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Biomedical subjects

K Taguchi

Publications and source records attributed to K Taguchi.

At least 73 records · Page 4Linked to original sources
PubMed1988

[Effects of sera of gynecological cancer and pregnancy on cellular immunity].

The effects of sera from untreated gynecological cancer patients in 1st, 2nd, 3rd trimesters of normal pregnancy on PHA and MLR induced lymphocytes blastformation, natural killer cell activity and killer T cell induction were analysed. 1. The 3H-thymidine uptake of lymphocytes by PHA and MLR significantly decreased in cancerous and 3rd trimester pregnant sera. It is thought that the existence of non specific immunosuppressive factors in these conditions, and this phenomenon might be caused by coating and/or masking of the surface of the effector cell. The factors might have an effect on the proliferation phase of lymphocyte blastoformation. 2. Normal human lymphocytes pretreated with cancerous sera inhibited natural killer cell activity. This phenomenon could not be demonstrated with pregnant sera. 3. Cancerous and 3rd trimester pregnant sera suppressed the process of killer T cell induction caused by alloantigen.

Cytotoxicity, Immunologic↗
PubMed1988

[Flow imaging of the cardiovascular system using magnetic resonance imaging].

Blood flow images by magnetic resonance imaging (MRI) using a 0.25 T unit were evaluated for nine normal volunteers and 108 subjects with a variety of cardiovascular abnormalities. Using the non-gated short-spin echo (SE) technique, blood flow in the cardiovascular systems was not imaged in the normal volunteers. Using end-systolic and end-diastolic SE techniques for the normal subjects, blood flow in the cardiac chambers was not clearly imaged. Blood flow in the ascending aorta and aotric arch often did not appear in the gated SE images of the normal subjects. However, blood flow in the descending aorta was often observed in the gated SE images. Blood flow imaging was demonstrated by both non-gated and gated SE techniques in regions where blood flow was relatively slow; for example, in the left atrium of mitral stenosis, in an aortic aneurysm, in a false lumen of an aortic dissection, and in the left ventricle having old myocardial infarction. Using the non-gated inversion recovery (IR) technique, no blood flow was imaged in the cardiovascular system except in the left atrium of one case with mitral stenosis. Using the non-gated short SE technique, there was good correlation between the thrombus formation and the presence of blood flow images in the left atria of 17 patients with mitral stenosis, and in the aneurysmal portions of the aorta or in the false lumens of aortic dissection of 18 patients. It was suggested that mural thrombi in such diseases were related to the relatively slow blood flow. Blood flow imaging easily distinguished stagnant blood flow from mural thrombi using non-gated short SE, end-systolic SE, and IR techniques. Thus, blood flow imaging using MRI should become an important means of evaluating the cardiovascular system.

Adult↗
PubMed1987

Ion chromatographic determination of nitrogen dioxide and sulphur dioxide in the atmosphere using tri-ethanolamine-potassium hydroxide-coated cartridges.

Nitrogen dioxide (NO2) and sulphur dioxide (SO2) in air were sampled by the use of a Sep-Pak C18 cartridge impregnated with triethanolamine-potassium hydroxide. The trapped NO2 and SO2 were eluted with a 8 mM sodium carbonate-3 mM sodium hydrogencarbonate solution and simultaneously determined by ion chromatography. In the active sampling mode, NO2 was determined with 5.2% relative standard deviation at 95 ppb and SO2 was determined with 2.4-5.3% relative standard deviation at 54-184 ppb. The recoveries were 85-98% for NO2 and 91-105% for SO2. In the passive sampling mode, the average concentrations of NO2 and SO2 were determined with 2.4-6.8 and 2.8-7.9% relative standard deviation, respectively, at atmospheric levels for 6-24 days.

Air Pollutants, Occupational↗
PubMed1987

Cystic parathyroid adenoma with coexistent sarcoid granulomas.

A 55-year-old woman with sarcoidosis developed hyperparathyroidism that was associated with fluctuating serum calcium levels. Ultrasonography and a computed tomography (CT) scan of the neck demonstrated a cystic lesion in the lower posterior area of the left thyroid lobe. Histological examination after subsequent surgery revealed sarcoid granulomas within a parathyroid adenoma. The pathogenesis of this rare association is discussed.

Adenoma↗
PubMed1987

The distribution of alpha and beta subunits of S-100 protein in malignant schwannomas arising from neurofibromatosis of von Recklinghausen's disease.

The immunohistochemical localization of the alpha and beta subunits of S-100 protein in 4 cases of the malignant Schwannomas arising from von Recklinghausen's disease was investigated by the indirect immunoperoxidase method. S-100 alpha-positive cells were few in presumably normal peripheral nerves, moderate in numbers in plexiform neurofibromas and numerous in malignant Schwannomas. In contrast, S-100 beta immunoreactivity, abundantly detected in normal peripheral nerves and plexiform neurofibromas, was completely negative in all of 4 cases of malignant Schwannoma. In addition, double immunostaining method for both subunits revealed their simultaneous existence in cells in the normal nerves and neurofibroma. These results suggest that malignant change of Schwann cells convert their subunit composition of S-100 protein from beta to alpha in these malignant cells. Although the mechanisms for the proportional conversion of the subunits are as yet undetermined, the immunoreactivity of S-100 alpha subunit may be a useful marker for Schwannoma in malignancy.

Adult↗
PubMed1987

Covalent immobilization of chitosan derivatives onto polymeric film surfaces with the use of a photosensitive hetero-bifunctional crosslinking reagent.

Partially N-acetylated chitosan was covalently immobilized onto polymeric film surfaces using the photosensitive hetero-bifunctional crosslinking reagent, methyl 4-azidobenzoimidate, which was previously attached to the chitosan by the reaction between an imidoester group of the reagent and a free amino group of the chitosan. The grafting was accomplished by irradiating with ultraviolet light the modified chitosan being coated on the film surfaces to photolysis arylazide groups, thus crosslinking the chitosan and the underlying substrate polymer together. For ultraviolet absorption and infrared spectroscopy, the irradiation time of 3 min was found to be sufficient for the photolysis of the azide group. The thickness of the immobilized chitosan layer was estimated to be of the order of 30-150 nm using attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR). The chitosan molecules immobilized on the surfaces could be chemically modified by several reagents and also treated with a heparin solution to form a polyelectrolyte complex on the surface. The ionically bound heparin was partially released into a phosphate buffer solution.

Acetylation↗
PubMed1987

Malignant Brenner tumor with peritoneal metastasis.

A case of malignant Brenner tumor with peritoneal metastasis in a 67-year-old woman was reported. The multilocular cystic tumor of right ovary was 420 g in weight, and their cystic walls were covered with multilayered tumor cells showing papillary pattern very frequently. The tumor was histologically transitional cell carcinoma with occasional glandular structures but no squamous differentiation corresponding to grade 2 or 3 urinary bladder carcinoma. The pattern of benign Brenner tumor was not identified, but there was some area of proliferating Brenner tumor. Immunohistochemically, carcinoembryonic antigen was detected in several tumor cells, especially in the intercellular spaces among them, and cytokeratin was detected only in some tumor cells. Ultrastructurally, the malignant Brenner tumor shared many common features with the benign one and also bladder tumor. Intercellular spaces with microvilli were frequently found and thought to be important for diagnosis. The morphologic criteria of this rare tumor are discussed.

Aged↗
PubMed1987

An immunohistochemical study on the distribution of glial fibrillary acidic protein, S-100 protein, neuron-specific enolase, and neurofilament in medulloblastomas.

In order to clarify the differentiation of medulloblastomas, the authors studied on the morphological features and immunohistochemical expression of glial fibrillary acidic protein (GFAP), S-100 protein, neuron-specific enolase (NSE), and neurofilament (NF) in 31 medulloblastomas. GFAP was detected only in a small number of tumor cells of 5 medulloblastomas; S-100 protein in both small tumor cells and some so-called spongioblastic cells in 16 medulloblastomas; NSE in the more abundant tumor cells and the matrix in 28 medulloblastomas; NF in a few tumor cells of 12 medulloblastomas; GFAP and NF in 2 medulloblastomas, but each of them in different tumor cells. These results suggest that medulloblastomas have a capacity of differentiation along neuronal and/or glial lines. The conventional morphological markers of differentiation in medulloblastomas such as spongioblastic cells and Homer Wright rosettes were not necessarily compatible with expression of immunohistochemical markers such as GFAP or NF. NSE and S-100 protein seem less valuable markers of differentiation because they were detected in both neuronal and glial elements. But NSE, which was observed in most medulloblastomas, might have a value as a marker for medulloblastomas.

Adolescent↗
PubMed1987

Effects of ingested 4000ppm aluminum on the essential metals, especially zinc, in intact and ethanol treated mice.

The effects of ingested Al on the essential metals were investigated using mice. Animals were divided into 4 groups: 1) Control, 2) Al, 3) EtOH and 4) Al+EtOH groups. Powdered commercial food, containing 1.26% P, 1.36% Ca, 70ppm Zn, 15ppm Cu, 200ppm Fe and 3.1ppm Al, was used to prepare the diets. For Al-treated groups, Al(AlCl3) was added to powdered food at a concentration of 4000ppm. The co-existing effect of EtOH which is known to affect the essential metals, was also investigated as a possible modulater of Al toxicity at a concentration of 5% for 22 days, followed by 10% for 36 days in the drinking water. After 58 days feeding with food containing Al and / or EtOH containing water, the Al effects on serum and femur P and Ca were found to be slight except for a significant decrease of serum P concentration in the Al+EtOH group. In this group, femur weight was less and femur Al concentration was more compared with the Al group. The effects on Fe and Cu were little. We observed a significant decrease of serum Zn concentration with 4000ppm Al diet in both the Al-treated groups. The fact that serum ALPase activity, a Zn enzyme, increased in disregard of a significant decrease of serum Zn concentration suggested the enzyme release from injures tissues. It is noticeable that a significant decrease of serum Zn concentration was observed when dietary Zn was sufficient. It is reported that the dietary intake of Zn is under the recommended allowance for many people. Since Al compounds are widely used as drugs, food additives and a conditioned latent Zn deficiency is rather common in human diseases, the effects of Al on the Zn metabolism are to be investigated further.

Aluminum↗