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At least 19 recordsLinked to original sources
PubMed1978

In vitro modulation of lymphocyte responses to phytohaemagglutinin by plasma in mother and baby at the time of birth. Increased lymphocyte responses in babies of mothers with lepromatous leprosy.

Peripheral blood lymphocytes from nineteen healthy mothers, mothers with borderline tuberculoid leprosy and fourteen mothers with borderline or polar lepromatous leprosy, and their newborn babies, were stimulated in vitro with phytohaemagglutinin (PHA). The responses in medium supplemented by serum from a pool of healthy non-pregnant individuals were compared with responses in medium supplemented by plasma from the mothers or from their babies, to assay for the presence of non-specific effects on T-cell responses. It was found that plasma from the mothers at the time of labour profoundly suppressed their own lymphocyte responses to PHA. However, the lymphocyte responses of healthy mothers were not significantly suppressed when cultivated in the presence of plasma from the babies, indicating that the suppressive factor(s) of normal pregnancy did not pass the placental barrier. Plasma from mothers with leprosy had a greater inhibitory effect on their babies' lymphocytes than plasma from healthy mothers. This raises the possibility that plasma from leprosy patients contains suppressive factors other than those associated with pregnancy. Babies of lepromatous leprosy mothers, who might have been exposed to mycobacterial antigens in utero, had higher PHA responses than the other babies, possibly due to a compensatory reaction to early stresses in the immune system.

Female↗
PubMed1975

A mother-instruction program: Documenting change in mother-child interactions.

Measures of mother-child interaction change are reported in a series of 30 mothers and their children, aged 2 to 10. Videotaped play sessions were analyzed in detail to provide baseline measures from which individualized modification guidelines were derived. Mothers were instructed in eight weekly sessions via bug-in-the-ear. Postinstruction observations provided quantification of observed changes following instruction. The target of change was mother-child behavior contingency patterns, effected by intervening into the mother component on those patterns. Measured changes in mother and child behaviors, mother-child contingency patterns, and mother's preceptions of child behaviors are compared.

Affect↗
PubMed1976

Escherichia coli O antibody content in milk from healthy Swedish mothers and mothers from a very low socio-economic group of a developing country.

The antibody content of milk from healthy Swedish mothers was compared with that of milk from mothers of a very low socio-economic group in a developing country. Antibodies of various immunoglobulin classes against E. coli O antigens were determined with the enzyme-linked immunosorbent assay (ELISA). The milk antibodies which mainly belonged to the secretory IgA class appeared in similar concentrations in milk from the two groups using E. coli antigens of Swedish as well as Pakistani origin. The secretory IgA antibodies could be demonstrated in the stool of the breast-fed infants of the undernourished mothers. Also the concentration of serum IgG and IgA antibodies to E. coli O antigens were similar in the Pakistani and Swedish mothers. The serum IgM antibody levels of the Pakistani mothers were higher, however, presumably due to a higher frequency of infections. It was noted that the milk production decreased considerably upon the hospitalization of the healthy and well-to-do Swedish mothers. The small milk volumes of the undernourished Pakistani mothers suggest that the lactation failure observed was mainly due to inadequate milk flow and not to decreased milk quality. The results indicate the necessity of studying the nutritional, psychological and social factors responsible for low milk yield and add yet another reason to stimulate prolonged breastfeeding.

Adult↗
PubMed1975

Glucose tolerance in newborn infants of healthy mothers: its relationship to the mothers' insulin response to glucose infusion.

It has earlier been postulated that a low insulin response to a glucose infusion is characteristic for the prediabetic individual (Cerasi & Luft 1967c). There is also evidence that some infants of individuals with low insulin response might have a carbohydrate metabolism that is in some respects similar to that of newborn infants to diabetic mothers (Edström et al. 1974). In the present study 15 infants to low insulin responders (ILR) and 22 infants to high insulin responders (IHR) were subjected to an intravenous glucose load (IVGTT) at 2-24 h age. A significant difference in glucose tolerance was found between the groups, the mean k-value for the ILR being 1.39 plus or minus 0.41 and that for the IHR 1.05 plus or minus 0.09 (P smaller than 0.05). No mothers were found to have a gestational diabetes (with the possible exception of one low insulin responders) but during late pregnancy the mean k-value at IVGTT in the low responders decreased from non-pregnant values (the mean difference being 0.41 plus or minus 0.20, P smaller 0.025) while the high responders did not show a corresponding decrease (mean difference 0.12 plus or minus 0.25, P greater than 0.05). No other differences between the groups of infants that could influence the k-value could be found apart from the mothers being low or high insulin responders. Our findings show that a low insulin response in the mothers might effect the glucose tolerance of the foetus even in the absence of continuous maternal hyperglycaemia in late pregnancy.

Birth Weight↗
PubMed1979

Gn allotypes in mother-father-cord trios. A selective transfer of autologous, fetal IgG to the mother.

When tested at a standard dilution (1:30), mother-cord Gm phenotypes are identical. A more sensitive assay reveals that the fetus does possess paternal antigen, that is, does produce small amounts of autologous IgG. The paternal antigens, in both the mother and the cord plasma, appear in a mosaic, one that suggests the fetus has the ability to selectively transfer his own IgG subclasses to the mother.

Antigens↗
PubMed1977

Herpes gestationis. A high titre of anti-HLA-B8 antibody in the mother and pemphigoid-like immunohistological findings in the mother and the child.

A mother with herpes gestationis and her child without cutaneous lesions had analogous immunohistological findings. In the skin they had deposits of IgG and C3 component of complement at the basement membrane zone. Circulating IgG antibody to the basement membrane was also demonstrated in both. The mother also had a high titre of anti-HLA antibody against a histocompatibility antigen (HLA-B8) present in the child. A possible role of this HLA antibody in the pathomechanism of herpes gestationis is discussed.

Adult↗