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Biomedical subjects

A I Neĭmark

Publications and source records attributed to A I Neĭmark.

At least 37 records · Page 2Linked to original sources
PubMed1977

[State of the hemodynamics in the remaining kidney after nephrectomy].

The state of hemodynamics of the kidney left after nephrectomy was examined by determining renal blood flow and rheorenography. In the two experimental series nephrectomy was accompanied by hemorrhage with the subsequent auto-blood and homologous blood transfusion. Nephrectomy produced a blood flow reduction in the remaining kidney associated with the lowering of the blood compression and vasospasm. The blood flow returned to the normal at the end of the first 24 hours, and then increased progressively. Hemorrhage during the operation aggravated the hemodynamic disorders in the remaining kidney during the first postoperative hours. The use of autoblood promoted their quick disappearance, within two hours. At the same time the use of homologous blood led to persistence of hemodynamic disorders up to three days after the operation.

Animals↗
PubMed1975

[Phase structure of cardiac activity and the function of renal vessels in nephrogenic hypertension].

A total of 25 patients with renal affections, in whom an elevated arterial pressure had been ascertained clinically, were examined for the phasic structure of the cardiac action and for the functional state of the renal vessels by employing rheography. Of these patients 8 had urolithiasis, 6-tuberculosis, 7-polycystosis and 4-renal tumours. Their systolic pressure averaged 160-220 mm and diastolic-80-110 mm. In patients with nephrogenic hypertension the tone of systemic vessels and the peripheral resistance are shown to go up. The changes are accompanied by a phasic syndrome of a high diastolic pressure. A complex investigation into the phasic structure of the cardiac activity and the functional condition of the renal vessels by employing rheography makes it possible to disclose the sequential lesion of the vessels in patients suffering from nephrogenic hypertension.

Adult↗
PubMedDate not supplied

[Use of isradipine and lipostabil for protection of the kidney during extracorporeal lithotripsy].

The authors analyse the effects of ESWL on renal function in 180 patients with nephrolithiasis. Renal performance was judged by the level of enzymes. Pharmacological defense of the kidney was made with isradipine and lipostabil given for 12 weeks before lithotripsy and 4 weeks after it. Isradipine proved a good corrector of renal function after lithotripsy as it decreased enzymuria, promoted normalization of the activity of alkaline phosphatase, gamma-glutamyl transferase, alpha-glucosidase and lactate dehydrogenase to the end of the first postoperative month. This indicates quicker recovery of renal parenchyma after ESWL. Lipostabil also improved enzymic indices. Its moderate protective action on renal parenchyma normalized levels of some enzymes one month after ESWL.

Adult↗
PubMedDate not supplied

[Color ultrasonic angiography in evaluation of chronic prostatitis treatment results].

Fifty-six patients with chronic prostatitis were treated. Routine clinical examinations were supplemented with ultrasonic examination of the prostate via the transurethral access. In addition to the gray-scale examination of prostatic status, color Doppler mapping was carried out in order to evaluate vascular pattern and bloodflow in the prostate. The studies were carried out before and after treatment, which included routine therapy. Suppressed bloodflow in the central and peripheral zones of the prostate (more pronounced inhibition in the peripheral zone) was observed in all patients before treatment. Multiple-modality treatment stimulated function of the main arterioles, arteriovenous shunts were involved in functioning, and prostatic hemodynamics in general was improved, which promoted better delivery of drugs into the focus and eventually eliminated the inflammatory process.

Adolescent↗
PubMedDate not supplied

[Urinary stress incontinence in women: comparison of treatments].

A technique of surgical treatment of urinary stress incontinence (USI) in women is proposed. It consists of three stages. Stage 1 (intervaginal)--anterior colporaphy with plastic reconstruction of urogenital diaphragmatic muscles. Stage 2 (an original procedure)--fixation of the neck of the urinary bladder to musculus rectus abdominis and aponeurosis by means of three caprone ligatures by dissection of the anterior abdominal wall to the peritoneum. Stage 3--posterior colporaphy, perineolevatoroplasty. Stage 3 is conducted if the patient has marked rectocele simultaneously or 6 months after the initial operation. As shown by examination of 60 patients 1-20 years after the operation, good results were achieved in 91.2% of cases. The proposed method is simple, effective, involves all the pathogenetic links, corrects the changes in anatomofunctional condition of the lower urinary tracts restoring the "integral sphincter mechanism of the pelvis". It is recommended for treatment of females with moderate and severe USI or patients with enuresis type 2 and 3.

Adult↗
PubMedDate not supplied

[Role of spermatic plasma enzyme in pathogenesis of relative male sterility].

A complex of biochemical tests and standard techniques were used in males with relative sterility (RS) for ejaculate study allowing to detect pathology by qualitative and quantitative characteristics of the activity of spermatic plasma enzymes: alkaline phosphatase, acid phosphatase, gamma-glutamyl transferase, dipeptyl aminotransferase IV. A comprehensive evaluation of spermatic plasma enzymes of membrane-bound and intrastructural location made in 602 patients helped to establish severity and pathogenetic mechanisms of spermatozoon membrane damage in male RS. Hyperenzymospermia in patients with RS was of membrane origin and could be due to destabilization of the membrane and spermatozoon intrastructural elements. Staging of and an original approach to pathogenesis of impaired fertilizing ability of spermatozoa in males with RS are proposed.

Acid Phosphatase↗
PubMedDate not supplied

[Role of physico-chemical and biochemical composition of urine in the genesis of combined nephrolithiasis and cholelithiasis].

Enzymuria, principal fractions of phospholipids, crystal-inhibiting urine activity were measured in 120 patients with nephrolithiasis combined with cholelithiasis. The patients were divided into two groups: group 1-80 patients with symptoms of nephrolithiasis and latent cholelithiasis; group 2-40 patients with symptoms of cholelithiasis and latent nephrolithiasis. It is shown that hyperenzymuria/microproteinuria, high excretion of phospholipids and cholesterol with urine in patients with nephrolithiasis and its complications not only affect physico-chemical properties of urine promoting atypical salt crystallization with stone formation but also determine characteristics of phasic urine conditions. High urine concentration of phospholipid (acyl derivatives) degradation products and cholesterol in patients with combination of nephrolithiasis with cholelithiasis changes solubilizing and micello-forming ability of urine and can directly stimulate crystal formation and development of aseptic inflammation in renal parenchyma. Low total crystal-inhibiting urine activity, altered surface-free energy due to surface-active substances, high calcium ionization and low urine magnesium ionization are not only pathognomonic criteria of nephrolithiasis but also parameters reflecting high risk of oxalate-calcium formation in patients with nephrolithiasis combination with cholelithiasis.

Adult↗
PubMedDate not supplied

[Prospects for preoperative low-intensity laser therapy in preventing postoperative thrombohemorrhagic complications in adenomectomy].

The authors analyse the results of preoperative preoperation of 143 patients with benign prostatic hyperplasia (BPH). Conventional preoperative preparation (antibiotics, uroantiseptics and phytotherapy) was used in combination with intravascular laser irradiation of blood (group 1, 30 patients), local laser therapy (transurethral and transrectal) (group 2, 27 patients), variation of laser methods (group 3, 28 patients) and alone (61 patients, group 4). Such preoperative preparation was aimed at prophylaxis of thrombohemorrhagic complications after adenomectomy. The efficiency of the treatment was assessed by hemostasis parameters. It was found that conventional antiinflammatory therapy had a weak effect on hemostasis, the greatest positive effects being achieved with combined laser preoperative preparation. Hyperfibrinogenemia, thrombinemia and activation of XII + a-dependent finrinolysis were stopped in patients of group 3. Because of less number of postoperative hemorrhages, hemotransfusions and transfusions of blood preparations were used less frequently, red cell parameters improved, exacerbations of chronic pyelonephritis occurred less often.

Adult↗
PubMedDate not supplied

[Treatment of patients with invasive bladder cancer].

Radical surgery was made in 85 patients with invasive cancer of the bladder. 89.4% patients had the tumor of stage T2-T3. After the operation all 85 patients received 3 courses of adjuvant chemotherapy M-VAC in modification of the Cancer Research Center. The interval between the courses was 3 weeks. The patients were divided into two groups. The test group (n = 43) received surgical treatment, M-VAC chemotherapy and immunocorrection (general magnetotherapy, phytotherapy = cyclopheron). The control group (n = 42) received only surgery and adjuvant chemotherapy. It was found that the above immunocorrection reduces the number of postoperative complications 3.8 times, side effects by chemotherapy by 1.4 times. Absolute count of T lymphocytes and their active forms elevated by 42.8 and 35.7%, respectively, while CIC diminished by 48.8%. The addition of immunocorrection to combined treatment of patients with invasive cancer of the bladder decreased the number of recurrences for 2 years twice. 3-year survival was 1.5 times longer.

Acridines↗
PubMedDate not supplied

[Treatment of stable dysuria in women].

The authors analyse treatment results for 88 women suffering from stable dysuria (SD). 44 of them with diagnosis "proliferative cystitis" underwent TUR of the bladder mucosa. The rest were treated conventionally. Biopsy of the bladder was made in all the patients. It is shown that mechanisms of SD development lies in that developing metaplasia of the squamous epithelium prevents close contacts between the surface cells leading to urine penetration into the submucous layer. This provokes frequent and painful micturition. The area of the bladder triangle contains vaginal epithelium (embryological) which changes according to the menstrual phases. Dysuria is more pronounced in the premenstrual period, i.e. in the period of marked desquamation of the squamous epithelial. Desquamation of the surface layer of metaplastic squamous epithelium cells and its thinning ease urine diffusion via intercellular space to the nerves and muscles of the bladder detrusor, thus deteriorating clinical symptoms. Thus, pain in full bladder results from functional failure of metaplastic multilayer squamous epithelium. To eradicate SD in such a situation, TUR of the bladder is recommended.

Adult↗
PubMedDate not supplied

[Use of "Serebrianyĭ Kliuch" mineral water in the postoperative treatment of patients with nephrolithiasis after extracorporeal shock-wave lithotripsy].

27 patients with nephrolithiasis were exposed to extracorporeal shock-wave lithotripsy (ESWL). They were divided into two groups: group 1 of 10 patients who were exposed to ESWL and drank tap water and group 2 of 17 patients who were exposed to ESWL and drank silver-containing mineral water Serebryany klyuch. In group 2 there was a marked diuretic effect manifesting with intensive excretion of electrolytes (K, Na), phosphorus and uric acid. This led to improvement and normalization of renal function, promoted faster elimination of concrement fragments and more frequent (by 52.3%) complete elimination of the concrements.

Drinking↗