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Biomedical subjects

B Daicker

Publications and source records attributed to B Daicker.

At least 37 records · Page 2Linked to original sources
PubMed1985

Massive peripheral retinal sclerosis. Correlation between light and scanning electron microscopic findings.

Peripheral retinal sclerosis (PRS) is especially massive in cases of high myopia and retinitis pigmentosa. The distribution and configuration of the sclerotic formations in nine such cases were studied and compared by light microscopy and SEM. Different aspects of the sclerotic structures are described. It is shown that no formations of PRS lie isolated within the degenerated retinal tissue as could be supposed by light microscopy. They are always in multiple contact to or originate from the vitreo-retinal border layer and/or peripheral retinal vessels. This leads to the supposition that these preexisting collagenous structures participate in some way in the formation of PRS.

Aged↗
PubMed1985

Constricting retroretinal membranes associated with traumatic retinal detachments.

The author describes the clinical, autoptical, light microscopical and ultrastructural features of a particular type of retroretinal membrane in four eyes with total rhegmatogenous retinal detachment after severe anterior segment trauma. The membranes originate from defects of the most posterior pars plana at the site of disinsertions or detachments of the ciliary epithelium. From here they spread over parts of the whole posterior face of the detached retina encircling and constricting its folds. These formations are primarily composed of fibrin and secondarily become populated by macrophages, fibroblasts, pigment epithelial cells, as well as fibrous astrocytes, and finally are organized. The significance of such membranes for the therapy and prognosis of posttraumatic detachments is discussed.

Adolescent↗
PubMed1985

[Iatrogenic teflon granuloma of the eyelid. (Teflon paste, an unsuitable filling material for plastic eyelid surgery)].

A paste of granular Teflon was injected into the upper lid of a patient for remodeling the upper palpebral furrow, which had been retracted by scars. Large foreign-body granulomas developed a few weeks later, necessitating two excisions. The causes of this unsatisfactory result with a filling material which is well established in laryngeal surgery are discussed. The authors advise against using it in well vascularized loose tissue.

Adult↗
PubMed1985

Multiple cotton wool spots following bone marrow transplantation for treatment of acute lymphatic leukaemia.

Three patients with acute lymphatic leukaemia developed visual impairment due to occlusion of small retinal vessels with multiple cotton wool spots after treatment which included whole body and skull irradiation followed by bone marrow transplantation and cyclosporin A. Withdrawal of cyclosporin A and treatment with corticosteroids was followed by recovery of visual acuity. This retinopathy and the retinal changes seen in the immunodeficiency syndrome are thought to be closely related. The possible role of cyclosporin A is discussed, though cotton wool spots and retinal haemorrhages have never been described in renal transplant patients during treatment with this drug. Withdrawal of cyclosporin A, which is highly effective in preventing graft-versus-host disease, can be fatal. Irradiation of the skull prior to bone marrow transplantation and intrathecal administration of methotrexate may be the most important factors causing the retinal ischaemic signs described here. The inclusion of an ophthalmologist in the team monitoring transplant patients would lead to increased documentation and a better understanding of this disease.

Adult↗
PubMed1985

Mesectodermal leiomyoma of the ciliary body extending into the anterior chamber.

A neoplasm of the ciliary body extending from the equator to the iris and the anterior chamber was observed in an 18-year old girl. Because the visual acuity was lost and the clinical diagnosis was uncertain the eye was enucleated. Both optic and electron microscopic investigations allowed the diagnosis of the mesectodermal type of leiomyoma of the ciliary body.

Adolescent↗
PubMed1981

[Metastatic tumors of the uvea (author's transl)].

Uveal metastases are now the most common intraocular tumors. The ophthalmologist is becoming increasingly involved in their diagnosis and treatment due to advances in systemic cancer therapy. These metastases can often be distinguished from autochthonous tumors by reason of their location, appearance and behavior. A synopsis of these characteristics is exemplified by a short review of the literature and by original histological and clinical material from patients with uveal metastases arising from a wide range of primary tumors. The lessons which may be derived from this material for the diagnosis and local treatment of these metastases is discussed.

Breast Neoplasms↗
PubMed1979

[Studies on pigmented surface wrinkling retinopathy by scanning electron microscopy (author's transl)].

The light- and scanning electron microscopic appearance of 3 areas of pigmented epiretinal fibroplasia (pucker) are described in an eye removed following detachment surgery. The centre of each area of pucker consists of a fibroglial sheet covered by retinal pigment epithelium. The surface morphology of these cells resembles typical or slightly degenerated epithelium. Extensive areas of these pigment epithelial sheets were pigmentfree. There was no evidence that the pigment epithelial sheets exerted either direct or indirect traction on the inner surface of the retina. The origin of these cells and their role in the formation of retinal wrinkling is discussed.

Aged↗
PubMed1979

[The histological substrate of the extraocular muscle thickening seen in dysthyroid orbitopathy (author's transl)].

The diagnosis of dysthyroid orbitopathy can be confirmed in over 80% of cases by demonstrating thickened extraocular muscles on computertomograms. The criteria are briefly discussed and the histological picture of the muscle thickening is described. The changes are variable and depend upon the course of the disease. Fatty infiltration is the most important factor causing muscle thickening, mucopolysaccharide deposition and fibrosis contribute less to the increased muscle volume, while inflammatory cell infiltration and proliferation of the endomysium play a minor role. The fatty infiltration and fibrosis, representing late changes, are probably therapy resistant in contrast to the other changes.

Adipose Tissue↗
PubMed1979

[Leiomyoma of the ciliary body - misdiagnosis leading to an unconventional but successful surgical approach].

Report on a leiomyoma of the ciliary body in a 12-year-old girl. The clinical findings were misinterpreted as a traumatic ciliary body cyst because of the associated iridodialysis, the fact that the tumor could be transilluminated, because it appeared cystic on ultrasonography, and because there was a history of severe cranial trauma. In the course of an attempt to puncture the presumed cyst a cherry-sized ciliary body tumor was revealed. It proved possible to shell this out without performing an iridocyclectomy. An elective enucleation would have been performed had the true diagnosis been known preoperatively. Due to the misdiagnosis and the resulting unconventional approach the eye was preserved with some residual functions. the histological picture was that of a leiomyoma, a tumor rarely found in the ciliary body. The histological and electronmicroscopic appearance are described and compared with the few cases previously reported.

Adolescent↗
PubMed1978

[Studies on fibrous and fibro-glial surface wrinkling retinopathy by scanning electron microscopy (author's transl)].

The scanning electron microscope was used to examine 16 cases of epiretinal membrane formation and retinal puckers which occurred in a variety of primary retinal disorders. In this first section the authors describe three types of epiretinal membranes: (1) Fibrous acellular membranes with and without vitreous adhesions. Retinal puckering was caused by vitreous traction with collagen strands binding the residual folds. (2) Fibrous membranes containing isolated glial cells. (3) Fibrous membranes partly covered by sheets of glial cells. In all three forms the acellular fibrous component is believed to represent vitreous cortex remnants. The invariable presence of these fibrous membranes at sites of retinal pucker and their relationship to wrinkled internal limiting membrane suggests that contraction of these membranes is responsible for retinal puckering. Morphological evidence of glial membrane contraction and collagen production by glial cells was not found.

Connective Tissue↗
PubMed1978

[The macular fatty degeneration of the peripheral retina a variety of the snail track degeneration (author's transl)].

A previously undescribed form of snail-track degeneration with scattered flecks was found in three eyes with absolute glaucoma. Light- and electron-microscopic examination of these lesions in the retinal periphery revealed atrophy and gliosis with massive accumulation of fat within the astrocytes and Müller's cells. It was not possible to explain the patchy distribution of the lesions. The fatty change in the macroglia is believed to indicate 'in situ breakdown' of slowly atrophying retina. Morphologic and pathogenetic similarities suggest that all forms of snail-track degeneration with snowflakes represent nonspecific fatty degeneration of the retina.

Adult↗
PubMed1978

[Ocular findings in reno-facial dysplasia (Potter-syndrome) (author's transl)].

The clinical and pathological details of a case of reno-facial dysplasia are presented and described. Hyperplasia and lamination of Bowman's membrane, corneal endothelial dystrophy with degenerative changes in the posterior stroma, hypoplasia of the retinal ganglion cell and nerve fibre layers, and severe changes in the retinal and iris blood vessels are believed to be pathognomonic ocular features of this syndrome, in addition to cataract and signs of immaturity. These findings are compared with the few descriptions of the syndrome previously published. The corneal damage is postulated to result indirectly from oligohydramnios which causes chronic compression of the globes and thus endothelial damage due to contact with the spherical cataracts. The pathological changes in the retinal and iris vessels are either genetically determined or the result of chronic hypoxia.

Abnormalities, Multiple↗
PubMed1978

[Spotty fatty retinal degeneration (author's transl)].

The author describes the macroscopical, microscopical and ultrastructural features of a peculiar form of snail track degeneration, which was found in 3 eyes with absolute glaucoma. The snowflakes are concentrated to scattered patches in an extensive frosted area of the peripheral retina. The glittering points consist of neutral fat in a gliotic and atrophic retina. Electron microscopy examination shows fat droplets within the astrocytes and Müller cells. These findings are believed to be the expression of a "in situ break down" of a very slowly atrophying retina by the macroglia.

Adult↗
PubMed1977

[Findings on retinal surface by scanning electron microscopy. II. Vitreous detachment (author's transl)].

The authors describe their findings by scanning electron microscopy of the surface of the retina following secondary and primary senile posterior vitreous detachment. These findings are correlated with those of transmission electron microscopy. Extended nets formed by vitreous fibrils can be found on the retinal surface. The fibrils form a continuous feltwork, which cannot be traced by biomicroscopy or dissection of enucleated globes. This feltwork desintegrates in places or over a wide area and the basal membrane of the Müller cells becomes exposed. Structural differences in consequence of the two examination techniques well as possible artifacts are shown.

Age Factors↗
PubMed1977

[Findings on retinal surface by scanning electron microscopy. III. Epivascular glial clusters (author's transl)].

The findings by scanning and transmission electron microscopy of multiple glial excrescences from the retina into the cortical vitreous body are described. These formations are located in lines above superficial retinal vessels. The findings are compared with those from light microscopy of similar formations. The pathogenesis and the possible significance as retinovitreal attachments for rhegmatogenous defects of the retina and for posterior vitreous detachments are discussed.

Aged↗
PubMed1977

[Necrotizing hypersensitivity-angiitis Zeek with ocular involvement (author's transl)].

A clinical and pathological report is given of a case of necrotizing angiitis Zeek. This rare condition is related to polyarteriitis nodosa, but has an acute course and involves the small vessels. The histology of ocular complications has not been observed up to now. Clinically it appeared as a severe panuveitis and hemorrhagic retinitis. Histologically the vessels of the retina, the choroid, the sclera and the optic nerve show inflammatory signs similar to those of the viscera and the brain. The literature concerning the ocular involvement due to necrotizing angiitis is reviewed and compared with the present case.

Acute Disease↗