Biomedical subjects

D Gardiol

Publications and source records attributed to D Gardiol.

At least 55 records · Page 3Linked to original sources

PubMed1977

[Anatomical and clinical correlates statistical analysis].

A retrospective study of the clinico-pathological correlation was undertaken on 1000 consecutive autopsies required by a university department of medicine. For each case the following data were collected on a standardized card: information on the patient, the hospital stay, the therapy; the main clinical and pathological diagnoses, classified according to their importance; judgements on the clinico-pathological correlation related to each single diagnosis as well as to each case as a whole. The data were analyzed by computer. Two samples of the results are presented her. 1. 18 cases of active tuberculosis were observed. In 7, among which 5 were autopsy discoveries, the tuberculosis was rated as the cause of death. 2. General estimate of clinico-pathological correlation. In the cases where the clinical picture was obscure the autopsy was able to solve the problem completely in 2 cases out of 3. Even when the clinival situation was thought to be obvious, the post mortem examination brought to light important errors or omissions in just over 30% of the cases. On ther other hand, in one case out of 10, the autopsy could not solve in part or in whole the clinical problems involved. There results show that routine autopsies are generally still useful today, but fail fairly ofter to meet the clinician's expectation. These failures can probably be in part corrected.

Autopsy↗

PubMed1976

Pigmentation and dysfunction of Gunn rat thyroid: correlation between morphological and biochemical data.

The thyroid gland of homozygous Gunn rats is moderately enlarged and displays a brownish-black discoloration. Light microscopic examination discloses that the follicular cells are filled with brown granules, which are shown, under the electron microscope, to be modified colloid droplets. Most of them possess a strong acid phosphatase and a mild peroxidase activity and contain a melanin-like pigment, according to histochemical analysis. In comparison with normal Wistar rats, Gunn rats possess significantly higher plasma thyroxine and lower triiodothyronine as well as an increased plasma TSH level. The soluble protein content of the thyroid is reduced in the Gunn rat, as is the total intrathyroid iodine content. The hyperthyroxinaemia of homozygous Gunn rats is due to a hereditary deficiency in hepatic glucuronyl transferase activity. The excess circulating thyroxine is of little functional importance because it is firmly bound to plasma proteins. But Gunn rats have a slight hypothyroid goitre for reasons not yet elucidated. The functional as well as morphological data at present available suggest a modified thyroid iodine metabolism and an altered composition of the thyroglobulin which may induce abnormalities in colloid proteolysis. The observed pigment may result from peroxidation of tyrosine. These alterations are probably independent of the sole enzymatic deficiency so far encountered in these animals and may probably be ascribed to a primary enzymatic defect in the thyroid gland itself.

Acid Phosphatase↗

PubMed1976

The healing of liver wounds.

Cases of traumatic hemobilia are often characterized by a protracted history with recurrent episodes of hemorrhage over many years. It seems that while the liver regenerates quickly and profusely it heals slowly and poorly. This is in contradistinction to the kidneys where lesions often heal within a short time. In order to investigate the cause of this peculiar behavior a series of experiments was performed where local lesions were produced in the musculature, in the kidneys and in the liver of dogs. The healing process was studied at different intervals. There was essentially no difference between the rate and character of healing in the three localities. As the lesions that produce hemobilia are open to the biliary tract, another series of experiments was performed where the healing took place in presence of bile. The effect of this was striking with a very diminished production of fibrinous exudate, granulating tissue and fibrous scar.

Animals↗

PubMed1976