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Biomedical subjects

G Müller

Publications and source records attributed to G Müller.

At least 559 records · Page 31Linked to original sources
PubMed1983

[Conservative therapy of mastopathy].

In this publication about the conservative therapy of mastopathy is referred. The expression "mastopathy" should be replaced by a histopathological classification. The etiology of this disease is discussed. At the moment hormonal treatment and treatment without hormones is used. The therapy of this disease isn't very important because of the high incidence. A preliminary report about a randomized study for conservative treatment of mastopathy is given, which could influence the therapeutic procedure of conservative treatment even now.

Female↗
PubMed1982

[Serum theophylline levels in aminophyllin treatment in children].

Long-term treatment of childhood asthma with theophylline or theophylline ethylenediamine (Aminophyllin) preparations requires dosage according to the various age groups. In order to achieve therapeutically satisfactory concentrations, estimations of theophylline levels in serum showed that in cases of good correlation between Aminophyllin dosage and theophylline levels smaller children required higher Aminophyllin doses than big children or adults. The therapeutic range of theophylline is around 7 to 15 mg/l beyond the newborn age. In order to obtain these concentrations children from the 1st to the 4th year require Aminophyllin doses of 6 mg/kg t.i.d., children between 5 and 12 years 5.5 mg/kg t.i.d. and adults beyond the 50th year of life 3 to 3.5 mg/kg t.i.d. Generally the first dose should be higher and is 6-7 mg/kg or 6-6.5 mg/kg or 4 mg/kg, respectively. Regular estimations of serum theophylline levels greatly help to improve safety of long-term treatment.

Adult↗
PubMed1982

[Rare variant of a Turner-Ullrich syndrome].

A 25-year-old patient with 45-X0-Turner syndrome exhibited at autopsy dysgenesis of the ovaries and anomalies of the phenotypus and the great blood-vessels (especially coarctation of the aorta). Also found were abnormalities of the urogenital tract, osteoporosis, spider finger, "pectus excavatum" and idiopathic medionecrosis which had led to a rupture of the ascending aorta. This combination of symptoms of Turner syndrome on the one and of Marfan syndrome on the other suggests that in our case two different syndromes coincided accidentally due to a chromosomal aberration. Also worth mentioning is an extraordinary structure of the media in the great blood vessels of the pelvic and femoral region, a texture nerve previously described in the literature.

Adult↗
PubMed1982

[Differential diagnosis of endangiitis and arteriosclerosis obliterans].

41 males at the age from 20 to 40 years with chronic obstruction of the arteries of the extremities were on the basis of anamnestic and clinical findings subdivided into the groups obliterating endangiitis (group I = 20 patients) and obliterating arteriosclerosis (group II = 11 patients). In 10 patients in this way no decision for one of the two diagnoses could be made (group III). By multidimensional variance and discriminance analysis of various clinico-chemical parameters the separation of the groups I and II could be proved. The efficiency was 93.6% in the discrimination with 10 characteristics. With the help of the calculated non-elementary, linear characteristics of discriminance the patients could be classified into the group III. 7 patients could be classified into the group II and 3 patients into the group I. Thus we succeeded in differing 23 patients with obliterating endangiitis from 18 patients who as arteriosclerotics belong to the metabolic syndrome.

Adult↗
PubMed1982

[Investigations on the correlation between vinyl chloride (VCM)-uptake and excretion of its metabolites by 15 VCM-exposed workers. II. Measurements of the urinary excretion of the vcm-metabolite thiodiglycolic acid ].

Fifteen workers employed in a PVC producing plant were investigated concerning their individual vinyl chloride (VCM) exposure and the urinary excretion of the VCM metabolite thiodiglycolic acid (TdGA). The urine concentrations found were in the range 0.94-20.4 microgram/ml. These could be compared with exposure data calculated from VCM air analyses performed by personal air sampling and corrected with respect to the exposure times of the workers. The amounts of TdGA excreted within 24 h were correlated with the effective VCM body concentrations calculated from the exposure data as mean values for 12 h periods (Spearman coefficient P=alpha less than 0.005). This correlation resembles a function of the Michaelis-Menten type. It could be shown that during short exposure periods of less than 5 min, the metabolite formation in relation to the exposure data was lower than during longer periods of exposure although, as would be expected, there were some fluctuations of the exposure level. Therefore, the VCM body concentrations could not normally reach steady state values.

Environmental Exposure↗