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Biomedical subjects

A Ooshima

Publications and source records attributed to A Ooshima.

At least 181 records · Page 10Linked to original sources
PubMed1977

Increased lysyl oxidase activity in blood vessels of hypertensive rats and effect of beta-aminopropionitrile on arteriosclerosis.

The activity of lysyl oxidase which catalyzes the initial step of cross-linking of collagen and elastin polypeptides was measured in blood vessels of the hypertensive rat. The enzyme activity was increased in the aorta and mesenteric artery when hypertension was induced in 8-week-old rats with administration of deoxycorticosterone acetate (DOCA) and 1% saline. Reserpine diminished this increase in vascular lysyl oxidase activity concomitant with reduction in blood pressure. When beta-aminopropionitrile, a specific inhibitor of lysyl oxidase, was administered before the onset of DOCA-salt hypertension, the aortic collagen content was reduced markedly. Concomitant with reduction in the aortic collagen content, the development of hypertension and arteriosclerotic changes in the kidney was partially prevented. These results would indicate that hypertension increases the amount and the degree of cross-linking of vascular collagen and that the deposition of excess collagen in the vascular wall contributes to the development of hypertension and arteriosclerosis.

Amino Acid Oxidoreductases↗
PubMed1975

Vascular lesions in the various substrains of spontaneously hypertensive rats and the effects of chronic salt ingestion.

Among different races, countries and districts there are definite differences in incidence of hypertensive vascular diseases, for example cerebral bleeding. Hereditary and dietary factors presumably play significant roles. Experimental studies under controlled conditions and utilizint suitable animals are indispensable for analysis of the related factors. For confirmation, hypertensive vascular changes in the spontaneously hypertensive rats were histopathologically studied and related to the difference of substrains. Dietary effects of sodium chloride on these vascular changes were investigated by providing the animals with 1% saline for drinking.

Animals↗
PubMed1974

Increased collagen synthesis in blood vessels of hypertensive rats and its reversal by antihypertensive agents.

Collagen synthesis is increased in the aortas, mesenteric arteries, and to a lesser extent, in the hearts of rats either made hypertensive with desoxycorticosterone acetate-salt or that are spontaneously hypertensive. Several markers of collagen biosynthesis were shown to be increased, including prolyl hydroxylase (EC 1.14.11.2; proline, 2-oxoglutarate dioxygenase), prolyl hydroxylase-related antigen, total collagen content, and the incorporation of [(3)H]proline into total protein and into collagen. The antihypertensive agents chlorothiazide and reserpine, when administered before the onset of hypertension in the rats treated with desoxycorticosterone acetate-salt, prevented or diminished the increase in collagen biosynthesis. When reserpine was given after the onset of hypertension, prolyl hydroxylase activity was decreased concomitant with the decrease in blood pressure. Treatment with reserpine is particularly effective in diminishing arterial prolyl hydroxylase activity.

Animals↗