Systems analysis and design of an integrated dental hygiene clinic system.
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Academic Medical Centers↗
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Results for “Software Design”
Explore indexed PubMed citations for clinical trials, systematic reviews and public health research. Read source abstracts and follow each citation to its original PubMed record.
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Designing a patient care medication and recording system that uses bar code technology.
Bar code technology has been implemented in a variety of health care applications to facilitate computerized data entry. In this report, the author describes the potential application of a patient medication administration and recording system that uses bar code technology for data entry. The need for nursing to collaborate with pharmacy and information systems developers is discussed, and issues for consideration in the design of the medication system are outlined.
Drug Therapy↗
SSToSS--sequence-structural templates of single-member superfamilies.
The presence of sequence homologues and the availability of structural information of proteins enable better understanding of the biological function of a protein family. A majority of entries in protein structural databank are single member superfamilies for which it is hard to derive motifs due to the paucity of structural homologues. Important conserved segments for these superfamilies have been identified and compiled into a database, SSToSS (Sequence Structural Templates of Single member Superfamily). Conserved regions, recognized by permitted amino acid exchanges, are mapped on the structure and various structural features (solvent accessibility, secondary structure content, hydrogen bonding and residue packing) are examined. These conserved segments with high structural feature content are projected as sequence-structural templates for the particular superfamily member. Interactive three-dimensional displays of the templates in three-dimensional structure (in Chime and RASMOL) are provided for better understanding and visualization. In SSToSS database, we also provide the application of sequence-structural templates in three different areas: multiple-motif based sequence search, multiple sequence alignment and homology modeling. In each case, the inclusion of the sequence-structural templates can give rise to sensitive and accurate results. This enables the inclusion of singletons to provide added value to the recognition of additional members, comparative modeling and in designing experiments.
Amino Acid Motifs↗
[The design and realization of Web-view PACS browser].
This article analyses the system structure and realization model of Web-view PACS browser in combination with the characteristic of PACS, and presents the realizing process of the web-view PACS browser using JSP mode and B/S model.
Computer Communication Networks↗
The evaluation of radioactive microsphere data: remarks on the use of the BMDP and SAS statistical software packages.
We investigated the suitability of BMDP and SAS as an integrated tool for the evaluation of regional blood flow data obtained from the radioactive microsphere technique. Both packages were applied to a recent study on muscle blood flow with a 3-factorial design. The organization of data and files, the strategy of data reduction, and the evaluation by means of statistical and graphical techniques are shown. The method may be applied to any microsphere study design. A considerable amount of time can be saved and data integrity may be improved. The statistical quality of the results may benefit from the broad spectrum of statistical tests available.
Algorithms↗
The Trial Protocol Tool: The PRACTIHC software tool that supported the writing of protocols for pragmatic randomized controlled trials.
OBJECTIVE: To develop a tool that would make it easier for researchers, especially those in low- and middle-income countries, to write research protocols for pragmatic randomized controlled trials. STUDY DESIGN AND SETTING: A series of focus groups was held at the inaugural meeting of the Pragmatic RAndomized Controlled Trials in Health Care (PRACTIHC) project in 2001 to develop a desired specification for the Trial Protocol Tool. A working group of five individuals from the PRACTIHC group was formed to develop content for the tool. RESULTS: The Trial Protocol Tool was developed in English and Spanish as a Microsoft Windows HTML help system. A Web-based version is also available. This main body of the tool provides information, advice, and resources about the major headings that should be part of every research protocol. Illustrative examples are used throughout and are taken directly from the tool's protocol library. Additional resources include checklists, programs (e.g., a sample size calculator), and example documents (e.g., patient information leaflets). CONCLUSION: The Trial Protocol Tool packages all the key requirements for the development of a research protocol into one resource. We believe that the use of the tool will help researchers to design effective trials and to write high-quality protocols.
Clinical Protocols↗
Informatics infrastructure of CAD system.
A computer aided diagnosis (CAD) system requires several components which influence its effectiveness. An image processing methodology is responsible for the analysis, database structure archives and distributes the patient demographics, clinical information, and image data. A graphical user interface is applied in order to enter the data and present it to the user. By designing dynamic Web pages a remote access to the entire is granted. The computer aided diagnosis system includes three layers, which might be installed on various platforms. Elements of the application software are designed independently. Integration of all components is another issue discussed in the presented paper. Implementation of a computer aided diagnosis system improves and accelerates the analysis by giving to the user objective measurement tools. It also standardizes the decision-making process and solves the problem of replicability. Finally, it permits a set of images and features to be collected and recognized as a medical standard and be applied in education and research.
Diagnosis, Computer-Assisted↗
LaboImage: a workstation environment for research in image processing and analysis.
Numerous images are produced daily in biomedical research. In order to extract relevant and useful results, various processing and analysis steps are mandatory. The present paper describes a new, powerful and user-friendly image analysis system: LaboImage. In addition to standard image processing modules. LaboImage also contains various specialized tools. These multiple processing modules and tools are first introduced. A one-dimensional gel analysis method is then described. The new concept of 'normalized virtual one-dimensional gel' is introduced, making comparisons between gels particularly easy. This normalized gel is obtained by compensating for the bending of the lanes automatically; no information loss is incurred in the process. Finally, the model of interaction in a multi-window environment is discussed. LaboImage is designed to run in two ways: interactively, using menus and panels; and in batch mode by means of user-defined macros. Examples are given to illustrate the potentialities of the software.
Algorithms↗
A database of cardiac arrhythmias.
OBJECTIVE: To describe a database of cardiac arrhythmia recordings, useful for the development and testing of ECG rhythm processing or monitoring algorithms and devices. METHODS: The raw data were acquired within the Wisconsin-Dane County emergency medical technician-defibrillation program and contained emergency rhythm recordings of an average length of 30 minutes. The raw data were integrated into a software platform designed for the annotation and visualization of the recordings. RESULTS: Currently the database contains the following arrhythmia episodes: ventricular fibrillation (56), asystole (65), electromechanical dissociation (31), and other arrhythmias (42). The software, resident on personal computers, also can transmit any of the database recordings, through a digital-to-analog converter board, to a device under test. CONCLUSIONS: The database technique described will provide a useful means of objectively assessing electronic devices for their ability to detect arrhythmias. The database is unique in that it contains lengthy episodes of arrhythmias. The database will be extended to include additional cases.
Arrhythmias, Cardiac↗
Designing graphics programming interfaces for mobile devices.
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Algorithms↗
Enhancing the usability of a task analysis method: a notation and environment for requirements specification.
This paper presents a notation and computer-based tool for the Sub-Goal Template (SGT) method, a task-analytic approach to specifying information requirements. In particular, it focuses upon the ergonomic redesign of a notation used in the SGT method for specifying contingent sequences in operators' tasks. Two experiments are reported in which two notations for redescribing sequences that involve making a choice between task alternatives are compared: a disjunctive form (Either ... or ...)-used in the original SGT scheme, and a conditional form with a redundant negative (If ... then ... if not ...), which has been promoted as a notation for capturing procedural sequences in computer programming. In experiment 1, performance with the conditional notation was better than with the disjunctive notation for redescribing simple and moderately complex task plans, although there was no difference for the most complex task plans. In experiment 2, a computer environment for specifying task plans using the SGT method was compared with a paper-based equivalent. In general, the computer environment was found to be easier to use and led to greater accuracy in plan redescription, although it was slower perhaps as a result of the constraints that it placed on participants. This paper argues for the necessity of ergonomic design in developing notations and tools to support task analysis methods.
Computers↗
Improving perinatal outcome through data management: the design of the small area analysis system.
The decentralization of health management requires that appropriate tools be developed for decision support at the local level. The Improved Pregnancy Outcome Data Management System (IPODM) was designed to enable health managers and physicians with little computer experience to access over 500 variables derived from United States Census and California Vital Statistics sources. Using an interactive format one can create datasets describing the sociodemographic composition and perinatal outcome of individuals residing in individual census tracts (or zip codes) and in aggregates of these basic units such as neighborhoods, health catchment areas, or municipal districts. IPODM allows one to analyze this information in terms of tables, plots, maps, and basic statistical procedures using an interactive format. This paper describes the system designed for the State of California and the principles that guided the design.
Database Management Systems↗
Scenario-based participatory design of a collaborative clinical trial protocol authoring system.
We present our experience of using prototype scenarios to actively involve users in the design of a collaborative clinical trial protocol authoring system. This method enables us to do usability testing and elicit prompt user feedback at the early phase of de-sign. We conclude that it is an effective approach to the design of complex medical information systems.
Clinical Protocols↗
[Current status and future potentials of multislice computed tomography].
This overview article gives a short introduction into present status and future potential of multislice computed tomography. The main benefits of established 4- to 16-slice CT systems are larger volume coverage, better utilization of the X-ray tube output and above all improved transverse resolution. Spiral examinations with 16 submillimeter slices are a breakthrough on the way towards isotropic scanning for routine applications. ECG-controlled CT-examinations of the heart benefit from both the improved temporal and spatial resolution of the new generation of 16-slice CT systems. Compared to 4-slice scanners, cardiac examinations are clinically more robust. The most important potential for improvement of multislice cardiac CT is a further enhancement of temporal resolution which requires increased gantry rotation speed for robust clinical performance. Combined systems such as CT PET scanners will gain increasing importance in the near future. In general radiology the race for more slices will continue, finally leading to the introduction of CT systems with area-detectors.
Angiography↗
Development and screening of a polyketide virtual library for drug leads against a motilide pharmacophore.
A virtual library of macrocyclic polyketide molecules was generated and screened to identify novel, conformationally constrained potential motilin receptor agonists ("motilides"). A motilide pharmacophore model was generated from the potent 6,9-enol ether erythromycin and known derivatives from the literature. The pharmacophore for each molecular conformation was a point in a distance-volume space based on presentation of the putative binding moieties. Two methods, one fragment based method and the other reaction based, were explored for constructing the polyketide virtual library. First, a virtual library was assembled from monomeric fragments using the CHORTLES language. Second, the virtual library was assembled by the in silico application of all possible polyketide synthase enzyme reactions to generate the product library. Each library was converted to low-energy 3D conformations by distance geometry and standard minimization methods. The distance-volume metric was calculated for low-energy conformations of the members of the virtual polyketide library and screened against the enol ether pharmacophore. The goal was to identify novel macrocycles that satisfy the pharmacophore. We identified three conformationally constrained, novel polyketide series that have low-energy conformations satisfying the distance-volume constraints of the motilide pharmacophore.
Combinatorial Chemistry Techniques↗
bioWidgets: data interaction components for genomics.
MOTIVATION: The presentation of genomics data in a perspicuous visual format is critical for its rapid interpretation and validation. Relatively few public database developers have the resources to implement sophisticated front-end user interfaces themselves. Accordingly, these developers would benefit from a reusable toolkit of user interface and data visualization components. RESULTS: We have designed the bioWidget toolkit as a set of JavaBean components. It includes a wide array of user interface components and defines an architecture for assembling applications. The toolkit is founded on established software engineering design patterns and principles, including componentry, Model-View-Controller, factored models and schema neutrality. As a proof of concept, we have used the bioWidget toolkit to create three extendible applications: AnnotView, BlastView and AlignView.
Amino Acid Sequence↗
A tele-operated mobile ultrasound scanner using a light-weight robot.
This paper presents a new tele-operated robotic chain for real-time ultrasound image acquisition and medical diagnosis. This system has been developed in the frame of the Mobile Tele-Echography Using an Ultralight Robot European Project. A light-weight six degrees-of-freedom serial robot, with a remote center of motion, has been specially designed for this application. It holds and moves a real probe on a distant patient according to the expert gesture and permits an image acquisition using a standard ultrasound device. The combination of mechanical structure choice for the robot and dedicated control law, particularly nearby the singular configuration allows a good path following and a robotized gesture accuracy. The choice of compression techniques for image transmission enables a compromise between flow and quality. These combined approaches, for robotics and image processing, enable the medical specialist to better control the remote ultrasound probe holder system and to receive stable and good quality ultrasound images to make a diagnosis via any type of communication link from terrestrial to satellite. Clinical tests have been performed since April 2003. They used both satellite or Integrated Services Digital Network lines with a theoretical bandwidth of 384 Kb/s. They showed the tele-echography system helped to identify 66% of lesions and 83% of symptomatic pathologies.
Algorithms↗