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Biomedical subjects

L Molnár

Publications and source records attributed to L Molnár.

At least 91 records · Page 5Linked to original sources

Bronchial papillomas of various origins.

There were five cases of solitary papillomas and three of chronic infectious papillomatosis induced by a foreign body, one caused by broncholithiasis. The five isolated papillomas had verrucous appearances. The common opinion, that the solitary papilloma is likely to be a pedunculary tumor, seems untrue. Squamous or cylindric epithelium covering the same tumor may vary from region to region. We believe that multiple polyps caused by inhalation of hot, burning, and corrosive gases are of inflammatory origin. Once the causative factor (eg, a late diagnosed foreign body) is removed, the inflammatory papillomatosis may resolve spontaneously. After the removal of a benign papilloma, recurrence is usually caused by lack of operative radicality rather than by malignancy. Laser technique and other coagulation methods make it possible to remove most tumors by performing bronchoscopy with only little risk. Papillomas showing the signs of atypia and peribronchial spreading require later surgery.

Adult↗

Lymphocyte subpopulations and immunoglobulins in idiopathic thrombocytopenic purpura (ITP).

Data gained from observations of the humoral and cellular immunity of 22 patients with ITP (11 in remission and 11 splenectomised) are presented. The amount of T-lymphocytes according to E-rosetting decreased significantly. In tests performed with monoclonal sera the amount of OKT-4 cells was significantly lower then normal, and the ratio of OKT-4/OKT-8 was also reduced. The C-4 complement fraction showed a significant reduction, and a rise was observed in the three Ig classes. No differences could be found, however, between patients in remission and in relapse, and between the splenectomised cases, those treated with prednisolone, and those who had no such treatment. Apart from the primary role of antiplatelet antibodies that cause thrombopenia, a complex disturbance in immune regulation also occurred in ITP, and this manifested with changes in the T-lymphocyte subpopulations. Its pathological progress still remains to be justified, but the plasma of healthy individuals and gammaglobulin have a favorable effect by blocking their receptors and they result in the cessation of the symptom and thrombocytopenia.

Adult↗

Correlation between the results of carcinoembryonal antigen (CEA) test and the clinical stage of colorectal carcinoma.

Correlation between results of CEA test and clinical stage of colorectal carcinoma is described. No correlation was found between the different stages and the actual CEA titre. Normalization of an increased preoperative serum CEA level indicated, however, nearly always the radical character of the intervention. Critically high (above 30 ng/per ml) CEA value observed in Dukes' stages C and D can be considered bad prognostic signs. Patients like these died within one year. Results of CEA tests are also useful complementary data contributing to the diagnosis of recurrence or distant metastases.

Adult↗

Experimental focal cerebral ischaemia in rabbits.

A highly reproducible form of experimental embolization of the intracranial arteries is presented in rabbits. The injection of a silver or gold ball into the internal carotid artery caused occlusion predominantly of the middle cerebral artery and/or its branches. At the moment when embolization took place, the characteristic signs of acute cerebral ischaemia occurred in the electroencephalogram, local cerebral blood flow and steady (DC) potentials. Several hours after the ball had been injected the extent of the focal lesions became recognizable on sections stained for myelin. The procedure is simple, rapid, inexpensive and practically always successful. The extent of the lesion may be influenced by the change of both the ball size and the posture of animals. Moreover, the site of occlusion is easily discernible both on radiographs and to the naked eye.

Animals↗

Serum beta-2 microglobulin in chronic lymphocytic leukaemia.

Serum-beta-2-microglobulin was measured by radioimmunoassay in 25 patients with chronic lymphocellular leukaemia in stages III-IV according to the Rai classification. A significant positive correlation was found between the absolute lymphocyte count and the serum-beta-2-microglobulin level. No similar relationship was observed between the score indicative of organ infiltration and the beta-2-microglobulin valve. On the evidence of the results, the increased production of beta-2-microglobulin is attributed in the first place to the circulating lymphocytes. The assay has been found to provide a reliable indicator, suitable for the monitoring and evaluation of therapy.

Aged↗