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Machine learning in control of functional electrical stimulation systems for locomotion.

Two machine learning techniques were evaluated for automatic design of a rule-based control of functional electrical stimulation (FES) for locomotion of spinal cord injured humans. The task was to learn the invariant characteristics of the relationship between sensory information and the FES-control signal by using off-line supervised training. Sensory signals were recorded using pressure sensors installed in the insoles of a subject's shoes and goniometers attached across the joints of the affected leg. The FES-control consisted of pulses corresponding to time intervals when the subject pressed on the manual push-button to deliver the stimulation during FES-assisted ambulation. The machine learning techniques used were the adaptive logic network (ALN) [1] and the inductive learning algorithm (IL) [2]. Results to date suggest that, given the same training data, the IL learned faster than the ALN, while both performed the test rapidly. The generalization was estimated by measuring the test errors and it was better with an ALN, especially if past points were used to reflect the time dimension. Both techniques were able to predict future stimulation events. An advantage of the ALN over the IL was that ALN's can be retrained with new data without losing previously collected knowledge. The advantages of the IL over the ALN were that the IL produces small, explicit, comprehensible trees and that the relative importance of each sensory contribution can be quantified.

Adult↗

The Wadsworth BCI Research and Development Program: at home with BCI.

The ultimate goal of brain-computer interface (BCI) technology is to provide communication and control capacities to people with severe motor disabilities. BCI research at the Wadsworth Center focuses primarily on noninvasive, electroencephalography (EEG)-based BCI methods. We have shown that people, including those with severe motor disabilities, can learn to use sensorimotor rhythms (SMRs) to move a cursor rapidly and accurately in one or two dimensions. We have also improved P300-based BCI operation. We are now translating this laboratory-proven BCI technology into a system that can be used by severely disabled people in their homes with minimal ongoing technical oversight. To accomplish this, we have: improved our general-purpose BCI software (BCI2000); improved online adaptation and feature translation for SMR-based BCI operation; improved the accuracy and bandwidth of P300-based BCI operation; reduced the complexity of system hardware and software and begun to evaluate home system use in appropriate users. These developments have resulted in prototype systems for every day use in people's homes.

Animals↗

Medical education: how is change to come about?

The challenge to medical education as we enter the last decade of the century and face the next millenium is how to utilize the new knowledge of human learning to train medical students in applying the fruits of rapidly advancing science and technology to the moral imperative of fulfilling social needs. To bring about the reforms defined in the Edinburgh Declaration, adopted as globally applicable by the World Conference on Medical Education, intrinsic and extrinsic elements must act in synergy. The intrinsic elements are teachers, students and institutional frameworks; the extrinsic elements political will, administrative commitment and societal pressure. In the developing world, while there is much that medical schools themselves can do through intrinsic changes, their dependence on government support is so pervasive that such government support becomes an essential prerequisite for change. The creation of a cohesive organizational framework involving health and education ministries, the academic sector and professional bodies for a systematic and continuing study of medical education and for inducing and sustaining change are essential to facilitate the change process.

Developing Countries↗

Sudden hypoxia during anesthesia in a patient with Kartagener's syndrome.

We report a case of anesthesia in an adolescent with recurrent left pneumothorax, Kartagener's syndrome, and severe learning disability with behavioral difficulties. After induction of anesthesia, he rapidly developed severe desaturation as measured on pulse oximetry. Placement of an intercostal chest drain did not remedy the situation and he was found to have blocked the left main bronchus with viscous secretions. Subsequent suctioning relieved the obstruction. Despite successful postoperative thoracic epidural analgesia and minitracheostomy for bronchial toilet, he developed bronchopneumonia that resolved with antibiotics. We discuss anesthesia for patients with Kartagener's syndrome and for patients with pneumothorax.

Acute Disease↗

Neurobiology. Long-sought protein packages glutamate.

Glutamate, one of two neurotransmitters that send the basic "stop" and "go" signals that most other neurotransmitters merely modulate, is called into action wherever rapid-fire excitatory signals are needed--say, for vision or learning. For decades, researchers have been looking for the protein that packages glutamate for express delivery to other neurons. On page 957, researchers report that they've found this elusive transporter, dubbed VGLUT1.

Animals↗

Restoration of pulsatile luteinizing hormone secretion after fasting in rhesus monkeys (Macaca mulatta): dependence on size of the refeed meal.

In men and adult male rhesus monkeys brief periods of fasting (i.e. 1-2 days) can often lead to a suppression of hypothalamic-pituitary-testicular axis activity, marked by decreased circulating concentrations of LH, FSH, and testosterone. Refeeding a normal meal can rapidly restore normal secretory patterns of LH and testosterone. To learn more about the nature of the signal that links reproductive hormone secretion to nutrient intake, we examined whether the degree of restoration of pulsatile LH and testosterone secretion after a brief period of fasting is influenced by the size of the refeed meal. Adult male rhesus monkeys had indwelling venous catheters surgically implanted and were maintained on swivel/tether systems for remote collection of blood samples. Monkeys were fasted for 1 day and then on the following day they were refed one of five meals which varied in size and calorie content (i.e. 0 Cal/0 pellets Purina monkey chow; 100 Cal/5 pellets; 200 Cal/10 pellets; 300 Cal/15 pellets; or 600 Cal/30 pellets). Blood samples were collected from 0800-2400 h at 20-min intervals on the days of refeeding and assayed for LH and testosterone content. After a day of fasting, the frequency of pulsatile LH secretion the following morning was very low (0.56 +/- 0.1 pulses/3 h, measured from 0800-1100 h). When monkeys were not refed (i.e. were subjected to a second day of fasting; 0 pellet group) LH pulse frequency remained low [2.88 +/- 0.72 pulses/13 h, measured from 1100-2400 h (equivalent to 0.66 pulses/3 h)] throughout the day and evening hours. Refeeding monkeys 5, 10, 15, and 30 pellets caused a progressive stimulation of pulsatile LH secretion (3.17 +/- 0.54, 3.67 +/- 0.56, 5.5 +/- 0.67, and 6.38 +/- 0.53 pulses/13 h, respectively). Like LH pulse frequency, mean circulating LH and testosterone concentrations progressively increased as the size of the refeed meal was increased. For all three parameters (i.e. LH pulse frequency, mean LH concentration, and mean testosterone concentration) there was a significant, P less than or equal to 0.001, linear trend with increasing meal size. These findings indicate a very strong relation between the level of nutritional intake and the level of central drive to the reproductive axis during nutritional recovery from fasting, and suggest a physiological parameter that responds in a progressive fashion to increasing food intake serves as the signal to link central drive to the reproductive axis to changes in nutrient intake.(ABSTRACT TRUNCATED AT 400 WORDS)

Animals↗

Regulation of pineal rhythms in chickens: refractory period and nonvisual light perception.

Pineal serotonin N-acetyltransferase activity and melatonin content exhibit marked daily rhythms in chickens; peak values occur during the period of low locomotor activity which coincides with dark in a 24-h light-dark regime. We studied the regulation of these daily rhythms by measuring pineal serotonin N-acetyltransferase activity, hydroxyindole-O-methyltransferase (HIOMT) activity, and melatonin content in experiments in which birds were exposed to light-to-dark and dark-to-light transitions at atypical times. We observed that there is a refractory period for dark-initiation of the increase in pineal N-acetyltransferase activity and melatonin content. We also learned that a dark-to-light transition causes a rapid decrease in dark-elevated pineal N-acetyltransferase activity and melatonin content. The rapid decrease occurs in blinded chickens as well as sighted ones. HIOMT activity did not change consistently in any of the experimental treatments.

Acetyltransferases↗

Adhesion and reattachment of compound ascidians to various substrata: weak glue can prevent tissue damage.

Sessile, soft-bodied, compound ascidians are successful competitors for substrata in crowded benthic and epibiotic marine communities and can be effective colonists of new sites, through adult rafting and reattachment. Adhesion to the substratum is essential for these ecologically important functions; we therefore studied the material properties of colony attachment to various substrata in the rafting ascidians Botrylloides sp. We found that, compared with the strength of the colony tissues, the glue attaching Botrylloides sp. to the substratum is very weak. This relative weakness may protect the soft-bodied colonies from damage if they are ripped from their host. For sessile animals, such a weak-glue 'strategy' is only effective if the animals can later reattach to a substratum. By detaching Botrylloides sp. colonies from host eelgrass blades and allowing them to reattach, before measuring peel strengths, we learned that the initial reattachment of a colony depends upon rapid new growth of the colony rather than on fresh secretion of glue beneath old zooids. We also found that the propagation peel force necessary to remove Botrylloides sp. from different substrata (e.g. mussel shells, barnacle basal plates or eelgrass blades) depends upon the surface texture of the host. Thus, the overall tenacity of a colony is affected by the types of substrata that it overgrows.

Adhesiveness↗

A 10-year serial, prospective study of laparoscopic cholecystectomy training in a single region.

AIM: To determine how surgical registrar training in laparoscopic cholecystectomy evolved in a single region in the 10 years since the introduction of this technique. METHODS: In 1993, 1996, and 2001, identical, standardised postal questionnaires were sent to all general surgical registrars in the Oxford region. The questionnaire enquired about the number of laparoscopic cholecystectomies performed, performed with supervision or simply assisted at within a set time period. RESULTS: There has been a significant increase in the number of procedures performed by trainees between 1993 and 2000, in comparison to the number purely assisted at. CONCLUSIONS: After an initial learning period for the consultant trainers, laparoscopic cholecystectomy has been rapidly adopted, and is now a major training operation, much as open cholecystectomy was in the past.

Cholecystectomy, Laparoscopic↗

Assessing and training teachers in the generalized use of behavior modification with autistic children.

This study investigated the feasibility of developing reliable, valid criteria for measuring and training the skills necessary to teach autistic children. The behaviors of 11 teachers and 12 autistic children were recorded in a series of different teaching situation. Teacher-training was initiated at different times for different teachers. The results showed: (1) it was possible to asses empirically whether a teacher was correctly using defined behavior-modification techniques; (2) generally, for any given session, systematic improvement in the child's behavior did not occur unless the teacher working in that session had been trained to use the techniques to a hight criterion; (3) all 11 teachers were rapidly trained to use these techniques; and (4) the teachers learned generalized skills effective with a variety of children and target behaviors.

Adolescent↗

The dual-task SRT procedure: fine-tuning the timing.

In the standard sequential reaction time study, subjects are presented with a repeating sequence of targets to which they must respond as rapidly as possible. With practice reaction times decrease, suggesting a learned ability to exploit the repeating patterns in the display. In a common variation, a second task is interposed, typically a tone-counting task in which subjects must keep track of the frequency with which particular tones occur. In the canonical experiment, these tones appear at varying times in the interval between the subjects' response to a target and the next target. Data are presented that show that this latter variable (the RSOA, response-secondary stimulus onset asynchrony) actually plays an important but previously hidden role in these experiments. A model based on an extension of the notion of the psychological refractory period is introduced to explain these findings.

Adult↗

Implementation of computerized student-patient logs in podiatric medical education.

In recent years, there has been a rapid increase in World Wide Web-based teaching and learning materials; however, present-day systems for recording student-patient interactions have trailed behind other academic areas in the appropriate use of technology. This article reviews the implementation of an innovative Web-based computerized student-patient log. This system represents considerable improvement in terms of efficiency and accuracy over traditional paper-based reporting systems. It facilitates faculty tracking of students' clinical experiences at geographically disparate locations and allows gaps in student knowledge to be more easily identified. Moreover, the Web-based system has the added advantage of making students responsible for their own learning, providing them with a sense of ownership of the data collected.

California↗

Concept mapping--a strategy for assessment.

Rapidly expanding knowledge has led to changing approaches to teaching, learning and assessing. The emphasis is on student-centred approaches that encourage lifelong learning skills. One such approach to learning is concept mapping. The case study in this article discusses the use of mapping as a successful strategy for assessment.

Concept Formation↗

Accreditation processes in the Slovak Republic.

This article provides a conceptual framework for understanding changes occurring in the accreditation process for institutions of higher learning in the Slovak Republic. Health sector transformation is occurring rapidly throughout the Central and Eastern European region as former socialist states are experimenting with market-oriented approaches. Educators and universities are playing an important role in the development of knowledge, skills and abilities of current and future health practitioners. Accreditation is viewed as an important process in the continuing development of quality health service management curricula and preparing competent practitioners for the health care field. Historical considerations are examined as well as future directions for accreditation in the Slovak Republic.

Accreditation↗

Hypocretin increases impulse flow in the septohippocampal GABAergic pathway: implications for arousal via a mechanism of hippocampal disinhibition.

Hypocretins (Hcrts), or orexins, are a recently described set of hypothalamic peptides that have been implicated in feeding, neuroendocrine regulation, sleep-wakefulness, and disorders of sleep, such as narcolepsy. Hcrt-containing neurons, which are located exclusively in the lateral hypothalamic area, provide a dense innervation to the medial septum/diagonal band of Broca (MSDB), a sleep-associated brain region that has been suggested to show intense axonal degeneration in canine narcoleptics. The MSDB, via its cholinergic and GABAergic projections to the hippocampus, controls the hippocampal theta rhythm and associated learning and memory functions that occur during exploratory behavior and rapid eye movement sleep. Neurons of the MSDB express the Hcrt receptor 2, which is mutated in canine narcoleptics, but lack the Hcrt receptor 1 mRNA. In the present study, we investigated the electrophysiological effects of Hcrt2 on MSDB neurons from rat brain slices. We report that Hcrt2 produces a reversible, reproducible, concentration-dependent and direct postsynaptic excitation of GABA-type neurons of the MSDB with an EC50 of 207 nm. This effect is sodium dependent but not potassium or chloride dependent and is attenuated by blockers of the Na+-Ca+ exchanger. Hcrt2 also increases impulse-dependent release of GABA within the MSDB. Using recordings from retrogradely labeled septohippocampal neurons, we found that Hcrt2-excited MSDB neurons project to the hippocampus and have a GABAergic physiological signature. Double-immunolabeling studies confirmed the presence of Hcrt receptor-2 immunoreactivity in septohippocampal GABAergic neurons, as well as the presence of Hcrt fibers adjacent to these neurons. Based on these results, we speculate that Hcrt2-induced activation of septohippocampal GABAergic neurons will, by engaging disinhibitory mechanisms in the hippocampus, promote generation of the hippocampal theta rhythm and associated behaviors.

Animals↗

NIC/Q 2000: establishing habits for improvement in neonatal intensive care units.

OBJECTIVES: The Vermont Oxford Network is a group of health professionals who are committed to improving the quality and safety of medical care for newborn infants and their families. Neonatal Intensive Care Quality Improvement Collaborative Year 2000 (NIC/Q 2000) was the second in a series of multiorganization improvement collaboratives organized and administered by the Vermont Oxford Network. The objective of this collaborative was to make measurable improvements in the quality and safety of neonatal intensive care, develop new tools and resources for improvement specific to the neonatal intensive care unit setting, evaluate improvement progress, and disseminate the learning. METHODS: The 34 centers that participated in NIC/Q 2000 learned and applied 4 key habits for improvement: the habit for change, the habit for evidence-based practice, the habit for systems thinking, and the habit for collaborative learning. A plan-do-study-act method of rapid-cycle improvement was an integral part of the habit for change. Multidisciplinary teams from the participating centers worked closely together in face-to-face meetings, conference calls, and dedicated e-mail listservs under the guidance of trained facilitators and expert faculty. Focus groups formed around specific improvement topics used critical appraisal of the published literature, detailed process analysis, benchmarking, and round-robin site visits to identify potentially better practices (PBPs). RESULTS: The focus groups developed a total of 51 PBPs. Each focus group has developed a "resource kit" summarizing its work. Many of these PBPs have been tested and implemented at the participating centers using rapid-cycle improvement. The PBPs and descriptions of individual center PDSA cycles are available to participants on NICQ.org, the dedicated Internet site for the collaborative. CONCLUSIONS: Collaborative quality improvement based on the 4 key habits can assist multidisciplinary neonatal intensive care unit teams in identifying, testing, and successfully implementing change.

Cooperative Behavior↗

[Laparoscopy in urology].

Since the past 10 years, results have established laparoscopy's efficacy. It is actually a consistent surgical option for a lot of indications met in urology. The rational behind performing laparoscopic procedures includes shorter hospital stays, less postoperative pain and a more rapid return to usual activity. Drawbacks of laparoscopy include significant learning curve, longer operative times and higher overall costs. One particular focus is the oncologic applications of laparoscopy for nephrectomy and specially for radical prostatectomy. Laparoscopy become nowadays an usual part of the armamenturium of urological teams.

Female↗

Health care economics, financing, organization, and delivery.

BACKGROUND: The US health care system is in a state of rapid evolution, with changing payment, organizational, and management structures. To learn how to function optimally in a system in which care is increasingly managed and competitive, today's medical students must understand the structural and economic underpinnings of the system within which they will practice. At the outset of the Undergraduate Medical Education for the 21st Century (UME-21) project, the great majority of medical school curricula were lacking in areas of health care financing and organizational structure. The institutions involved in the UME-21 project sought to address curricular deficiencies in two broad areas: (1) the structure and financing of the US health care system ("health policy") and (2) the manner in which this system is reflected in the organization and activities of health care providers ("care delivery"). This article discusses the development, implementation, and evaluation of the first of the two areas. METHODS: Data were abstracted from written reports provided by each of the UME-21 schools to the project's Executive Committee and sponsor. In selected cases, additional data were obtained by personal communications with project directors and evaluators. Local UME-21 project leaders verified all data presented. RESULTS: Curricular philosophy and teaching methods varied widely, but health policy curricula were predominantly preclinical and didactic in nature. At the school level, much was achieved in terms of student knowledge, curricula were generally well received by students, attitudes toward managed care generally moved in a positive direction, and behavior may have been positively influenced as well. At the project level, many potentially interesting changes exist within the 18 schools and between the UME-21 and other schools, but it is not clear whether or what parts of the health policy curricula were responsible for these changes. Nonetheless, as measured by changes in health policy-related items on the Association of American Medical Colleges Graduation Questionnaire, it appears that UME-21 schools outperformed their non-UME-21 counterparts. All of the UME-21 schools were enthusiastic about their health policy innovations, and this extended across all key stakeholders. Most schools avoided focusing on managed care and instead adopted more neutral themes that introduced the same material. Integrating the new material in conjunction with the more traditional aspects of the curriculum was also an effective implementation strategy. CONCLUSIONS: Health policy should be incorporated into both the preclinical and clinical years. The former emphasizes health care economics as one of the foundations of medical practice, whereas the latter provides the opportunity for its use on a daily basis in clinical settings. However, like any new curriculum, to achieve equal status with the traditional biomedical curriculum, it must be presented in a scholarly, rigorous, and reasonably comprehensive fashion. Mounting a scholarly health policy curriculum requires a wide-ranging, interdisciplinary faculty. If it is to become a central component of the medical school curriculum, creative approaches to faculty recruitment and development will be needed. This will require both careful educational policy formulation and new investment.

Curriculum↗