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Biomedical subjects

G Müller

Publications and source records attributed to G Müller.

At least 613 records · Page 34Linked to original sources
PubMed1980

[Increased success rate of renal transplantation by HLA-DR-typing: a retrospective analysis of the South-German co-operative study group for renal transplantation (author's transl)].

Retrospective HLA-DR-typing and the influence of HLA-DR antigen on transplantation prognosis was studied in 90 kidney donor-recipient pairs. It was clearly demonstrated that HLA-DR compatible donor kidney provides a significantly better transplant prognosis than if there is HLA-DR incompatibility. Donor kidneys with only one identical HLA-DR antigen gave a six-month survival rate of 80%. Only HLA-AB identical cadaver kidneys ("full house identity") give similar survival times. Because of relatively lower polymorphism of the HLA-DR alloantigen system, HLA-DR identical donor organs are discovered more frequently than when HLA-AB antigens are taken into consideration. HLA-DR identical donor kidneys (identical for both HLA-DR antigens) have an even better transplant prognosis than "full house identical" kidneys, since the survival rate in the former is 87% after six months.

HLA Antigens↗
PubMed1980

[Preneoplasms of the bronchial system in smokers and nonsmokers (author's transl)].

Parallel to the rapidly rising frequency of bronchial carcinoma with almost 27,000 deaths in 1978, preneoplasms of the bronchial system are now almost daily observations for the pathologist. The question of cancerous prestages of the bronchial mucosa is closely coupled with the histogenesis of malignant neoplasms. Besides epithelial anomalies such as basal cell hyperplasia and squamous epithelial metaplasias, precancerous epithelial dysplasias of Grades I to III and carcinoma in situ must be differentiated. According to the results of extensive histological investigation connections between smoking, smoking habits and carcinogenic constituents in the condensate of cigarettes on the one hand and both frequency and severity of preneoplastic and neoplastic changes in the bronchial system on the other are well known.

Bronchial Neoplasms↗
PubMed1980

[Lipid resorption and intestinal lipoprotein metabolism].

In a survey the present state of our knowledge about lipolysis, formation of micelles, lipid resorption, intracellular lipid transport, lipid resynthesis, lipoprotein synthesis, lipoprotein secretion and their regulation are summarized. Before their resorption the nutritive lipids are saponified by lipases. Fatty acids, monoglycerides, cholesterol and phosphatides are resorbed via a micellary phase. In the enterocytes the resorbed lipids are resynthetized together with endogenic constituents to triglycerides, phosphatides and cholesterol esters, which together with apoproteins as chylomicrons and VLDL reach the blood circulation via the lymphatic channels.

Bile Acids and Salts↗
PubMed1980

Information coding in the visual system: a new hypothesis.

Experiments on subjective color sensations using a special signal generator and a standard TV monitor (black and white) led to a new hypothesis on information coding in the visual system. According to this hypothesis a trigger signal is required which restores the phase correlation of the pulse-coded spiking of the neurons transmitting visual information from the eye to the brain. The "shift effect" ("periphery effect"), either artificially induced or initiated by microsaccades, might act as the postulated trigger.

Color Perception↗
PubMed1980

Electron microscopical particle counting in virology. III. Parameters governing the efficiency of sedimentation techniques and its improvement with the application of poly-L-lysine.

In the preceding study the degree of adsorption of virus to electron microscope grids has been shown to be an important parameter governing the efficiency of sedimentation techniques used for particle counting. In the present study the application of poly-L-lysine not only improves the binding ability but makes it more reproducible. In addition the distribution of adsorbed particles between grid bars and holes is characterized and its importance as an additional parameter for such techniques discussed. For accurate particle titre estimation and for assessing the efficiencies of sedimentation techniques in virus diagnostics the product of these parameters represents a correction factor which must be taken into consideration. Furthermore it could be demonstrated, using the technique here described over the surface of a poly-L-lysine treated grid after drying. This phenomenon makes possible the estimation of a titre through particle counting on gravimetrically determined volumes.

Adsorption↗
PubMed1980

Antigen controlled immuno diagnosis-- 'ACID test'.

A test for the presence of antibodies in sera is described in which the binding of the antibody to a morphologically identifiable antigen, visualized using staphylococcal protein A-coated gold, serves as the criterion for specificity. This 'Antigen Controlled Immuno Diagnosis' (ACID test) as applied to T4 bacteriophage, vaccinia virus and Enterobacterium Yersinia has proved to be reliable and simple to carry out.

Animals↗
PubMed1980

[The azygos vein lobe and its clinical significance (author's transl)].

The incidence and development on the azygos vein lobe are reviewed briefly. Examination of 10 000 radiographs of normal people showed that it occurred in 0,7% of cases. The clinical significance of the azygos vein lobe is discussed. In particular it may important in evaluating post-operative radiographs of patients in intensive care.

Azygos Vein↗
PubMed1980

Avoidance of certain systematic pitfalls in the detection of HLA-DR antibodies defining find specificities.

A selective screening program has been established to identify rapidly and effectively the fine specificity of HLA-DR antibodies in pregnancy anti-HLA sera. Following initial HLA-A, B, C screening sera with extra- or multispecific reactions were selected and specifically tested after platelet absorption on isolated B- and T-lymphocyte populations of the serum donor's husband. Identification of the HLA-DR serum. Multispecific anti-DR sera were defined and rendered operationally monospecific by titration. Some critical steps in a reliable assessment of HLA-DR typing reagents could be worked out. Weak HLA-A, B antibodies, B-cell auto- and Lewis antibodies may cause positive reactivity preferentially or even selectively on B lymphocytes. Of particular importance was the hidden presence of HLA-C specific antibodies, since they cannot be absorbed out of stored platelets. In addition they are not readily detectable through screening on typed panel cells. Because of the frequently very high linkage disequilibrium between HLA-B and HLA-C alleles it is difficult to select appropriately dissecting panel cells. The two points demonstrated above gain even more weight when isolated T and B cell populations are used for HLA-DR typing, because HLA-C antibodies preferentially kill B cells. In this fashion contaminating HLA-C antibodies are not only difficult to detect but can mimic the presence of HLA-DR antibodies.

Antibodies↗
PubMed1980

[Amylase excretion in the feces].

The amylolytic excretion in stool was determined in 100 patients with various gastroenterologic diseases and in 55 healthy subjects. The amylolytic activities were detected in disc electrophoresis. The fecal amylase elimination correlates with the weight of stool and is augmented in pancreatopathies, and in other gastroenterologic diseases. The measurement of amylase activity in stool is not suitable for the diagnosis of exocrine pancreatic dysfunction.

Amylases↗