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Biomedical subjects

L Clodius

Publications and source records attributed to L Clodius.

At least 55 records · Page 3Linked to original sources
PubMed1979

Resurfacing denuded areas of the beard with full thickness scalp grafts.

Reconstruction of a beard-bearing area, such as the upper lip, necessitates hair-bearing grafts no thicker than a full thickness skin graft, in order to allow for normal movement. In the normal scalp, however, most of the follicles reach into the subcutaneous fat. By preoperative epilation it seems possible to induce the catagen phase of the hair cycle during which the follicles migrate into the corium and thus will be transplanted as complete morphological units. The clinical results support this concept.

Adolescent↗
PubMed1979

The history of the artificial eye.

The history of the artificial eye, from antiquity to the present, is described. Around the beginning of the nineteenth century, glass eyes replaced the earlier metal ones--not always well tolerated. In 1835, cryolite glass was used instead of lead glass; to this day it remains the lightest and most desirable substance for making artificial eyes.

Eye, Artificial↗
PubMed1979

A morphological assessment of macrophages attaching to subcutaneously implanted coverslips in dogs with chronic lymphoedema.

In an experimental model of chronic lymphoedema in the dog leg it has been shown that the presence of lymphoedema was associated with reduced numbers of macrophages found on subcutaneously implanted coverslips. Total numbers of mononuclear cells were not, however, significantly affected. When expressed as a percentage of the total mononuclear cells attached, the lymphoedematous limbs always had only half those of the corresponding normal limbs. Similarly, the percentage of macrophages with two or more pseudopods on the coverslips in the lymphoedematous limbs was only 1/3 of that for the same morphological criteria in normal limbs. However, when the macrophages with vacuoles were expressed as a percentage of the total macrophages, there was always a higher percentage in the lymphoedematous limbs compared with the corresponding normal ones.

Animals↗
PubMed1978

The effects of chronic cervical lymphostasis on regions drained by lymphatics and by prelymphatics.

Chronic cervical lymphostasis was induced in cats. The effects in regions directly drained by lymphatics (facial skin and retrobulbar tissue), and in regions primarily drained by prelymphatics (cerebral cortex, retina, papilla, iris, choroid and Circle of Willis) were studied ophthalmoscopically and electron microscopically. It was found that in all regions there was considerable oedema, increases in protein concentration and excess collagen, together with increased numbers of macrophages. The lymphatics, where these existed, had many open junctions: both these vessels and the prelymphatics were very dilated, with considerable increases in protein concentration.

Animals↗
PubMed1978

Lymphoedema of the rabbit ear following partial and complete lymphatic blockade; its effects on fibrotic development, enzyme types and their activity levels.

The dorsal surface of the rabbit ear was found to be a suitable place for the production of long-lasting lymphoedema. Its major tissues (skin and sub cutaneous) are those to which secondary lymphoedema is confined in clinical situations. After 32 weeks of partial lymphatic blockade total tissue activity levels of neutral proteinase and beta-glucuronidase were depressed while alkaline phosphatase was elevated. Subsequent complete lymphatic blockade for a further 5 weeks resulted in severe fibrosis of the s.c. tissues. The total tissue activity levels of 3 characteristic lysosomal macrophage hydrolases--acid protease, beta-glucuronidase and acid phosphatase--were significantly increased. There were strong correlations between the activity levels of these enzymes and the extent of fibrosis, increased fibrosis being characterized by higher activity levels. This, together with other evidence, suggested--as fibrosis became more severe--the total number of macrophages increased, but a high proportion of these were non-stimulated. Since these cells (when stimulated) are normally responsible for the lysis of collagen and removal of fibrotic tissue the impairment of their function as occurs in chronic lymphoedema results in further fibrosis and the continuation of the vicious circle.

Acid Phosphatase↗
PubMed1978

[A new use for the freely transplanted omentum. Management of a late radiation injury of the brachial plexus using freely transplanted omentum and neurolysis].

A short review of the structural characteristics and the function of the greater omentum is presented. The results of treatment of secondary lymphedema by free transplantation of the omentum with microvascular anastomoses in the canine model and their relevance for clinical application are discussed. Clinical indications, operative technique, and results of omental transplantation and exoneurolysis of the brachial plexus in seven patients with constrictive, radiation induced brachial plexus paralysis, with and without secondary lymphedema, are reviewed. No effect of the grafted omentum on arm-lymphedema was observed over the entire observation period of 1 1/2--4 years. Minor degree reversion of neurodegenerative changes was found in two patients, in all other patients, these changes stopped. The most impressing result was the immediate and permanent disappearance of pain in all patients.

Adult↗
PubMed1978

[Antibiotic prophylaxis in plastic reconstructive surgery].

In plastic reconstructive surgery the use of prophylactic antibiotics is considered for wounds in which tissue trauma can not exactly be delineated as in gun shot wounds, bites, contusions; for extensive surgery lasting more than three hours in the oral area, with opening of the maxillary sinuses; when large foreign bodies are implanted; if there is massive intraoperative contamination and for patients with reduced antibacterial defence mechanisms. A principal factor leading to infection is reduced tissue oxygenation, which can be reversed by the use of benzopyrones as experimentally demonstrated.

Animals↗
PubMed1977

Experimental blood vascular and lymphatic occlusion in the rabbit ear and the effect of benzopyrones.

The effects of lymphostasis and its treatment by a mixture of benzopyrones were studied in the pinnae of rabbit ears. The blood and lymph circulations to the dorsal surfaces of the ears were largely interrupted by excising a portion of skin down to the perichondrium from one edge to the other. The untreated ears became very lymphoedematous, became necrotic and tell off between 7 and 34 days after the operation. The treated ears were much less lymphoedematous, both to the naked eye and by electron microscopy. Owing to the ubiquity of action of the benzopyrones, the phagocytic capacity of the macrophages is enhanced, removing the accumulating protein, the metabolic products and thus the oedematous fluid. This improves the tissue oxygenation, encouraging lymphatic and vascular regeneration and, to a lesser degree, recanalisation. Also, the red blood cells are protected against lactacidotic rigidification and they and the macrophages are given an increased chance of survival in the remaining stagnant areas by the enhancement of glucose up-take and transport. Upon these factors rests the ability of the tissue to survive. The fact that the ears in the treated groups did not fall off, gives a real indication of the potentiality of the benzopyrones.

Animals↗