PubMed Health⌕ Search

Biomedical subjects

D Lolis

Publications and source records attributed to D Lolis.

At least 73 records · Page 4Linked to original sources
PubMed1980

A study of the kinetics of cephapirin and cephalexin in pregnancy.

The kinetics of cephapirin and cephalexin were studied in 60 pregnant women after the administration of single 1 g doses of the antibiotics given by the intramuscular and oral route, respectively. Maternal serum, amniotic fluid and cord serum concentrations were measured at intervals after the dose by the agar diffusion method. The results showed that the mean peak concentration of cephalexin in maternal serum, after 1 hour, was significantly greater than that of cephapirin. Both antibiotics crossed the placenta barrier and reached levels in the amniotic fluid and cord serum adequate for the in vitro inhibition of pathogens involved in materno-foetal infections.

Amniotic Fluid↗
PubMed1980

Ampicillin and gemtamicin in the treatment of fetal intrauterine infections.

The optimum clinical results in the treatment of fetal intrauterine infections are obtained by the administration of the appropriate antibiotic, which reaches an adequate concentration in the fetal serum. The pharmacokinetics of ampicillin and gentamicin were studied in 60 pregnant women. Ampicillin and gentamicin were given intramuscularly prior to cesarean section. At delivery maternal serum, amniotic fluid and cord serum antibiotic levels were tested. Assays of the levels of antibiotic were performed by agar diffusion method using Staph. aureus A.C.T.C. 25923 (American Type Control Collection) and E. coli N.C.T.C 1346, as standard organisms. During peak time, concentration of ampicillin in the maternal serum was found to be significantly higher than those of the amniotic fluid and cord serum (p less than 0.001). Peak levels of the antibiotic in the amniotic fluid was also significantly higher than in the cord serum (p less than 0.001). Our results, also showed that the determined levels of ampicillin, especially during peak time, are sufficient to inhibit in vitro, a high proportion of infecting pathogens in the maternal serum and amniotic fluid, but have little effect against organisms in the fetal serum. Concentration of gentamicin in the maternal serum during peak time was found higher than those of the amniotic fluid, but there was not a significant difference. Maternal serum peak levels of the drug were also higher than in cord serum, with a very significant difference (p less than 0.001). Maximum levels of gentamicin in amniotic fluid were higher than in cord serum, also with a very significant difference, (p less than 0.001). Gentamicin levels in amniotic fluid and fetal serum, especially, during peak time, would be adequate to inhibit in vitro the most common pathogens, sensitive to the drug.

Adult↗
PubMed1979

Gentamicin in the treatment of lower genital tract infections: level of the drug in menses, cervical mucus and vaginal fluid.

The concentration of gentamicin in serum, menses, cervical mucus and vaginal fluid of 39 women under treatment with this antibiotic (80 mg every 8 hr i. m.) was tested by the agar diffusion method. The levels of the drug in the serum varied from 1.88-5.41 micrograms/ml with a peak one hour after the last dosage. In the menses the levels ranged from 2.06-5.87 micrograms/ml with a peak also one hour after the last dosage. The concentration of gentamicin in the cervical mucus and vaginal fluid varied from 0.67-5.14 micrograms/ml and 0.63-6.43 micrograms/ml with a peak three hours after the last administration of the drug. Results are briefly discussed.

Bacterial Infections↗
PubMed1978

Toxoplasma antibodies and spontaneous abortion.

One hundred and fifty-two women with spontaneous abortion were investigated by hemagglutination (HA) and immunofluorescence antibody (IFA) tests for toxoplasmosis. In 48 cases, quantitive immunoglobulin (Ig) studies and mouse inoculation with gestational material were performed. Positive toxoplasma antibody titers were observed in 62 cases (40.8%) using HA and in 52 cases (38.2%) using IFA. This prevalence was significantly higher than that observed in 80 normal women who served as controls. Toxoplasma gondii was isolated in two cases. No correlation was found between antibody titers and IgG, IgM or IgA levels. We conclude that toxoplasmosis should be considered as the cause of abortion when a patient's antibody titer exceeds 1:256.

Abortion, Spontaneous↗
PubMed1978

Leucocyte alkaline phosphatase activity during high risk pregnancies.

142 determinations of leucocyte alkaline phosphatase (LAP) activity have been done in 103 cases of high risk pregnancy. A statistically significant elevation of LAP score has been found in high risk pregnancies due to diabetes mellitus, toxaemia, renal diseases and third trimester haemorrhage, but not in pregnancies complicated by cardiac disease, chronic hypertension, Rh sensitization or anaemia.

Alkaline Phosphatase↗
PubMed1978

Maternal serums and amniotic fluid levels of human placental lactogen in gestational diabetes.

Human placental lactogen (hPL) levels were measured radioimmunologically in maternal serum and in amniotic fluid between the 37th and 39th weeks of gestation in sixteen gestational diabetic and thirty normal pregnant women. There was no significant difference in maternal serum hPL levels between diabetic (6.1 microgram/ml) and normal pregnant women (6.4 microgram/ml). In contrast, the diabetic group was found to have significantly (P less than 0.001) higher concentrations of amniotic fluid hPL (1.2 microgram/ml) than normal pregnant women (0.8 microgram/ml).

Amniotic Fluid↗
PubMed1978

Amniotic fluid, maternal and fetal blood insulin in overweight pregnant women.

The effect of excessive maternal weight gain on insulin levels during pregnancy (15 cases) was compared with the insulin levels in a control group (20 normal pregnancies) by radioimmunologic determination of insulin in the amniotic fluid and in maternal and fetal blood. The mean values of insulin in the control group were as follows: mother 24.9 +/- 0.51, fetus 10.86 +/- 0.48 and amniotif fluid 6.08 +/- 0.42 muU/ml, and in patients with excessive weight gain during pregnancy, maternal insulin mean values were 39.45 +/- 1.86, fetal 20.99 +/- 3.39 and amniotic fluid 12.25 +/- 1.15 muU/ml. Insulin concentrations in maternal blood (P less than 0.001), fetal blood (P less than 0.001) and amniotic fluid (P less than 0.001) were higher in excessive weight gain pregnancies as compared to the control group.

Amniotic Fluid↗
PubMed1978

Acute appendicitis complicating pregnancy.

Seventeen cases of acute appendicitis complicating pregnancy were analysed. The presenting symptoms were abdominal pain, nausea and anorexia. The usual physical findings were direct abdominal tenderness and rectal tenderness. Correct diagnosis was more difficult when gestation was advanced. This was reflected both by the severity of the disease process found at operation and by the increasing foetal mortality rate. Delay in diagnosis and treatment is the main factor causing high maternal and foetal death rates, especially when pregnancy is advanced.

Acute Disease↗
PubMed1977

Comparative study of amniotic fluid and maternal blood serum human placental lactogen in normal and prolonged pregnancies.

The levels of human placental lactogen (hPL) were measured in maternal blood and amniotic fluid in normal and prolonged pregnancies. Statistical analysis of the hPL levels showed that values rose in both blood and amniotic fluid, reaching maximum levels between Weeks 34 and 36 (6.70 microgram per milliliter in blood serum, 0.85 microgram per milliliter in amniotic fluid). Thereafter, there was a decline, a significant fall occuring between Weeks 40 and 42 and in the prolonged pregnancy group (43 weeks and more) (t = 6.9 and p less than 0.001 in serum levels; t = 3.9 and p less than 0.001 in amniotic fluid levels). There was also a very close correlation (r = 021; p less than 0.005) between maternal blood and amniotic fluid hPL levels in normal pregnancies before labor.

Amniotic Fluid↗
PubMed1977

Ovarian neoplasms and pregnancy.

Sixteen cases of benign cystic ovarian neoplasms (13 serous cystadenomas and 3 dermoids) were discovered among 5,616 pregnancies. The only serious complication was torsion of the ovary containing the tumor in one case.

Abdomen, Acute↗
PubMed1976

Pyometra.

Thirteen cases of pyometra without preoperative diagnosis in which vaginal or abdominal surgery was performed, are analysed in the present paper. The histologic examination revealed endocervicitis in all cases, while positive cultures for bacteria were found preoperatively in only eight of the above cases, thus, pyometra was considered to be a symptom of obstruction of the cervical canal.

Female↗
PubMed1976

[Management of cervical incompetence with cerclage according to Shirodkar. A report on 110 cases].

The authors report a 110 cervical cerclage operations for cervical incompetence. Shirodkar's technique was used and cerclage was carried out between the 9th and 20th week of amenorrhea. Out of 110 patients submitted to the procedure, 98 gave birth to a live infant weighing more than 1000 g which amounts to a success rate of 89%. Duration of pregnancy ranged between 26 and 41 weeks. If only pregnancies having proceeded to 37 weeks of amenorrhea are considered, the success rate amounts to 68%.

Adolescent↗
PubMedDate not supplied

Increased nuchal translucency thickness in a fetus at risk for beta-thalassaemia.

In Greece and other Mediterranean countries up to 10% of the population are carriers of beta-thalassaemia and this is the most common indication for chorion villus sampling (CVS): Cytogenetic analysis of the samples is not carried out routinely, but is confined only to women aged 35 years or more. In this report we present a case that illustrates how the measurement of fetal nuchal translucency may be useful in selecting the cases where in addition to the DNA analysis for beta-thalassaemia the samples can be tested for chromosomal defects.

Adult↗
PubMedDate not supplied

Fetal heart rate following coelocentesis.

For psychological reasons, coelocentesis was performed in 20 women prior to termination of pregnancy, at 6-11 weeks of gestation. The fetal heart rate (FHR) was measured immediately before the procedure and at 1, 5, and 10 min afterward. There was no significant difference between FHR before coelocentesis compared to the values at 1 min (mean = 158, range 114-178; z = -0.629, P = 0.529), 5 min (mean = 160, range 121-179; z = -0.191, P = 0.848), or 10 min (mean 159, range 117-183; z = -0.214, P = 0.83) after the procedure. These findings suggest that coelocentesis does not have a major effect on the fetal cardiovascular system.

Female↗