[Pelvic melanoma].
Report of a patient diagnosed with having a pelvian mass which histologically was a melanoma. Discussion of the possible causes of retrovesical mass and treatment of the melanoma.
Humans↗
Biomedical subjects
F Algaba
Publications and source records attributed to F Algaba.
[Carcinosarcoma of the prostate. Immunophenotype, morphologic course and clinico-pathologic differential diagnosis].
The observation of a patient with a malignant tumor of the prostate initially classified as adenocarcinoma with desmoplasia, reclassified as adenocarcinoma with a malignant spindle cell component of uncertain cell line following two large tumor recurrences over a period of 4 months, and subsequently as carcinosarcoma with heterologous mesenchymal areas has prompted us to review the 11 reported cases of prostatic carcinosarcoma and the diagnostic algorithm of the proliferative processes of the prostate with elongated cells in order to recognize (from the histological features and the inclusion and exclusion immunophenotypes) the pseudosarcomatous stromal reactions, fusicellular changes of the carcinoma, benign and malignant phyllodes tumors and carcinosarcoma.
Adenocarcinoma↗
[A nephrogenic adenoma during treatment with intravesical BCG].
Two patients who had undergone resection of a transitional cell bladder tumor presented with nephrogenic adenoma of the bladder during treatment with BCG. Nephrogenic adenoma presenting in the course of intravesical chemotherapy has been previously reported in 5 cases and can mimic tumor recurrence. Thus, we consider the present case to be of special interest.
Adenoma↗
Carcinoma in situ as a prognostic factor for G3pT1 bladder tumours.
G3pT1 bladder cancer has traditionally been regarded as a superficial tumour with a high risk of progression. We have studied 37 patients with initial G3pT1 bladder tumours treated between January 1981 and December 1985. They were divided into 2 groups according to the association with carcinoma in situ (Cis) at the time of diagnosis. Clinical behaviour was analysed at 5 years. The first group (without Cis) showed progression and recurrence rates similar to those of low grade, low stage bladder tumours. The second group (with Cis) had a similar rate of recurrence but their progression rate was 65%.
Aged↗
Histological evaluation of superficial bladder tumors treated by Nd-YAG laser and transurethral resection.
Based on 3 study groups we have tried to analyze some concepts concerning the treatment of superficial bladder tumors by the Nd-YAG laser. In the first group of 34 superficial bladder tumors, we evaluated the accuracy of cold-cup biopsy in staging the tumor before treatment with the laser (100% for grade and 90% for stage). The possibility of identifying the tumoral grade in the lasered mass is 73%. In the second group of 53 random superficial bladder tumors we compared the effects of laser and transurethral resection (TUR) with regard to recurrence and progression after a 3-year follow-up: no significant differences are found between the treatments. In the third group the histologic changes in the bladder wall after treatment with the laser or TUR were evaluated by cold-cup biopsy (31 lasered cases and 24 resected cases) and by resector loop biopsy (11 lasered cases and 11 resected cases) between 12 and 24 months after treatment, without significant differences in terms of fibrosis.
Aluminum↗
Intratubular germ cell tumor. Relation with 'burned-out' tumor and testicular germinal neoplasia.
The study of one case of a 'typical' testicular seminoma (1.2 cm in diameter) allows us to observe its association with extensive intratubular germ cell tumor (IGCT) and its correlation with a progressive sclerosis of the seminiferous tubules. Based upon this case, and after verification of morphologic, histochemical and immunohistochemical identities between the IGCT, the interstitial neoplastic cells and those from the seminoma, we speculate on the interrelation between the IGCT, the germinal testicular tumors, and the 'burned-out' tumor.
Adult↗
[Treatment of bladder endometriosis using the Nd-Yag laser].
The good results achieved in the treatment of gynecological endometriosis via laser laparoscopy prompted us to perform endoscopic Nd:Yag laser photocoagulation in the present case of symptomatic vesical endometriosis described herein. To our knowledge, this is the first reported case in the world literature.
Adult↗
Treatment of transitional cell carcinoma of the ureter: is the controversy justified?
Between 1938 and 1985, 73 patients with ureteral tumors underwent surgery at Puigvert Foundation (1 case with bilateral synchronous tumors). Sixty-three patients were males and 10 females. Ages ranged between 49 and 78 (mean of 62) years. Tumoral stages were: pTa 5 cases; pT1 56 cases; pT2 10 cases, and pT3 2 cases. Radical treatment was performed in 38 cases and conservative treatment in 35 cases. Follow-up ranged between 2 and 20 (mean of 7) years. The overall survival rate at 5 years was 100, 82 and 50% for stages pTa, pT1 and pT2-3, respectively (p less than 0.05). Analyzed together, the actuarial survival at 5 years was 90.3% with conservative surgery and 67.8% with radical surgery (p not significant). The survival by stages for the patients treated with radical surgery was: 100% in pTa; 69.6% in pT1, and 57.1% in pT2-3. For those treated conservatively, survival was 100% in pTa, 95.8% in pT1 and 33.3% in pT2. Thus patients presenting with infiltrating tumors should not be treated conservatively, while patients with superficial lesions had a similar evolution whether treated by conservative or radical surgery.
Carcinoma, Transitional Cell↗
[Laser therapy of superficial tumors of the bladder].
Based on the treatment with Nd-YAG laser of 109 superficial bladder tumors (52 initial cases and 57 recurrences), herein we report on its indications, technical aspects, and clinical advantages. In order to evaluate the difference between laser therapy and TUR, three groups were studied to compare both techniques. 1) We evaluated the incidence of tumor recurrence in 27 cases submitted to laser therapy and 26 cases submitted to TUR. At 2 years no significant differences were observed relative to tumor recurrence or progression for both groups. 2) We evaluated bladder parietal involvement for each technique. All but one of 109 cases that had been submitted to laser therapy had preserved initial bladder capacity. Biopsies performed in areas post-laser therapy (31) and post-TUR (24), and with the resector loop in 22 cases, revealed no histologic difference between both groups (replacement fibrosis and elastic fibers). 3) We evaluated the incidence of urethral stenosis after laser therapy (22) and TUR (55). Urethral stricture was significantly lower (4.5%) for those treated with laser than for those treated by TUR (16.3%). On the basis of the overall (109 cases) and the partial (study groups) results, we consider laser treatment of superficial bladder tumors to be limited to single, less than 2-3 cms, or small, multiple initial or recurrent neoformations.
Evaluation Studies as Topic↗
Placental proteins in high-grade urothelial neoplasms. An immunohistochemical study of human chorionic gonadotropin, human placental lactogen, and pregnancy-specific beta-1-glycoprotein.
We examined the presence of human chorionic gonadotropin (HCG) in 16 low-grade and 47 high-grade urothelial neoplasms, including two cases with trophoblastic-like differentiation. In HCG-positive tumors, the presence of human placental lactogen (HPL) and pregnancy-specific beta-1-glycoprotein (SP-1) also was assessed. HCG immunoreactive cells were found in nine of the 47 high-grade tumors (19%), whereas none of the low-grade tumors were positive for HCG. This hormone was predominantly detected in the most undifferentiated and pleomorphic areas; however, HCG-positive cells also were found in areas of carcinoma in situ and well-differentiated transitional cell carcinoma in two cases. The serum HCG level was increased in two of the four cases studied. HPL and SP-1 immunoreactive cells were observed in seven and five cases, respectively, and it was found that tumors positive for SP-1 also were positive for HPL. Five tumors, including the two with trophoblastic differentiation, contained the three placental proteins. The HPL and SP-1 immunostained cells were usually found in the same areas of the tumor that were positive for HCG, but there was always a lower number of HPL and SP-1 immunoreactive cells than HCG immunoreactive cells. In one case, HPL and SP-1 could be found in areas of well-differentiated transitional cell carcinoma. These findings suggest that the morphologic and functional trophoblastic differentiation in urothelial carcinomas is a progressive phenomenon evolving from transitional cell carcinomas.
Adult↗
Inflammatory malignant fibrous histiocytoma of the spermatic cord with eosinophilia.
Explore the source record for details and available documents.
Aged↗
The role of repeat transurethral resection in stage A1 carcinoma of the prostate.
Between 1983 and 1987 repeat transurethral resection (TUR) was performed in 20 patients with a diagnosis of stage A1 prostatic carcinoma. The average weight of the resected tissue in the repeat TUR was 8.81 g (range 3-20 g). In 5 of 20 cases (25%) residual prostatic cancer was identified. By adding the number of foci with cancer obtained at the initial operation with the repeat TUR, 16 cases (80%) remained as A1 and 4 cases (20%) were reclassified (upstaged) to A2. The usefulness of this technique in the restaging of patients with incidental carcinoma of the prostate is analyzed.
Adenocarcinoma↗
[Nephrotic syndrome associated with ampulloma].
A patient is reported who presented simultaneously classic nephrotic syndrome and adenocarcinoma of the Vater ampulla. Morphological study of the renal biopsy revealed changes characteristic of membranous glomerulonephritis and subepithelial deposits. These deposits stained specifically for IgG and C'3 with a granular pattern, but deposits of CEA-antiCEA immune complexes were not found in glomerular capillaries. The association of nephrotic syndrome with lymphoproliferative diseases and a large variety of solid tumors, like carcinoma of the breast, bronchogenic, colon and stomach has been communicated, but the present case constitutes the first known association with adenocarcinoma of the Vater ampulla.
Adenocarcinoma↗
Value of radical cystectomy in bladder cancer with pelvic node involvement.
Of the 241 patients with bladder cancer treated with cystectomy and urinary diversion between January, 1978, and May, 1985, pelvic lymphadenectomy was performed in 150. In 41 of the 150 patients, pelvic node involvement was shown in the pathology study (27%). The preoperative clinical stages showed bladder muscle invasion in all 41 cases. Node invasion was found in 16/77 cases with radiation therapy and in 25/73 cases without radiation therapy (p less than 0.05). Operative mortality was 3 cases (7.3%). Of the 38 patients who survived the operation, 35 (94%) died of cancer within an average of 8 months. Twenty-seven showed 1-3 pelvic nodes involved, 7 showed 4-6, and 4 patients had more than 6 nodes involved. These differences between survival rates are not statistically significant (p = 0.35). Two patients died of a disease not related to the tumor, and only 1 is alive 4 years after operation (2%).
Adult↗
Balanitis xerotica obliterans: surgical treatment.
A case of BXO treated with complete surgical removal of the mucosal lesion and skin flap meatoplasty with excellent results 26th months later is reported.
Adult↗
Villous adenoma of the prostatic urethra.
We present a case of villous adenoma of the prostatic urethra, without malignant transformation. A review of the diagnostic and therapeutic criteria and pathogenic hypotheses on this kind of lesion in the lower urinary tract are made.
Adenoma↗
Correlation between tissular levels of prostatic acid phosphatase and prostate-specific antigen and hormonal response of metastatic prostatic cancer.
A correlation between the serum levels of testosterone and the tissular intensity of prostatic acid phosphatase (PAP) and prostate-specific antigen (PSA) in normal prostates has been demonstrated. In prostatic cancer patients, we studied the correlation between the percentage of neoplastic cells secreting PAP and PSA and the response to androgen deprivation, and found no relationship between them. Therefore it is not possible to predict the response to hormone therapy through the grade of tissular PAP or PSA.
Acid Phosphatase↗