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PubMed1994

Drug therapy and memory training programs: a double-blind randomized trial of general practice patients with age-associated memory impairment.

A double-blind randomized trial was performed involving 162 patients with age-associated memory impairment (AAMI) selected and followed by their general practitioners. Two intervention methods--a drug and a cognitive therapy--were assessed in combination. Three randomized parallel groups of 54 patients each, aged 55 years and over, were followed and treated for 3 months. After a placebo wash-out period of 10 days, one group received 2.4 g of piracetam, another group, 4.8g, and the third, a placebo. A total of 135 patients, 45 in each group, completed the study. Combined therapy was most effective in patients whose baseline performance on memory tests was lowest. The best results were observed with 4.8 g of piracetam, especially when training sessions began after 6 weeks of drug treatment. This result was confirmed by the global impression of the principal investigator.

Aged↗

PubMed1996

Concurrent validity of Spanish-language versions of the Mini-Mental State Examination, Mental Status Questionnaire, Information-Memory-Concentration test, and Orientation-Memory-Concentration test: Alzheimer's disease patients and nondemented elderly comparison subjects.

One-hundred fifty-eight elderly Spanish-speaking U.S. residents (81 patients diagnosed with Alzheimer's disease and 77 subjects without dementia) were tested with Spanish-language versions of four brief cognitive assessment instruments: the Mini-Mental State Examination (S-MMSE), the Mental Status Questionnaire (S-MSQ), the Information-Memory-Concentration test (S-IMC), and the Orientation-Memory-Concentration test (S-OMC). Within-group performances were highly correlated for all four instruments. All tests distinguished between the demented and nondemented groups, but best discrimination was achieved with the S-IMC, which correctly classified 98% of subjects. This version was also the best predictor of functional disability, as measured by impairments in instrumental activities of daily living. Within the normal comparison group, neither gender nor a subject's monolingual/bilingual status affected test performance. These four Spanish-language cognitive screening tasks may aid in the evaluation of dementia among Spanish-speaking patients.

Adult↗

PubMed1996

Memories out of order: thought suppression and the disturbance of sequence memory.

Participants in 2 experiments watched a filmed story and then left the lab--with instructions not to think about the film, with instructions to think about the film, or with no instructions. Memories of the film, assessed on participants' return to the lab some 5 hr later, showed reliable effects of thought suppression on memory for the sequence of events in the film. Participants who suppressed thoughts of the film were less able to retrieve the order of events by several measures than were those in the other groups, even thought their retrieval of the events themselves as assessed by recognition, free recall, and cued recall was not generally impaired.

Adult↗

PubMed2000

Working-memory capacity, proactive interference, and divided attention: limits on long-term memory retrieval.

Two experiments examined how individual differences in working-memory capacity (WM) relate to proactive interference (PI) susceptibility. We tested high and low WM-span participants in a PI-buildup task under single-task or dual-task ("load") conditions. In Experiment 1, a finger-tapping task was imposed during encoding and retrieval of each list; in Experiment 2, tapping was required during encoding or retrieval. In both experiments, low spans showed greater PI than did high spans under no load, but groups showed equivalent PI under divided attention. Load increased PI only for high spans, suggesting they use attention at encoding and retrieval to combat PI. In Experiment 2, only low spans showed a dual-task cost on List 1 memory, before PI built up. Results indicate a role for attentional processing, perhaps inhibitory in nature, at encoding and retrieval, and are discussed with respect to theories of WM and prefrontal cortex function.

Adult↗

PubMed1994

Spatial memory and N-methyl-D-aspartate receptor antagonists APV and MK-801: memory impairments depend on familiarity with the environment, drug dose, and training duration.

Rats given N-methyl-D-aspartate (NMDA) antagonists were tested in the radial maze in spatial working memory (WM) and reference memory (RM) tasks. Female rats given (+)-10,11-dihydro-5-methyl-5H-dibenzo [a,d] cycloheptene-5,10 imine (MK-801; 0.0625 mg/kg ip) before daily testing in an 8-arm WM task were impaired even after 70 days. Control rats learned quickly, were assigned to a group given MK-801 or saline, and were trained to avoid 4 of the 8 arms. MK-801 impaired this reversal learning but did not affect WM performance. Male rats were trained on an 8-arm WM task for 19 days and then given intracranial aminophosphonovaleric acid (APV; 33 mM), which impaired both WM and motor behavior. Male rats were trained for 65 days to enter 4 of 8 arms and then given intracranial APV (20 or 30 mM). WM and RM were normal in the familiar environment but were both impaired in an unfamiliar environment. Results suggest that the mnemonic effects of NMDA antagonists depend on environmental familiarity, dose, and training duration.

2-Amino-5-phosphonovalerate↗

PubMed1994

Young children's performance on a task sensitive to the memory functions of the medial temporal lobe in adults--the delayed nonmatching-to-sample task--reveals problems that are due to non-memory-related task demands.

Delayed nonmatching-to-sample performance was examined in children and found to be poor from 12 months until almost 2 years even at 5-s delay, although 5 s is well within such children's memory capacity. After 12 months of age, performance did not differ by delay (5 or 30 s). Because children's problems seemed largely unrelated to the task's memory demands, the 2 final studies explored the role of other cognitive abilities (deduction of an abstract rule, speed of processing, and resistance to interference or distraction). Telling children the rule or quadrupling sample presentation time had little effect. Because a salient stimulus (the reward) might interfere with keeping one's attention on the sample, the reward was omitted during initial sample presentation. This helped; at the 5-s delay, 15-month-olds performed at least as well as 21-month-olds in the basic condition, and 12-month-olds performed almost as well. Implications for the cognitive abilities improving during the 2nd year and for the functions of the medial temporal lobe are discussed.

Aptitude↗

PubMed2003

Long-term semantic memory versus contextual memory in unconscious number processing.

Subjects classified visible 2-digit numbers as larger or smaller than 55. Target numbers were preceded by masked 2-digit primes that were either congruent (same relation to 55) or incongruent. Experiments 1 and 2 showed prime congruency effects for stimuli never included in the set of classified visible targets, indicating subliminal priming based on long-term semantic memory. Experiments 2 and 3 went further to demonstrate paradoxical unconscious priming effects resulting from task context. For example, after repeated practice classifying 73 as larger than 55, the novel masked prime 37 paradoxically facilitated the "larger" response. In these experiments task context could induce subjects to unconsciously process only the leftmost masked prime digit, only the rightmost digit, or both independently. Across 3 experiments, subliminal priming was governed by both task context and long-term semantic memory.

Attention↗

PubMed2006

Comparing two perceived characteristics of autobiographical memory: Memory detail and accessibility.

Four samples of participants recalled autobiographical memories. While some evidence emerged from regression analyses suggesting that judgements of the amount of detail contained in each memory and judgements of the ease with which events could be recalled were partially independent, the analyses generally showed that these judgements were similarly predicted by various event characteristics (age, typicality, self-importance, emotional intensity at event occurrence, rehearsal types). Co-occurrence frequency data yielded similar conclusions, showing that while ease ratings and detail ratings occasionally diverged, they were more often consistent with each other. Finally, the data also suggested that events that prompted emotional ambivalence were not judged to be more easily recalled, or to contain more detail, than non-ambivalent events.

Adolescent↗

PubMed1997

Left and right hemisphere memory traces: their formation and fate. Evidence from events during memory formation in the chick.

In the domestic chick, different versions of a particular learning experience are elaborated by right and left hemispheres (left: selection of cues allowing selection of appropriate response; right: elaboration of relatively complete and unselected record). During memory formation, further processing of the traces is associated with a series of brief points of trace reactivation, which recur with differing periodicity in association with the two hemispheres (16 min: left; 25 min: right). As a result there is a series of near coincidences, which allow interaction between the two traces. The first, at 48-50 min, is associated with such marked changes in what is available to recall that it has been identified as the onset of long-term memory. The period is shown here to begin with a left hemisphere event, which overlaps with a right hemisphere event, beginning at 50 min, in a way that helps to explain why the interaction that occurs at this time is predominantly one in which the left hemisphere accesses right hemisphere material. It is argued that the main change during hemispheric interaction is the establishment of linkages between different trace ''fragments''.

Journal Article↗

PubMed2003

A prospective study of memory for child sexual abuse: new findings relevant to the repressed-memory controversy.

Previous research indicates that many adults (nearly 40%) fail to report their own documented child sexual abuse (CSA) when asked about their childhood experiences. These controversial results could reflect lack of consciously accessible recollection, thus bolstering claims that traumatic memories may be repressed. In the present study, 175 individuals with documented CSA histories were interviewed regarding their childhood trauma. Unlike in previous studies, the majority of participants (81%) in our study reported the documented abuse. Older age when the abuse ended, maternal support following disclosure of the abuse, and more severe abuse were associated with an increased likelihood of disclosure. Ethnicity and dissociation also played a role. Failure to report CSA should not necessarily be interpreted as evidence that the abuse is inaccessible to memory, although inaccessibility or forgetting cannot be ruled out in a subset of cases.

Adolescent↗

PubMed1995

Language, memory, and aging: an electrophysiological exploration of the N400 during reading of memory-demanding sentences.

Twenty-four young and 24 middle-aged academics carried out a language recognition task in which sentences were presented that made either a high or a low demand on working memory (WM). The sentences ended either normally (i.e., congruent) or with an incongruous word. Middle-aged subjects had smaller WM scores, a marginally slowed down recognition performance, and a smaller and delayed N400 component. The event-related potential (ERP) difference between congruent and incongruent endings was smaller in the high-load condition for younger subjects and totally disappeared for the middle-aged subjects. ERPs for all subjects showed a WM-related positivity in the middle of the sentence and a WM-related negativity at the sentence ending. These shifts could be associated with either storage and retrieval processes or with clause wrap-up processes. Most ERP-effects were dependent on WM capacity. Age differences in sentence processing are not simply explained by age itself but depend to a large extent on individual memory capacity.

Adult↗

PubMed1999

In memory of loved ones who have enriched our lives: helping staff create and hold memorial services in nursing homes.

This article describes the introduction of periodic memorial services in a nursing home for residents who died. The planning process as well as objections and concerns are discussed. A sample service is described, including the letter of invitation to family members and friends of deceased residents. The article concludes with three sample "tributes" to those whose lives were celebrated in a memorial service.

Aged↗

PubMed1992

Interference in memory for tonal pitch: implications for a working-memory model.

The degree of interference caused by different kinds of stimuli on memory for tonal pitch was studied. Musically trained and untrained subjects heard a sequence of two tones separated by an interval of 5 sec. The tones were either identical in pitch or differed by a semitone. Subjects had to decide whether the tones were identical or not. The interval was filled with tonal, verbal, or visual material under attended and unattended conditions. The results revealed clear group differences. Musically trained subjects' retention of the first test tone was only affected by the interposition of other tones. In contrast, the performance of musically untrained subjects was also affected by verbal and visual items. The findings are discussed in the framework of Baddeley's (1986) working-memory model.

Adult↗

PubMed1999

Impaired allocentric spatial working memory and intact retrograde memory after thalamic damage caused by thiamine deficiency in rats.

Rats were tested on an allocentric-spatial working-memory task--delayed matching-to-place (DMTP) in a water maze--before and after either pyrithiamine-induced thiamine deficiency (PTD) or electrolytic lesions of the lateral internal medullary laminae (IML), an area damaged by PTD. DMTP trials consisted of paired swims, with the escape platform in a new location on each trial. PTD rats were impaired at retention delays of 300 s, but not at delays of 4 or 60 s. Rats with IML lesions performed normally at all delays. Both groups displayed normal retention of object-discrimination problems that they had learned at different intervals before treatment (5 weeks, 3 weeks, and 1 week). The results suggest that PTD causes delay-dependent deficits of allocentric spatial working memory and that damage outside the IML is probably responsible. Neither PTD-induced diencephalic damage nor restricted IML lesions appear to produce a global retrograde amnesia.

Animals↗

PubMed1998

Memory Clinics in Switzerland. Collaborative Group of Swiss Memory Clinics.

Currently, eleven Memory Clinics (MC) in Switzerland offer their services to patients, caregivers and family doctors. Their primary goal is the early diagnosis and management of dementia in elderly outpatients. Special emphasis is put on the detection of reversible causes of dementing disorders. Diagnoses and medical, pharmacological, neuropsychological and social treatment recommendations are established in a multidisciplinary consensus conference and communicated back to the referring physicians. The psychosocial therapies and supportive activities include counseling, memory training for patients, neuropsychological rehabilitation, caregiver groups, relaxation and biofeedback training, day care centers, Alzheimer's Tanzcafé, and special vacations for dementia patients. These activities vary from MC to MC according to the availability of resources. Research activities are an integral part of all MCs and range from the attempt to identify preclinical markers of Alzheimer's disease to studies of neuropathological correlates of cognitive disturbances. Moreover, patients are encouraged to participate in studies investigating new medications. MCs play an important role in the education and training of health care professionals and in raising awareness and support in the general population.

Aged↗

PubMed2004

Static telepathology consultation service between Tata Memorial Centre, Mumbai and Nargis Dutt Memorial Charitable Hospital, Barshi, Solapur, Maharashtra: an analysis of the first 100 cases.

Telepathology is the practice of pathology at a distance. Static telepathology is employed to achieve teleconsultation between a tertiary cancer referral centre, Tata Memorial Centre and a sister concern in rural area viz. Nargis Dutt Memorial Cancer Hospital, Barshi, Solapur. This is an analysis of the first 102 cases. Two transcontinental consultations have not been included in statistical analysis. A diagnosis was offered in 99 (99%) cases; whereas it was deferred in only I (1%) case. Clinically important or relevant diagnosis were achieved in 93/ 99 (93.93%) of cases. Major discrepancies were encountered in 6/99 (6.06%) of cases. A total of 79% of cases were reported within 3 days, of which 32% were reported within 8 hours (a single working day) and 47% within 1-3 days. Telemedicine can be used effectively to bridge the gap between medically underprivileged, geographically distant rural areas and advanced centers with technical expertise using cheaper static store and forward methodology.

Cancer Care Facilities↗

PubMed1994

The activity of synaptosomal calcium channels is inversely correlated with working memory performance in memory impaired, aged rats.

Aged, memory-impaired rats do not learn an 8-arm radial maze task but differ in their performance along testing. The aim of this study was to determine whether any of the systems that govern calcium homeostasis in synaptosomes may be related to that difference in performance. A negative correlation between initial (5 s) K(+)-stimulated 45Ca2+ uptake and the behavioral scores from the last testing sessions was obtained K(+)-stimulated 45Ca2+ uptake showed also a negative correlation with an improvement score that evaluates the progress made by the rat along testing. The results support the notion that calcium inflow through synaptosomal voltage gated calcium channels in old rats is inversely correlated with their behavior. This may explain the beneficial effects of organic calcium channel blockers on behavioral performance in aged animals.

Aging↗

PubMed2003

The subtype-selective nicotinic acetylcholine receptor agonist SIB-1553A improves both attention and memory components of a spatial working memory task in chronic low dose 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated monkeys.

Monkeys that receive chronic low dose (CLD) 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration develop deficits in spatial delayed-response task performance. The present study examined the extent to which SIB-1553A [(+/-)-4-[[2-(1-methyl-2-pyrrolidinyl)ethyl]thio]phenol hydrochloride], a novel neuronal nicotinic acetylcholine receptor (nAChR) agonist with selectivity for beta4 subunit-containing nAChRs, could counteract this cognitive deficit produced by CLD MPTP exposure. Prior to MPTP treatment, monkeys displayed a delay-dependent decrement in performance on a variable delayed response task. CLD MPTP treatment caused a shift to a delay-independent pattern of responding on this task, such that short-delay trials were performed as poorly as long-delay trials. At lower doses (e.g., 0.025 mg/kg), SIB-1553A significantly improved performance on short-delay trials but only at 24 h after drug administration. At higher doses (e.g., 0.50 mg/kg), SIB-1553A significantly improved performance on both short- and long-delay trials at both 20 min and 24 h after drug administration. When tested 24 h after drug administration, monkeys performed long-delay trials with greater accuracy than they did under normal (pre-MPTP) conditions. These results suggest that at lower doses, SIB-1553A may be more effective in improving attentional deficits associated with CLD MPTP exposure, whereas at higher doses, SIB-1553A may effectively improve both attentional and memory performance.

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine↗