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Biomedical subjects

F Guilbert

Publications and source records attributed to F Guilbert.

At least 55 records · Page 3Linked to original sources
PubMed1986

[Odontogenic myxoma. A histoenzymologic and ultrastructural study. Apropos of 5 cases].

The myxoma of the jaws represent 8% of the odontogenic tumours in our series (324 cases). The 5 cases described here were studied by histoenzymological and electron microscopic methods. The first method demonstrated in the majority of tumoral cells a high level of activity of alkaline phosphatases and ATPases similar to that noted in odontoblasts of the dental pulp. In addition, an acid phosphatase activity was also present in numerous cells but usually at a low intensity. Ultrastructurally, the tumour was composed of 3 main cellular types: young round cells with numerous ribosomes; stellate secretory cells with well-developed granular ergastoplasma and Golgi apparatus; fusiform cells with characteristics of fibroblasts. Some macrophages and myofibroblasts were also present. The intercellular substance was granulofilamentous and in one of our cases calcifications were obvious upon some collagen fibers. All these results seem to corroborate the hypothesis of odontogenic nature of the tumour. Early odontogenic induction induces the transformation of fibroblasts into cells with enzymatic activities similar to those of odontoblasts and the calcification of collagen fibers seen in one of our cases would express an early mineralization.

Esterases↗
PubMed1985

[Angiomas of the jaws. Diagnostic and therapeutic problems (apropos 12 cases)].

Difficulties encountered during surgery on maxillary angiodysplasias were studied in relation to case-reports of patients treated in the stomatology and maxillofacial surgery unit directed by professor Vaillant, Hôpital Salpêtrière, Paris. Findings allowed certain conclusions to be drawn with respect to diagnostic and therapeutic features and to compare these with those reported in the international literature.

Adolescent↗
PubMed1985

[Mandibular mucoepidermoid tumor].

One case of mandibular mucoepidermoid tumour was observed in a 57 years old man. A progressive swelling of the mandible was shown with an osteolytic feature on roentgenograms. It was treated by hemimandibulectomy. Grossly, the neoplasm was partly cystic. Histologically, it was mainly composed of intermediate clear cells. Its ultrastructure was quite similar to that of mucoepidermoid tumours in other sites. Heterotopic salivary lobules, though lacking in our case, seem to play the major role in the genesis of these tumours.

Carcinoma↗
PubMed1985

[Benign tumors and mandibular resection. The place of resection grafts in the treatment of benign tumors of the mandible].

Data were analyzed from case-reports of 80 patients undergoing resection graft procedures for benign mandibular tumors, and operated upon and followed up in the Stomatology and maxillo-facial surgical Unit, Hospital Salpêtrière, Paris from 1970 to 1984. In 27 cases surgery was by first intention; in the others it followed one or several previous operations, their multiplicity sensibly affecting the decision to operate and the development of postoperative suppurations.

Adolescent↗
PubMed1985

[Parotid sialadenosis. A histoenzymologic and ultrastructural study].

A case of sialadenosis was studied by means of several morphological methods (light microscopy with micrometric measurement, transmission and scanning electron microscopy, immunopathology, histoenzymology). In that disease, these investigations seem to corroborate the hypothesis of a dyscrinism, true perturbation of the salivary excretion with storage of secretory granules in the cells and consecutive hypertrophy. This dyscrinism should result from a deterioration of branches of autonomic nervous system. In the case reported here, no etiology was proved but the hypothetic part of a recent antiulcerous treatment by Tagamet was suggested.

Adult↗
PubMed1984

Histoenzymological and ultrastructural study of a bifocal calcifying epithelial odontogenic tumor. Characteristics of epithelial cells and histogenesis of amyloid-like material.

A calcifying epithelial odontogenic tumor, simultaneously located in the two jaws (maxilla and mandible) was examined by histochemical and electron microscopic methods. Squamous tumor cells without secretory polarity were different from those of common ameloblastoma. High activities of alkaline phosphatase and ATPases were demonstrated by light and electron microscopy on the cytoplasmic membrane, findings similar to those in the stratum intermedium cells of the normal dental germ from which these tumor cells seem to arise. The tumor cells, like preameloblasts of the dental germ, also produce a granulo-filamentous material in intracytoplasmic vesicles and discharge it into the stroma. This "pseudo-amyloid" substance represents an abnormal protein of the enamel matrix and calcification, mainly occurring in that substance, might be an attempt at mineralization.

Adenosine Triphosphatases↗
PubMed1983

Ameloblastic fibrosarcoma of the jaws--report of three cases. Clinico-pathologic, histoenzymological and ultrastructural study.

The ameloblastic fibrosarcoma is a rare variety of neoplasm. Three new cases reported here occurred within preexistent benign odontogenic tumors (ameloblastic fibroma or fibro-odontoma). These large, osteolytic tumors, spreading to adjacent soft parts, recurred after surgical treatment in two cases. One of them had a lethal course, with pleuro-pulmonary, mediastinal lymph node and hepatic metastases. Histologically, these sarcomas show a malignant mesenchymal component and few benign ameloblastic islands, which often disappear after one or several recurrences. Histoenzymologically, a high level of alkaline phosphatase and ATPase activities is always present, a feature not present in common fibrosarcomas. The ultrastructural study demonstrates, in analogy with odontogenic myxomas, clear cells provided with numerous microfilaments, secretory cells and also some fibroblasts and myofibroblast-like cells. In addition to these pleomorphic cells, a great number of peculiar granular cells with numerous lysosomal bodies were also found. The histogenesis of these tumors in unknown. Perhaps the epithelial component, being unable to assume its functions of organization, may initiate the malignant transformation of its odontogenic mesenchyme.

Acid Phosphatase↗
PubMed1981

[Salivary gland cylindromas. Retrospective study of 65 cases (author's transl)].

A retrospective study of prognostic, clinical, and histological features in 65 cases of salivary gland cylindromas treated in the Hôpital Salpêtrière, Paris, was conducted. Vital prognosis was related to the initial size of the tumour, the presence of pain, and evidence of cellular anomalies or invasion of neighbouring structures on histological examination. Metastatic spread is related to peritumoural extension, and local recurrence has a prognostic value because of its relationship to later metastatic involvement.

Adult↗
PubMed1980

[Intraoral minor salivary gland tumors. Report of 296 cases (author's transl)].

296 intraoral minor salivary gland tumors were observed among 702 salivary tumors. The study emphasizes a frequent palatine location, observed in more than 50 per cent of theses tumors. Pleiomorphic adenomas (or so called mixed tumors), are frequently encountered; but it is noteworthy that the proportion of muco-epidermoid tumors or adenoid cystic carcinoma is higher among theses tumors than among major salivary glands; this fact explain a poor overall prognosis of minor salivary gland tumors.

Adenoma↗