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Biomedical subjects

J Borowski

Publications and source records attributed to J Borowski.

At least 73 records · Page 4Linked to original sources
PubMed1980

The effect of Listeria monocytogenes lipids on the activity of nonspecific immune mechanisms.

The administration of Listeria monocytogenes lipids (LML) in mice resulted in the development of population of macrophages with increased phagocytic and microbicidal activity, as well as higher content of the lysosomal acid hydrolases. The elevation of the serum level of lysozyme, complement and properdin in guinea pigs after LML injection was observed. The normal macrophages cultured in vitro were also activated by LML independently on the presence or absence of autologous lymphocyte. It is concluded that the mechanism of the increase of the host resistance evoked by LML depends on the direct stimulatory effect of LML on the activity of the mononuclear phagocyte system.

Animals↗
PubMed1980

Activity of cephamandole against some gram-negative bacilli and staphylococci.

Sensitivity of cefamandole was tested in 560 strains including staphylococci and gram-negative bacilli. Staphylococcus aureus and Staphylococcus epidermidis strains were highly sensitive to cefamandole; beta-lactamase producers were slightly less sensitive. About 50% of gram-negative bacilli were sensitive to the concentration of cefamandole obtainable in serum, mainly to 15 micrograms/ml.

Alcaligenes↗
PubMed1979

Effect of Listeria monocytogenes lipids on the course of infections with some gram-negative bacilli in mice.

The effect of Listeria monocytogenes lipids on the course of infections with Salmonella enteritidis, Yersinia pseudotuberculosis, Pseudomonas aeruginosa and Klebsiella pneumoniae was studied in mice. The lipids were extracted with chloroform and methanol and used in various doses before and after infection with the bacilli. The lipids significantly increased mouse resistance toward the examined bacteria. The protective effect depended, to a large extent on the applied dose of lipids and its timing.

Adjuvants, Immunologic↗
PubMed1979

Influence of lipids from Listeria monocytogenes on the course of infections due to some gram-positive bacteria in mice.

The influence of lipids from Listeria monocytogenes on the course of infections due to some gram-positive cocci Streptococcus pyogenes, Streptococcus faecalis and Staphylococcus aureus and L. monocytogenes was studied in white mice. Varying doses of the lipid preparation were administered before infection. Mortality of the animals and rate of elimination of the bacteria from the organs and blood circulation were recorded. In appropriate doses, the lipids markedly enhanced resistance to the aforementioned bacteria. Mortality was substantially reduced, and elimination of the infectious agent from tissues and blood was significantly accelerated.

Animals↗
PubMed1978

The effects of lipids from Listeria monocytogenes on bacterial and fungal infections in mice.

Investigations were made on the influence of lipids from Listeria monocytogenes upon the course of infections induced by bacteria and fungi. Chloroform-methanol extract of the lipids was given to animals in various doses and at various intervals before and after infection. Mortality of mice and elimination rate of bacteria from the blood and organs were estimated. It was observed that the lipids markedly increased natural immunity of the animals against bacterial and fungal infections. The mortality rate of mice was decreased and the elimination of bacteria and fungi from the tissues was accelerated. Our suggestion is that the observed effect of lipids probably depends on the stimulation of mononuclear phagocyte system.

Animals↗