Dr. Jerzy Sarosiek at Gastroenterology Research Laboratory, University of Virginia Health Sciences Center, Charlottesville, VA and currently, Gastroenterology Research Laboratory, Kansas University Medical Center, Kansas City, KS, USA. The dynamic and insightful research endeavors implemented at the Medical School of Bialystok revealed new information regarding enzymatic pathways of mucin synthesis especially its carbohydrate components such as hexosamines. These discoveries become instrumental in our understanding of the alimentary tract mucin synthesis and function in health and disease. Similarly innovative mucus research conducted across the Atlantic Ocean uncovered the novelty of mucin elaborated within the esophageal submucosal mucous glands in humans by demonstration that its chemical characteristics are different both from human salivary and gastric mucins. In addition, a novel method for the measurement of the thickness of the gastric mucus layer ex vivo in humans has also been developed. These pioneering works are continued at both mucus exploration centers attracting younger generation of investigators enticed by the mystery of the structure and function of the mucus barrier and its leading role in mucosal protection against injury as well as immediate and unequivocal contribution to mucosal repair and reconstitution process.

Gastric Mucosa↗

A telemedicine guideline for the practice of teleconsultation.

UNLABELLED: To establish a guideline for the use of teleconsultation, which is one of the most important applications in telemedicine beeing perfomed very frequently in daily medical practice in almost any field of medicine. EVIDENCE: The recommendations are based on expert knowledge, because of the lack of evidence based data in the telemedical scientific literature. In addition, scientific articles of the highest level of evidence available published between 1970 and 1999 were reviewed. DEVELOPEMENT AND CONSENUS PROCESS: A guideline draft was prepared using the attributes of clinical practice guidelines developed by the Institute of Medicine (IOM) of the National Academy of Sciences. This draft was reviewed by telemedicine experts and the content of the guideline was approved by 100% group consensus in 5 meetings held between 1997 and 2000 by a panel of members of the Subproject 4 Group of the Global Health Care Application Project of the G8 countries. CONCLUSIONS: The guideline gives recommendations on all aspects of teleconsultation in any field of medicine and will be updated regularly implementing new evidence.

Computer Security↗

[The "Young Researchers" project--the effect on scientific research and educational potential in Slovenia].

The aims and the development of the "Young Researchers" project, financed and headed by the "Research Association of Slovenia", have been described in this article. The goal of this project is to obtain new personnel resources for scientific research and developmental functions with a substantial expansion of personnel potential in research activity; a proportion of the 2000 young researchers is supposed to take part in the project by the end of 1990. They will renew the advisory personnel (researchers for renovation), and the other part, together with a defined number of already qualified researchers from research and university organizations, should be involved directly in immediate development and new production (researchers for development). The authors pointed to employment problems of new resources of young researchers (problems of administrative nature), as well as problems of qualification, and those of financial nature which appeared gradually during the implementation of the project. The actual project status has been presented after four years of its implementation, and the success of the project up to now, has been evaluated in terms of the project in general, and in medical science especially.

Research Personnel↗

A clinical simulations laboratory ten years later.

Ten years ago a significant investment was made in simulations technology for medical education. A simulations complex was developed at St. Louis University School of Medicine consisting of a Group Activity/Observation Area, Skills Area, and simulated Physicians Offices Suite complete with observation and videotaping facilities. Since its inception, medical school faculty and other health science educators have utilized this area in ever-expanding and innovative ways. This is a success story about medical educators taking risks, implementing new ideas, and realizing those ideas.

Curriculum↗

A statewide approach to health care personnel maldistribution. The California Area Health Education Center System.

An Area Health Education Center (AHEC) system has been established in California to address the maldistribution of physicians and other health care professionals. The AHEC program uses educational incentives to recruit and retain health care personnel in underserved areas by linking the academic resources of university health science centers with local educational and clinical facilities. The medical schools, working in partnership with urban or rural AHECs throughout the state, are implementing educational programs to attract trainees and licensed professionals to work in underserved communities. The California AHEC project entered its fifth year in October of 1983 with the participation of all eight medical schools and the Charles Drew Postgraduate School of Medicine, 35 other health professions schools, 17 independent AHECs and more than 400 clinical training sites. Educational programs are reaching more than 22,000 students and practicing health professionals throughout California. We review the current status of the California AHEC system and use the AHEC programs at Loma Linda University to illustrate the effect this intervention is having.

Area Health Education Centers↗

Change in junior high school students' AIDS-related knowledge, misconceptions, attitudes, and HIV-preventive behaviors: effects of a school-based intervention.

A school-based AIDS-prevention program for junior high school students was developed and implemented in an inner-city area in northern California that serves predominantly African-American and Asian students. The curriculum, taught by science teachers, consisted of twelve classroom sessions using both didactic and interactive exercises covering sex education, HIV biology, drug use, decision-making and refusal skills, and public response to AIDS and community resources. Changes from baseline of self-reported responses to questions on pre- and posttests concerning AIDS knowledge and misconceptions, tolerance toward persons with AIDS, and high-risk behaviors were compared between intervention and control schools. Students in the intervention schools had a significant increase in AIDS knowledge (p < .0001) and became more tolerant of people with AIDS (p < .001) compared with students in the control school. Changes in high risk behavior could not be detected, perhaps due to the small number of sexually active students (24% of the sample). Students who increased their AIDS knowledge (p < .0001) as a result of the intervention became more tolerant of people with AIDS. A school-based HIV-prevention curriculum, taught by trained classroom teachers, can modify middle adolescents' HIV-related knowledge about the casual transmission of HIV, and their attitudes toward persons with AIDS.

Adolescent↗

Evaluation of monograph selection in a health sciences library.

This article reports on an evaluation of recent monograph selections in a small academic health sciences library. Actual use of each new book was determined from date-due slips. Data were analyzed by broad subject, discipline, and number of uses. The startling result was that more than 60% of recent selections had been used little or not at all. To determine factors affecting use, the author examined aggregate data, used intuition, and assessed the raw data in more detail. Recommendations made to management were approved and implemented. The study bolstered confidence that it is possible to select materials with the highest potential for use and to depend on remote access for other needed works. It is suggested that other health sciences libraries undertake such studies and question the need to strive for comprehensive collections.

Book Selection↗