[Effect of dipyridamole on the dynamics of left-ventricular contraction].
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Biomedical subjects
Publications and source records attributed to K Markiewicz.
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35 young, healthy men were divided at random into two groups. Each of them made physical effort of different intensity and different quantity of the work performed. It was found that intraocular pressure was decreased in both groups but its drop was bigger in the group whose work was more strenouos. From the difference of performance of intraocular pressure in both the controlled groups we can conclude the degree of reduction of intraocular pressure and length of its duration may depend on quantity of the work performed. The pulse and blood pressure seem not to affect the intraocular pressure.
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Gastric basal secretion was studied at rest, in the course of one hour's exertion and one hour's restitution in 10 patients with chronic duodenal ulcer, aged 21-52. The subject performed exercise on a Monark ergometer under a load that gave constant pulse rate acceleration equal to 50% of the age-related maximum. Gastric juice samples were collected with the subjects sitting, in three successive phase of rest, exercise, and restitution. It was found that during exercise there was an increase in the gastric juice volume, HCl levels in it, basal secretion volume, and overall sodium, potassium, chloride, calcium, and magnesium content, their concentration in the juice having remained constant. In the course of restitution the above values did not differ in any significant way from those obtained at rest.
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The effect of glucagon on the circulatory system was studied in 22 healthy men. The drug was administered in doses of 50 microgram/kg of body weight for 30 sec. In the case of 5 subjects, arrhythmias occurred that manifested themselves as ventricular and supraventricular extrasystoles. In the case of 1 subject, who had sporadic ventricular fusion beats in the preexamination period, the arrhythmia increased following glucagon injection.