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Biomedical subjects

D Prokopowicz

Publications and source records attributed to D Prokopowicz.

At least 37 records · Page 2Linked to original sources
PubMed1986

[Histopathologic and biochemical evaluation of the effect of cortisone on the liver in experimental post-alcoholic liver damage in the rabbit].

Possible protective effects of cortisone in experimental post-alcohol liver damage were evaluated in relation to dose and duration of treatment. Model examinations were undertaken in 100 rabbits divided into groups of 10. No protective effect of cortisone could be demonstrated. Treatment did not alter biochemical indices of liver function. Histologic examination revealed somewhat less extensive fatty changes following chronic alcohol exposure in animals receiving 1 mg cortisone per kilogram body weight.

Alanine Transaminase↗
PubMed1985

[Effect of alcohol on the development of biochemical and morphologic findings of liver damage in the rabbit].

Ethanol 48% was applied to the experimental model in 3 examined groups of rabbits in different periods of administration and differentiated daily doses on order to investigate the influence of ethanol upon the formation of morphological and biochemical indices of the liver lesion. Biochemical investigations were carried out on 3 and 7 day of the experiment and repeated at week by intervalls. All the animals were dissected and morphological examinations of the liver were carried out. Total analysis of the results obtained of the biochemical and morphological examinations of the liver in 3 analysed groups of animals proved that the biochemical index of postalcoholic lesion of the liver was a rise in guanase activity, and not in activity aminotransferases. In the investigations of fat balance, however the increase of triglycerides and cholesterol was observed. Morphological examinations showed post-alcoholic lesions of the liver, especially intensified in animals under longlasting alcohol influence, but in reducted doses.

Alanine Transaminase↗
PubMed1979

[The behaviour of serotonin in blood, the activity of monoaminooxidase in serum and of 5-hydroxyindoloacetic acid in twenty-four hour urine in patients with viral hepatitis (author's transl)].

The level of serotonin in blood, the activity of MAO in serum and the value of 5-HIAA in 24 hour urine were estimated in 76 patients with viral hepatitis divided according to clinical parameters into three groups (mild, mild to severe and severe clinical course). A statistically significant increase of serotonin level in blood compared with the healthy control group was found. Highest values were observed in patients with the severe form of viral hepatitis. Decreased values of 5-HIAA in 24 hour urine in the early course of the disease showed a tendency to increase in later examinations. The activity of MAO in serum was significantly lowered in all clinical forms of viral hepatitis.

Adult↗
PubMed1979

Injury of liver in experimental salmonellosis of rabbits infected by salmonella agona.

Liver injury was investigated in the course of salmonellosis evoked by Salmonella agona in experimental infection of rabbits. Histological and biochemical examination (proteinogram, the level of bilirubin, fibrinogen, cholesterol and its esters in blood, activity of asparine and alanine aminotransferases and alkaline phosphatase and guanase in blood) were carried out in 70 animals. Liver injury showing degeneration, steatosis and necrosis was found in the course of salmonellosis. Hepatitis gigantocellularis was sporadically observed. Biochemical parameters were not in correlation with the observed histological changes.

Animals↗
PubMed1979

[The dynamics of humoral and cellular immunity changes in patients with acute phase of trichinellosis (author's transl)].

21 patients with acute trichinellosis have been studied. The behaviour of IgG, IgA and IgM in the serum of patients as well as the percentage of lymphocytes T and B was the aim of these studies. Statistically significant increase of IgG in serum has been observed since the third week of the clinical observation. During the whole period of observation the level of IgA was lowered--though the decrease was not statistically significant--whereas the level of IgM increased considerably. Decreased percentage of lymphocyte B in the peripheral blood during the first week of the clinical observation, later on increased significantly. The percentage of T lymphocyte was lowered during the whole period of the clinical observation of patients.

Acute Disease↗
PubMed1979

[The dynamics of the immunocytoadherence test with Trichinella spiralis-antigen in the experimental rabbit trichinellosis (author's transl)].

The authors analysed the dynamics of the immunozytoadherence test in experimental trichinellosis. The evaluation was carried out by mixing the lymphocytes of the infected rabbits with sheep erythrocytes encoated with antigen Trichinella spiralis. In three groups of infected rabbits (group I - 15 000 larves per rabbit, group II - 20 000 larves per rabbit, group III - 30 000 larves per rabbit) the examinations were performed 3, 6, 10, 20, 47, 82, 110, 140, 170 and 230 days after infection. It was observed that the maximum percentage of rosette occurred 10 days after infection. In the course of the observation the percentage demonstrated a tendency to decrease. The observed dynamics of the immunozytoadherence test indicates its value in diagnostic and prognostic evaluation of trichinellosis.

Animals↗