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Biomedical subjects

I Andersen

Publications and source records attributed to I Andersen.

At least 37 records · Page 2Linked to original sources
PubMed1988

Necrotic bullous erysipelas.

During the last few years streptococcal infections have been reported in connection with various cutaneous manifestations with severe or fatal outcome. A 62-year-old female with chronic interstitial nephritis was admitted with progression of confluent bullous lesions on her right leg. She had contracted a superficial scratch on her right foot 2 days prior to admission. Within 16 hours she deteriorated rapidly with symptoms on sepsis. Blood cultures and cutaneous swabs disclosed growth of beta-haemolytic streptococci group A. In spite of correct penicillin treatment she died 28 hours after admission. Skin biopsies from her right leg showed severe necrosis. This report is a reminder that new, cutaneous manifestations of streptococcal disease are still emerging.

Erysipelas↗
PubMed1986

Antibodies to isolated hepatocytes in chronic active liver disease. Identification and diagnostic significance of bile canalicular antibodies.

A branched or net-like immunofluorescence pattern was demonstrated across the surface of isolated rabbit hepatocytes. We presume that this staining pattern is related to bile canaliculi on the cell surface, since it was closely correlated with the presence of bile canalicular antibodies, as detected by immunofluorescence on liver sections. Reaction with the putative bile canaliculi on rabbit hepatocytes was produced by 20 of 26 sera from patients with chronic active liver disease, 13 of 120 sera from patients with various liver diseases, and 1 of 40 normal blood donor sera.

Adolescent↗
PubMed1985

Scandinavian experiences with indoor air pollution.

The building illness syndrome (BIS) with complaints about dryness and irritation of the mucous membranes of the eyes, nose and throat, and headaches is very common in Scandinavian buildings. The causes for BIS may be psychosocial, biological, physical or chemical factors in the indoor environment. Of these the chemical factors are considered to be the most important. BIS can be caused by formaldehyde, but the main sources of this emission are now controlled in the Scandinavian countries. As BIS complaints still are common, organic gases and vapors are considered to be the most important cause of BIS today. These gases and vapors are emitted from many building materials, and mixtures of these have been shown to be irritating in concentrations about 5 mg m-3, a concentration which is often found in new buildings. It is still an unsolved problem if BIS is due to the mixture of the organic gases and vapors themselves, or decomposition products in low concentrations, as for example peroxyacetyl nitrates known from outdoor air pollution. Irrespective of the cause, the rational approach would be a reduction of the emissions of organic gases and vapors from building materials or an increase of ventilation rates. The latter solution is not desirable due to the economic burden and to the need for energy conservation. We therefore suggest that building materials should be tested for emission of pollutants, so that materials emitting high concentrations of toxic substances can be identified and replaced by materials emitting less toxic substances and with emission of a lower rate.

Air Pollutants↗
PubMed1983

Epidermal nuclear immunoglobulin deposits in some connective tissue diseases: correlation with ENA antibodies.

In-vivo nuclear deposits of IgG were demonstrated by direct immunofluorescence in epidermal cells of normal skin from 6 patients with serum antibodies to an RNase-sensitive extractable nuclear antigen (ENA). Addition of complement to the skin sections showed that C3 could bind to epidermal cells with IgG deposits. A skin biopsy from a patient with polymyositis and serum antibodies to ENA, but without nuclear IgG deposits, showed nuclear binding of C3 after addition of complement to the skin sections. The clinical diagnoses of patients with immunofluorescent staining of epidermal cells were mixed connective tissue disease (MCTD) 4 cases, systemic lupus erythematosus (SLE) 2 cases, and polymyositis 1 case. No epidermal nuclear IgG deposits could be demonstrated in 5 cases of SLE, 2 cases of MCTD, one case of polymyositis, or 15 cases of rheumatoid arthritis without antibodies to ENA.

Adult↗
PubMed1983

Serum antibodies to Aspergillus fumigatus in patients with rheumatic diseases.

IgG and IgA serum antibodies to Aspergillus fumigatus were determined in 47 patients with rheumatic disorders, 4 patients with pulmonary aspergillosis associated with rheumatic disease, and in 36 healthy controls. Antibody titres determined by indirect immunofluorescence were comparable in patients with rheumatic diseases and in controls, except for 2 patients with IgG antibody titres within the upper range of patients with aspergillosis. IgG antibody levels to 2 partially purified A. fumigatus antigens (I and VIII), determined by enzyme-linked immunosorbent assay (ELISA), were higher in rheumatic patients than in controls and with antigen VIII the difference reached statistical significance for all subgroups of rheumatic patients. IgA antibody levels by ELISA were also increased in rheumatic patients compared with the control group: IgA levels against antigen I fell within the range of patients with aspergillosis in 7 patients with rheumatic disorders. This suggests that some rheumatic patients are more strongly sensitized to Aspergillus antigens than normal subjects.

Adolescent↗