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Biomedical subjects

F Michot

Publications and source records attributed to F Michot.

At least 91 records · Page 5Linked to original sources
PubMed1984

Multiple myeloma occurring in association with a preexisting neuromuscular disease (progressive muscular dystrophy). A chance occurrence or a nosological entity?

This paper describes 3 patients with progressive limb-girdle muscular dystrophy who many years after this disorder was diagnosed were found to have a monoclonal gammopathy. The authors examine whether this was a fortuitous occurrence together of two rare disorders or whether they might be causally related. So far no other similar cases have been reported in the literature.

Action Potentials↗
PubMed1982

[Sacral epidural anesthesia in the treatment of lumbosacral backache].

The technique for caudal epidural injections in the treatment of low back pain and sciatica are described and the results are reported. In 75 patients treated by epidural injection the results were excellent in 60% and good in 24%. 16% of the patients showed no improvement. After caudal epidural injection the use of antiinflammatory drugs, analgesics and relaxant agents was significantly lower than previously. The method is safe, simple and effective and the cost is low.

Adult↗
PubMed1981

[Radiation-induced intestinal lesions. Prognosis and surgical management (author's transl)].

Thirteen patients with intestinal lesions consecutive to radiotherapy for carcinoma of the uterus were operated upon between 1973 and 1979. The small bowel was involved in 9 patients and the colon and rectum in 4 patients. Urinary tract lesions were associated in 3 patients of each group. Intestinal necrosis, progression of the lesions and extensive pelvic fibrosis were the only criteria of poor prognosis. Twenty-two operations were performed: 4 for urinary tract lesions and 18 for intestinal lesions. Five patients died during the immediate post-operative period and five died within 2 to 30 months after surgery, including 4 whose carcinoma recurred. The operative technique should be selected according to the extent and severity of radiation-induced damage, as determined by pre-operative examination and thorough exploration of the abdominal cavity once opened. Limited lesions of the small bowel can be treated by resection, but intestinal bypass with latero-lateral anastomosis seems to be preferable in cases with extensive lesions. Patients with colorectal lesions should have defunctioning colostomy prior to any other procedure dictated by the state of affairs. Multiple anastomosis, extensive resections and excessive dissections should be avoided.

Adult↗
PubMed1981

[The effect of sulfinpyrazone on the coagulation-inhibiting action of acenocoumarol].

To investigate the possible clinical interaction between the platelet function regulator sulphinpyrazone (SP) and the oral anticoagulant acenocoumarol (AC), 22 in-patients of either sex were included in a single blind within-patient trial vs. placebo. After one week of stabilizing treatment with AC alone the patients were randomly allocated to two sequences (11 patients each), either SP + AC for weeks 2--3 followed by placebo + AC for weeks 4--5, or the reverse sequence, i.e. placebo + AC followed by SP + AC for the same periods. 17 patients completed the full five weeks. Four dropped out during SP treatment, all but one following some form of bleeding episode. One patient dropped out for the same reason during placebo. Apart from the bleeding episodes, no other undesirable effects were recorded. The daily dose of SP was always 800 mg. A statistically highly significant interaction (p less than 0.01) between SP and AC was found. The addition of SP to AC led to a drop in mean prothrombin time and rendered necessary a consequent reduction (of about 20%) in mean AC dosage. It is concluded that when initiating and withdrawing treatment with SP in a patient receiving AC, the prothrombin time should be checked daily for a few days to adapt (reduce) the dosage of AC to the change in prothrombin time induced by SP.

Acenocoumarol↗
PubMed1981

[Exploratory laparotomy of the acute abdomen (author's transl)].

The results of exploratory laparotomy in 48 patients with an acute abdomen are reviewed. Overall mortality was 29 p. cent (14 cases) and was influenced by three main factors: patients over 50 years of age, multiple visceral lesions, and when exploratory laparotomy was conducted for an acute painful febrile abdominal syndrome (10 deaths in 32 cases) or during the postoperative period (4 deaths in 11 cases). In contrast, exploratory laparotomy is a benign procedure in patients with abdominal contusions. It is essential, therefore, to try to establish the diagnosis before proposing laparotomy, which should only be performed when all other diagnostic investigations have proved negative.

Abdomen, Acute↗
PubMed1980

[Value of Noxyflex for peritoneal toilet in acute generalized peritonitis. A controlled study of 48 cases (author's transl)].

The efficacy of Noxythiolin in solution for peritoneal toilet during operation on 48 patients with acute generalized peritonitis was evaluated. The trial was prospective, with random selection of patients who were divided into two groups with identical backgrounds, initial affections, and therapies applied. No significant differences were noted in prognosis, bacteriological findings or subsequent course in the survivors in the two groups. The only favorable effect noted in the group treated with Noxythiolin was the frequency with which further operations had to be performed, but the difference was nos significant. Though the use of peritoneal antiseptics isjustified when positive bacteriological test are reported, the determining element in peritoneal toilet appears to be the volume of liquid employed, independently of its composition.

Acute Disease↗
PubMed1980

[Gastrocolic excision for ulcers and cancer. Discussion on ideal surgical procedures (author's transl)].

Seven patients were treated by gastrocolectomy for either ulcers or cancers. Two patients had ulcerating gastrojejunocolic fistulae, four had cancers of the stomach, and one had cancer fistulae, four had cancers of the stomach, and one had cancer of the transverse colon. Two patients treated by immediate colon anastomosis for cancer, died after the anastomosis broke down, while the three other cases, treated by delayed colon anastomosis, survived. Both patients with ulcerating lesions survived, one after immediate and the other after delayed colon anastomosis. This latter procedure appears, therefore, to be imperative in cancer cases and of value, when used prudently, in ulcer cases.

Adult↗
PubMed1978

Influence of sulphinpyranzone (Anturan) on thrombo-elastography.

Sulphinpyrazone (Anturan, 200 mg four times daily) was administered orally to 10 patients for two weeks. Thrombo-elastographic determinations revealed no disturbance of coagulation and it may therefore be concluded that Anturan can also be safely administered pre-operatively.

Aged↗