Acute cerebral ischemia in cats (both carotid arteries occlusion during 30 min after permanent occlusion of both vertebral arteries) was accompanied by postischemic hypoperfusion and hypo-oxygenation of the cerebral tissue. Intravenous infusion of cerebrocrast (1 micrograms.kg-1.min-1 during 60 min) prevented manifestation of the postischemic phenomena. Antihypoxic effect of cerebrocrast involved the cerebral blood flow increase, brain oxygen consumption lowering and Hb-O2-affinity decrease.

Acute Disease↗

PubMed1992

[Antioxidant effects of antihypoxic drugs in cerebral ischemia].

Cerebral ischemia in rats (both carotid arteries occlusion) during 30 min, 3 hours and recirculation (1 hour) after ischemia (30 min) stimulated diene conjugates and fluorescent products accumulation in brain tissue. Intraperitoneal injection of sodium hydroxybutyrate (100 mg/kg), bemitil (50 mg/kg), ethomersol (50 mg/kg) reduced brain lipid peroxidation and did not yield in this respect to emoxypin (5 mg/kg). In contrast to emoxypin, sodium hydroxybutyrate, bemitil and ethomersol had no antiradical activity.

Animals↗

PubMed1992

[Effects of cerebrocrast on local cerebral circulation and EEG in cats with cerebral hemorrhage].

In experiments on awake cats before and after intracerebral hemorrhage influence of cerebrocrast and nimodipine intravenous infusion (1 microgram/kg-1/min-1 during 60 min) on cerebral blood flow (CBF) in the cortex, thalamus and reticular formation and power of (alpha + beta)-, theta-, and delta-waves was investigated. During cerebrocrast infusion increasing CBF and improving bioelectrical activity were demonstrated.

Animals↗

PubMed1991

[The evaluation of the efficacy of antihypoxic agents lowering hemoglobin oxygen affinity in acute cerebral ischemia].

Influence of natrii hydroxybutyrate (100 mg/kg), ascorbate (100 mg/kg), cavinton (5 mg/kg), bemitil (50 mg/kg), ethomersol (50 mg/kg) on Hb-O2 affinity and cortex PO2 after both carotid artery occlusion in rats was investigated. Correlation (r-0.87; P less than 0.05) between lowering of Hb-O2 affinity and antihypoxic effect was demonstrated in the line of these drugs.

Acute Disease↗

PubMed1991

[Effects of ethomersol on cerebrovascular blood circulation and oxygen metabolism of the brain in acute transient ischemia and recirculation].

Intravenous infusion of ethomersol (50 mg/kg during 60 min) decreased cerebral tissue hypoxia at the end of acute cerebral ischemia in cats (30-min occlusion of both carotid and both vertebral arteries). In recirculatory period ethomersol prevented the postischemic hypoperfusion and especially hypo-oxygenation. Ethomersol-induced reduction of Hb-affinity to O2 was demonstrated.

Acute Disease↗

PubMed1990

[Dimethyl sulfoxide as a corrector of disorders of cerebral hemodynamics, oxygen and carbohydrate metabolism of the brain and lipid peroxidation in the early period after intracerebral hemorrhage].

Intraperitoneal injection of DMSO (0.7 g/kg) in rats 1h after intracerebral hemorrhage prevented brain conjugated diens and fluorosciene products increase and limited cerebral ++anti-radical activity. In experiments on cats 1h after intracerebral hemorrhage intravenous infusion of DMSO (0.3 g/kg) for 30 min improved cerebral hemodynamic, oxygen and glucose metabolism; cats mortality was decreased.

Animals↗

PubMed1989

[Antihypoxic and antioxidative properties of bemitil].

The authors discovered antihypoxic properties of the bemitil (pretreatment injections 50 mg/kg intraperitoneally) in the experiments on rats with the circulatory or hypoxic hypoxia. There was limitation of pO decrease and diene conjugates and Schiff bases production increase with the drug in the circulatory hypoxia conditions. Bemitil restricted malondialdehyde accumulation in the rat brain homogenate under the activation of free radicals processes. In the mitochondrial suspension incubation similar effect of the medicine was accompanied with limitation of organelle degradation. Bemitil showed no antiradical activity.

Animals↗

PubMed1988

[Isothiobarbamine prevention of disorders of carbohydrate and oxygen metabolism and of the development of brain edema in the early period after an intracerebral hemorrhage].

In experiments on cats after injection of isothiobarbamine intravenously (50 mg/kg) at 30 min, intracerebral hemorrhage prevented activation of brain glucose utilization, depression of brain oxygen utilization, surplus lactate accumulation in brain, early development of brain edema and death of cats.

Animals↗

PubMed1988

[Activation of lipid peroxidation in the brain in cerebral hemorrhage].

The effect of intracerebral hemorrhage (injection of 0.15 ml of autogenic blood during 2 min in capsula interna) on lipid peroxidation in brain tissue was studied in rat experiments. Intracerebral hemorrhage resulted in a progressive increase of conjugated diene and malonic dialdehyde concentrations, and a decrease in the levels of cerebral lipids antiradical activity. This effect appeared by the 3-rd hour and was significantly manifest 24 hours after the blood injection into the brain.

Animals↗

PubMed1984

[Pathogenetically based correction of cerebral circulatory hypoxia in the acute period of experimental intracerebral hemorrhage].

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Acute Disease↗

PubMed1977

[Effect of dibazol on cerebral blood supply and EEG in experimental intracerebral hemorrhage].

A hemorrhage into the right internal capsule in vigilant cats is accompanied by a drop of focal cerebral blood flow in the sensomotor cortex, in the thalamus and reticular formation of the middle brain of both hemispheres, an appearance of slow-wave high amplitude in the EEG activity and in some cases of convulsive discharges. Such changes of the blood flow and bioelectrical activity are preserved in survived cats after 24 hours following hemorrhage. An intracarotid singular injection (Img/kg) and especially a 30 minute infusion of 0.5% solution of dibasol brings about in most of the cases an increase of the blood flow in the studied brain structures, and is accompanied by a partial normalization of bioelectrical activity.

Animals↗