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Biomedical subjects

A J Veliath

Publications and source records attributed to A J Veliath.

At least 37 records · Page 2Linked to original sources
PubMed1987

Genital amebiasis.

Five cases of amebiasis of the genital tract involving the cervix, vulva and penis are described. All presented as an ulcerating mass and were clinically suspected to have a tumor. In two cases the amebiasis co-existed with a carcinoma, an association which is extremely rare. The spouse of a patient with penile amebiasis was found to have amebiasis of the cervix suggesting a sexually transmitted mode of infection. The need for histopathological confirmation of all suspected genital malignancies is emphasised due to the striking resemblance of genital amebiasis to a carcinoma. The co-existence of amebiasis with carcinoma is of interest and suggests a possible etiological relationship.

Adult↗
PubMed1986

Papillary carcinoma in a giant lateral thyroglossal cyst.

The development of carcinoma in a thyroglossal cyst is rare. This report describes the presence of papillary carcinoma in a giant thyroglossal cyst and reviews the literature regarding the clinico-pathological features of the disease and its management.

Carcinoma, Papillary↗
PubMed1986

Cell surface blood group antigens in carcinoma of the penis.

Fifty benign epithelial lesions and squamous cell carcinomas of the penis were studied for specific red cell adherence (SRCA), to identify any difference in the cell surface antigens of these tumours that may explain their biologic behaviour. It was observed that 87% of benign lesions as well as 54% of squamous cell carcinomas of the penis were SRCA-positive suggesting that the SRCA test was not of sufficient specificity for differentiating benign and malignant tumours. A striking observation was that 91% of squamous cell carcinomas which had metastasized to the inguinal nodes were SRCA-negative in the primary tumour as well as the metastatic focus in the lymph nodes suggesting that the loss of cell surface antigen is associated with an aggressive potential and a tendency for invasion and spread. To our knowledge this is the first study of cell surface blood group antigens in tumours of the penis.

Antigens, Surface↗
PubMed1985

Cysticercosis in South India.

A total of 38 cases of human cysticercosis were diagnosed by histopathological examination within a period of 10 years in JIPMER Hospital which serves the population of Pondicherry and adjoining regions of South India. Analysis of our cases showed that there was no sex predilection and 34 of the 38 cases were within the first three decades of life. A curious yet striking feature was that in 37 of the 38 cases the lesions were localized above the level of the umbilicus. Lesions of the subcutaneous tissue formed the largest group with 18 cases. Seventeen of the 38 cases were confined to the eyes, forming the largest series to be reported from India. In six cases there was evidence of brain involvement with postmortem confirmation in three. The JIPMER Hospital records showed a high incidence of epilepsy in this region with a ratio of one out of every four patients attending the neurology clinic. As cerebral cysticercosis is a known cause of epileptiform convulsions, it is suggested that many cases of epilepsy may in fact be due to cerebral cysticercosis. The majority of our patients were drawn from the rural population. We analysed the social customs and related factors which are peculiar to this region and were indirectly responsible for the high incidence of cysticercosis.

Adolescent↗
PubMed1984

Perianal condylomata acuminata in a male child.

A one year old male child presented with a perianal growth of two months' duration. Clinical and histopathological findings confirmed the diagnosis of condylomata acuminata, which regressed completely following topical treatment with podophyllin.

Anus Neoplasms↗
PubMed1984

Malignant pilomatrixoma. Report of a case.

Malignant pilomatrixoma of the skin in a 39-year-old female is described. After radiation therapy the patient has been free of recurrence for the past three years. A review of the literature shows that these tumours are extremely rare, with only six previously published cases.

Adult↗
PubMed1983

Does isopathic phenomenon occur in leprosy?

Twenty-five patients of leprosy classified according to the criteria of Ridley and Jopling (1966) were studied to verify the existence of isopathic phenomenon, using lepromin and autoclaved BCG as antigens. BCG as well as lepromin injection sites showed tuberculoid granulomas in all the cases of tuberculoid, borderline tuberculoid, mid-borderline and indeterminate leprosy. In lepromatous and borderline lepromatous cases BCG injection sites showed infiltration of foam cells containing AFB and foci of epithelioid cells, while lepromin injection sites showed infiltration of foam cells containing AFB only. These findings in the present study do not support the occurrence of isopathic phenomenon in leprosy with BCG.

BCG Vaccine↗
PubMed1980

Macrophage culture from untreated leprosy cases.

Macrophage cultures from the peripheral blood were performed in 25 untreated bacteraemic leprosy patients. The monocytes on conversion to macrophages in culture continued to harbour solidly stained M. Leprae till the termination of culture. It is suggested that the majority of these bacilli are viable and capable of multiplication intracellularly in macrophages if cultures could be maintained for sufficiently long periods. It was observed that bacteraemia in Leprosy can be detected by the culture technic. It has been found to be more sensitive than the leukocyte adherence method.

Cells, Cultured↗
PubMed1979

Behaviour of macrophages to Mycobacterium leprae. A tissue culture study.

Macrophage culture was performed on 45 healthy adults who were initially categorised on the basis of their Lepromin reactivity using Dharmendra antigen. There were 25 individuals in the Lepromin positive group and 20 in the Lepromin negative group. The cultures were challenged with M. leprae and the macrophages studied at varying time intervals of culture. No difference was evident in the behaviour of cultured macrophages to M. leprae in both the groups. The Lepra bacilli were phagocytosed by the macrophages and retained essentially intact till the termination of culture. The Lepromin reactivity of a healthy individual was not reflected on the macrophage function in vitro. The observations suggested against the possibility of an intrinsic genetically determined macrophage defect in dealing with M. leprae.

Adult↗