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Biomedical subjects

Longin Marianowski

Publications and source records attributed to Longin Marianowski.

At least 19 recordsLinked to original sources
PubMed2006

The occurrence of genital types of human papillomavirus in normal pregnancy and in pregnant renal transplant recipients.

OBJECTIVE: The aim of this study was to evaluate: 1) The prevalence of human papillomavirus (types 6 and 11 carrying a low risk of neoplasia, and type 16 implicated as cause of cervical neoplasia and cancer) in normal pregnant women and pregnant renal transplant recipients. 2) The correlation between maternal HPV infection and HPV presence in the cord blood and the oral cavity of the neonate. Evaluation of a likely, additional route of HPV transmission to the fetus, apart from the infected birth canal during vaginal delivery. The correlation between the mode of delivery in HPV-infected patients and the presence of HPV in their offspring. DESIGN: Thirty-nine pregnant patients were included in the study. The study group consisted of nine pregnant renal transplant recipients. The control group consisted of 30 patients with normal pregnancy. The DNA of HPV types 6, 11 and 16 was studied in the discharge from the cervical canal, the maternal venous blood, the cord blood and the buccal smear obtained from the neonates. SETTING: A university teaching hospital delivering approximately 2000 women annually. RESULTS: Human papillomavirus (HPV) was found in 10 (26%) of 39 subjects. HPV types 6 and 11 was found in 7 (18%) of 39 subjects while HPV type 16 was present in 5 (13%) of the subjects. The co-occurrence of HPV types 6, 11 and 16 was detected in 2 patients from the control group. Transmission of HPV was established in 70% of study patients and their offspring. CONCLUSIONS: 1) The HPV was found with 26% pregnant women. 2) The occurrence of HPV infections with pregnant renal transplant recipients in comparison with normal pregnancy was on similar level. High percentage of HPV transmission from mother to neonate was obtained. 3) The cesarean section probably doesn't protect from HPV infection. 4) There's a suggestion, the HPV infection of fetus may occur in utero.

Adult↗
PubMed2005

Serum lipids concentration in women with benign and malignant ovarian tumours.

UNLABELLED: Early diagnosis can improve clinical effects of ovarian carcinoma treatment. Until now, a satisfying screening method has not been found. Serum lipid and lipoprotein association with neoplasm is already established. In our study, we have examined concentration of total cholesterol, free cholesterol, HDL cholesterol, HDL3 and HDL free cholesterol fraction, triglycerides, and apolipoproteins: AI, AII and B and aimed to prepare the most likely model of lipid profile in women suffering from ovarian neoplasm. The serum lipid parameters were analysed in 91 operated patients: 64 with ovarian malignant tumour, 27 with benign ovarian cysts and 44 apparently healthy age-matching pair women as a control group. THE RESULTS: concentration of two parameters: apolipoprotein AI and free cholesterol allows for excluding ovarian neoplasm in 95.5%; examination of six parameters: apolipoprotein AI, free cholesterol, HDL-free cholesterol, HDL total cholesterol, apolipoprotein B and HDL3 fraction allows for diagnosing ovarian malignancy with 97% probability. This probability does not depend on staging of cancer, patient's age, nor BMI. No statistically significant difference between malignant and benign ovarian tumour has been confirmed.

Adult↗
PubMed2005

[Comparative analysis of labor in twin pregnancies in years 1987-91 and 1997-2001].

OBJECTIVE: The aim of the study was to evaluate the course of twin pregnancy deliveries with particular regard to parity, the way of pregnancy termination, indications for cesarean section and sterility treatment. MATERIALS AND METHODS: The studied material consisted of two groups of patients who gave birth to twins in our clinic: the first one of 62 women in years 1997-2001 and the second group of 92 women in years 1987-1991. The average age of patients was 29.4 vs 28.7 respectively. RESULTS: There were 48.3% of primiparas in the first group, comparing to 44.5% in the second. The average time of pregnancy termination was 35 vs 35.97 Hbd respectively. Premature labours contributed to 80.6% vs 52% of all cases, which was statistically significant (p<0.001). Obstetrical procedures were applied in 6.5% vs 25% of cases respectively (p = 0.003). The indications for cesarean section have changed in regard to the position of the second fetus (when first in cephalic longitudinal lie, second in other than cephalic) and therefore contributed to 78.5% of cases in first and only 12.5% in second group. Thus the application of obstetrical procedures on the second fetus decreased to 18.2% vs 63% (p=0.002). In both groups cesarean sections were most often performed when the position of the first fetus was other than cephalic. In both groups the mediana of Apgar score of the second twin was lower than of the first. But the number of stillborns and general neonatal deaths significantly decreased over the years (0.8% and 2.4% vs 4.9% and 5.36%). Comparing both studied groups, the rate of the twin pregnancy after sterility treatment is rising: 16% vs 7.6%. CONCLUSIONS: The significance of the second twin position as an indication for cesarean delivery has risen over the years, thereby displacing the use of obstetrical procedures in those cases. In spite of earlier pregnancy termination and higher premature labour rate, there is a significant drop in the number of stillborns and neonatal deaths. In the age of infertility treatment, the number of twin pregnancy is rising.

Adult↗
PubMed2005

The occurrence of genital types of human papillomavirus in normal pregnancy and in pregnant women with pregestational insulin dependent diabetes mellitus.

OBJECTIVE: The aim of the study was to evaluate the prevalence of human papillomavirus, both types of a low oncogenic risk (HPV 6, 11) and a type carrying a high oncogenic risk (HPV 16) in the genital tract of the pregnant patients, their venous blood, the cord blood and the oral cavities of the neonates. Normal pregnant women and pregnant women with insulin dependent diabetes mellitus (IDDM) diagnosed before pregnancy were included in the study. DESIGN: The study group consisted of 15 pregnant women aged 22 to 32 years with IDDM diagnosed before pregnancy. The control group consisted of 30 patients aged 18 to 38 years, with normal pregnancy. The DNA of HPV types 6, 11 and 16 was studied in the discharge from the cervical canal, the maternal venous blood, the cord blood and the buccal smear obtained from the neonates. To detect of viral DNA the PCR was used. SETTING: A university teaching hospital delivering approximately 2000 women annually. RESULTS: Human papillomavirus (HPV) was found in 12 (26.7%) of the 45 pregnant women. Of the 15 patients with pregestational IDDM the DNA of HPV was detected in four (26.7%) of the patients. The DNA of HPV types 6 and 11 was found in three (20%) patients. The DNA of HPV type 16 was detected in one pregnant patient in the study group (6.67%). Of the 30 control patients, HPV DNA was detected in eight (26%). In two (6.6%), infection with oncogenic and non-oncogenic types of HPV was diagnosed. The DNA of HPV types 6 and 11 was found in six (20%) subjects. Of the 30 control patients, the DNA of HPV type 16 was detected in four (13.3%). The transmission of HPV from HPV-positive mother to fetus was found in 50% of cases. CONCLUSIONS: (i) There was a similar level of occurrence of HPV infections in pregnant women with IDDM when compare with normal pregnancy. (ii) High percentage of HPV transmission from mother to neonate was determined. (iii) The cesarean section probably does not protect the neonate from HPV infection. (iv) There is a suggestion that fetus may be affected by HPV infection during intrauterine life.

Adult↗
PubMed2004

Prevention of postmenopausal bone loss by pulsed estrogen therapy: comparison with transdermal route.

OBJECTIVE: To compare the efficacy of pulsed estrogen therapy following intranasal 17beta-estradiol (E2) (S21400) with patch E2 in preventing postmenopausal bone loss and on bone turnover. METHODS: In this multinational open study, 361 postmenopausal women aged 51.5 (S.D. 4.6) years were treated with S21400 300 microg per day or patch E2 (delivering 50 microg per day), two patches per week, for 56 weeks. Bone mineral density (BMD) was assessed at the spine and hip using dual X-ray absorptiometry at baseline and week 56 (W56). Bone turnover markers (osteocalcin, bone alkaline phosphatase, urinary type I collagen C-telopeptides) were measured at baseline and weeks 12, 28 and 56. RESULTS: Spine and hip bone mineral density significantly increased in both groups (P < 0.001 versus baseline). Mean (S.D.) percent increases were 2.1 (3.0) at the spine (both groups), and 1.2 (2.4) and 1.1 (2.2) at the hip in the S21400 and patch E2 groups, respectively. Bone mineral density also significantly increased (P < 0.001 versus baseline) in osteopenic patients following S21400 and patch E2: 3.1 (3.5) and 2.4 (3.5) at the spine, and 2.0 (2.6) and 1.2 (2.7) at the hip, respectively. Bone metabolism was normalized at week 56 with a significant decrease (P < 0.001) from baseline in all markers: 56% and 53% for type I collagen C-telopeptides, and 24% and 25% for osteocalcin in the S21400 and patch E2 groups, respectively. CONCLUSION: Pulsed estrogen therapy was as effective in normalizing bone turnover and preventing postmenopausal bone loss as a reservoir patch.

Administration, Cutaneous↗
PubMed2004

[Assessment of mothers' knowledge about breastfeeding].

OBJECTIVES: The aim of this study was to assess the level of knowledge of problems referring to breastfeeding among women in childbirth. MATERIALS AND METHODS: The study was based on a questionnaire, which consisted of 20 questions with multiple choice answers. 108 women in puerperium were surveyed-54 in the Obstetrical Ward in Puck and the same number in the I Clinic of Obstetrics and Gynaecology in Warsaw. The results were analysed according to age, education and attendance to labour school. Statistical analysis was performed afterwards. RESULTS: For all the surveyed women, breastfeeding is a natural need and an important element of the emotional bond with a newborn. For 78.7% of the women questioned, the priority of breastfeeding was the health of their baby, 16.7% point to the advantages of the optimal composition of human milk, 37% of mothers found breastfeeding convenient. On the other hand, 37% consider artificial milk only a substitute. For 60% of women magazines were the source of education, books 53.7%, acquaintances and family 32.4%. Only a small percentage (24.1%) of women took advantage of labour classes, although it is an extremely successful method of teaching. 17.6% of women were not looking for any information about breastfeeding during the pregnancy. CONCLUSIONS: Differences in preferences and level of knowledge between women from big and small centre were shown, although there was no difference in access to it. Magazines and books, not medical staff, were the most popular source of information. The level of knowledge depends on education and labour class attendance. It seems that the system of lactational guidance should be extended on obstetrical wards, concentrating especially on women with poorest education.

Adult↗
PubMed2004

[Biologic tissue response to sutures].

The search for the ideal suture material has continued for decades. Implantation of foreign materials, including surgical sutures causes cellular response. Use of materials of natural origin is connected with a more pronounced reaction than that caused by synthetic sutures. The above review summarizes properties of suture materials that may be useful for choosing indication of the appropriate material in varying surgical situations.

Absorbable Implants↗
PubMed2004

[Echocardiographic abnormalities in infants with heart murmur].

OBJECTIVES: Congenital heart diseases are very serious problem of current perinatology. Early detection of congenital heart diseases and new possibilities of their treatment have decreased mortality rate in neonates. THE AIM OF THE STUDY: Was to present the reasons of the heart murmurs found in newborns, based on postnatal echocardiography. MATERIAL AND METHODS: The study group consisted of 107 neonates born in The Obstetrics and Gynaecology Clinic of Medical University in Warsaw in the period from 1st October, 2001 until 30th September, 2002, found to have murmurs during the observation in The Neonatology Department. RESULTS: Heart murmurs were detected in 107 infants out of 1291 born in The Clinic in this period. Out of the study group, echocardiography results were normal in fourteen children, and in ninety-three patients the echocardiography revealed one of the following abnormalities: persistent foramen ovale (FO), persistent ductus arteriosus (PDA), ventricular septum defect (VSD), insufficiency of tricuspid valve (IT) and others. CONCLUSIONS: The most frequently observed abnormality in echocardiography in infants with heart murmur was persistent foramen ovale. The rate of heart abnormalities was the highest in infants with birth weight below 1500 G.

Ductus Arteriosus, Patent↗
PubMed2004

[Concentration of bilirubin in the umbilical blood as an indicator of hyperbilirubinemia in newborns].

UNLABELLED: The aim of this study was to estimate the correlation between concentration of bilirubin in the umbilical blood and occurrence of icterus in newborns. MATERIAL AND METHOD: The study investigations covered 187 healthy, full-term newborns in good general condition. Newborns with serological incompatibility were not included into the study. In 155 (83%) cases babies were born through natural passages, in 32 (17%) by Caesarean section. The umbilical blood was taken immediately after delivery and the venous blood on the 3rd day of life to determine concentration of bilirubin. The concentration of bilirubin was determined by spectrophotometry. Bilirubin values lower than 12.9 mg% were considered physiological. Hyperbilirubinemia was recognized when the concentration of bilirubin was over 12.9 mg%. Pearson test was used to estimate the correlation between bilirubin value in the umbilical blood and the venous blood. In case when the value of correlation coefficient was statistically significant the linear regression equation was determined. RESULTS: The mean value of total bilirubin in the umbilical blood was 1.30 mg% +/- 0.47 and in venous blood on the 3rd day of life 8.07 mg% +/- 3.08. The value of concentration coefficient between concentration of total bilirubin, unconjugated and conjugated bilirubin was adequately 0.49 (p < 0.001), 0.31 (p<0.005) and 0.5 (p<0.001). No one with umbilical bilirubin concentration lower than 1 mg% developed hyperbilirubinemia. CONCLUSION: The concentration of bilirubin in the umbilical blood can be useful indicator of risk of icterus in newborns. The special care is need for newborns whose concentration of bilirubin in umbilical blood is over 1 mg%.

Adult↗
PubMed2004

The naloxone test in Klinefelter syndrome.

UNLABELLED: AIM TO THE STUDY: The investigation of the influence of anti-opioid drug on hypophyseal and gonadal hormones secretion in case of Klinefelter syndrome. MATERIAL AND METHODS: The naloxone test (0,4 mg iv) was performed in 14 patients with Klinefelter syndrome aged from 19 to 32 and in 12 age matched control subjects with azoospermia and normal spermatogenesis in testicular histology. The plasma levels of FSH, LH, prolactin, testosterone and estradiol were established before and after 30, 60, 60 and 120 minutes respectively, following the drug administration. RESULTS: Basal FSH, prolactin and estradiol levels were significantly higher whereas basal testosterone was significantly lower in patients with Klinefelter syndrome than in the control group. After the naloxone administration the mean plasma prolactin level decreased significantly (p=0.01) in Klinefelter subjects. The respective diminution in control group was not significant. The levels of FSH and LH as well as testosterone and estradiol did not change during the naloxone test in both Klinefelter and control subjects. CONCLUSIONS: The naloxone administration in Klinefelter syndrome caused the decrease in plasma prolactin levels but did not affect the plasma level of another hypophyseal and gonadal hormones. The opioid controlled gonadotropin secretion is altered in case of Klinefelter syndrome.

Adult↗
PubMed2004

[Course of twin pregnancies and labors in the 1st Department of Obstetrics and Gynecology, Medical University of Warsaw].

DESIGN: The aim of the study was to analyze the course of twin pregnancies and labors in the I Department of Obstetrics and Gynaecology, Medical University of Warsaw. MATERIALS AND METHODS: 124 cases of multiple pregnancy and labor that occurred in the I Department of Obstetrics and Gynecology within the period from 1994 to 2001 were retrospectively analyzed. RESULTS: The study revealed high risk of premature labor, premature rupture of the membranes (PROM), intrauterine growth retardation (IUGR) and pregnancy induced hypertension (PIH) in twin pregnancy. High incidence of cesarean sections was seen both in premature and at-term labors. Significant differences between the mean birth weight and Apgar score of I and II twin were observed. Differences in condition of the neonates were smaller in the group of twins born by cesarean section. CONCLUSIONS: The higher incidence of both obstetrical complications and cesarean sections is associated with twin pregnancies. An increased obstetrical risk and lower Apgar score are observed in case of vaginal delivery of the second twin. Cesarean section seems to improve obstetric results and diminish the differences in condition between the neonates.

Academies and Institutes↗
PubMed2003

[Accuracy of transvaginal sonography, sonohysterography and hysteroscopy in diagnosis of intrauterine pathology].

OBJECTIVES: Sonohysterography (SHG) is a relatively new technique in evaluation of intrauterine disorders. We compared the diagnostic accuracy of this method with that of transvaginal sonography(TVS) and diagnostic hysteroscopy (DH) in diagnosis of intracavitary abnormalities in women with abnormal uterine bleeding, inconclusive endometrial view at TVS and thickened endometrium. METHODS: In prospective study, pre- and postmenopausal women underwent TVS, SHG, and DH. The findings at TVS and SHG were compared with hysteroscopic and histologic findings (obtained from operative hysteroscopy, hysterectomy and d&c). Sensitivity, specificity, positive and negative predictive values were calculated for focally growing lesions. RESULTS: 150 patients were included in the study. There was very good agreement between SHG and DH in the diagnosis of focally growing lesions. SHG was more sufficient in detecting intracavitary abnormalities than TVS. Problems with distention of the uterine cavity were due to cervical stenosis and endometrial carcinoma. CONCLUSION: SHG is more accurate in the diagnosis of intracavitary abnormalities than is TVS. SHG is almost as good as DH at detecting focally growing lesions in the uterine cavity.

Adult↗
PubMed2003

[Pregnancy and labor in obese women].

DESIGN: An assessment of the course of pregnancy, labour and perinatal outcome in obese women was performed. MATERIAL AND METHODS: 127 obese (BMI > 27) and 1315 non-obese healthy women with singleton pregnancy were compared. All the women gave birth in 1st Department of Obstetrics and Gynecology, Medical University in Warsaw. RESULTS: Weight gain during pregnancy was markedly lower in obese women. The total percentage of gestational complications was significantly higher in pre-pregnancy obese women as well as the rate of cesarean deliveries. The birth weight and neonatal outcome was similar in analyzed groups. CONCLUSIONS: Pregnancy in obese women is associated with increased risk of complications reflecting the higher rate of cesarean deliveries.

Adult↗
PubMed2003

[Hysterectomy after caesarean section].

OBJECTIVES: The indications for hysterectomy after caesarean section, postoperative period, and pathological examination of women. In whom hysterectomy hampered operated delivery, are being hereby analysed. MATERIALS AND METHODS: The study group consisted of 15 patients who gave birth in I Clinic Medical Academy in Warsaw in 1995-2001. RESULTS: In 7 with 15 women (46.7%) the supravaginal amputation was carried on at the rest in 8 (53.3%), the corpus and cervix of uterine was resected. In pathomorphological examination a trophoblast growth into uterine muscle was found. In 8 women (53.3%). In 5 (33.3%) in histological examination empty vessels were recognized. In one patient (6.7%) carcinoma praeinvasivum of uterine cervix and in one (6.7%) carcinoma of ovary were found. CONCLUSIONS: Uterine atonia and abnormalities of placentae were the main indications for hysterectomy after delivery.

Adult↗
PubMed2003

[Chances in current prenatal diagnosis].

Authors present the actual trends in prenatal imaging diagnoses: screening obstetrical ultrasound (performed in every ultrasound lab), genetic (targeted) US + fetal echocardiography (performed in selected ultrasound lab), US 3D and 4D, panoramic studies, surgical US, fetal MR and social US study. Authors also present opinion about who, where and how should perform counseling after detection of fetal anomaly. Also current trends in obstetrical education are presented based on examples from West Europe and USA.

Congenital Abnormalities↗
PubMed2003

[Maternal and umbilical bilirubin concentration at the time of delivery depending on course of pregnancy and labour].

OBJECTIVES: Newborns hyperbilirubinemia is an interesting, complicated and controversial clinical problem. An elevated concentration of it can be connected with increased risk of jaundice. Also, maternal bilirubin can play a part in the development of jaundice in mature newborns. MATERIAL AND METHODS: The research included a group of 173 healthy, full-term newborns in generally good condition, with body mass between 5 and 95 percentile. Infants were born in 2002 at 1st Department of Obstetrics and Gynaecology Medical University in Warsaw. The maternal blood was collected during labour and the umbilical blood was collected immediately after delivery. RESULTS: The mean value of maternal bilirubin was 0.62 mg/dl, and of total bilirubin in the umbilical blood was 1.61 mg/dl. CONCLUSION: The differences between respective values in children delivered by caesarean section, whose mothers suffered from the infection during pregnancy or narcotic analgetic drugs that had been administered during labour were not statistically significant. Maternal bilirubin was higher in mothers with proteins < 6.0 g/dl. The umbilical bilirubin was statistically increased in children whose mothers oxytocin received.

Adult↗
PubMed2003

[Protocol of GNRH antagonist in poor responders in IVF-ET cycles].

INTRODUCTION: Response to stimulation is one of the factors that affect the results of infertility treatment in IVF-ET cycles. Poor responders as well as the occurrence of ovulation prior to the oocyte retrieval is a main reason of nearly 30% of cancellations of the treatment cycles. In poor responders high doses of gonadotrophins are sometimes required. However administration of gonadotrophins alone does not prevent premature LH surge. The aim of the study was to assess controlled ovarian stimulation protocols with GnRH antagonists (Cetrotide) in poor responders. MATERIAL AND METHODS: The study group consisted of 27 infertile women, mean age 35.8 (range 28-45) undergoing the second IVF cycle. In those women the first cycle was either cancelled due to the lack of follicles' development or the small number of growing follicles (1-2). Ovarian stimulation was started on the 2 day of cycle with administration of 225 IU or rFSH or hMG. Cetrotide was administered subcutaneously in a daily dose of 0.25 mg starting when estradiol serum concentration reached 150 pg/ml with a lead follicle 14 mm diameter and continued throughout the gonadotrophin treatment until HCG administration. RESULTS: In 31 cycles the mean number of MII oocytes retrieved was 4.71 (range 1-10). In one woman there was no mature oocytes obtained during pick-up. In one case the cycle was cancelled due to the bad response. The mean duration of cetrotide administration was 5.16 days. The mean number of rFSH and HMG ampoules was 23 and 30 respectively. The fertilisation rate was 64%. Embryo transfer was performed on the 3rd day after pick-up. The pregnancy rate in this group was 22%. There weren't any adverse effects of Cetrotide in treated women. No case of ovarian hyperstimulation syndrome occurred. CONCLUSION: Ovarian stimulation protocol with GnRH antagonist is effective in poor responders in IVF-ET cycles.

Adult↗