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Biomedical subjects

E L Dovedova

Publications and source records attributed to E L Dovedova.

At least 37 records · Page 2Linked to original sources
PubMed1987

[Systemic, cellular and molecular adjustments induced by administration of peptides having different opioid activities].

Comparative study of effects of the peptides with different opiate activity on metabolism and neurophysiological processes in brain structures (cortical-subcortical, brainstem) revealed resemblance and specifics of delta-sleep inducing peptide (DSIP) and tetrapeptideamide (TPA) effects on subcellular (metabolism of neurotransmitters), cellular (bioelectrical activity) and systemic (behaviour) levels. Both peptides activated serotoninergic system and suppressed responses of brain structures to visual and acoustic stimuli. These peptides also reconstructed multi-sensory peculiarities of brain structures, changing the sensory supply of adaptive behaviour. As opposed to the DSIP, systemic effect of TPA included motor function and resulted in changes of cholinergic system activity levels. DSIP can be useful in studies of informational neuroses in clinics.

Acetylcholinesterase↗
PubMed1987

[Characteristics of the action of tetrapeptidamide on the body in short- and long-term administration].

It has been elucidated that the structures of the motor system of the rabbit and rat brain undergo significant alterations in monoamine metabolism 30 min after the administration of the synthetic enkephalin analogue Tyr-D-Ala-Gly-Phe-NH2 and in acetylcholinesterase activity and protein metabolism on the 3rd-6th day. It i suggested that a prolonged tetrapeptidamine-induced change in the motor functions may be due to a specific response on the part of the corticosubcortical structures of the motor systems.

Acetylcholinesterase↗
PubMed1986

[Effect ot tuftsin on cerebral monoamine oxidase and acetylcholinesterase activity].

The administration of a tetrapeptide tuftsin at a dose of 300 mkg/kg body weight for 30, 75 min or 3 days leads to the changes in specific activity of monoamine oxidase, forms A and B, and acetylcholinesterase in synaptosomal and cellular mitochondrial subfractions from the rabbit sensorimotor cortex and nucleus caudatus. The reciprocity of neuro-transmitter systems and specific peptide effects on the brain structures have been demonstrated. The results suggest that tuftsin has an activating effect on dopamine metabolism.

Acetylcholinesterase↗
PubMed1983

[Protein synthesis and oxidative activity of the brain in oxygen deficiency].

Biochemical and electron microscopic research methods showed disorders of the metabolism and the ultrastructure of the rat brain under the impact of experimental hypoxia and anoxia. Two to 3.5 hours after the exposure, the synthesis of protein in the neuronal fractions was impaired and the activity of the oxidative enzymes in the subfractions of synaptosomes and mitochondria was inhibited. The tissue ultrastructure was also impaired which was most pronounced in the synaptic processes of neurones. The data indicate fine morphochemical correlations at the subcellular level in the period immediately following post-hypoxic brain survival.

Adenosine Triphosphatases↗
PubMed1982

[Action of the "delta-sleep peptide" on monoamine oxidase and acetylcholinesterase activity in subcellular fractions from different rabbit brain formations in vivo].

Administration of delta-sleep-inducing peptide (DSIP) in vivo in a dose of 30 microgram/kg bw brings about MAO-A (substrate-serotonin) activation in synaptosome subfractions and cellular mitochondria from the brain structures (motor cortex, nucleus caudatus, thalamus). Activity of MAO-B (substrate-p-nitrophenylethylamine) and acetylcholinesterase was inhibited negligibly and specifically in subcellular fractions of the test brain structures. The results suggest that DSIP effects the regulatory or modulation function in the synapse. As one of the elements of sleep mechanisms this peptide induces a number of processes, particularly in serotonin metabolism.

Acetylcholinesterase↗
PubMed1980

[Biochemical characteristics of membrane fractions from different types of cerebral cortex synaptosomes].

The activity of acetylcholinesterase (ACE) and Na, K-ATPase is distributed among three subfractions of synaptic membranes isolated from light (C) and heavy (D) synaptosomes of the optic area of the rabbit cerebral cortex. The levels of specific activity of both enzymes in C subfractions are similar to those in D subfractions. At the same time the specific activity of ACE and Na, K-ATPase in membrane fractions from both light and heavy synaptosomes is different. Such a biochemistry of subsynaptic components from certain brain structures favors studying a fine morphochemical organization of an isolated nerve terminal and its relationship with the activity of CNS in different functional states.

Acetylcholinesterase↗
PubMed1980

[Features of metabolism in subcellular fractions of the motor cortex during restoration of visual nerve impulses].

Experimental data are obtained on cytochromoxidase (CO), acetylcholinesterase (AchE), MAO and ATPase activities in subfractions of synaptosomes and cellular mitochondria from the rabbit motor cortex following long-term visual deprivation. The first stage is characterized by elevated protein content and activation of enzymatic systems except K+; Na+--ATPase and CO. The tendency towards normalizing of protein content and activity of enzymes, particularly AchE and MAO occurred within 4 weeks. These data show that changes of enzymatic activity in subcellular components of the motor cortex following the sensory deprivation, are reversible but the process of neuronal recompensation in the integrative--starting system is complex and demands a longer time than in visual one.

Acetylcholinesterase↗
PubMed1978

[Biochemical characteristics of the synaptosomes and mitochondria of the motor area of the cerebral cortex following switching off of sensory impulsation].

Changes in the specific activity of cytochrome oxidase, monoamine oxidase, acetylcholinesterase and Na,K-ATPase in the light and heavy synaptosomes and mitochondria of neurone bodies fractions in the motor cerebral cortex of rabbits were demonstrated under conditions of light (visual) deprivation. These changes were specific of different metabolic cycles and differed in individual cell ultrastructures. The influence of sensory impulsation on functional neuron activity in different projection regions of the cerebral cortex is discussed.

Acetylcholinesterase↗
PubMed1978

[Effect of cytotoxic hypoxia on the metabolism and ultrastructure of cortical synaptosomes and mitochondria].

The study is concerned with morphochemical changes in the metabolism and ultrastructure of the mitochondria and synaptical endings from the cortex of the hemispheres in rats under the influence of cyanide (7mg/kg) following 30 min, 2 hours and 24 hours after its administration. Subfractions of the light and heavy synaptosomes, as well as in the mitochondria of the cell bodies showed changes in the activity of the enzyme systems (cytochromoxidase, K+, Na+-ATPase and Mg2+-ATPase) and disturbances of the ultrastructure of the eliminated organella. After 24 hours the metabolism normalized, which may be explained by a biochemical brain plasticity at the subcellular level under conditions of histotoxic hypoxia.

Adenosine Triphosphatases↗