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Results for “spatial dependency”

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PubMed1997

Brain aging: changes in the nature of information coding by the hippocampus.

Advanced age in rats is associated with a decline in spatial memory capacities dependent on hippocampal processing. As yet, however, little is known about the nature of age-related alterations in the information encoded by the hippocampus. Young rats and aged rats identified as intact or impaired in spatial learning capacity were trained on a radial arm maze task, and then multiple parameters of the environmental cues were manipulated to characterize the changes in firing patterns of hippocampal neurons corresponding to the presence of particular cues or the spatial relationships among them. The scope of information encoded by the hippocampus was reduced in memory-impaired aged subjects, even though the number of neurons responsive to salient environmental cues was not different from that in young rats. Furthermore, after repeated manipulations of the cues, memory-intact aged rats, like young rats, altered their spatial representations, whereas memory-impaired aged rats showed reduced plasticity of their representation throughout testing. Thus changes in hippocampal memory representation associated with aging and memory loss can be characterized as a rigid encoding of only part of the available information.

Aging↗

PubMed1996

Positional loss in strabismic amblyopia: inter-relationship of alignment threshold, bias, spatial scale and eccentricity.

In order to understand the spatial loss in strabismic amblyopia and its relationship to the contrast sensitivity deficit, we measured alignment performance for a three element vertical alignment task in which the elements were equi-visible, spatial Gabors. We derived the threshold and bias and compared these for stimuli of different spatial scale and eccentricity. Our results suggest that: (1) the deficits for alignment thresholds and bias are uncorrelated; (2) in the majority of strabismic amblyopes, both deficits are scale invariant; (3) the form of the regional distribution depends on the spatial measure used and the scale at which it is measured; and (4) there is a poor correlation between the deficit for either spatial measure and the contrast sensitivity loss.

Amblyopia↗

PubMed1994

The origins of luminance and pattern responses of the pattern electroretinogram.

A luminance response is spatially insensitive and dependent upon temporal contrast. The contribution of luminance to the pattern onset electroretinogram (PERG) can be estimated from the temporal contrast of a pattern's illuminance profile on the retina. A profile can be computed for different spatial frequencies by resynthesising the Fourier transform of the pattern after it has been filtered by the eye's MTF. A pure luminance response does not fully account for the amplitude of the PERG. The residual response is called "pattern specific". After the effects of spatial contrast degradation have been corrected for the response is spatially bandpass tuned with a peak that changes with eccentricity. An optimum foveal stimulus is estimated to be 3.5' arc. The pattern specific response component shows a correlation with inner nuclear and ganglion cell volumes. When the relationship of the luminance ERG with temporal contrast was explored empirically it was found to behave in good approximation to the theoretical predictions.

Electroretinography↗

PubMed2003

Orientation discrimination in foveal and extra-foveal vision: effects of stimulus bandwidth and contrast.

The parameter E2 is used in many spatial scaling studies to characterize the rate at which stimulus size must increase with eccentricity to achieve foveal levels of performance in detection and discrimination tasks. We examined whether the E2 for an orientation discrimination task was dependent on the spatial frequency bandwidth of the stimulus used. Two methods were employed. In Experiments 1 and 2 stimuli were presented at a fixed high level of contrast across viewing conditions. In both experiments the E2s recovered for narrowband stimuli were larger than those recovered for broadband stimuli. In Experiment 3 we controlled for the potentially confounding effects of perceptual contrast by measuring orientation thresholds over a range of stimulus contrast levels. Only thresholds which had reached an asymptotic level, such that increases in stimulus contrast led to no further changes to thresholds, were included in the calculation of E2. We observed that E2s recovered in the latter condition were in the range of 1.29 degrees -1.83 degrees and similar for narrowband and broadband stimuli. We conclude that a failure to consider the role of perceptual contrast may result in inflated estimates of E2.

Contrast Sensitivity↗

PubMed2005

Effects of spatial congruity on audio-visual multimodal integration.

Spatial constraints on multisensory integration of auditory (A) and visual (V) stimuli were investigated in humans using behavioral and electrophysiological measures. The aim was to find out whether cross-modal interactions between A and V stimuli depend on their spatial congruity, as has been found for multisensory neurons in animal studies (Stein & Meredith, 1993). Randomized sequences of unimodal (A or V) and simultaneous bimodal (AV) stimuli were presented to right- or left-field locations while subjects made speeded responses to infrequent targets of greater intensity that occurred in either or both modalities. Behavioral responses to the bimodal stimuli were faster and more accurate than to the unimodal stimuli for both same-location and different-location AV pairings. The neural basis of this cross-modal facilitation was studied by comparing event-related potentials (ERPs) to the bimodal AV stimuli with the summed ERPs to the unimodal A and V stimuli. These comparisons revealed neural interactions localized to the ventral occipito-temporal cortex (at 190 msec) and to the superior temporal cortical areas (at 260 msec) for both same- and different-location AV pairings. In contrast, ERP interactions that differed according to spatial congruity included a phase and amplitude modulation of visual-evoked activity localized to the ventral occipito-temporal cortex at 100-400 msec and an amplitude modulation of activity localized to the superior temporal region at 260-280 msec. These results demonstrate overlapping but distinctive patterns of multisensory integration for spatially congruent and incongruent AV stimuli.

Acoustic Stimulation↗

PubMedDate not supplied

[Asymmetry of movement direction as a tactic in the feeding behavior of rats].

The sign and degree of spatial-motor asymmetry in rats were studied in conditions both of spontaneous or signalled choice in an U-maze and spontaneous multiple choice in a radial labyrinth. It was shown that during investigation of a new environment, motor asymmetry in rats was feebly expressed in all conditions of experiments, irrespective of the labyrinth scheme and experimental procedures. In the process of training, adequate behaviour was formed and in some conditions a distinctly expressed spatial asymmetry appeared, while in other cases it was absent. Apparently, while investigating an "unknown" situation (where rats can move rightwards and leftwards), the strategy of "displacement" is characteristic of them. Later the rate of asymmetry manifestation depends on concrete spatial and temporal characteristics of already "familiar" surroundings.

Animals↗

PubMed1990

Role of spatial location in integration of pictorial information across saccades.

Identification of a fixated object in a visual display is facilitated by integrating information from a preview of that object in the periphery with information extracted on the subsequent foveal fixation (Pollatsek, Rayner, & Collins, 1984). These experiments investigated the extent to which this integration is dependent on the spatial location of the information remaining constant. Two preview objects were presented in the periphery; Ss fixated that region and named a single target object that appeared in the same spatial location in which one of the two preview objects had been presented. Of primary interest was the facilitative effect when a preview object was identical to the target object as a function of whether they were in the same spatial location. The major finding was that although there was a small effect of switching, there was still a substantial preview benefit even when the location of the identical object switched. In addition, the switching effect did not interact with the level of identity between the preview and target. There was also a preview benefit in conditions in which there were no eye movements and the preview and target objects were at least 5 degrees apart. Thus, the data indicate that the process object identification is relatively insensitive to location information and that object information and location information are coded fairly independently.

Adult↗

PubMed2005

Sampling the soil in long-term forest plots: the implications of spatial variation.

Long-term monitoring of forest soils as part of a pan-European network to detect environmental change depends on an accurate determination of the mean of the soil properties at each monitoring event. Forest soil is known to be very variable spatially, however. A study was undertaken to explore and quantify this variability at three forest monitoring plots in Britain. Detailed soil sampling was carried out, and the data from the chemical analyses were analysed by classical statistics and geostatistics. An analysis of variance showed that there were no consistent effects from the sample sites in relation to the position of the trees. The variogram analysis showed that there was spatial dependence at each site for several variables and some varied in an apparently periodic way. An optimal sampling analysis based on the multivariate variogram for each site suggested that a bulked sample from 36 cores would reduce error to an acceptable level. Future sampling should be designed so that it neither targets nor avoids trees and disturbed ground. This can be achieved best by using a stratified random sampling design.

Carbon↗

PubMedDate not supplied

A method for quantifying artefacts in mapping methods illustrated by application to headbanging.

Maps of disease rates (and other quantities) often must contend with variance associated with variable population sizes and low incidence within spatial units. These characteristics can lead to substantial statistical noise that can mask underlying spatial variation. As Gelman and Price illustrated, most conventional mapping methods fail to address this problem, and in fact can introduce statistical artefacts; mapped quantities can show spatial patterns even when there are no spatial patterns in the underlying parameter of interest. Kafadar evaluated the performance of the headbanging algorithm for spatial smoothing (Tukey and Tukey, Hansen) for eliminating small scale variation and preserving edge structure. Here we perform a simulation study to investigate the artefacts of maps smoothed by unweighted and weighted headbanging. We find substantial artefacts that depend on the spatial structure of the statistical variation (for example, the spatial pattern of sample sizes) and on the details of the spatial distribution of geographic units. The methods used here could readily be adapted to study other spatial smoothers; we choose headbanging because (i) it is an important method used in practice, and (ii) its heavily computational nature is naturally studied using simulation (in contrast to the analytical methods used by Gelman and Price).

Artifacts↗

PubMedDate not supplied

Relations between components of impedance cardiogram analyzed by means of finite element model and sensitivity theorem.

The main aim of the study is to establish a relation between different sources of Impedance cardiogram (ICG) as function of spatial distribution of conductivity. A three-dimensional model of a human thorax using the finite element method has been constructed. The model includes 35 horizontal layers consisting of up to 519 pentahedral elements that are automatically divided into tetrahedral ones before calculating the potential distribution. Electrode array configuration proposed by Kubicek et al. (Aerosp. Med. 37: 1208-1212, 1996) has been studied. A relationship proposed by Geselowitz (IEEE Trans. Biomed. Eng. 18: 38-41, 1971) has been used to calculate the sensitivity of the examined electrode array to conductivity changes inside the thorax. This relationship has allowed for the calculation of the contributions to ICG from spatially separated sources when modeling all changes in conductivity simultaneously. It has been confirmed that the main contributions to ICG signal come from ventricles, atria, aorta, and lungs. The relations between these components have been found to be dependent nonlinearly on spatial conductivity distribution. As a result, reliable and reproducible measurements of stroke volume (SV) using ICG are impossible. Nevertheless, ICG can be used to monitor relative changes of SV in all cases where the spatial distribution of conductivity and geometry of the subject, during the examination, is preserved. However, it does not mean that the accuracy of SV measurement will be the same in all these cases.

Biomechanical Phenomena↗

PubMed2003

Transmit SENSE.

The idea of using parallel imaging to shorten the acquisition time by the simultaneous use of multiple receive coils can be adapted for the parallel transmission of a spatially-selective multidimensional RF pulse. As in data acquisition, a multidimensional RF pulse follows a certain k-space trajectory. Shortening this trajectory shortens the pulse duration. The use of multiple transmit coils, each with its own time-dependent waveform and spatial sensitivity, can compensate for the missing parts of the excitation k-space. This results in a maintained spatial definition of the pulse profile, while its duration is reduced. This work introduces the concept of parallel transmission with arbitrarily shaped transmit coils (termed "Transmit SENSE"). Results of numerical studies demonstrate the theoretical feasibility of the approach. The experimental proof of principle is provided on a commercial MR scanner. The lack of multiple independent transmit channels was addressed by combining the excitation patterns from two separate subexperiments with different transmit setups. Shortening multidimensional RF pulses could be an interesting means of making 3D RF pulses feasible even for fast T(2)(*) relaxing species or strong main field inhomogeneities. Other applications might benefit from the ability of Transmit SENSE to improve the spatial resolution of the pulse profile while maintaining the transmit duration.

Computer Simulation↗

PubMed1991

Inhibitory refinement of spatial frequency selectivity in single cells of the cat striate cortex.

Single cells in the cat striate cortex are more selective for the spatial frequency of sinewave grating stimuli than are cells of the retina or lateral geniculate nucleus. We have explored the possibility that this enhancement of selectivity results from spatial-frequency-selective inhibition. Stimulation with two superimposed gratings, one to excite the cell and one to prove for inhibition, revealed spatial frequency-dependent response suppression in 74% of the total population studied. Suppression was slightly more prevalent in simple cells (80%) than in complex cells (68%). In 93% of the cases where suppression was found, its tuning was complementary to excitatory spatial frequency tuning, and the strongest suppression was usually found where the excitatory tuning function approached zero imp./sec. Characteristics of the phenomenon were independent of cortical layers. We conclude that organized inhibitory mechanisms serve to refine the spatial frequency bandpass of striate cortical cells. This provides evidence for another degree of nonlinearity in the organization of cortical receptive fields and supports the hypothesis that a fundamental function of the visual cortex is image dissection in the domain of spatial frequency.

Adaptation, Physiological↗

PubMed2002

A spatial model of the knee for the preoperative planning of knee surgery.

A model on the spatial mechanical behaviour of the passive knee is presented. The femoral articular surfaces were represented by generalized, sagittally elliptical, toroidal surfaces. The medial and lateral tibial articular surfaces were represented by a dished spherical surface and the lower hemihyperbolic region of a torus respectively. Anatomical articular cartilage, knee ligaments and the posterior capsule were represented by spring-like deformable elements with non-linear load versus deflection characteristics. All the forces that act on the femur relative to the tibia were represented by three orthogonal forces and three associated moments. Spatial, articulation-dependent femorotibial kinematic constraint equations of the passive knee were formulated in an analytically explicit manner, based on the natural coordinates of the articular surfaces. The constraint equations were solved algebraically in closed form. Equations were derived that describe spatial femoro-tibial motion, ligament length, ligament strain, ligament-based elastic potential energy and the quasi-static equilibrium of the passive knee. Software was written, simulations on the motion characteristics and load versus deflection characteristics of the knee were carried out and graphical results were presented. The simulation of planar flexion/extension was almost spontaneous. The time taken to simulate spatial six-degree-of-freedom femoro-tibial motion was less than 2.5 min. The models were found to be capable of representing real-life passive knees to a high degree of satisfaction. It has been demonstrated that the models can provide knee surgeons with additional information on major aspects of the preoperative planning of knee surgery. The models can be used to enhance the preoperative planning of ligament reconstruction, articular surfaces related surgery, osteotomy and patellar tendon transfer surgery.

Biomechanical Phenomena↗

PubMed1995

Tissue specificity of a glucocorticoid-dependent enhancer in transgenic mice.

The glucocorticoid-responsive units (GRUs) of the rat tyrosine aminotransferase were associated with the regulatory sequences of a cellular gene expressed ubiquitously--that coding for the largest subunit of RNA polymerase II. In transient expression assays, glucocorticoid responsiveness of the hybrid regulatory regions depends on the spatial relationship and number of regulatory elements. Two parameters affect the ratio of induction by glucocorticoids: the basal level of the hybrid promoter that is affected by the RNA polymerase II regulatory sequences and the glucocorticoid-induced level that depends on the distance between the GRUs and the TATA box. A fully active glucocorticoid-responsive hybrid gene was used to generate transgenic mice. Results show that a composite regulatory pattern is obtained: ubiquitous basal expression characteristic of the RNA polymerase II gene and liver-specific glucocorticoid activation characteristic of the tyrosine aminotransferase GRUs. This result demonstrates that the activity of the tyrosine aminotransferase GRUs is cell-type-specific not only in cultured cells but also in the whole animal.

Animals↗

PubMed1981

The relationship between response amplitude and contrast for cat striate cortical neurones.

1. The activity of forty-three neurones in the cat's striate cortex in response to laterally moving sinusoidal gratings of various contrasts was recorded, in order to examine the relationship between response amplitude and contrast. 2. Neurones seemed to exhibit contrast thresholds: stimuli of very low contrast failed to evoke a change in the response amplitude from the concurrent levels of spontaneous activity. 3. The suprathreshold portion of the response-contrast relation was found to be monotonic. Typically, the relation was adequately described as linear up to contrasts of about 0.3, above which, varying degrees of saturation were evident. 4. The response-contrast relation had a higher threshold and a shallower slope when the spatial frequency was not optimal for the neurone. 5. The slope, or gain, of the response-contrast relation for a stimulus of optimal orientation and spatial frequency varied considerably from neurone to neurone. The gains of special complex cells were significantly greater than those of either standard complex cells or simple cells. 6. The distributions of contrast threshold and contrast gain were examined for their dependence on optimal spatial frequency. Contrast threshold was significantly positively correlated with optimal spatial frequency, while contrast gain was significantly negatively correlated with optimal spatial frequency. This behaviour is consistent with an optical contribution to the measured response properties of striate cortical neurones.

Action Potentials↗

PubMed2006

Stability of two-dimensional spatial solitons in nonlocal nonlinear media.

We discuss the existence and stability of two-dimensional solitons in media with spatially nonlocal nonlinear response. We show that such systems, which include thermal nonlinearity and dipolar Bose-Einstein condensates, may support a variety of stationary localized structures, including rotating dipole solitons. We also demonstrate that the stability of these structures critically depends on the spatial profile of the nonlocal response function.

Journal Article↗

PubMed2004

Theoretical and numerical aspects of transmit SENSE.

The ideas of parallel imaging techniques, designed to shorten the acquisition time by the simultaneous use of multiple receive coils, can be adapted for parallel transmission of a spatially selective multidimensional RF pulse. In analogy to data acquisition, a multidimensional RF pulse follows a certain trajectory in k-space. Shortening this trajectory shortens the pulse duration. The use of multiple transmit coils, each with its own time-dependent waveform and spatial sensitivity, compensates for the missing parts of k-space. This results in a maintained spatial definition of the pulse profile while its duration is reduced. This paper describes the basic equations of parallel transmission with arbitrarily shaped transmit coils ("Transmit SENSE") focusing on two-dimensional RF pulses. Results of numerical studies are presented demonstrating the theoretical feasibility of the approach.

Computer Simulation↗

PubMed2001

Discharge of primate magnocellular red nucleus neurons during reaching to grasp in different spatial locations.

Reaching to grasp is of fundamental importance to primate motor behavior. One descending motor pathway that contributes to the control of this behavior is the rubrospinal tract. An important source of origin of the rubrospinal tract is the magnocellular red nucleus (RNm). Forelimb RNm neurons discharge vigorously during reach-to-grasp movements. RNm discharge is important for hand use, as coordinated whole-limb movements without hand use are not associated with strong discharge. Because RNm is functionally linked to muscles of the entire forelimb, RNm discharge may also contribute to use of the proximal limb that accompanies hand use. If RNm contributes to proximal limb use, we predict discharge to differ for reaches that differ in proximal limb involvement but require the same grasp. We tested this prediction by measuring discharge of individual RNm neurons while monkeys reached to grasp objects in four spatial locations in front of them. The animals reached from the waist to locations to the left, right, above, and below the shoulder of the "reaching" limb. RNm neurons of our sample were activated strongly during reach-to-grasp, and discharge of a third of the neurons tested depended on the spatial location of the object grasped. Discharge of RNm neurons and EMG activity of many of the distal and proximal forelimb muscles we tested were larger for reaching to grasp in the upper and/or right than lower and left target locations. Based on comparisons of each individual neuron's discharge patterns during reaches with and without preshaping the hand, we conclude that target location-dependent modulations in discharge rate of the majority of RNm neurons whose discharge differed for reaching to grasp in the four target locations contributed to aspects of hand preshaping that covaried with reach direction.

Action Potentials↗