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Biomedical subjects

D A Pass

Publications and source records attributed to D A Pass.

At least 37 records · Page 2Linked to original sources
PubMed1982

Pathophysiology of Mesocestoides corti infection in the mouse.

Liver histology and serum enzyme and protein changes were studies in two strains of mice showing different initial susceptibilities to infection with Mesocestoides corti. The results show an increase in ALT and AST levels during the period of invasion and proliferation in the liver and a decrease in the levels of these two enzymes following encapsulation of the parasite in the liver and liver regeneration. A progressive loss of albumin was accompanied by increases in the levels of the beta- and gamma-globulins. These changes are discussed in the light of our knowledge of the effects of this parasite upon its host.

Alanine Transaminase↗
PubMed1982

BCG-induced inhibition and destruction of Taenia taeniaeformis in mice.

Pretreatment of mice with BCG induced a high level of protection against infection with Taenia taeniaeformis. Protection was manifested both during and after establishment by the parasite suggesting that two separate mechanisms were stimulated by BCG. The first inhibits initial establishment by the parasite and may be antibody mediated. The second is responsible for the destruction of developing strobilocerci in the liver and may require the involvement of cellular defence mechanisms.

Animals↗
PubMed1982

The characterisation and pathogenicity of porcine enteroviruses isolated in Victoria.

Approximately 23 viruses were isolated from healthy pigs, pigs with encephalitis, and in cases of reproductive failure. Five viruses were identified as enteroviruses and a total of 10 isolates were shown to cross-react serologically to varying degrees. Twenty viruses were neutralised by a reference antiserum of serotype 8 porcine enterovirus. Intracerebral inoculaton of colostrum-deprived piglets with 2 of the characterised viruses caused lesions of encephalomyelitis which were not induced by oral infection. Intrafoetal inoculation of 2 sows with one characterised faecal isolate caused foetal death and abortion, but no adverse effects followed oral dosage.

Abortion, Veterinary↗
PubMed1982

Chronic eosinophilic gastroenteritis in the horse.

Four cases of chronic eosinophilic gastroenteritis in horses are described. The disease was manifested clinically by weight loss, malabsorption and diarrhea of soft, formless feces. A chronic inflammatory reaction, with diffuse and focal eosinophilic infiltrates, was present in the esophagus, stomach, small and large intestine, and mesenteric lymph nodes. The cause of the lesion was not determined but was thought to the due to an ingested allergen, as the lesion is indicative of an on-going, immediate hypersensitivity reaction. One horse had generalized acanthosis, hyperkeratosis, and ulcerative coronitis.

Animals↗
PubMed1980

Canine parvoviral myocarditis: a morphologic description of the natural disease.

Naturally occurring acute parvoviral myocarditis in puppies 3 to 8 weeks of age was characterised clinically by sudden death or death following a brief period of dyspnoea. Mortality within litters varied from 20% to 100%. The principal lesion was in the myocardium, which in most cases was mottled by pale patches and bands. Moderate to severe pulmonary oedema with marked peribronchial and perivascular oedema was present. In some cases, the wall of the gall bladder was oedematous. Microscopically the ventricular myocardium had myofibre loss, multifocal myofibre necrosis, a mononuclear cell infiltrate of variable intensity and reactive stromal elements. In every case there were Feulgen-positive, amphophilic, and reactive stromal elements. In every case there were Feulgen-positive, amphophilic, intranuclear inclusion bodies in myocardial nuclei. Ultrastructurally the inclusions were composed of dense granular material and particles resembling parvovirions. Pulmonary alveolar septae were thickened by fibroblasts. Peribronchial and perivascular lymphatics were distended with oedema fluid and occasionally erythrocytes. The pulmonary lesions were considered secondary to the myocardial dysfunction. Some of the puppies that survived the acute disease developed ventricular myocardial fibrosis and died in congestive heart failure.

Animals↗
PubMed1980

Canine laryngeal oncocytomas.

Solitary, protruding tumors were found in the wall of the larynx in three adult dogs with clinical upper respiratory obstruction. They were composed of cells with abundant granular acidophilic cytoplasm, the granularity caused by an unusually large number of mitochondria. The lesions were considered to be neoplasms arising from oncocytes as described in man. Oncocytomas have not been reported previously in domestic animals.

Adenoma↗
PubMed1979

Atypical porcine enterovirus encephalomyelitis: possible interraction between enteroviruses and arsenicals.

Porcine enteroviruses were isolated from weaner pigs that had nervous signs and mild non-suppurative meningoencephalomyelitis and ganglioneuritis. The clinical signs and lesions were not typical of enterovirus infection and it is believed that an organic arsenical present in feed enhanced pathogenicity of enteroviruses. Severe non-suppurative polioencephalomyelitis and ganglioneuritis were produced in gnotobiotic pigs by oral inoculation of the viruses.

Animals↗
PubMed1979

Poisoning of chickens and ducks by pyrrolizidine alkaloids of Heliotropium europaeum.

The disease produced by feeding chickens and ducks a commercial poultry feed containing heliotrine and lasiocarpine, pyrrolizidine alkaloids of Heliotropium europaeum, is described. Illthrift, ascites and degenerative lesions in the liver were the major findings. Similar lesions occurred in chickens fed a diet containing H. europaeum. The source of the alkaloids in commercial poultry feed was probably the seeds of H. europaeum harvested with wheat.

Animal Feed↗
PubMed1979

Clinical and electrocardiographic findings in suspected viral myocarditis of pups.

Surviving puppies from three separate litters in which deaths had occurred from suspected viral myocarditis were examined clinically and electrocardiographically. Of 11 puppies examined, 5 subsequently died or were euthanised within 11 days of initial examination. ECG changes present in these puppies for 1 to 11 days prior to death were small R waves (less than 0.4 mV in lead II), S-T segment elevation, QRS notching and paroxysmal ventricular tachycardia (PVT). No clinical signs referable to the ECG changes were present before the terminal episodes of apparent sudden death or death following a brief period of dyspnoea. Multifocial subacute myocarditis was present on post-mortem examination. A sixth puppy with small R waves remained clinically normal for a further 4 weeks. It then developed severe dyspnoea which persisted for 24 hours before euthanasia. Extensive fibrosis of the left ventricle was present on post-mortem examination.

Animals↗
PubMed1978

Evaluation of tests for the diagnosis of lead exposure in sheep.

Several laboratory tests that are currently used for the diagnosis of lead poisoning in man were evaluated for the detection of lead poisoning in sheep given 3 or 10 mg Pb/kg body weight/day for 7 weeks. Urinary porphyrins and basophilic stippling of erythrocytes were not sensitive indicators of lead poisoning in sheep, while urinary lead and urinary delta-aminolevulinic acid concentrations were too variable to have diagnostic value. However, erythrocyte delta-aminolevulinic acid dehydratase was strongly inhibited by exposure to relatively low doses of lead, while blood lead concentrations gave an indication of the level of exposure to lead poisoning.

Animals↗
PubMed1975

Fatal pox infection in a rough-legged hawk.

Natural pox infection occurred in a free-living rough-legged hawk (Buteo lagopus) in northeastern North Dakota. Gross, histological and electron microscopic findings were typical of pox infection, and characteristic lesions developed in red-tailed hawks (Buteo jamaicensis) but not in great horned owls (Bubo virginianus) following inoculation with case material. Death of the rough-legged hawk was attributed to starvation rsulting from inability to capture prey and to blood loss from foot lesions.

Animals↗