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Biomedical subjects

G Müller

Publications and source records attributed to G Müller.

At least 631 records · Page 35Linked to original sources
PubMed1980

[Lysozyme in sow's milk and its importance to bacterial population of the gastrointestinal tract in suckling piglets].

The lysozyme level was found to reach its highest point on the second day from parturition, followed by strong decline to a much lower value which then remained constant up to the 30th day of lactation. The rise recorded from the period between farrowing and the second day after birth as well as the decline up to the fourth day and the constant level up to the 30th day from parturition were statistically secured. Lysozyme levels in the milk of sows with no previous lactation record was found to be lower with significance than those recordable from sows with something between six and nine previous lactations. The conclusion has been that lysozyme levels are strongly affected by both lactation time and number of lactations. Lysozyme concentrations in sow milk on the first and second days from parturition were betweeen 6.8 and 11.0 microgram/ml, depending on the number of previous lactations. Such high lysozyme levels in sow foremilk over the first three days of age as well as all findings so far gained on the structure of bacterial cell walls are likely to suggest that the above enzyme affects bacterial population of the gastro-intestinal tract of suckling.

Animals↗
PubMed1980

[Improvement of the antepartal CTG by transcutaneous electric stimulation (author's transl)].

37 gravid patients with diagnosed symptoms and signs of placental insufficiency underwent during 10 days a treatment of transcutaneous electric stimulation. Fetal CTG showed compared to the situation before treatment a distinct increase in the amplitude of the oscillation pattern and a rise in the number of accelerations, which means an improvement of the fetal situation. In 10 cases Fischer-Score went up from 7 to 10, in other 10 cases from 8 to 10.

Electric Stimulation Therapy↗
PubMed1980

[Complications of angiography (author's transl)].

Report on complications on review of 2163 angiographic examinations-with comparison to these reported in the literature-with the resulting finding that there is no difference. The problems occuring in comparing individual data in this regard are pointed out.

Adult↗
PubMed1980

[Lysozyme levels in gastrointestinal mucous membrane extracts of swine and their response to immunization with Escherichia coli mutants].

Pigs of various age groups were found to have lyzozyme in all segments of the mucous membrane of the digestive tract, though typical Paneth's cells were absent. While no significant difference was found to exist between gastro-intestinal lyzozyme concentrations in store pigs, on the one hand, and sows, on the other, lyzozyme levels in piglets before weaning were found to differ by positions. Those in the distal jejunum were significantly higher than the proximal jejunum values, while the large intestine levels were below those of the ileum. The lyzozyme concentrations in all intestinal sections of store pigs were significantly in excess of those in piglets before weaning, all except for the stomach level. The proximal and distal jejunum and large intestine values and concentrations of that ferment in sows were lower than those in store pigs. Lyzozyme concentrations in the mucous membrane of the small intestine and in the lymph nodes of weaned piglets could not be raised by intraperitoneal nor oral immunisation, using Smd Escherichia coli mutants of serogroup O149:K91(B), K88ac. The above findings are discussed under the aspect of new insights into the importance of lyzozyme to local defence in the gastro-intestinal tract.

Aging↗
PubMed1980

The detection of mutagenic air pollutants from filter samples by the Salmonella/Mammalian S-9 mutagenicity test (Ames test) with S. typhimurium TA 98 (Part 1).

Particulate airborne pollutants, collected in 1977 at an urban point in Wanne-Eickel, G.F.R., were investigated for mutagenic activity in the Ames Salmonella/mammalian S-9 mutagenicity tet with S. typhimurium TA98. Two kinds of filters were used: Mikrosorbanfilters (polystyrene) and Membranfilters (cellulose nitrate). Sample preparations obtained following gel chromatography of solutions of the Mikrosorbanfilters showed only weak mutagenic activity. Soxhlet extracts of the Membranfilters gave positive dose-response relations (figs. 3-6), while splitting the initial extract into six fractions resulted in the bacterial reversion rates due to certain sub-fractions increasing over the reversion rates due to the unfractionated preparation (fig. 7). The highest activities were observed in the fractions of the polar compounds and of the polycyclic aromatic hydrocarbons. Some (30-50%) of the mutagenic activity was not enzymatically mediated. GC-MS analysis of the samples demonstrated the presence of an average content of around 11 microgram benzo(a)-pyrene/1000 m3 of air.

Air↗
PubMed1980

[Aneurysma of the portal vein. A case report (author's transl)].

Case report of one case of aneurysma of the portal vein observed by us with a review of the eight similar cases published in the world literature. Clinical and radiographic findings and the problems of diagnosis and therapy are pointed out. There was no indication for surgical intervention in any of the patients who had their condition diagnosed while alive. All authors conclude a portocaval shunt or a similar decompression to be the therapy of choice.

Aneurysm↗
PubMed1980

[New results about the role of lipase, colipase and bile acids in the fat digestion (author's transl)].

Pancreatic lipase B and a minor specific lipase A are involved in the digestion of fats. The lipolysis is a heterogeneous catalysis. Lipases, colipase(s), bile acids, bile lipids and calcium ions play a role in the lipolysis. Colipase(s) makes it possible for lipase to adsorb to the substrate in presence of bile acids activating the adsorption of lipase and protecting the lipase at the interfaces.

Bile Acids and Salts↗
PubMed1980

Relationship between urinary prostaglandin (PGE2 and PGF2 alpha) and sodium excretion in various stages of chronic liver disease.

A. No consistent changes in the urine PGE2 and PGF2 alpha related to sodium excretion could be found in hepatic cirrhosis with and without ascites. B. Intensive renal sodium retention in cirrhosis with ascites (urine Natless than 20 mEq/24 hr) is very often associated with increasing PGF/PGE ratio, whereas absolute urine PGE2 can be found low or normal. The PG shift is possibly due to a stimulation of the PGE2-9-keto-reductase. C. Application of saluretics and spironolactone in cirrhosis with ascites normalizes the PGF/PGE ratio in accordance with increasing sodium excretion. D. PG changes observed cannot be considered as a primary factor accounting for deranged renal sodium handling in cirrhosis. Anomalous PG pattern possibly reflects enchanced intrarenal vascular resistance.

Adult↗
PubMed1980

[Influence of straw manuring on the qualitative properties of the organic soil substances of a Lehm-Braunschwarzerde (author's transl)].

It is reported on the influence of a long-term field trial with straw manuring at different terms and different nitrogen fertilization steps on the qualitative properties of the organic soil substance. Straw manuring in autumn increased the carbon content in the soil. Increasing amounts of nitrogen intensified this effect. Straw manuring in spring only with simultaneously applied quantities of 100 and 200 kg N/ha, respectively, brought about an increased content of organic substances in soil. With straw manuring in autumn, fractionation of the organic substance in soil showed a smaller amount of humic acids. Increasing nitrogen addition reduced this amount still more than in the plots with straw manuring in spring. The quota of fulvic acids increased. Therefore, the higher content of organic substances, obtained with straw manuring in autumn, is based on an increase of the pre-stages of humic acids and non-humic matter.

Benzopyrans↗
PubMed1980

[Contributions to the problem of microbially induced urea transformation in soil II. Influence of irrigation on the carriage and the effect of urease inhibitors (author's transl)].

Inhibition of ureolysis by specific inhibitors presume at first efficiency of the chemical compound itself and at second the joint distribution of both the compounds in the soil. In model experiments it could be confirmed that some inhibitors were carried along with percolating water up to four centimeters, being efficacious in this range. Also for several formulations of urea with inhibitors a tendency of urea protection by the applied inhibitors from the surface up to a depth of 6 cm was established.

Soil Microbiology↗
PubMed1980

[Examinations on the occurrence of free-living amoebae with possible pathogenic traits in swimming pools (author's transl)].

Water of basins and filters taken from 9 indoor-pools and 5 heated outdoor-pools has been tested for free-living amoebae by means of filtration and subsequent cultivation on agar and in fluid media. In 94.6% of the samples taken from basins and in 60.7% of the samples taken from flushing back filter water, amoebae could be cultivated which all belonged to the genus of Acanthamoeba. They were tested for pathogenic symptoms by means of mouse inoculation tests, temperature tolerance tests, cross-reaction in the immunofluorescence test, and on tissue culture. 19 strains of amoebae could be re-isolated from lungs and brains of healthy mice. Only after the third series of inoculation from animal to animal, for mice characteristic pathogenic symptoms could be observed. The importance of acanthamoebae in swimming pools to the health of men cannot be estimated yet. But existing findings did not deliver reason for grave concern.

Amoeba↗
PubMed1980

[Problems relating to the use of radioactively labelled bacteria in animal experiments. 3. Distribution of activities in mice, following parenteral administration of Pasteurella multocida labeled with various radionuclides].

When radioactively labelled fully developed Pasteurella (P.) multocida antigens were parenterally applied to mouse, through intravenous, intraperitoneal or subcutaneous routes, activity distribution was found to depend both the technique of application and the radionuclide used. This has given rise to the conclusion that activity distribution could be equated with whole-germ distribution only under certain conditions. Experimental antigen distribution, accordingly, reflected a complex process in which transport, location, and metabolism of bacteria had to be considered as being in conflict with the given host organism. Iodine labelled 125 was split off bacteria at relatively high rate and accumulated in the thyroid gland. When 59Fe was used, interpretation of distribution was rendered more difficult by propagation of iron through the organs of the host. Relatively favourable data were obtainable from the use of 3H or 14C which could be used in the form of nucleic acid precursors (orotic acid) in labelling Pasteurella. Intraperitoneal and intravenous forms of administration were found to be the same for intra-organic activity distribution. Retention of activity in liver, spleen, and lung was recordable and established from all the reviewed techniques for the application of P. multocida complete antigen. While maximum concentrations were measured between the first and third days, activities still were detectable after 14 days (period under review). Relatively high radioactivity was recordable from the digestive tract, within short time from the use of the parenteral procedures tested. This seemed to suggest passage of complete or incomplete P. multocida antigen through the mucous membranes of the gastro-intestinal tract.

Animals↗