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Biomedical subjects

F Ide

Publications and source records attributed to F Ide.

At least 73 records · Page 4Linked to original sources
PubMed1995

Parotid sialolithiasis in a child.

The occurrence of sialolithiasis in children is uncommon, while parotid sialolithiasis in children is rare. A case of parotid sialolithiasis arising in a 4-year-old girl is presented.

Child, Preschool↗
PubMed1985

Oral focal mucinosis.

Two cases of oral focal mucinosis are described. Both were diagnosed clinically as fibroma of the gingiva. The clinical and histopathologic features of this unusual lesion are discussed.

Adult↗
PubMed1984

Immunohistochemical and ultrastructural analysis of the proliferating cells in histiocytosis X.

The cellular nature of the proliferating histiocytes in 6 cases of histiocytosis X was studied immunohistochemically and ultrastructurally. Immunohistochemically, S-100 protein was detected both in the cytoplasm and the nuclei of histiocytosis X cells as well as Langerhans cells in normal oral epithelium. These cells were always negative for lysozyme, alpha 1-antitrypsin, alpha 1-antichymotrypsin and immunoglobulins. S-100 protein was not detected in lysozyme-positive histiocytes and multinucleated giant cells often showed the signs of phagocytosis. Thus, S-100 protein appears to be a useful immunohistochemical marker for histiocytosis X cells. Ultrastructurally, Birbeck granules noticed in histiocytosis X cells were never seen in the phagocytic histiocytes with numerous lysosomes and phagosomes. These results emphasized the heterogeneous nature of the proliferating histiocytes involved in the lesions. Since histiocytosis X cells share characteristics, not only ultrastructurally but also immunohistochemically, with Langerhans cells, the hypothesis that histiocytosis X may be fundamentally an abnormal proliferation of Langerhans cells has been further supported.

Cell Division↗
PubMed1984

A microscopic focus of traumatic neuroma with intralesional glandular structures: an incidental finding.

A 50-year-old man received radiation therapy and chemotherapy for squamous cell carcinoma of the right floor of the mouth. Histologic examinations of surgical materials revealed the presence of benign ductal epithelial structures containing mucinous material within a small traumatic neuroma of the mandibular alveolar mucosa. Presumably, the residual salivary ducts of the sublingual glands may become incorporated during the development of a traumatic neuroma secondary to the destruction of tissue. Our search of the literature has failed to reveal a similar recorded occurrence.

Carcinoma, Squamous Cell↗
PubMed1984

Myospherulosis of the mandible. Report of a case and review of the literature.

A case of myospherulosis in a 67-year-old female is reported. The lesion appeared as a submucosal mass firmly attached to the buccal periosteum of the right molar region of the mandible. Although the records of our case did not specify what medication was placed in the lesion, clinicopathologic features further supported the hypothesis that myospherulosis may be a unique instance of iatrogenic disease caused by petrolatum-based antibiotic ointments.

Aged↗
PubMed1984

Periosteal ossifying fibroma of the palate.

An unusual case of the ossifying fibroma of a 54-year-old woman is reported. Clinically the lesion appeared as an exophytic mass on the hard palate and apparently originated outside of bone. Histologically the resected tumor is well encapsulated and made up of a richly cellular fibroblastic stroma containing foci of mature bone with a predominantly lamellar structure. While the possibility exists that the lesion is reactive, it appears to be a true neoplastic growth and a purely soft tissue process arising from the periosteum of the palate. Thus, we proposed the term periosteal ossifying fibroma for this distinct lesion in order to distinguish it from the common peripheral ossifying fibroma.

Diagnosis, Differential↗
PubMed1984

Unscheduled DNA synthesis in human bronchial epithelium treated with various chemical carcinogens in vitro.

A system was developed in which organ culture of human bronchial epithelium was used in combination with autoradiography for quantitative measurement of unscheduled DNA synthesis (UDS) in bronchial epithelial cells. Human bronchi obtained at surgery were cut into small sections and treated with various carcinogens plus [methyl-3H]thymidine in short-term organ culture. Significant numbers of silver grains, indicating UDS, were detected on the nuclei of epithelial cells of human bronchi treated with carcinogens, and the numbers were proportional to the concentrations of carcinogens. In this system seven representative carcinogens induced UDS. Four active metabolites of benzo[a]pyrene, and benz[a]anthracene also were found to induce very active UDS in human bronchial epithelium. These findings suggest that human bronchial epithelial cells can repair different types of DNA modification induced by chemical carcinogens.

Autoradiography↗
PubMed1983

Gingival salivary gland choristoma: an extremely rare phenomenon.

An unusual case of a gingival salivary gland choristoma in a 9-year-old girl is presented. Clinically, the lesion appeared as a tumorlike mass of the maxillary incisor region. Histologic examination of the lesion revealed the presence of pure mucous glandular elements within the connective tissue. The possible mechanisms of its development in this unusual location and the nature of this lesion are discussed.

Child↗
PubMed1982

Xanthic variant of non-ossifying fibroma (so-called xanthofibroma) of the mandible. An ultrastructural study.

An unusual case of a 37-year-old female with xanthomatous bone tumor of the right molar area of the mandible was presented. The tumor was asymptomatic and found to be a well-demarcated intraosseous radiolucent lesion on radiographic examination. Histologically the tumor consisted of two cell types, fibroblastic and xanthomatous cells. There was no osteoid, bone or cartilage formation. However, numerous psammomatous calcified bodies were seen in the fibrous area. Ultrastructural study showed fibroblastic cells in different stages of proliferation as the basis of the tumor which transform itself into xanthomatous cells. From the clinicopathologic findings, our case was thought to be a xanthic variant of non-ossifying fibroma (so-called xanthofibroma) of the mandible.

Adult↗
PubMed1982

Unscheduled DNA synthesis in human oral mucosa treated with chemical carcinogens in short-term organ culture.

Unscheduled DNA synthesis (UDS) was investigated by autoradiography in human oral mucosa treated with 10 representative chemical carcinogens. Small sections of gingiva in short-term organ culture were exposed for 2 hours to chemical carcinogens plus [methyl-3H]thymidine. Significant numbers of silver grains, indicating UDS, were detected over the nuclei of both epithelial cells and fibroblasts. All ultimate or proximate carcinogens tested induced UDS. Of five procarcinogens tested, only benzo[a]pyrene (BP) did not induce UDS, but the more activated metabolite of BP, (+/-)-trans-7 beta-8 alpha-dihydroxy-9 alpha, 10 alpha-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE I), was very effective in inducing UDS. Ultimate or proximate carcinogens induced higher levels of UDS than did procarcinogens. All the carcinogens that induced UDS showed clear dose-dependent effects. UDS levels were twofold to fivefold higher in the epithelial cells than in the fibroblasts, regardless of the type of carcinogen tested. Comparisons of the levels of UDS induced by 4-(hydroxyamino)quinoline 1-oxide, methyl methanesulfonate, or BPDE I did not reveal any significant differences. These findings indicate that human gingival epithelial UDS assay should be useful for short-term detection of environmental carcinogens that induce cancer in human oral mucosa.

Autoradiography↗
PubMed1982

Demonstration of in vivo DNA repair synthesis in mouse skin exposed to various chemical carcinogens.

Chemical carcinogen-induced unscheduled DNA synthesis in mouse skin in vivo was demonstrated with the aid of a mechanical device. An isotonic aqueous solution containing a carcinogen and [methyl-3H]thymidine was injected s.c. into an isolated portion of the skin clamped off with ring-shaped forceps. Dose-dependent unscheduled DNA synthesis was clearly demonstrated as silver grains on the nuclei of both epithelial and dermal fibroblastic cells in this portion of skin in response to treatment with methyl methanesulfonate, 1-methyl-1-nitrosourea, 4-nitroquinoline 1-oxide, and 4-hydroxyaminoquinoline 1-oxide. The range of variability was small among animals and within a single area of skin. These findings suggest that this system should be useful for quantitative measurement of unscheduled DNA synthesis in individual cells of the skin in vivo. Unscheduled DNA synthesis in response to various carcinogens was 3- to 5-fold more active in epithelial cells than in dermal fibroblastic cells. A time course study showed that active unscheduled DNA synthesis could be detected after 10 min, implying that adduct removal with resulting synthesis had occurred by this time.

Animals↗
PubMed1981

Detection of chemical carcinogens by assay of unscheduled DNA synthesis in rat tracheal epithelium in short-term organ culture.

A short-term organ culture of rat tracheal epithelium was used to detect the ability of 53 chemicals to induce UDS. In this system all direct-acting compounds (ultimate or proximate carcinogens) tested induced UDS. Of 24 compounds requiring metabolism (procarcinogens), nine induced UDS, viz., 4NQO, AF-2, BP, DMN, DEN, and NP. Urethane, AAF, and 2,7-AAF induced very slight UDS. 3-Methyl-4NQO for which carcinogenicity data is incomplete as positive in our system. Among the cancer chemotherapeutic agents tested only mitomycin C induced UDS. MC and DMBA, which are known to induce cancer of respiratory organs in experimented animals, and DAB, aflatoxin B1 and Trp-P-1, which are strong carcinogens in the liver, did not induce UDS within 2 h. With the longer exposure (24 h), these carcinogens also failed to elicit UDS. All the carcinogens that induce UDS showed clear dose-dependent effects. No non-carcinogens tested induced UDS. These results suggested that this system should be useful for screening environmental chemicals suspected of damaging DNA of the respiratory organ on the basis of organotropic effects for UDS induction in cultured rat tracheal epithelium.

Animals↗