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Biomedical subjects

J Freitag

Publications and source records attributed to J Freitag.

At least 37 records · Page 2Linked to original sources
PubMed1988

[Correlation between clinical and paraclinical findings in brain tumors in comparison with the operation site].

On the basis of clinical material consisting of 147 brain tumors, the authors carry out a comparative investigation involving the site of the ensuing operation to ascertain the accuracy of the clinical and paraclinical diagnoses. Computed tomographic findings were deliberately excluded with the intention of focusing on the accuracy attainable by traditional means. Clinical findings, X-ray examination of the skull, ophthalmological findings, electroencephalographic and echoencephalographic data, nuclear diagnosis, and angiographic findings were all taken into account.

Brain↗
PubMed1987

[Computerized tomography of the mediastinum--results of a retrospective study].

The results of the CT-investigations of the mediastinum on 500 patients can be described in the following way: the assessment of mediastinal lymph nodes was clearly improved by the CT. About half the positive mediastinal findings in malignant lymphomas was to be proved only in the CT. The diagnostics of mediastinal space-occupations was elevated to a higher degree. Statements concerning the coarse tissue are possible. In myasthenia gravis pseudoparalytica the computed tomography is the best method for demonstrating the morphologic relations. The individual changes of the thymus gland are, however, not certainly to be differentiated from each other. Among the vascular changes aneurysms and an arcus aortae dexter with right descending thoracic aorta can unequivocally be demonstrated. A particular advantage of the computer tomography consists in the possibility to separate the perfused lumen from the thrombotically closed one. The search for a primary tumour in the mediastinum is not useful in negative conventionally radiographic findings.

Aortic Aneurysm↗
PubMed1987

[Diagnosis of obliterating vascular processes in the supraaortic area].

For the diagnostics of obliterating vascular changes in the supraaortic area the invasive diagnostics of the vessels is not to be renounced now as before. The indication to the angiographic investigation results from clinical, perfusion-scintigraphic and Doppler-sonographic-findings. Of 390 patients 289 pathological angiographic findings in the supraaortic vascular area. In 101 patients normal findings were stated. Altogether 509 individual pathological findings were represented. In the comparison of the results of the investigations in the various diagnostic methods the clinical neurological investigation showed itself as particularly evident method. It should be decisive for the indication to the invasive diagnostics. The correspondence between the angiographic findings and the result of the perfusion-scintigraphic and Doppler-sonographic investigations, respectively, was the greater the more expressed the extracranial vascular findings represented themselves. In 127 patients with multiple obliterating vascular changes the size of the pathological changes and their localization could be established only angiographically.

Arterial Occlusive Diseases↗
PubMed1987

Differential effects of chronic testosterone treatment on the onset of puberty in male rats.

Immature male rats were daily injected with 5 or 10 micrograms testosterone propionate (TP)/100 g b.w. from day 5 after birth through day 30 or through the day at which spermatozoa appeared in preputial smears (SpA). The age and body weight at preputial separation (PS) and SpA as well as the testes weight on the day of SpA were recorded. Reduced testicular weights as compared to the controls injected with oil were found in all experimental groups. Whereas daily injections of 5 micrograms TP/100 g b.w. did not alter the age and body weight at PS and SpA, administration of the higher TP dose from day 5 through day 30 resulted in highly significant delay of PS and SpA. This effect was almost completely abolished if treatment was continued to the day of SpA. In otherwise untreated males, however, injections of 10 micrograms TP/100 g b.w. from day 30 through the day of SpA did not advance the spontaneous onset of puberty. The findings suggest that slight elevation of the circulating testosterone level during infancy causes impairment of testicular functions resulting in retardation of spermatogenesis and, presumedly, long-lasting reduction of testosterone secretion. The effect can be abolished by substitution of testosterone during the late prepubertal phase, but spontaneous sexual maturation can probably not be accelerated in this way.

Aging↗
PubMed1987

[Status of perfusion scintigraphy in the diagnostic strategy in cerebrovascular disorders and space-occupying lesions].

The results of an evaluation of the perfusion scintigraphy findings of 350 hospitalised neurological patients and 55 more strictly selected neurosurgical patients with cerebrovascular complaints, revealed an accuraty of 83%, a sensitivity of 89%, and a specificity of 83%. The selection of the patients had no influence on the results as a whole. Compared with contrast-medium angiography, incorrect diagnosis must be expected in 17% of the cases. This includes erroneous negative findings in 10% of the cases. Grounds for misinterpretations are suggested, and the biological and methodological limitations of the method are set forth.

Brain Ischemia↗
PubMed1986

Percutaneous angioplasty of carotid artery stenoses.

Percutaneous angioplasty is a well-established method of treating arterial stenoses and occlusions in various regions. In the carotid area this technique is still under discussion. The successful application of angioplasty in eight patients with carotid artery stenoses is reported.

Adult↗
PubMed1986

[1,000 pancreolauryl tests: evaluation of sensitivity, specificity and use in clinical routine].

1115 examinations with the Pancreolauryl-Test (PLT) were carried out and assessed on 918 non-selected patients with various gastro-enterologic diseases. Depending on the severity of the exocrine insufficiency, sensitivity varied in confirmed chronic pancreatitis (n = 54). Overall sensitivity was 69%, in chronic pancreatitis with steatorrhoe 100%, and 54% in moderate insufficiency. In all patients not suffering from pancreatic diseases (n = 789) specificity was 77%. Since the PLT was frequently pathological in patients with subtotal gastrectomy (gastric resection) and active peptic lesion, specificity was also determined excluding these cases (29% of all patients without pancreatic disease). This resulted in a specificity of 86%. Gastric hyperacidity should be taken into consideration as a possible source of errors (for example, in the condition following an ulcer). Age, weight and alcohol consumption as well as diseases of the bile duct and liver, had no influence on specificity. Urine collection errors, occurring in 10% of the patients investigated, could be avoided by determination of fluorescein in the serum. Our results from a series of examinations on non-selected patients with a 6% prevalence of chronic pancreatitis indicated that PLT is likely to increase predictive value in selected application. If the oesophagus-gastro-duodenoscopy is non-pathological but the PLT gives a pathological result, further pancreatic investigative procedures should be carried out.

Adult↗
PubMed1986

[Value of angiography and computerized tomography for preoperative evaluation of bladder cancer].

In a comparative study in 30 patients with tumour of the urinary bladder the value of angiographic and computer-tomographic investigation in the proof of tumours and for staging was controlled. In 30% of the cases the angiographic proof was not successful. A concordance to the histologically recognized degree of infiltration could be established by means of angiography in 36.6% and by computed tomography in 86.3%. When it is possible to apply computed tomography for staging we regard the performance of the angiography of the pelvis as no more indicated.

Angiography↗
PubMed1986

[CT findings in gastrointestinal tumors].

Any suspicion of lumino-abdominal tumour growth should be confirmed or invalidated by contrast medium examination. The authors of this paper, deviating from the generally accepted diagnostic strategies, used computed tomography and succeeded in recording gastrointestinal tumours from 25 patients. High-accuracy organ localisation of palpable intestinal tumours proved to be possible by means of computed tomography. Hence, primary diagnostic use of CT appears to be justified in exceptional cases.

Adult↗
PubMed1985

[Value of computer tomography in bronchopulmonary diseases in childhood].

In 20 children with bronchopulmonary symptoms and striking x-ray-thorax-findings computer-tomography examinations were carried out in addition to the usual diagnosis. Mediastinal demand for room and screening for tumor are recognized as essential indications in infancy for the application of CT-diagnosis in the chest. Computerized tomography is also indicated if an anomaly of blood vessels is suspected. In all other pulmonal diseases CT gives valuable information but in no case it replaces a bronchologic examination.

Adolescent↗
PubMed1985

[Value of computer tomography and lymphography for staging of malignant testicular tumors].

Findings of computer tomographic and lymphographic examinations of 74 patients were evaluated concerning their evidence in the pretherapeutic staging compared with the histological results of lymphonodectomy. The security of the computer tomography was about 82.4%, the specifity about 95.12%, the sensitivity about 66.66%. Lymphographically, a security of 85.14%, a specifity of 95.12% and a sensitivity of 66.66% was achieved. The combination of the methods achieved a security of 91.7%, a specifity of 100% and a sensitivity of 71.72% was achieved. Metastases of lymphatic nodes less than 0.5 cm diameter were not recognized by means of the two methods. In 2 cases no metastases, which were not covered by means of computer tomography, could not be recognized lymphographically in slightly enlarged lymphatic nodes. In contrast to this in 11 out of 74 patients (14.8%) in the computer tomography an enlargement of the findings was the result in comparison to lymphography. Since none of the two methods is absolutely reliable for the proof or the exclusion of smaller metastases, in a secure evidence of the computer tomography before a lymphonodectomy the lymphography can be omitted.

Adult↗