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PubMed1989

[Standardization by arm span of lung function tests in the elderly].

Kypho(scolio)sis in the elderly is known to cause body height reduction, and this may result in inaccurate estimation in the calculation of various predicted values based on body height in lung function test. A total of 91 patients without any known cardiopulmonary diseases were studied for the relationship between body height, arm span and predicted values of lung function tests. In addition, the kyphotic angle was evaluated for the quantitative assessment of the kyphosis. Our results showed that kyphoscoliosis in the elderly resulted in under- or overstimulation of an average of 1.2-3.9% when the arm span was used instead of the body height to obtain the predicted value of vital capacity. Furthermore, there was no significant correlation among the following parameters: the severity of kyphosis, body height or arm span and age. The arm span showed a good correlation with the body height. From these observations, it was concluded that instead of the body height the arm span could be used for calculating the predicted value on lung function tests as a more convenient methods in bed-ridden patients.

Aged↗

PubMed1995

Effect of rhDNase on lung function and quality of life in adult cystic fibrosis patients.

Accumulation of viscous sputum enhances lung damage in patients with cystic fibrosis. High contents of DNA, released by leucocytes, are the major cause of the high viscosity of this sputum. Recombinant human DNase I (rhDNase) decreases viscoelastic properties of sputum in cystic fibrosis and improves lung function. We have investigated the effect of rhDNase over a period of 6 weeks, 2.5 mg once daily, on lung function and quality of life in 12 adult patients with cystic fibrosis. Significant improvements in FEV1, IVC and daily peak flow values were measured. Airway resistance and FVC did not improve significantly. The cause of the improvements found is probably due to recruitment of previously, due to mucus plugging, unventilated lung areas. In addition, the awareness of symptoms related to sputum retention improved, although subjective parameters on general well-being and physical condition remained unchanged.

Adolescent↗

PubMed1994

Influence of lung function and reflex activity on the success of patient-triggered ventilation.

The influence of lung function and reflex activity on the success of patient-triggered ventilation (PTV) has been determined. Lung function was assessed by measurement of compliance using a single breath technique. Reflex activity was assessed by measurement of the strength of Hering Breuer reflex indicated by the degree of prolongation of expiration following end inspiratory occlusion. PTV was considered to have failed if the infant became apnoeic or required an increased level of respiratory support. Twenty premature infants (median gestational age 29 weeks) in the recovery stage of respiratory distress, were studied at a median postnatal age of 2.5 days. PTV failed ultimately in six infants, although compliance of the respiratory system of that group did not differ significantly from the rest of the cohort, their Hering Breuer reflex was significantly weaker (P < 0.01). In addition, the infants in whom PTV failed were significantly more immature and of lower birthweight (P < 0.01) compared with those in whom it succeeded. We conclude that failure of PTV is more likely in immature infants who have a weak Hering Breuer reflex.

Humans↗

PubMed2002

Prospective study of diet and decline in lung function in a general population.

We have investigated the relationship between decline in lung function and dietary intakes of magnesium, vitamin C, and other antioxidant vitamins in a general population cohort in Nottingham, United Kingdom. In 1991, we measured dietary intake by semiquantitative food frequency questionnaire, forced expiratory volume in 1 second (FEV1), and respiratory symptoms in a cross-sectional survey of 2,633 adults aged 18-70. Nine years later we repeated these measures in 1,346 of these individuals. In cross-sectional analyses, after adjustment for smoking and other confounders, higher intakes of vitamin C and magnesium, but not vitamins A or E, were associated with higher levels of FEV1 in both 1991 and 2000. In longitudinal analysis with adjustment for confounders, decline in FEV1 between 1991 and 2000 was lower amongst those with higher average vitamin C intake by 50.8 ml (95% confidence interval, 3.8-97.9) per 100 mg of vitamin C per day, but was unrelated to magnesium intake. There was no relationship between decline in FEV1 and intake of vitamins A or E. This study suggests that a high dietary intake of vitamin C, or of foods rich in this vitamin, may reduce the rate of loss of lung function in adults and thereby help to prevent chronic obstructive pulmonary disease.

Adult↗

PubMed1989

Lung function and respiratory symptoms among workers in a soft paper mill.

The aim of the present cross-sectional study was to investigate whether long-term exposure to soft paper dust causes impairment of lung function. Exposed workers (n = 287) and referents (n = 79) were investigated, using spirometry and questionnaires. Personal samplings of total dust showed that the actual mean concentrations did not exceed 3 mg/m3. The exposed subjects were divided into three categories according to historical and present exposure to paper dust; low exposure, moderate exposure and high exposure. The study did not show any lung function impairment due to exposure to paper dust. However, the exposed subjects had a significantly increased prevalence of symptoms from both the upper and lower airways as well as an increased prevalence of reported asthma. On the basis of our study, we conclude that lung function impairment does not occur among workers exposed to mean levels of soft paper dust below 5 mg/m3.

Cross-Sectional Studies↗

PubMed1994

Comparison of the effects on lung function of two methods of bronchodilator administration.

The aim of this study was to assess if administration of bronchodilator via a metered dose inhaler (MDI), rather than by a nebulizer, avoided the early paradoxical deterioration in lung function but, resulted in equally effective late bronchodilation. Fifteen children were studied at a median postnatal age of 9 months (range 9-18), all had been born prematurely at a median gestational age of 27 weeks (range 23-31). Lung function was measured by plethysmography before and 10 min after normal saline and 5 and 15 min after salbutamol given via an MDI and a nebulizer in random order. At 5 min, compared to baseline values, airways resistance (RAW) deteriorated by 16% after nebulized salbutamol but improved by 3% following salbutamol by the MDI (P < 0.03). At 15 min RAW improved by 14% following nebulized salbutamol and 15% after salbutamol via the MDI, there was no significant difference in the magnitude of bronchodilation between the two methods of administration. Our results therefore suggest, that as the early paradoxical deterioration in lung function is usually avoided by administering salbutamol via an MDI, this should be the preferred method of administration.

Aerosols↗

PubMed1991

Relationships between lung function and physical characteristics in young adult black and white males and females.

The relationships of lung function to physical characteristics in young adults have not been adequately described for different gender-race groups in the United States. As part of a study of the effects of ozone exposure upon Black and White men and women, we measured lung volumes, expiratory flow rates, and airways resistance on a sample of 314 healthy 18-35 yr old nonsmokers. Regression analysis indicated that lung function was adequately described as a linear function of either height or sitting height in each of the four groups, and that while not always significant, gender and race differences in the height and sitting height coefficients were consistently present with those of males and Whites larger than those of females and Blacks, respectively. Lung volumes were frequently observed to be associated with body mass index as measured by Quetelet Index (weight.height.2). The best fitting gender-race specific multiple regression models including these terms and occasional age terms are presented. Two additional models are presented, one of which simultaneously adjusts for both gender and race, and the other of which adjusts for gender for a given race. Comparison of predicted values from our study to those of other studies suggests that the population samples from this study may be similar to those of other American populations reported upon by others.

Adolescent↗

PubMed2006

The influence of large-scale airborne particle decline and traffic-related exposure on children's lung function.

Between 1991 and 2000, ambient air pollution in East Germany changed to resemble West German pollution levels: The concentration of total suspended particles (TSPs) decreased on a broad scale while traffic increased. During that time, we analyzed total lung capacity (TLC) and airway resistance (R(aw)) of East and West German children. We tested children 5-7 years of age (n = 2,574) with cooperation-independent body plethysmography in repeated cross sections. We used random-effect models to determine the mutually adjusted association between lung function and short-term and chronic particle exposure and its interaction with living near a busy road. Annual averages of TSPs declined from 77 to 44 microg/m2; averages on the day of investigation declined from 133 to 30 microg/m2. Differences in lung function between East and West German children vanished during the investigation time. The association of TSPs with R(aw) and TLC was stronger in children living > 50 m away from busy roads. East German children from this group had an R(aw) 2.5% higher [95% confidence interval (CI), 0.0-5.1%] per 40-microg/m2 increase of daily TSP averages. TLC decreased by 6.2% (95% CI, 0.04-11.6%) per 40-microg/m2 increase in annual mean TSPs, and this effect was equally pronounced in East and West Germany. TSP exposure decreased on a broad scale between 1991 and 2000. Lower concentrations of TSPs were associated with better measures of lung function in 6-year-old children. For children living near busy roads, this effect was diminished.

Air Pollutants↗

PubMed2003

Temporary tracheal occlusion in fetal sheep with lung hypoplasia does not improve postnatal lung function.

Prolonged fetal tracheal occlusion (TO) accelerates lung growth but leads to loss of alveolar epithelial type II (AE2) cells. In contrast, temporary TO leads to recovery of AE2 cells and their ability to produce surfactant. The aim of this study was to determine the effects of temporary TO in fetal sheep with lung hypoplasia on postnatal lung function, structure, and surfactant protein mRNA expression. Diaphragmatic hernia (DH) was created in 22 fetal sheep at 65 days of gestation. TO was performed between 110 days of gestation and full term (DH/TO, n = 7) and between 110 and 130 days of gestation (DH/TO+R, n = 6). Sham-operated fetuses (n = 11) served as controls. Lambs were delivered at approximately 139 days of gestation, and blood gas tensions were monitored over a 2-h resuscitation period. Temporary TO increased growth of the hypoplastic lung and restored surfactant protein mRNA expression and AE2 cell density but did not improve respiratory function above that of animals that underwent prolonged TO; DH/TO and DH/TO+R lambs were hypoxic and hypercapnic compared with Sham animals. Lung compliance remained low in DH/TO+R lambs, most likely as a consequence of the persistent increase in alveolar wall thickness in these animals.

Animals↗

PubMed1995

Effects of cigarette smoking on lung function in four population samples in the People's Republic of China. The PRC-US Cardiovascular and Cardiopulmonary Epidemiology Research Group.

As part of an ongoing study of cardiopulmonary risk factors in the People's Republic of China, we conducted lung function tests and obtained information about smoking habits on 6,765 Chinese men and women 35 to 56 yr of age residing in or around Beijing in the north and in or around Guangzhou in the south. Within each region, separate urban and rural populations were recruited. This study examined the relationship between tobacco consumption (both manufactured cigarettes and leaf tobacco) and lung function in a subset of current smokers and never smokers who had acceptable lung function data. All methods were strictly standardized. Overall, tobacco smoking was associated with a statistically significant mean difference in FEV1 among men (-89 ml) and women (-52 ml) relative to never smokers after adjusting for age, height, and residence. Differences between smokers of cigarettes and smokers of leaf tobacco were not significant. Among the subset of smokers who smoked only cigarettes, this decrement increased with increasing duration of cigarette smoking, but it was small (-4 ml/yr of smoking for FEV1 for both men and women) in comparison with the effects of smoking reported from western countries. Although the smoking effect tended to increase with increasing dose, these differences were small and generally not statistically significant. The relatively small smoking effect in this study may result from differences between developed and developing countries in the cumulative dose of tobacco products. Alternative explanations or contributing factors such as racial differences in susceptibility and differences in the form and delivery of tobacco cannot be discounted.

Adult↗

PubMed1997

Nasal septum lesions and lung function in workers exposed to chromic acid in electroplating factories.

The objective of this study was to compare workers from chromium, nickel-chromium, and zinc electroplating factories with regards to nasal septum lesions and lung function. Also investigated was the relationship between chromium levels in air and urine. A total of 189 workers from 11 electroplating factories (three chromium, six nickel-chromium, two zinc) were chosen from central Taiwan. All subjects were interviewed by constructed-questionnaire, given a nasal examination by a certified otolaryngologist and a lung function test. In the chromium factories 30.8% of the workers showed evidence of nasal septum perforations and 38.5% showed evidence of nasal septum ulcers. A Mantel extension test for trend showed that workers in the chromium factories were 31.7 times more likely to experience nasal ulcers than nickel-chromium and zinc factory workers. Those who worked in the electroplating tank area were 4.2 times more likely to experience ulcers and those with over 9 years' experience were 30.8 times more likely. A comparison of lung function adjusted for age, gender and smoking habit among workers showed that vital capacity (VC), forced vital capacity (FVC), and forced expiratory volume in 1 s (FEV1) were all significantly decreased among chromium factory workers. Because the results showed that the workers' health is being severely damaged by the harmful environment of chromium electroplating factories, the authors wish to suggest improvements in the workplace are vitally needed to ensure the safety of the workers.

Adult↗

PubMed1978

Smoking, lung function, physical performance and latent coronary heart disease in presumably healthy middle-aged men.

During a cardiovascular survey comprising 2014 presumably healthy men aged 40-59 years, latent (previously undetected) coronary heart disease (CHD), lung function and physical performance were related to differences in smoking habits. The survey examination classified 1 832 individuals as "normals" (without clinical signs/symptoms of CHD). Among the others, a strong supicion of CHD was found in 115, of whom 105 had diagnostic coronary angiography. No angiography was performed in another 35 individuals with slight, albeit typical angina pectoris. The remaining 42 men were excluded from this presentation for various reasons. The following findings were obtained: 1) in the 69 men with positive coronary angiography, the extent of coronary atheromatosis was positively related to the number of cigarettes smoked. 2) The smoking habits of the 35 individuals with slight angina pectoris but no angiography did not differ from those of the "normals". 3) Physical performance during a near maximal bicycle exercise test and lung function according to spirometry were strongly and negatively related to smoking (in "normals"). 4) Previous smokers and never-smokers among "normals" had almost identical lung function and physical performance.

Adult↗

PubMed1997

Atopy, lung function and bronchial responsiveness in symptom-free paediatric asthma patients.

In adolescence, some paediatric asthma patients will become symptom-free and require no further treatment. There is little information on the atopic status, lung function and bronchial responsiveness of these patients. Symptom-free asthma patients (n=118) aged 7.7-19.2 yrs, were evaluated 1 year after termination of therapy. Bronchial asthma had previously been diagnosed on the basis of recurrent wheezing episodes. Atopic status was assessed by skin-prick testing. Baseline lung function was measured by spirometry, flow-volume curve and plethysmography. Bronchial responsiveness was assessed nonpharmacologically by cold dry air challenge. Eighty one patients had at least one positive skin test result, and the remaining 37 were defined as nonatopic. In atopic subjects, the prevalence of bronchial hyperresponsiveness was significantly higher than in nonatopic patients (41 out of 81 versus 7 out of 37; p=0.001). Atopic subjects showed a significantly lower maximal expiratory flow at 25% remaining vital capacity (p<0.05) and a higher residual volume (p<0.05) than nonatopic subjects. Nonatopic subjects were significantly younger than atopic patients (p<0.01). These symptom- and medication-free paediatric and adolescent asthma patients could, thus, be divided into two groups: 1) atopic subjects with a tendency towards bronchial hyperresponsiveness; and 2) nonatopic subjects with better lung function and normal bronchial responsiveness In view of the increased understanding of the epidemiology of early childhood wheezing, these findings support the concept of different pathogenic mechanisms underlying wheezing episodes in early childhood.

Adolescent↗

PubMed1995

[Long-term prognosis of pulmonary sarcoidosis. 1. Prognostic value of lung function and symptoms].

A follow-up of 254 patients with intrathoracic sarcoidosis has been carried out after a median of 27 years from diagnosis. All patients could be traced. No excess mortality was found (80 deaths observed versus 66 expected). The causes of death were related to sarcoidosis in 41%. X-ray stage was related to survival with a significant excess mortality for stage 3. Early clearing of X-ray changes gave a favourable vital prognosis. Survival was related to lung function, especially forced expiratory volume in 1 second (FEV1) and total lung capacity (TLC). All deaths from sarcoidosis were seen among patients with respiratory symptoms at presentation. For sarcoidosis & sarcoidosis-related deaths (N = 33), presence of one or more of the respiratory symptoms increased the risk significantly. For overall mortality respiratory symptoms were also significant predictors; this was the case even after adjusting for age, sex, x-ray stage and lung function (FEV1 & TLC) at presentation. In conclusion, no excess mortality was observed after a median of 27 years follow-up. Lung function, respiratory symptoms and to some extent X-ray stage at time of diagnosis influenced long-term mortality in patients with intrathoracic sarcoidosis.

Adult↗

PubMed1997

[Effect of various factors on the results of lung function tests using multifrequent impulse oscillometry in calves and young cattle].

The applicability of impulse oscillometry (IOS) under clinical and field conditions was tested on 31 calves and 27 young bulls over a period from 3 to 5 months, respectively. Based on the obtained 492 test results (the average of four measurements), lung function criteria resistance and reactance, measured at frequencies of 5 to 15 Hz, showed to be diagnostically relevant. In healthy calves aged 4 to 12 weeks, resistance values lay between 0.22 to 0.36 kPa/(l/s) irrespective of frequency. Reactance values were in the range of -0.014 to 0.055 kPa/(l/s) at 5 Hz, but increased with growing frequency. Within the investigated groups no correlation could be established between factors age or body mass of the animals and resistance. Increasing age, however, led to a considerable increase in reactance. Alterations of the upper airway system were coupled with an increase in resistance values while reactance remained constant. Diagnostic evaluation of individual results relating to this category was hampered by the high interindividual test value variance of 25 to 31% between healthy animals. Diseases of the peripheral respiratory system, however, were clearly characterised by a significant decrease in reactance, as well as a negative frequency dependence of resistance. It is concluded that this method at lung function testing provides a sensitive tool for detecting and recording lung function disorders in young cattle.

Aging↗

PubMed2005

Perception of dyspnea in asthmatics with normal lung function.

UNLABELLED: The perception of dyspnea varies widely among asthmatics and it is influenced by many factors. The aims of our study were to investigate the perception of dyspnea during methacholine-induced bronchoconstriction in asthmatics with normal lung function and to evaluate the influence of bronchial responsiveness, age and gender to dyspnea perception in these patients. A total of 192 outpatients (aged 16-77 years) with stable asthma and normal lung function were examined. Methacholine challenge test was performed to each patient. The provocative dose of methacholine that reduces forced expiratory volume in 1 sec. (FEV1) by 20% (PD20) was estimated. Dyspnea perception of bronchoconstriction was evaluated using a Borg Scale and calculating the perception score corresponding to a fall in FEV1 of 20% (PS20). According to PS20+/-1 standard deviation subjects were divided into three groups: hypoperceivers, normoperceivers and hyperperceivers. From the hypoperceivers group we set up asthmatics with PS20=0 and defined them as nonperceivers. We found out that 43 (22.4%) patients were hypoperceivers, 116 (60.4%)--normoperceivers and 33 (17.2%)--hyperperceivers. The nonperceivers presented 6.3% (n=12) of all subjects. PD20 positively correlated with PS20 (r=0.252, p<0.001). Hypoperceivers showed significantly higher bronchial hyperesponsiveness (PD20=174+/-28 microg) comparing with hyperperceivers (PD20=323+/-50 microg, p=0.013). Bronchial responsiveness to methacholine of nonperceivers (PD20= 106+/-31 microg, range 15-253 microg) was the highest and PD20 was significantly lower comparing with normoperceivers (p=0.005) and hyperperceivers (p=0.001). Age and gender had no significant effect on the perception of bronchoconstriction. CONCLUSION: The part of asthmatics with normal lung function has impaired perception of dyspnea. Dyspnea perception depends on bronchial responsiveness, but not on age and gender of these patients.

Adolescent↗

PubMed1994

[Importance of ventilatory lung function for prediction of survival in elderly persons. Mortality cohort study in Cracow].

The objective of the study undertaken among elderly was to assess the strength and importance of biologic predictors of mortality (blood pressure, ventilatory lung function) in comparison with that of sociodemographic variables (age, sex, education), smoking habit, obesity and health self-assessment. The study covered a sample of elderly (698 males and 1211 females), inhabitants of Cracow city center who attended the mass screening x-ray clinic. The sample examined did not include patients of houses for elderly or geriatric wards. At the occasion of the x-ray examination an epidemiologic interview has been taken from each person and basic clinical measurements (anthropometry, blood pressure and ventilatory lung function) have been performed. Statistical analysis of relation between mortality over 5-year period and chosen predictors has been carried out with Cox proportional hazards model and PC BMDP programs. It was found that beside age FEV1 level is the strongest survival predictor among the elderly. Subjects who had better FEV1 by 500 ml showed significantly lower death risk, by 18% in males and 27% in females after allowing for age and height. The results obtained confirmed the expectation that ventilatory lung function is one of the strongest predictor of survival in elderly. In the sample studied the impact of education, smoking habit, obesity, health self-assessment on the mortality experience was not significant. The effect of hypertension appeared to be relevant only in the female group.

Aged↗

PubMed2001

Lung function tests for pre-school children.

There are a few devices for measuring lung function in pre-school children. Neither the interrupter technique nor the forced oscillation techniques have been standardised. We highlight some of the issues around the measurement of airway resistance using the interrupter technique and emphasise that, as with other lung function measurements, operators should have a proper understanding of the methods before they can be applied. Both methods for measuring airway resistance have potential for clinical and research application.

Airway Resistance↗