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Biomedical subjects

F Guilbert

Publications and source records attributed to F Guilbert.

At least 73 records · Page 4Linked to original sources
PubMed1991

[An unusual form of primary epithelioma of the mandible: odontogenic clear cell carcinoma. Clinical and morphologic study].

One case of aggressive intramandibular epithelial tumor is presented. This tumor demonstrated an unusual pattern with areas of follicular ameloblastoma together with undifferentiated trabeculae or lobules composed of basophilic cells and of clear glycogenic-rich cells. The odontogenic nature of this tumour and its analogies with common ameloblastoma were demonstrated by electron microscopy, immunohistoenzymology and immunohistochemistry. The signification of such a neoplasm is discussed.

Adenocarcinoma↗
PubMed1991

Acinic cell carcinomas of salivary glands histoprognosis. Value of NORs stained with AgNOR technique and examined with semi-automatic image analysis.

Twenty one patients surgically treated for acinar cell salivary gland carcinomas were studied retrospectively. Four cases were excluded from the results because of an inadequate follow-up time (less than 5 years). The rest was classified into two groups: eleven patients with a favorable outcome were still alive without any recurrence after a mean follow-up period greater than 10 years; in six other patients, recurrences and metastases occurred followed by death in four cases. Previously for such tumors a high degree of histological undifferentiation usually gave rise to a poor prognosis, although some exceptions were noted. Thus, in an attempt to find a more reliable prognosis criterion, we evaluated by semi-quantitative image analysis nucleolar organizer regions by means of AgNOR count and mean area in all these cases. Our results significantly correlated with the clinical prognosis: a high count (more than 3) and a small mean area were always found in tumors with an unfavorable outcome whereas lower counts and larger mean areas were found in tumors with a favourable clinical course. Thus, this method showed promise as establishing the prognosis of acinar cell tumours.

Adult↗
PubMed1991

[Metastases of malignant tumor in the jaw. Analysis of 30 case reports].

30 metastases of malignant tumors in jaws were retrospectively studied. They occurred more often in women than in men (17 F/13 H). In 21 cases, the primitive cancer was known and had been treated 1 to 4 years before. In the other cases (9), the bone metastasis led to the discovery of a latent tumor. Clinical signs and symptoms included swelling, pain, loosening of teeth, labio-mental anaesthesia and rarely pathologic fracture. Radiologically, all but two patients had radiolucent lesion. These metastases almost always involved the mandible (95% of cases) and in that bone, most often molar area and angle. Histologically, the majority of lesions were adenocarcinomas from breast (33%) and alimentary canal (stomach, colon). Epidermoid bronchial carcinomas were seen in 5 cases and malignant melanomas in 2 cases. Only one sarcoma of this series was arising from a liposarcoma of the thigh. In all but one patients, evolution was quickly lethal.

Adult↗
PubMed1991

[Dental implantology and expertise. Apropos of 6 cases].

Dental implants are used with increasing interest each day. This costly material, which is reimbursed neither by Public Social Protection Agencies nor by private health insurance companies, has become a cause for lawsuits. We analyzed the experts' conclusions regarding legal mementos and expert reports, wherein medical liability (4 cases) and repair of dental injury (2 cases) were put into question. The experts stress the need to regard this technique as surgical, and to have it necessarily yield results. Repair of damage caused by dental trauma using implants does not alter conventional approaches in terms of social security cover for maintenance and replacement of dental prosthesis. Difficulties encountered by experts in evaluating injuries sustained by bone-adapted implants are evoked.

Dental Implantation, Endosseous↗
PubMed1991

[Congenital microphthalmos. Orbital and palpebral expansion].

Ocular atrophy in prime infancy leads to lack of orbital growth. Current treatment of plastic surgery in severe deformities is unsatisfactory, whereas tissue expanding techniques using intraorbital balloon are effective on orbital cavity growth. This procedure makes use of conjunctival shells or aesthetic ocular prosthesis easier, and allows an improved reconstruction. Description of implants and surgical technique of insertion used.

Child↗
PubMed1990

[Extra-nodal lymphoma of the cervicofacial region: anatomo-pathological aspects].

The B lymphomas formed the great majority (greater than 90%) of lymphomas in a series of 80 extra-nodal lymphomas of the cervico-facial region, all categorised by immuno-histochemistry. They also tended to be tumours of the highly malignant type (61%): lymphoblastic, immunoblastic, centroblastic and Burkitt's lymphomas.

Facial Neoplasms↗
PubMed1990

[Malignant maxillofacial extra-nodal lymphoma].

64 patients with extra-nodal maxillo-facial NHL were seen between 1969 and 1989. These rare tumours (1 to 4% of stomatological tumours) tended to occur more often in men (60% of cases) between the ages of 40 and 70. Bony involvement was common (maxillary and mandibular involvement), though more rarely the salivary glands or mucosa were involved, presenting as a swelling with lysis of underlying bone. Highly malignant varieties (85% of cases) were most commonly encountered. The treatment remains medical, involving chemotherapy (C.H.O.P. or high dose methotrexate) and gives an actuarial survival rate of 50% at 3 years.

Adult↗
PubMed1990

[Lymphoma of the salivary glands. New nosologic frontiers].

The classification of salivary lymphomas, including the ambiguous Mikulicz syndrome, has been considerably modified in recent years thanks to advances in immuno-histochemistry. Following the distinction between pseudo-lymphoma and true lymphoma, made possible by the latter, the situation has now become less clear due to the existence of possible transition between the two entities. Moreover, the increasing identification of a particular form of lymphoma involving the salivary glands in Sjogren's syndrome (MALT type lymphoma - centrocytic-like) analogous to that seen in the gastrointestinal tract, now opens up the possibility of very early diagnosis of these tumours. However, the significance in terms of treatment of this monoclonal variant as a tumour criterion still remains difficult to define.

Diagnosis, Differential↗
PubMed1990

[Benign paralysis of the 6th cranial nerve in children].

Acquired sixth nerve palsies in infants and children that occur without fever primarily suggest a tumor or intracranial hypertension. In a few instances, the cause is benign and spontaneous recovery occurs although relapses are occasionally seen. We report seven episodes of benign sixth nerve palsy in four children aged 5 1/2 months to 8 1/2 years. An ENT infection was the precipitating factor in four of these seven episodes. Recovery consistently occurred within 4 days to 6 weeks. None of the children had residual oculomotor impairment. The various etiologic hypotheses put forward in the literature are discussed. No study provides a pathophysiologic explanation for these transient palsies.

Abducens Nerve↗
PubMed1990

[Metastasis of a malignant melanoma simulating a primary mandibular sarcoma].

The rare case reported here was a mandibular metastasis of a malignant melanoma located in the nape of the neck and surgically removed. 4 years later, occurred a fibrosarcomatous mandibular tumour without local recurrence. The metastatic nature of this tumour was difficult to prove by means of immunohistochemical and ultrastructural methods. This case illustrated the eventuality of a desmoplastic change in metastasis of a common malignant melanoma. The histogenesis of this rare type of melanoma was discussed.

Diagnosis, Differential↗
PubMed1989

[Pleomorphic adenoma of the salivary glands. Impact of the myxoid component on the prognosis].

In a series of 570 pleomorphic adenomas of main and accessory salivary glands, we found 48 recurrences (8.04%). These recurrences occurred between several months and 19 years after surgical treatment. They were more frequently noted in parotid tumors. Comparatively to a control series, in recurrent tumors myxoid structures were more frequent than epithelial structures, as demonstrated by immuno-markings (anti-protein S 100 and anti-vimentin sera). Besides, in these tumors, extracapsular myxoid expansions were commonly seen. The proliferative potential of myoepithelial cells which are the main cellular component of myxoid areas, is thus suggested as a mainly factor of recurrence of pleomorphic adenomas.

Adenoma, Pleomorphic↗
PubMed1989

[Facial circumscribed ossifying myositis. Anatomo-clinical and tomodensitometric study].

1 case of circumscribed myositis ossificans of the temporal muscle is reported in a 21 years-old man. The initial complaint was a sudden non traumatic swelling. Roentgenography showed a characteristic feature: peripheral radio-opacity around a non-opacified area. Under microscope, we could find 3 zones: a central fibroblastic area, an intermediate zone with immature osteoid bone, a peripheral zone with mature lamellar bone. In addition, we used histoenzymological and electron microscopical methods. The difficulties of diagnosis, the pathogenesis and the prognosis of this disease were also discussed.

Adult↗
PubMed1989

[Central reparative giant cell granuloma of the jaw. Morphological study].

8 cases of central giant cell reparative granuloma of the jaws were morphologically studied. If the histological feature of this disease is theoretically characteristic (giant cells, fusiform cells, numerous vessels and more or less active osteogenesis) in fact other giant cells lesions, especially true giant cell tumors, often set a problem to the pathologist. In addition, the etiopathogenesis of that granuloma is discussed by means of the results of immunohistochemical, histoenzymological and ultrastructural findings.

Adolescent↗
PubMed1989

[Cystic lymphoid hyperplasia of the parotid in relation to acquired immunodeficiency syndrome (HIV+). Apropos of 2 cases].

Cystic lymphoid hyperplasia of the parotid, a rare disease, was recently described in patients with acquired immunodeficiency syndrome. We reported here 2 new cases of this illness. The 2 HIV+ patients showed an enlargement of parotid gland. A superficial parotidectomy was performed. The histological and immunohistochemical studies were completed in one case by a histoenzymological and ultrastructural study. We could see numerous cystic cavities lined with a cylindrical or metaplastic malpighian epithelium and surrounded by a lymphoid tissue, similar to a true lymph node with germinal centers. In these lymphoid structures, we could find some epithelial remnants and numerous epimyoepithelial islands. Besides, anomalies similar to those described in persistent generalized lymphadenopathies were obvious: hyperplastic germinal centers with multiplication of B lymphocytes and thin mantle zone, perifollicular hypervascularization, numerous macrophages, plasmocytes and T lymphocytes with increase of T8 cytotoxic subset in interfollicular and paracortical areas. An early opportunist infection is suggested in the histogenesis of this disease.

Acquired Immunodeficiency Syndrome↗
PubMed1989

[Cystic hamartoma of the mandibular angle. Apropos of a case].

A large cyst of mandibular angle was surgically removed in a 20 years-old woman. This cyst was discovered during childhood and was associated with a branchial para-mandibular cyst. It was histologically lined either with a malpighian epithelium with sebaceous islands or with a ciliated cylindrical epithelium. Because of its topography, its association with a branchial cyst and its histological feature quite similar to that of a cyst of thyroglossal duct, this cyst was thought to represent a simplified salivary ectopy composed only of a cystic secretory duct without any salivary parenchyma.

Adult↗
PubMed1989

[Value of modern imagery in the study of coronoido-malar malformations. Apropos of 2 cases].

We report two cases of mechanical limitation of buccal opening. CT scanning of bone anomalies diagnosed on standard radiography allowed to define malformation of the coronoid piston on the one hand, and the temporo-malar groove on the other: a combination of Langenbeck's and Jacob's disease in one case and Langenbeck's disease in the other. Coronoidectomy, systematically bilateral, demonstrated these morphological anomalies together with formation of coronoido-malar neo-arthrosis.

Adolescent↗
PubMed1988

Cherubism. Histo-enzymological and ultrastructural study.

The 3 cases of cherubism reported affected the mandible. They were all studied by means of histo-enzymological and ultrastructural methods. This study demonstrated 3 stages in the morphological evolution of the disease, corroborated by clinical data. The 1st stage was characterized by an osteolytic granuloma with round, fusiform and giant-cells and a high level of activity of acid phosphatase. The 2nd stage showed repair with proliferation of highly active fibroblasts (increase in activity of leucine aminopeptidase). The 3rd stage exhibited an osteogenesis with high activity of alkaline phosphatase and ATPase. The pathogenesis of this rare osteodysplasia is discussed.

Adolescent↗