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Biomedical subjects

G Neumann

Publications and source records attributed to G Neumann.

At least 55 records · Page 3Linked to original sources
PubMed1984

[Stress studies with dipyridamole in patients with coronary heart disease in comparison to coronary angiography, myocardial scintigraphy and ergometry findings].

In 102 patients with typical symptoms of angina pectoris who underwent a coronary angiography a Dipyridamol test was performed. The result was a sensitivity of about 84% concerning the coronary heart disease and a specifity of about 93%. In the same test persons the ECG after work showed a sensitivity of about 84% and a specifity of about 57%. Dipyridamol test and bicycle ergometry are methods of the same value for the preinvasive diagnostics of the coronary heart disease which should supplement each other. The higher specifity of the ECG changes in the Dipyridamol test was evident in comparison to the bicycle ergometry. In 85 of our patients the Tl-201-scintigraphy was carried out under Dipyridamol and ergometer stress. For the Tl-201-scintigraphy under Dipyridamol a sensitivity of about 70% and a specifity of about 81,5% was the result. In the Tl-201-scintigraphy under ergometer load a sensitity ob about 84% and a specifity of about 57% was the result. The proportion of exactly positive findings increased with the number of the stenosed vessels under ergometer as well as Dipyridamol intervention. A negative load scintigraphy does not exclude a coronary heart disease, but renders a three-vessel-disease very improbable.

Angina Pectoris↗
PubMed1984

Wegener's granulomatosis in childhood. Review of the literature and case report.

Wegener's granulomatosis (WG) is a rare disease in pediatric patients. The case of a 14-year-old girl with generalized WG is described and the pediatric literature reviewed. Thirty additional cases of WG in childhood have been traced in previous studies. Diagnostic problems are discussed in the context of clinical, radiological and biopsy findings.

Adolescent↗
PubMed1984

[Vagino-cytological studies in prostitutes].

Numerous papers on the high incidence of precancerous lesions of the uterine cervix in prostitutes have been published mainly in Anglo-American literature. The reported data were compared with those of prostitutes in a South German city. In a retrospective study on 239 prostitutes and a control group of 502 patients of the same age distribution the data regarding the vaginal flora and the obtained cytologic groups (modified Papanicolaou classification "M unchner Nomenklatur ") were compared. The prostitutes showed a higher rate of cocci in otherwise "comparably clean" smears. The incidence of trichomonas vaginalis was five times higher among the prostitutes. In contradiction to American and British publication there was no higher incidence of smears pointing to precancerous lesions among the prostitutes. It seems that the characteristic "low socioeconomic status" does not apply to prostitutes in our region.

Adult↗
PubMed1984

Progesterone interaction with eosinophils and with responses already induced by oestrogen in the uterus.

Progesterone pretreatment decreases oestrogen-induced uterine eosinophilia and other non-genomic responses that are possibly mediated by eosinophils. To investigate the mechanisms of this interaction, the present study describes the effects of progesterone on oestrogenic responses already induced by oestrogen treatment and the in-vivo and in-vitro effects of progesterone on blood eosinophils. Progesterone treatment of oestrogen-pretreated animals potentiated uterine eosinophilia 24 h after progesterone treatment but decreased it at later times and increased eosinophil degranulation in vivo. In addition, progesterone degranulated blood eosinophils in vitro. These findings demonstrate interaction of progesterone with oestrogenic responses mediated by eosinophils. Progesterone interaction with other oestrogenic responses was analysed for comparison; evidence is shown suggesting a role of eosinophils in oestrogen-induced uterine luminal fluid accumulation.

Animals↗
PubMed1984

[Computer assisted determination of left-ventricular contraction abnormalities using two-dimensional echocardiography. I. Analysis various study methods and determination of normal values].

In 181 patients without signs of heart disease we determined the normal contraction pattern of the left ventricle in the echocardiographic 2- and 4-chamber views by means of the shortening of 48 radiants and the changes of 5 pre-defined areas. We used an extracardiac fixed axis reference system and an intracardiac floating reference system. We also calculated in 68 of the patients the interobserver variability of the data in each evaluation method. We demonstrated that the range of normal contraction and the reproducibility in the area-change method with a floating axis system was smaller compared to the radial shortening method. The interobserver variability in the 4-chamber view was better than in the 2-chamber view. Using the intracardiac fixed reference system in both methods, deviation from normal and interobserver variability was not acceptable for the detection of left ventricular wall motion abnormalities in both apical views. In general, we could also demonstrate that the interobserver variability was better and the range of deviation was smaller in the apical 4-chamber view than in the 2-chamber view. The practicability and quality of the apical projections were superior to the parasternal projections in the long and short axis. We conclude from our studies that left ventricular wall motion abnormalities in the echocardiographic 2- and 4-chamber views could best be demonstrated by using an area-change method with an intracardiac floating reference system.

Arrhythmias, Cardiac↗
PubMed1984

[Morphology of atypical and metastatic pheochromocytoma in computed tomography].

14 cases of pheochromocytoma were investigated by CT including two of them in full detail. The morphology of pheochromocytoma and the changing CT picture with increasing tumor size are discussed. Diagnostic procedure and usefulness of CT as well as differential diagnosis of adrenal tumors are pointed out. Adrenal and extra-adrenal localization of pheochromocytoma and signs of their malignant degeneration are demonstrated.

Adolescent↗
PubMed1984

[Quantitative, computer-aided determination of left ventricular contraction abnormalities in two-dimensional echocardiography. II. Application in patients with coronary heart disease].

In 105 selected patients with documented transmural myocardial infarction and segmental wall motion abnormalities in the 2-dimensional echocardiogram we determined the sensitivity, specificity and predictive accuracy of a semi-automatic computerized wall motion analysis method. The extent and localization of the LV-contraction abnormalities were documented by visual inspection of the 2-D echocardiograms by two experienced cardiologists and confirmed by angiographic and coronarographic findings. These findings were compared with computerized evaluation methods using an area-change method (5 areas) and a radial shortening method in a floating axis reference system. In the 2-chamber and 4-chamber views the area-change method was more sensitive (2-CH: 70% vs 49%, 4-CH: 79% vs 72%) and had a higher predictive accuracy (2-CH: 90% vs 87%, 4-CH: 86% vs 82%) than the radial shortening method. The specificity between the two methods was not different. In both views, however, we found distinct regional differences between the apex and the anterior and posterior wall. We conclude from our studies that in patients with myocardial infarction, computerized wall motion analysis in the 2- and 4-chamber views is accurate and reliable as compared to the visual diagnosis of two experienced observers. The area-change method in an intracardiac floating system seems to be superior to the radial shortening method.

Angiocardiography↗