PubMed Health⌕ Search

Biomedical subjects

G Freundl

Publications and source records attributed to G Freundl.

At least 55 records · Page 3Linked to original sources
PubMed1984

[Natural family planning (symptothermal method) and objective ovulation parameters--a pilot study].

This pilot study involved 20 cycles contributed by six apparently healthy women. They were all experienced users of the symptothermal method of NFP and trained as NFP-teachers. In a double-blind study NFP-parameters like S-19 = F1, appearance of any mucus = F2 and appearance of fertil mucus = F3 also peak mucus symptom +4 = L1 and 3. day of high basal body temperature = L2 are related to ovulation detected by ultrasonic measurement of follicular growth and hormonal values (LH, total Oestrogen in urine). We have focused on the calculation of the first day and the end of the fertile phase. In relation to the maximal follicular diameter (mfd = day 0) the LH-peak was located at day -0,7. The peak mucus symptom was observed at day -0,58. F1 was seen 10,4 +/- 2,6 days, F2 6,2 +/- 2,6 days, F3 2,8 +/- 1,4 days before day 0. L1 was located at 3,37 +/- 1,74 days, L2 4,1 +/- 1,95 days after day 0. Using at least 2 indicators as recommended with the symptothermal method none of 19 cycles failed to detect the beginning of the fertile phase, but 3 out of 20 failed to detect the end. In 19 out of 20 cycles natural signals observed by the participants indicated ovulation. It must be mentioned that all our women were highly motivated persons.

Body Temperature↗
PubMed1983

[Interaction of spermatozoa and the cervical mucus].

Interactions between spermatozoa and cervical mucus are important for the process of fertilization, especially in cases of sterility, whereby the whole system including both participants has to be evaluated. We have investigated couples, where the husband was suffering from a reduced fructose content or increased viscosity of the seminal plasma. We found that reduced fructose did not interfere with fertility; however increased viscosity of the seminal plasma did significantly reduce the chances of pregnancy. The various disturbances in spermatozoal morphology (Düsseldorf scheme) interfered with fertility in quite different ways. From the different forms of spermatozoa in cervical mucus one can define a specific disturbance in the man. Using cytophotometry for multiple spermatozoa, Feulgen-DNS-determination and aktin-determination of the single spermatozoon we found additional parameters to evaluate the infertile couple.

Cervix Mucus↗
PubMed1981

The effect of cervical mucus on measurable Feulgen DNA content of human spermatozoa.

The DNA content of morphologically normal Feulgen-stained human spermatozoa (SP) without and with vacuoles was determined by visible light absorption at 560 nm. In an experimental device designed according to the sperm penetration meter of Kremer, sperm penetration into cervical mucus (CM) was allowed to take place for a 60-min period. Smears of the native and mucus-penetrated spermatozoa were applied to glass slides and fixed in a mixture of methanol, formalin, and acetic acid for 1 h. Hydrolysis was performed in 1 N HCl. The slides were stained using hematoxylin. Bull spermatozoa stored at -96 degrees C were applied as an internal standard to ach slide. Of a total of 1,464 spermatozoa measured, 485 came from the ejaculate, 491 had travelled through the cervical mucus for a distance of 15-30 mm, and 193 had migrated for 31-45 mm. The remaining 295 bull spermatozoa were also measured. It was found that after cervical mucus passage the content of Feulgen DNA material measured changed in two different ways: in some of the samples the Feulgen DNA content increased with passage through the cervical mucus, whereas in other samples the Feulgen DNA content decreased during cervical mucus passage. As in the ejaculate, we found a marked variation of the DNA content of spermatozoa after CM passage. The filtering effect of the CM on pathologic SP was not complete.

Animals↗
PubMed1981

Serum levels of oestradiol-15 beta and luteinizing hormone related to follicular growth as monitored by ultrasound in women with normal menstrual cycles.

Serum levels of oestradiol-15 beta (Oe2), luteinizing hormone (LH) and progesterone (P) in 20 healthy women were correlated to the size of the ripening follicle during the follicular phase of normal menstrual cycles. Growing follicles were measured by ultrasound using the full bladder technique. In each individual case a good correlation (r = 0.88) between the Oe2 values and the size of the maturing follicle was found. However, since all women examined ovulated at a different Graafian follicle diameter (range 17 to 26 mm), the corresponding Oe2 values showed quite a large variation (range 0.78 to 2.5 nmol/l). The cervical score correlated to follicular maturation up to a follicle size of 19 mm (maximal cervical reaction). From there on no further improvement of the cervical parameters could be observed. We conclude that ultrasound monitoring of follicular growth can be a useful addition to the Oe2 and P measurements in the clinical management of the infertile woman. Bifollicular maturation can be diagnosed early, when the endocrinological data are combined with follicle size. Moreover, a correlation can be made between follicular growth and oestradiol production in the individual cycle.

Adult↗
PubMed1980

[Gonadoblastoma in an HY-negative pure XY-gonadal dysgenesis (author's transl)].

A case is reported of a gonadoblastoma in a pure XY-gonadal dysgenesis which was HY antigen negative. The salient clinical features were amenorrhoea and tall stature. The FSH was markedly increased, combined with low E2 and testosterone values. Cytogenetically a 46-XY karyotype was found. The HY antigen titre was in a male level. The gonadal streaks which were removed showed microscopically islands of tumour cells with 2 cell lines which were interpreted as germ cells and granulosa cells. Newer concepts of the influence of the HY antigen on the differentiation of the testicles and differentiation of the ovaries are discussed. Treatment consists of removal of the gonadal streaks and estrogen treatment.

Adolescent↗
PubMed1978

[Cervical smears in women under 30 years age (author's transl)].

A report is given about the results of cytological examinations of cervical smears taken from women under 30 years age living in smaller towns or rural areas. Of 113 585 smears taken between 1968 and 1977 11 717 (10,35%) belonged to the mentioned age group. 29 smears were pathological. When examined histologically 19 (0,15%) showed a carcinoma in situ or a microcarcinoma. The situation in smaller towns or rural areas is the same as in urban areas. In respect of these findings the authors are asking for routinely screening of women between 20 and 30 years of age.

Adolescent↗
PubMedDate not supplied

Natural family planning with and without barrier method use in the fertile phase: efficacy in relation to sexual behavior: a German prospective long-term study.

A large prospective long-term study with users of natural family planning (NFP) methods has been conducted to analyze the relation between unintended pregnancy rates and sexual behavior with special reference to barrier method use in the fertile phase. Seven hundred and fifty eight NFP beginners, 19-45 years of age, 14870 cycles, 28 unintended pregnancies were studied. Of the couples, 54.2% use NFP only or predominantly and 45.9% use mixed methods (additional barrier method use in the fertile phase in 55.7% of the cycles). The overall pregnancy rate after 12 cycles of exposure is 2.2% according to the actuarial method. There is no significant difference between NFP users and mixed methods users and also no significant effect of duration of use in the first 5 years of exposure. During "perfect use" the pregnancy rate at 12 months is 0.63%. When only protected intercourse takes place in the fertile phase the pregnancy rate is 0.45%. The symptothermal method of NFP is most unforgiving for imperfect use (unprotected intercourse in the fertile phase). However, it is extremely effective when either abstinence or protected intercourse is used in the fertile phase.

Adult↗