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At least 127 records · Page 7Linked to original sources

Intraoperative digital subtraction neuroangiography: a diagnostic and therapeutic tool.

We report our experience with intraoperative digital subtraction neuroangiography to demonstrate its application as a diagnostic and therapeutic technique. Intraoperative neuroangiography was performed on 53 occasions in 43 patients using a portable imaging system. Thirty-two procedures were performed for diagnostic purposes after resection of arteriovenous malformations, clipping of aneurysms, or carotid endarterectomy. Unexpected problems were disclosed in seven cases and were surgically remedied immediately in four. In addition, angiography was used as a therapeutic tool in 21 cases to facilitate intraoperative embolization of a vascular lesion or to enable the angioplasty of a vessel inaccessible without direct surgical exposure. We found that by allowing a combined interventional neuroangiographic and neurosurgical approach, intraoperative angiography opened new avenues for treatment of intracranial vascular abnormalities.

Cerebral Angiography↗

Image file interoperability for data protection, communication and trans-system connectivity.

DICOM (Digital Imaging and Communication in Medicine) is a set of international imaging standards developed for medicine and extended to incorporate other professions. These standards encompass primary digital and secondary capture images made for dental diagnostic procedures. The standards provide a basis of interoperability for digital system outputs, providing portability and reducing the danger of obsolescence that would render valuable diagnostic information impossible to display. The American Dental Association, through the activities of its Working Group 12.1, is promoting interoperability within DICOM as the industry standard for digital imaging in dentistry.

Computer Communication Networks↗

The diagnosis of sleep apnea: questionnaires and home studies.

Alternatives to the standard method of diagnosing sleep apnea (SA) are becoming increasingly popular due to the expense and/or. In some cases, the limited availability of polysomnography (PSG). The most common diagnostic alternatives have been clinical prediction rules and portable monitoring. Most portable monitors record one or more signals such as oxygen saturation, heart rate, airflow, or ribcage and abdominal movements. To date, most published studies of these monitors have had serious methodologic problems that have limited the acceptance of this technology. We have developed a two-step diagnostic approach for SA based on a clinical prediction rule and the results from a simple, but reliable and accurate, portable monitor that records oxygen saturation, snoring, and body position. The preliminary results indicate that such a strategy is very useful in a population of outpatients suspected of having SA and would preclude the need for PSG to investigate for this possibility in the majority of patients. However, before portable monitoring becomes widely adopted, each system should be more thoroughly tested, and increased attention should be directed at the design of the study so that the results are more generalizeable to other sleep clinic populations.

Algorithms↗

Diagnostic imaging in acute cardiopulmonary disease.

Optimum use of portable radiography and the newer imaging modalities requires careful coordination between the radiologist and intensivist. This article discusses the current imaging approach to patients with acute pulmonary disease, acute cardiovascular disease, and postoperative and iatrogenic problems.

Acute Disease↗

Accuracy of international normalized ratio determined by portable venous-blood coagulation monitor versus a central laboratory.

BACKGROUND: The CoaguChek is a portable monitor unit for measuring the international normalized ratio (INR). The purpose of the study was to evaluate the accuracy of a portable prothrombin time (PT) monitor (CoaguChek, Roche Diagnostics, Mannheim, Germany) compared with the laboratory method. MATERIAL AND METHOD: Paired venous blood INRs were performed in 220 consecutive outpatient tests mainly in anticoagulated (n = 210) and non-anticoagulated (n = 10) individuals. Accuracy was evaluated in 220 tests by parallel assessment of INRs (CoaquChek and laboratory). Accuracy was determined using statistic regression analysis and clinical agreement (expanded and narrow criteria). Agreement in dual INR measurement also was evaluated as a function of increasing INR. RESULTS: The CoaguChek significantly correlated with the laboratory measurement (r = 0.89). The proportion of dual INR measurements that satisfied the clinical relevant expanded, and narrow agreement criteria was 90 per cent and 86 per cent respectively. Eighty-two per cent of all dual measurements were within 0.5 INR units. The accuracy of the portable monitor was greatest for INR values less than 3.0; above this INR level the portable monitor overestimated laboratory INR values. CONCLUSIONS: The CoaguChek is an accurate alternative to laboratory assessment of INR at values < 3.0. The authors suggest the use of the monitor in non anticoagulated patients or anticoagulated patients at values less than 3, as most physicians in Thailand prefer lower INR than in Western countries.

Aged↗

[Evaluation of infrequent episodes of palpitations with a patient-activated hand-held electrocardiograph].

UNLABELLED: The disadvantage of most devices presently available for cardiac rhythm event monitoring is that they require either permanently attached electrodes or the subcutaneous implantation of the device. The aim of the study was to evaluate the feasibility and diagnostic yield of a hand-held, portable electrocardiograph for the evaluation of infrequent episodes of palpitations. In contrast to other devices, this electrocardiograph records and stores the electrocardiograms with integral electrodes, which makes long-term attached electrodes not unnecessary. METHODS: The study included 55 consecutive patients with palpitations less than once a week. The patients received the electrocardiograph Miniscope MS-3 with integral tripod electrodes (Schiller AG, Switzerland) to record a one-channel electrocardiogram during a recurrent episode. The frequency of device activation and the atrial rhythm during an episode was assessed. RESULTS: Forty-one (75%) patients had at least one episode within 38 +/- 22 days. The first episode occurred within the first week in 18 cases, during the 2nd in 9, during the 3rd in 9, during the 4th in 2 patients, and in 3 patients between the 4th and 12th week. All episodes could be properly analyzed: Twenty-three patients had sinus rhythm, 7 paroxysmal atrial fibrillation, 7 paroxysmal atrial flutter, and 4 an AV node reentry tachycardia. Eleven of the 23 patients with sinus rhythm additionally had premature atrial or ventricular contractions. Mean heart rate was 111 +/- 45 bpm. A second episode was recorded in 22 and a third episode in 12 patients. All patients had during the subsequent episode the same cardiac rhythm as during their first episode. CONCLUSIONS: Patients evaluated for their infrequent palpitations had during event monitoring a recurrent episode in 75% that occurred in 88% within the first 4 weeks. All patients were able to activate the electrocardiograph and could store an electrocardiogram with the integral electrodes. Patient-activated event monitoring reliably identified patients with an atrial arrhythmia who need further invasive evaluation and treatment, and ruled out patients with sinus rhythm and premature contractions.

Adult↗

Oesophageal reflux disease. Diagnosis, pathophysiology and treatment with special reference to the role of sucralfate.

The direct cause of oesophageal reflux disease is readily apparent, as oesophageal reflux of gastric contents has a deleterious effect on the oesophageal mucosa. Reflux is a direct result of a multiplicity of aetiological factors which interact in many ways. The symptoms of the disorder can masquerade as other conditions such as cardiovascular, respiratory and abdominal problems. The diagnosis is suggested from the symptoms and confirmed by endoscopy with biopsy. Among additional diagnostic test, oesophageal pH monitoring using a portable system is a simple procedure providing qualitative and quantitative information appropriate for clinical practice. A critical review of drug therapy shows that antacids and alginate acid have no greater value than a placebo. The effects of H2-receptor antagonists are under investigation, but the results are conflicting. Ranitidine seems to have some advantages over cimetidine. Antepsin, a new cytoprotective principle for treating ulcerative inflammations in the upper digestive tract, provides an interesting alternative for the treatment of gastro-oesophageal reflux disease, and the properties of Antepsin granulate seem especially appropriate for the treatment of reflux oesophagitis. During longitudinal treatment of three months provides at least partial restoration of the motor function of the distal oesophagus.

Adult↗

Pericardial effusion and tamponade: evaluation, imaging modalities, and management.

Pericardial effusions may be present in a variety of clinical situations, often presenting challenging clinical diagnostic and therapeutic problems. Although several imaging modalities are available, ECHO has become the diagnostic method of choice due to its portability and wide availability. CT and MRI may also be employed and may be more accurate. A pericardial effusion under pressure may result in hemodynamic compromise and tamponade. Although there are several echocardiographic clues to tamponade (including diastolic chamber collapse, Doppler flow velocity paradoxus, and inferior vena cava phlethora), the diagnosis remains a clinical and hemodynamic one. The clinical signs include elevated jugular venous pressure, hypotension, tachycardia, and pulsus paradoxus. Hemodynamic measurements include equalization of diastolic pressures and decreased cardiac output Treatment of tamponade involves drainage of the effusion and prevention of reaccumulation. Needle pericardiocentesis via the subxiphoid approach is a reasonable initial treatment. However, this may need to be accompanied by catheter drainage or surgical pericardial window. A new catheter based technique--percutaneous balloon pericardiotomy-- appears useful in select patients with malignancy in order to avoid more invasive surgical procedures. Occasionally, in patients with recurrent effusions, instillation of sclerosing agents into the pericardial space or even total pericardiectomy may be necessary.

Cardiac Tamponade↗

Change in differential diagnosis and patient management with the use of portable ultrasound in a remote setting.

OBJECTIVE: Physicians practicing in remote areas are typically limited in their choice of diagnostic tools. The goal of this study was to determine whether the use of a portable ultrasound (US) device on selected patients in a remote setting would alter physician diagnosis and management. METHODS: This was a prospective observational study of the affects of US on physician decision making deep in the Amazon jungle. A battery-operated Sonosite 180 Plus with 2 interchangeable transducers (4-7-MHz broadband intercavitary transducer and 2-5-MHz broadband abdominal transducer) was used. The patient population consisted of local tribal people. Two of the physicians on the team performed all US examinations. Team physicians requesting US examinations filled out a survey before and after the US examination. Before the US, the referring physician filled out a survey describing the patient's initial complaint, pertinent past medical history and physical findings, and an initial (pre-US) differential diagnosis and planned treatment with expected disposition. After the results of the US were reviewed with the referring physicians, the doctors were asked to fill out the remainder of the survey, allowing comparison of pre- and post-US differential diagnosis, treatment plan, and disposition. RESULTS: A total of 25 US studies were performed during this study (1 trauma US scan, 6 hepatobiliary studies, 5 transabdominal pelvic scans, 7 transvaginal pelvic studies, 3 renal studies, and 3 abdominal aortic scans). The monitor on the US unit experienced a rare failure shortly after being used at 17,000 ft and then 10 times at sea level, and no further US scans could be performed. US scan results dramatically altered the disposition of 7 patients, including 4 patients who avoided a potentially dangerous 2-day evacuation to more definitive medical care. Three patients were found to need rapid referral to the nearest clinic for surgical evaluation. CONCLUSIONS: When used in a remote location, portable US provides a significant benefit that can dramatically alter disposition and treatment.

Brazil↗

Portable metagenomics for preventive surveillance and outbreak control in livestock and poultry: Pathogen detection, resistome profiling, and antimicrobial stewardship.

Conventional diagnostics for livestock and poultry outbreaks commonly rely on culture or targeted PCR panels, which may be too slow or too narrow to guide early control decisions. Portable metagenomics, particularly real-time nanopore sequencing, offers a route to broad pathogen detection, antimicrobial-resistance gene profiling, and outbreak investigation within an integrated workflow. This implementation-focused review evaluates how near-point-of-care metagenomics may support preventive veterinary medicine through earlier detection, surveillance, cohorting, biosecurity decisions, and antimicrobial stewardship. We synthesize sample-to-answer workflows for enteric and respiratory disease in food-producing animals, including sampling, nucleic-acid extraction, host depletion or target enrichment, library preparation, sequencing, bioinformatics, quality control, and interpretation. Applications in calf diarrhea, bovine respiratory disease, poultry outbreaks, mastitis, and resistome monitoring are considered alongside the central limitation that detection alone does not establish causation. Pathogen and resistance-gene signals must therefore be interpreted with clinical signs, lesions, epidemiology, controls, and confirmatory testing. We also propose a minimum reporting checklist, intended as a practical framework rather than a validated consensus standard. Portable metagenomics is not a replacement for conventional diagnostics, but appropriately validated workflows can reduce uncertainty during time-sensitive outbreaks and support more judicious antimicrobial use.

Animals↗

[The diagnosis of sleep apnea syndrome with a portable device. Our experience with 100 cases].

UNLABELLED: Portable devices might be an alternative method to diagnose patients suspected for obstructive sleep apnea syndrome (OSAS). We have analized one hundred patients consecutively referred to our especialized out-patient clinic for sleep breathing disorders. We have used a previously validated portable device-Polygraphics CNS-which records thoracoabdominal movement, nasobuccal airflow, ECG, oxymetry, body position, and continuous positive airway pressure (CPAP). Sixty patients showed an apnea/hypopnea index (AHI) > 15. Seven patients showed an AHI > 10f plus symptoms suggestive of OSAS. Two patients had an AHI between 5-10 and very high suspicion for OSAS; a subsequent CPAP treatment showed the disappearance of respiratory events and an evident improvement in oxymetric records. Twenty two patients showed an AHI < 5. Nine patients could not be classified and other diagnostic method were deemed necessary. CONCLUSION: A previously validated cardiorrespiratory portable polygraphic device was useful in most cases for taking diagnostic decisions in OSAS.

Adult↗

Ratite diagnostic imaging.

Diagnostic imaging of ratite species is a challenge, even to the specialist. A portable radiography unit is frequently inadequate to penetrate the coelomic cavity of large birds, but should provide diagnostic quality radiographs of the extremities. Ultrasonography allows visualization of the coelomic structures, but will not penetrate gas or air. Use of both technologies often provides diagnostic information helpful to the clinician.

Animals↗

Exercise echocardiography: technique and diagnostic value.

Exercise echocardiography has experienced a rapid rise in clinical acceptance because of its recognized ability to detect coronary artery disease in addition to attractive features such as portability, versatility and relatively low cost. To achieve and maintain accuracy and diagnostic yield, adequate training of the sonographer and the cardiologist is essential.

Coronary Disease↗

Therapeutic concordance of two portable monitors and two routine automatic oral anticoagulant monitoring systems using as reference the manual prothrombin time technique.

Two models of capillary blood prothrombin time (PT) monitoring systems were evaluated for analytical performance and then compared with two routine PT systems using the reference manual technique and a high-sensitivity thromboplastin. Two sets of 60 and 80 plasmas were analyzed from anticoagulated patients stabilized over 3 months in an INR range 2-3.5 for therapy. Capillary PT determination was performed in two portable monitors, CoaguChek S and CoaguChek PT (Roche Diagnostics), and plasma automatic methods were Neoplastine/STA (Diagnostics Stago) and PT-FibrinogenHsPlus/ACL7000 (Instrumental Laboratories). Thromboplastin Bilbao (TBi), an in-house high-sensitivity rabbit thromboplastin (ISI=1.08), recommended as the reference reagent by an External Spanish Oral Anticoagulant Quality Assessment, was used in the PT manual technique. The two monitors' coefficients of correlation with the reference system were 0.74 for CoaguChek S and 0.81 for CoaguChek PT. The automatic routine systems showed a correlation of 0.92 (Neoplastine/STA) and 0.91 (PT-FbHsPlus/ACL7000). Clinical agreement expressed as the percentage of simple correlation ranged between 75.0% (CoaguChek S) and 88.9% (Neoplastine/STA). The systems having the best kappa index with the manual technique were CoaguChek PT (71.9%) and the Neoplastine/STA system (73%). The routine PT management systems exhibited better correlation and percentage of concordance when using the TBi/manual technique than did the portable monitors, which moreover performed unequally in this regard.

Anticoagulants↗

A simple diagnostic test for pupillary abnormality in diabetic autonomic neuropathy.

A simple portable pupillometer using Polaroid photography has been developed for use in the diagnosis of diabetic autonomic neuropathy. The pupil diameter per cent (PD%), defined as the percentage of iris diameter to which pupil diameter had dilated in darkness, was measured from the instant colour prints. An age-related normal range was constructed from measurements in 163 healthy subjects in whom PD% declined linearly by 3% per decade. The PD% was measured in 15 patients with automatic neuropathy and 12 were identified with abnormally low values indicating a failure of sympathetically mediated dilatation. Results were consistent with the standard television pupillometric technique and had the same high repeatability with a coefficient of variation of 3.2%.

Adolescent↗

Protecting patient privacy against unauthorized release of medical images in a group communication environment.

In this paper, we identify and study an important patient privacy protection problem related to medical images. Following Health Insurance Portability and Accountability Act (HIPAA) mandate on privacy protection of patients' medical records, efforts have been devoted to guaranteeing the confidentiality of data and medical images during storage and transmission via an untrustworthy channel. However, to our knowledge, there has not been any effort towards protecting against unauthorized release of images by an authorized recipient. In this paper, we study the problem of tracing illegally distributed medical images in a group communication environment and identify a set of design requirements that must be met. We propose a fingerprint model suitable for many-to-many multicast, that is computationally efficient and scalable in user storage and key update communication. Simulation results also show that our scheme is highly robust to typical medical image processing and collusion attacks, while yielding high quality watermarked images.

Diagnostic Imaging↗

Laboratory and clinical evaluation of the impact Uni-Vent 750 portable ventilator.

BACKGROUND: Transportation of critically ill, mechanically ventilated patients from intensive care units for diagnostic and therapeutic procedures has become common in the last decade. Maintenance of adequate oxygenation and ventilation during transport is essential. We evaluated the Impact Uni-Vent 750 portable ventilator in the laboratory and in the clinical arena to determine its usefulness during inhospital transport. MATERIALS & METHODS: In the laboratory, we determined the Uni-Vent 750's ability to assure tidal volume (VT) delivery in the face of decreasing compliance of a test lung and tested the alarm systems. Using a two-compartment lung model modified to simulate spontaneous breathing, we also evaluated the responsiveness of the demand valve. The clinical evaluation was accomplished by comparing arterial blood gas values and ventilator settings in the intensive care unit before transport to those during transport. RESULTS: As lung compliance was reduced from 0.1 to 0.02 mL/cm H2O [1.0 to 0.20 L/kPa], a slight, statistically insignificant decrease in delivered tidal volume was observed. All alarm systems operated according to manufacturer's specifications. The demand valve triggered appropriately with PEEP from 0 to 20 cm H2O [0 to 1.96 kPa]. Sensitivity settings less than -6 cm H2O [-0.59 kPa] sometimes resulted in inability to trigger the demand valve. During patient transport, arterial blood gas values and ventilator settings were comparable to those observed in the ICU. Because an FIO2 of 1.0 was used during transport, mean (SD) PaO2 was significantly greater 89 (26) vs 341 (78) [11.8 (3.5) vs 45.3 (10.4) kPa]. CONCLUSIONS: The Uni-Vent 750 is a reliable transport ventilator, capable of maintaining adequate oxygenation and ventilation in a majority of mechanically ventilated patients. The Uni-Vent 750's ability to (1) provide CMV, AMV, and SIMV; (2) provide low and high pressure alarms; and (3) provide PEEP compensation is unique among portable ventilators.

Adult↗