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The correlation of visual evoked potentials (VEP) and visual field indices (Octopus G1) in glaucoma and ocular hypertension.

Flash evoked responses and the visual field indices (VFI) of the Octopus G1 program were recorded from 42 eyes of 21 patients, aged 23-76 years (mean 51 years); 29 eyes had open-angle glaucoma (OAG) and 10 ocular hypertension (OH). Three eyes were normal. The early component of the VEP called P 120 had lower amplitude in glaucomatous eyes compared with normal or hypertensive eyes. Mean sensitivity (MS), mean defect (MD), and short time fluctuation (SF), indicative of diffuse non-specific nerve fiber los, correlated significantly (P less than 0.05). Reliability factor (RF), which is indicative of psychodynamic factors, also correlated significantly (P less than 0.05) in eyes with OAG.

Adult↗

[Vascular headache. Changes in visual evoked potentials].

The authors examined visual evoked potentials using the method of the visual full field stimulation hemi-field, using a check-board patterned structural stimulus in 69 patients with the diagnosis of vascular headache. The peak latencies of the waves did not differ significantly in the group of patients with vascular cephalea, as compared with the control group; this applies to both ways of stimulation. The es amplitudes of waves (P1 = P100 and N2) were significantly higher in the group with vascular cephalea after stimulation by the visual field. Of half the visual field stimulation did not reveal statistically significant differences in the latencies waves. The results may indicate an increased electrophysiological activity of the visual system in the interparoxysmal period in patients with vascular cephalea.

Adult↗

Effects of spatial frequency and orientation on visually evoked cortical potentials.

Visually evoked cortical potentials (VECP) were recorded from an array of 4 electrodes along the midline over the occipital cortex in 10 normal subjects. Grating stimuli of different spatial frequencies were presented on a circular test field and spatial tuning curves and potential distribution evoked by vertical, horizontal and oblique stimuli were compared. The peak latencies were the shortest for the stimuli of 2.3 cycles per degree grating oriented vertically. The peak latencies increased for horizontal and further for oblique gratings. The effects of spatial frequency or orientation on the location of the major positive components of the VECP were not significant when recorded on the midline scalp.

Adult↗

Electrode position and the multi-focal visual-evoked potential: role in objective visual field assessment.

PURPOSE/METHODS: To improve the performance of visual-evoked potentials (VEP) in the assessment of the human visual field, the multi-focal cortically scaled pattern VEP was recorded up to 250 of eccentricity in normal subjects. Monopolar and varying bipolar electrode positions were used. RESULTS: The monopolar response was strongly biased towards the lower hemifield. Bipolar leads straddling the inion (2 cm above and below) achieved approximately equal signals from the upper and lower visual field. Division into sectors of similar wave-form augments the analysis compared with summed full-field responses. CONCLUSION: With this technique, the multi-focal VEP can be used to objectively assess the visual field.

Cerebral Cortex↗

Reversible visual evoked potential abnormalities in vitamin E deficiency.

A patient with cystic fibrosis and cirrhosis developed a progressive neurological syndrome associated with ataxia, proximal weakness, and ophthalmoplegia. Profound deficiencies of vitamins A, D, and E were present. Visual acuity and results of retinal funduscopy were normal. The pattern reversal visual evoked potential was initially abnormal (P100 latency, 136 and 130 ms from left and right eyes, respectively) but became normal (less than 3 standard deviations from mean control P100 latency) over a two-month period when vitamin E was administered. This case documents a potentially reversible visual evoked potential abnormality in a visually asymptomatic patient with vitamin E deficiency.

Adult↗

Vector analysis of visual evoked potentials in migraineurs with visual aura.

OBJECTIVE: To assess the capability of vector analysis of visual evoked potentials (VEPs) for revealing alterations in posterior visual pathways in migraineurs with visual aura. METHODS: VEPs to pattern reversal (PR) and LED goggle stimulation were obtained in 23 patients suffering from migraine with visual aura, in an orthogonal Fpz-Oz and T3-T4 montage and displayed as a two-channel Lissajous' trajectory. VEP latency and amplitude at Fpz-Oz, bc segment amplitude (V) and bc vector orientation angle (theta) were compared with a previously collected normative database for individual assessment, and group comparisons with the previously collected normal sample were made. Electrophysiological measures were also correlated with time from onset of disease and from the last crisis, and with the side of symptoms. RESULTS: No individual alterations in VEP latency or amplitude were observed. However, 36.4% of patients showed alterations in vector orientation to PR and 78% to LED goggles. Group differences with respect to normal subjects were found not only in vector orientation but also in midline VEP and V, only for PR stimulation. A significant relationship was found between the laterality of vector deviation and the laterality of symptoms. CONCLUSIONS: Vector analysis of VEP revealed alterations possibly corresponding to asymmetrical visual cortex activation in migraineurs with visual aura, mainly to diffuse light stimulation. SIGNIFICANCE: An electrophysiological parameter of individual value for revealing asymmetric activation of visual cortex in migraineurs is proposed.

Adolescent↗

Prognostic value of visual evoked potentials (VEP) in infants with visual inattentiveness.

Visual evoked potentials elicited by strobe flash (fVEPs) were recorded in 56 infants (3 months to 15 months of age) with visual inattentiveness but without prechiasmal problems. Their visual status was reexamined one or more years later when 41 children were found to be visually competent (Group NB) and 15 were blind (Group B). We also evaluated a group of 32 age-matched children who had no visual symptoms (Group C). It was found that well organized VEP waveforms over one or both hemispheres (Types U and S), or those with a characteristic negative shift (Type N) suggest favorable prognosis. Integrated voltage of the VEP correlated well with long-term prognosis for visual recovery. The vertex VEP also (had) provided some predictions for visual prognosis. Overall results indicate good prognosis if related to sufficient voltage and complexity of the VEP components.

Blindness↗

[Visual evoked potentials in optochiasmal arachnoiditis].

Visual evoked potentials (EP) were studied in 24 patients with optochiasmal arachnoiditis. Distinct changes were registered in the visual EP in the form of increased latent period of the response, diminution of its amplitude and separability, and poor structuralization. The critical level of visual acuity for the specific and nonspecific visual EP was determined. From analysis of the visual EP time-course during treatment the authors established the criteria of the prognosis for the recovery of visual functions in patients with optochiasmal arachnoiditis.

Adolescent↗

Laminar field potentials and unit activity in the cortex during visual evoked potentials in feline generalized penicillin epilepsy.

Modifications of the visual evoked potential during generalized epilepsy were investigated in feline generalized penicillin epilepsy. Visual evoked potentials and their intracortical profiles were averaged during intraburst periods and during the wave of the spike and wave complex to a fixed latency from the preceding spike. During interburst periods, the evoked potentials showed an increase in the amplitude of the early positive peak and the appearance after a variable latency period of a second consistent peak during the late phase of the evoked potential. Laminar profiles of visual evoked potentials and their current source density analysis compared with the activity of single cortical units suggested an early excitation of neuronal populations at layers II, III and IV, as seen before penicillin, followed by a variable inhibitory period and by a subsequent rebounded excitation at those same levels. In evoked potentials recorded during the wave of the spike and wave complex, the early phase was unchanged and the late positive peak and the corresponding deep sink were greatly reduced or nonexistent, although the rebounded activation of cortical units was still evident. These data support the conclusion that during feline generalized penicillin epilepsy a larger number of cortical neurons are activated and a sequence of excitation-inhibition-excitation, probably involving also subcortical structures, is brought about. Moreover, the inhibitory phase of the spike and wave complex is soon disrupted whenever a consistent sensory stimulus arrives at the cortex.

Action Potentials↗

Rhythmic variations of P100 component of pattern-reversal visual evoked potentials.

Pattern-reversal visual evoked potentials (EPs) were recorded in seven adult subjects to assess the existence of rhythmic variations in processing visual information at a primary stage. During a session of two hours, sixty EPs were recorded on the left and right cerebral hemispheres. The amplitude of N75-P100 component was measured. Remarkable variations were found with a periodicity from 15 to 60 min in six out of seven subjects. No hemispheric differences were found in the rhythmic variations. The results are in agreement with the behavioral data which show ultradian variations in visual performance depending on a general activation oscillator.

Activity Cycles↗

Test-retest reliability of swept visual evoked potential measurements of infant visual acuity and contrast sensitivity.

The aim of the study was to describe variations in swept visual evoked potential (SWEEP-VEP) assessment of visual acuity and contrast sensitivity in infants and to evaluate the best way to estimate visual performance from obtained SWEEP-VEP data. The visual performance of 92 infants (6-40 wk of age) was measured in two separate visits. Results were verified with repeated tests in seven adults. There was a strong association between the two measurements of infant visual acuity (r = 0.91, p < 0.001), with no constant bias and an inter-assay coefficient of variation of 8.4%. The intra-assay coefficient of variation was 17% and in repeated sessions all obtained acuity measures were normally distributed, indicating that the mean and not the maximum threshold best estimates visual acuity. This estimate of visual acuity also had lower test-retest variability than those calculated from the maximum threshold or threshold from the average EEG signals (p = 0.001). Test-retest measures of infant contrast sensitivity had a correlation coefficient of 0.72 (p < 0.001) and an inter-assay coefficient of variation of 23%. With the observed test-retest variability, SWEEP-VEP is less valid for estimating the visual performance of individual subjects, but it can give reliable group means. This method was well suited to describe visual development in the infants, which for acuity as well as contrast sensitivity increased by 0.64 octave per doubling in age. However, the variability of the SWEEP-VEP method can be a limiting factor, for example, in the assessment of the potential effect of dietary docosahexaenoic acid in a homogeneous group of infants.

Adult↗

Visual evoked potentials.

The recording of visual evoked potentials (VEPs) is an important means of obtaining reproducible, quantitative data on the function of the anterior visual pathways. In this review, the technical aspects of recording VEPs are briefly discussed, components of the VEPs are described, and the clinical uses of VEPs are considered. It is concluded that VEPs are useful in providing information concerning the functional integrity of the anterior visual pathways. They are especially useful in evaluating patients with visual symptoms but no objective findings on examination and in patients without visual symptoms but with diseases that are known to involve the visual pathways commonly and subclinically. Lastly, the utility and limitations of VEPs in various neurological disorders are summarized, bearing in mind the widespread availability of advanced neuroimaging techniques.

Acoustic Stimulation↗

The effect of spatial frequency and contrast on the latency in the visual evoked potential.

The latency in the visual evoked potential was measured at spatial frequencies of 2-12 c/deg in 10 subjects. The contrast levels of the sinuosoidal grating patterns were set at 1.5, 1.75, 2.0, 2.25, 2.5, 2.75 and 3.0 log units above each subject's contrast sensitivity threshold. Two factors were shown to influence the latency: suprathreshold contrast and, to a lesser extent, spatial frequency. The visual evoked potential latencies at contrast sensitivity threshold were extrapolated. These threshold latencies showed considerable variation with spatial frequency and between subjects. Therefore, the visual evoked potential latency cannot be considered a useful tool for estimating the contrast sensitivity function.

Adult↗

Hemispheric differences for visual evoked potentials from checkerboard stimuli.

Visual evoked potentials (VEPs) were elicited in right-handed male subjects with an alternating checkerboard pattern stimulus presented to either the left or right visual half-field. The sizes of the individual checks in different conditions were 0.25, 0.5, 2.0, or 4.0 cycles/degree of visual angle. The amplitude of the P100 VEP decreased while peak latency increased as check size decreased across both visual field conditions. Left hemisphere responses demonstrated significantly larger P100 amplitudes compared to the right hemisphere responses, although the interaction between hemisphere and stimulus size was not significant. No hemispheric effects of P100 latency were observed. The results suggest that the left hemisphere is engaged more than the right hemisphere for the sensory analysis of visual stimuli composed of straight edges over a wide range of spatial frequencies.

Adult↗

Selective attention to stimulus location modulates the steady-state visual evoked potential.

Steady-state visual evoked potentials (SSVEPs) were recorded from the scalp of human subjects who were cued to attend to a rapid sequence of alphanumeric characters presented to one visual half-field while ignoring a concurrent sequence of characters in the opposite half-field. These two-character sequences were each superimposed upon a small square background that was flickered at a rate of 8.6 Hz in one half-field and 12 Hz in the other half-field. The amplitude of the frequency-coded SSVEP elicited by either of the task-irrelevant flickering backgrounds was significantly enlarged when attention was focused upon the character sequence at the same location. This amplitude enhancement with attention was most prominent over occipital-temporal scalp areas of the right cerebral hemisphere regardless of the visual field of stimulation. These findings indicate that the SSVEP reflects an enhancement of neural responses to all stimuli that fall within the "spotlight" of spatial attention, whether or not the stimuli are task-relevant. Recordings of the SSVEP provide a new approach for studying the neural mechanisms and functional properties of selective attention to multi-element visual displays.

Adult↗

Dynamic topography of pattern visual evoked potentials (PVEP) in psychogenic visual loss patients.

We investigated to measure the objective visual acuity using pattern visual evoked potentials (PVEP) to help the diagnosis with psychogenic visual loss (PVL) who ranged in age from 7 to 14 years old. Pattern stimuli consisted of black and white checkerboard patterns (39, 26, 15 and 9') with a visual angle of 8 degrees and a contrast level of 15%. The pattern reversal frequency was 0.7 Hz. This resulted in an average of 100 PVEP per session. Visual acuity of 0.1 was consistent with the 39' pattern, 0.2 with the 26' pattern, 0.5 with the 15' pattern, and 1.0 with the 9' pattern. As the results, five PVL patients could measure visual acuity with this method in the present study. The PVEP is useful in evaluating the visual acuity and helped to diagnose the PVL patients. In addition we used the dynamic topography to study the difference in the results of the PVEP. The dynamic topography obtained from the results of the PVEP was analyzed. The flow type of the P100 component diverged into three types (separated type, hollow type and localized type) in the PVL patients and the normal children. The localized type was observed in 59.1% of normal children and in 56.3% of PVL patients. While the separated type was shown in 6.8% of normal children and in 8.3% of PVL patients. There were not significant differences between the PVL patients and the normal children in each type.

Adolescent↗

Fractal analysis of steady-state-flicker visual evoked potentials: feasibility.

Electrophysiological models of visual evoked potential recording have assumed that response variability is caused predominantly by random noise added to a true steady signal. Since neuronal geometry has a fractal structure, neural activity may demonstrate deterministic nonlinear dynamics, i.e., chaos. We recorded several-minute time-series traces of the visual evoked potential magnitude in response to full-field flicker from three glaucoma patients and one normal subject. When plotted in phase space, the steady-state response derived from a lock-in amplifier shows an apparent so-called strange attractor (extended nonrepeating loops) rather than the pattern expected from a signal-plus-noise model (a fuzzy dot). The fractal dimension of this attractor may be a more sensitive indicator of early optic-nerve damage than are visual evoked potential latency or amplitude measures.

Electrophysiology↗