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Biomedical subjects

F Granier

Publications and source records attributed to F Granier.

At least 55 records · Page 3Linked to original sources
PubMed1986

[Prolactin stimulation test using TRH in affective disorders (72 cases)].

Authors report results of stimulation test of prolactin by T.R.H. in 72 inpatients with affective disorders. They find well known effects of physiological factors (age, sex), and treatments (neuroleptics, lithium, L-Dopa). They did statistical analysis on plasma levels before and after T.R.H. stimulation. This test has no value for differential diagnosis between types of depressions. But it shows particular relation between high levels of prolactin and bipolarity.

Adult↗
PubMed1986

[Cyclosporin in the treatment of bullous pemphigoid: preliminary study].

Bullous pemphigoid is a typical autoimmune disease. It is classically treated with systemic corticosteroids alone or combined with immunosuppressants. Cyclosporine A (CyA), a new immunosuppressive agent with high activity in organs and bone marrow transplantation, could be expected to prove effective in this disease owing to its action on lymphocytes. Seven patients with bullous pemphigoid were treated with CyA in daily doses of 6 to 8 mg/kg bodyweight. Treatment was monitored by measurements of serum CyA, creatinine and liver enzyme levels. The effectiveness of treatment was assessed on clinical changes. The seven cases are dealt with individually, with a brief case-report for each of them. The only side-effects observed were reversible rises in serum creatinine levels and hypertrichosis in two cases; these are usual reactions to the drug. Hormonal assays were normal in two female patients. Concerning results, our patients fell into two groups. Among those treated with CyA alone there were two failures and two sustained satisfactory results. Treatment was successful in all patients treated with CyA during relapses under corticosteroid therapy, but two patients relapsed after CyA was discontinued. It is concluded that CyA is of no interest in the acute phase of bullous pemphigoid, that the long-term stability of the results obtained is doubtful and that this potentially nephrotoxic drug should be avoided or administered with extreme caution in elderly people, since their renal function may be at the limit of normality.

Adrenal Cortex Hormones↗
PubMed1986

[Psychiatric manifestations of Steinert's disease].

Authors report one case of psychiatric manifestations of Steinert's disease, with biological data. They compare it with historical and actual descriptions of these manifestations, particularly for clinical and biological symptomatology. Main hypothesis is a central localization of this polysystemic process, under a genetical determinism.

Electroencephalography↗
PubMed1985

Depression and anxiety: mianserin and nomifensine compared in a double-blind multicentre trial.

Mianserin and nomifensine were compared in 61 depressive patients in a randomized double-blind multicentre study. During the first week the antidepressant dosages were low, mianserin 30 mg and nomifensine 50 mg. After the first week dosages were doubled to 60 mg and 100 mg respectively. At baseline there were no significant differences between treatment groups for sex, age, class of depression, previous treatment, somatic symptoms, previous vital events, global clinical appreciation, global sleep appreciation, and depression assessed on the Hamilton Depression Rating Scale (HDRS), Montgomery-Asberg Depression Rating Scale (MADRS) or the Hamilton Anxiety Rating Scale (HARS). Assessments were made at 7, 14 and 28 days. There were no significant differences between treatment groups for HDRS, MADRS or HARS, either globally or when divided into endogenous and reactive subgroups. Compared with nomifensine there were significantly greater scores with mianserin for global clinical appreciation and global sleep appreciation. There were more withdrawals and dosage changes with nomifensine than with mianserin. Regarding concomitant treatment, significantly less anxiolytics were prescribed to the mianserin group. This study confirms that mianserin is an effective and sedative antidepressant whereas nomifensine is an effective and stimulating antidepressant.

Adjustment Disorders↗
PubMed1984

[Initial results of a pharmacokinetic study of pipothiazine and its palmitic ester (Piportil L4) in a schizophrenic population].

Plasma kinetics of pipotiazine have been studied in ten schizophrenic patients after oral administration of single dose of pipotiazine at 7 a.m. (30 mg, drops). Peak plasma concentrations are reached one hour after administration (41.8 +/- 19,9 ng/ml) and then rapidly decline until 24 h (2.2 +/- 1.2 ng/ml). During the following days plasma concentrations remain stable at the same sampling times. After 3 days wash-out and first intramuscular injection of pipotiazine palmitate (100 mg) main pharmacokinetic data are found: plasma concentrations of pipotiazine are not detectable during at less 3 days after injection, maximal drug level is attained during second week after i.m. (1.7 +/- 0.9 ng/ml). A period of decline is then recorded. Furthermore the mean ratio between pipotiazine plasma concentration after oral and i.m. administration is about 20. When pipotiazine palmitate is given every fourth week, steady state seems to be reached as early as the second month.

Administration, Oral↗
PubMed1983

[Glomerulopathies in the aged (excluding diabetes)].

Fifty-five cases of glomerular disease in non-diabetic patients above sixty years of age were studied retrospectively. Primary glomerular disease was found in 36 cases, among which 14 cases with minimal changes glomerulopathy (25.4%) and 7 cases with membranous glomerulopathy (12.7%). The remaining 19 patients had secondary glomerular disease, mainly with amyloidosis (12 cases: 21.8%). In these three main forms of glomerulopathy, symptoms were similar, making differential diagnosis impossible before histological examination. Significant responses to treatment can be achieved in minimal changes and extracapillary proliferative glomerulopathies: among the 14 patients given corticosteroids, 9 recovered or experienced very significant improvement. However, one patient under cortico-steroids died from perforation of the sigmoid. In order to establish the best treatment, investigations should be carried out as in younger patients, since they do not seem to involve a significantly higher risk.

Adrenal Cortex Hormones↗
PubMed1983

[Use of benzodiazepines in the treatment of depression].

The double-blind controlled trials between benzodiazepines and antidepressants show that benzodiazepines have not specific antidepressive action in depression. The benzodiazepines exert limited effect on the anxiety of endogenous and melancholia. They have definitive properties in neurotic depressions and mixed anxious-depressive states. In theses states, they may extenuate inhibition and elevate mood. Benzodiazepines are primarily anxiolytic rather than antidepressant -- But in some cases, anxiety and depression are not easily distinguished.

Amitriptyline↗
PubMed1983

[Clinical trial of loxapine succinate in the treatment of 30 cases of psychotic states].

An open clinical study of loxapine succinate was developed on 30 hospitalized psychiatric patients in order to confirm its antipsychotic properties and its originality opposite the other major neuroleptics. Dosages ranged from 100 to 200 mg per day in 12 cases (40%), and more than 200 mg in serious psychosis or unamenable to therapeutic for which inferior dosages were inefficacious (11 cases). 56,7% of favourable results have been obtained, with a fair improvement of whole symptoms, paranoïd schizophrenic attack and acute delusions. Tolerance was remarkable: no neuro-vegetative manifestation was reported. The considerable sedative effect of loxapine had involved moderate and no invalidating drowsiness in 23% of cases. The extra-pyramidal occurring symptoms disappeared within 2 or 3 days. So loxapine succinate in proving to be a major first intention neuroleptic, suiting a considerable antipsychotic efficacy to a good tolerance, allowing new perspectives in the therapeutic and the approach of psychotic patients.

Acute Disease↗
PubMed1982

[Effects of clonidine on opiate withdrawal symptoms. Results - biochemical mechanisms (author's transl)].

Clonidine was administered to nineteen patients in an inpatient setting after abrupt discontinuation of chronic opiate addiction (morphine, héroin, dextromoramide). Clonidine produces a decrease sometimes very rapid in opiate withdrawal signs but does not suppress the whole affects associated with. These data support the hypothesis that clonidine has antiwithdrawal effect by replacing opiate-mediated inhibition with alpha 2 mediated inhibition of brain noradrenergic activity.

Adult↗
PubMed1981

[Interest of a new method of graphic analysis for the study of the organization of stage II sleep in man (author's transl)].

The organization of stage II and its modifications according to its occurrence in the cycle are studied using an analogical method of graphic analysis. The latter offers a continuous display on a limited record length, of the EEG amplitude in the sigma, alpha, theta and delta bands, of the muscle tone and of eye movement. Thus, it is noted that stage II, preceding paradoxical sleep at the end of the cycle, differs from stage II at the beginning of the cycle by 3 essential elements: the different evolution of delta activity during this stage and its irregular or alternating characteristics at the end of the cycle; the existence of a high muscle tone and an abundant phasic muscle activity during stage II at the end of the cycle; the different relation of these two types of stage II with the depth of the cycle. These observations, compiled from 100 records in healthy, non-insomniac subjects, are compared to those from studies on the heterogeneity of stage II and from those which provide evidence for the existence of phasic phenomena during slow sleep prior to the paradoxical stage in man as well as in the animal.

Electroencephalography↗