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K Inomata

Publications and source records attributed to K Inomata.

At least 109 records · Page 6Linked to original sources
PubMed1979

Phosphorylation of adenosine in aqueous solution by electric discharges.

Dehydration reactions involving condensing reagents in aqueous solution have been studied as models of chemical evolution, and one such reagent has been found to be produced in the supposed primitive Earth conditions. We assumed that the dehydration condensation in aqueous solution could occur if the condensing reagents, which appear to be produced by electric discharges in the gas phase, could be carried to the aqueous solution through the recycling of water washing the wall of the vessel. We present here an experimental study of the dehydration condensation between phosphate and adenosine in aqueous solution using a new discharge apparatus (Fig. 1) which simulates prebiotic chemical evolution. The apparatus was designed so that water recycles in a vessel containing a solution at a relatively low temperature (approximately 30 degrees C), achieved by showering water at 18 degrees C from above the vessel. This is a simulation of the recycling system of water on the Earth, depending on a large difference in temperature between the ocean surface and the sky.

Adenosine↗
PubMed1978

[A case of malignant lymphoma (lymphosarcomatous type) of the brain (author's transl)].

A relatively rare case of malignant lymphoma of the brain was reported. A 64-year-old male was admitted to our hospital, October 2, 1976, complaining of right hemiparesis and expressive aphasia. Neurological and radiological examinations revealed a huge space-occupying lesion in the left frontoparietal region. An external decompressive surgery and biopsy were performed. The excised specimens was diagnosed as malignant lymphoma (lymphosarcoma type) histologically. Radiation (5000 rad of 60Co) and chemotherapy with anticancer drugs were carried out after the operation. The patient, however, died at seven months after the onset. On necropsy the tumor was infiltrated extensively in the left frontal, parietal, temporal and occipital lobes, but extended not to the thalamus, basal ganglia and ventricular system. This case was suggested primary malignant lymphoma of the brain, according to the physical and radiological examinations of the whole body, although the autopsy was performed only about the brain. The nomenclature, clinicopathological and immunological problems of malignant lymphomas of the nervous system were also discussed, reviewing the previously reported cases.

Brain↗
PubMedDate not supplied

[Biological monitoring of exposure to alkylating xenobiotics by determining them in complexes with plasma proteins, hemoglobin, mercapturic acids from urine of rats and industrial workers. I. Acrylonitrile].

A parent molecule of acrylonitrile (cyanoethylene, CE) may be isolated from its the model compound S-(2-cyanoethylene)-1-cysteine, as well as from its N-acetyl derivative and hemoglobin (Hb) and plasma proteins from the intoxicated animals and workers engaged in manufacturing synthetic rubber made from acrylonitrile. The developed procedure consists in the 1.5% H2O2 oxidation of a CE adduct for 30 min, followed by addition of a sample into the gas chromatographic injector at 250 degrees C, resulting in the release of CE from the adducts and in the current ingress of carrier gas into the capillary column in order to separate and determine with a FTD detector. There was a dose-response relationship between the formation of CE adducts with rat blood proteins, urinary mercapturic acids when the poison was given in a dose of 1-50 mg/kg. CE covalently bound to Hb was detected in the workers exposed to its monomer in working places.

Acetylcysteine↗