[EEG and local cerebral blood flow recording in different regions of the brain in awake cats].
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Animals↗
Biomedical subjects
M B Plotnikov
Publications and source records attributed to M B Plotnikov.
[The correction of the increased blood viscosity syndrome in brain ischemia in rats with a combination of dikvertin and ascorbic acid].
In experiments in vitro on a model of the syndrome of increased blood viscosity dikvertin reduced blood viscosity, weakened aggregation of red cells and raised their property of becoming distorted. A mixture of dikvertin and ascorbic acid improved the hemorrheologic parameters better than do dikvertin and tanakan. On a model of chronic ischemia of the brain of rats attended with deterioration of blood rheologic parameters, it was demonstrated that a course of treatment with a dikvertin and ascorbic acid complex decreases the manifestations of the syndrome of increased blood viscosity.
Animals↗
[The hemorheological effects of Lychnis chalcedonica L. extracts].
The hemorrheological effects of extracts from Maltese cross campion (Lychnis chalcedonica L.) prepared using 40% (I) and 70% (II) aqueous ethanol solutions were studied in vitro in comparison with tanakan on the model of high blood viscosity syndrome. Under the hyperthermia conditions, extracts I and II at a concentration of 1 x 10(-5) g/ml limited the growth of blood viscosity and thrombocyte aggregation and the drop in thrombocyte deformability. The effects of both extracts were comparable to those of tanakan. Prolonged (5 days) administration of extract I (daily dose, 150 mg/kg p.o) in rats with arterial hypertension (SHR) decreased the viscosity of whole blood and plasma, reduced the concentration of fibrinogen, and increased the deformability of erythrocytes. No reliable effects of the extracts in vivo upon the erythrocyte aggregation and hematocrit were observed.
Animals↗
[Evaluation of major pharmacokinetic parameters of high molecular weight polyethylene oxide using polymer hydrodynamic properties].
The pharmacokinetics of high-molecular-weight polyethylene oxide (HMW PEO)--a parent compound in the polietoks drug--was experimentally studied in cats. A PEO concentration in the blood was determined by measuring a decrease in the hydrodynamic resistance for a blood sample flowing in the turbulent mode via a glass capillary. Variation of the polymer concentration in the blood is described by a single-exponent function with an elimination halftime of T1/2 = 3.15 h. According to the calculation, 99.6% of the initial amount of PEO losses the antiturbulent activity within 24 h.
Animals↗
[Laxative effect of poly(ethylene oxide) 1500 per se and in combination with bisacodyl].
The results of experiments on rats showed evidence of a laxative activity of poly(ethylene oxide) (PEO-1500) upon peroral administration. This effect is related to the polymer ability of retaining water, which increases the intestinal content volume and accelerates the intestinal peristaltic activity. The anticonstipative effect of PEO-1500 is comparable to that of forlax, but less pronounced than the effect of bisacodyl. The joint administration of PEO-1500 with bisacodyl produces a synergistic effect exceeding the separate action of both agents.
Animals↗
[Effect of Rhaponticum carthamoides extract on hemorheological properties of blood in rats with arterial hypertension].
The hemorheological activity of a dry extract from Rhaponticum (Leuzea) carthamoides (Willd.) Iljin. was studied in spontaneously hypertensive rats (SHRs). A 14-day treatment of the test rats with a daily dose of 150 mg/kg improved the rheological characteristics, as manifested by a reduced viscosity of the whole blood and plasma, increased spontaneous erythrocyte aggregation and fibrinogen concentration, and increased erythrocyte deformability and electrophoretic mobility against the untreated control level.
Animals↗
[Effect of trimethoxybenzoate-1,2-oxyethylbenzimidazole and dibazol on the blood supply of the brain].
Tests staged on cats demonstated that intact animals and under conditions of the cerebral circulation restricted through intra-arterial infusion of serotonin-1,2-oxyethylbenzimidazole trimethoxybenzoate hydrochloride and dibazol caused with their intracarotic injection a material increase of the blood supply to the brain, exercising a vasodepressor action on the major functional divisions of its vascular system.
Animals↗
[Hemorheological effects of polyethylene oxide in rats with acute myocardial ischemia].
The effect of polyetox, a medicinal form of high-molecular-weight poly(ethylene oxide) (HMWPEO) on the rheological properties of blood and the necrotic zone size was studied in rats with an acute myocardial ischemia model (on the 5th day after coronary artery occlusion). The drug was infused intravenously in a single daily dose over a period of three days, which resulted in a final HMWPEO concentration of 1 x 10(-6) g/ml in the blood. The first treatment was carried out 1 h after coronary artery occlusion. Animals in the cotrol group with myocardial infarction exhibited high blood viscosity syndrome with stable decrease in the hydrodynamic index. The administration of polyetox reduced blood viscosity, decreased the erythrocyte aggregation, and increased the antiturbulent properties (hydrodynamic index) of the blood. The myocardial infarction zone decreased by 38%, which was manifested in improved EEG parameters.
Animals↗
[Experience in the use of polyosm in the treatment of edematous maculopathy].
The efficiency and tolerability of using a new osmotic diuretic, i.e. polyosm (a solution of polyethylene oxide 400 for the intravenous administration), was studied in patients with edematous maculopathy of different geneses. The drop-by-drop introduction of polyosm, 200 ml (the dose amounted to 0.8-1 g/kg in terms of polyethylene oxide 400), one per day and during 3 days, proved the efficiency of the preparation as a corrector of edematous maculopathy, which was confirmed by an involution of the eye-tissue edema, reduced sizes of the central scotoma, and by an improved visual acuity. The tolerability of the course-based administration of polyosm by patients was found to be good and satisfactory. No negative impact produced by the preparation on the indices of central hemodynamics was detected; the hypotensive effect of polyosm was found, as a normalized level of the systolic and diastolic pressure, only in patients with an originally high arterial pressure. Hypokalemia was, after the course-based use of polyosm, of a moderate nature.
Adult↗
[The mechanisms of the ethomersol correction of postischemic hypoperfusion].
In rat experiments during brain ischemia (30-min carotid artery occlusion), ethomersol administered intraperitoneally in a dose of 50 mg/kg before occlusion or at the end of ischemia eliminated postischemic hypoperfusion. The effect of the drug was due to its spasmolytic and antiaggregatory activities. An analysis of the vasodilating action of ethomersol revealed its capacity to block potential-dependent calcium channels and partially intracellular calcium mobilization when the adrenergic and serotoninergic receptors were activated. The antiaggregatory activity of the drug appeared as inhibited platelet aggregation, which was induced by ADP, serotonin, arachidonic acid, thrombin, and as enhanced antiaggregatory activity of the vascular wall.
Animals↗
[Preparation polyosm in the treatment of glaucoma].
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Adult↗
[Hemodynamic and rheological effects of polyetox in rats with crush syndrome].
Polyetox, a medicinal form of high-molecular-weight poly(ethylene oxide) (HMWPEO) improved peripheral blood supply, normalized the overall oxygen consumption, decreased erythrocyte aggregation, and reduced blood viscosity at low shear rate, and restored the antiturbulent properties (hydrodynamic index) of blood in the experiments on rats with crush syndrome. In rats with low resistance, polyetox increased the cardiac output.
Animals↗
[Cerebroprotector activity of Rhaponticum carthamoides extract in rats with brain ischemia].
Electron microscopy and electrophysiological data reveal pronounced structural and functional disturbances in cerebral cortex of rats with model brain ischemia. A 5-day treatment with a dry extract from Rhaponticum carthamoides (Willd.) Iljin. in a daily dose of 150 mg/kg (p.o.) equivalent to 2.7 mg ecdysterone per kg body weight reduced manifestations of the ischemic damage, improved the structure of neurons, and restored brain activity (EEG parameters).
Animals↗
[The main pharmacokinetic parameters of p-tyrosol upon intravenous injection in rats].
The main pharmacokinetic parameters ofp-tyrosol upon intravenous injection have been experimentally studied in rats. The drug concentration in the blood was determined by means of spectrofluorimetry. It is established thatp-tyrosol rapidly penetrates into organs with high blood supply. The drug is rapidly eliminated from rat organism, with T1/2 approximately 70 min.
Animals↗
[The main pharmacokinetic parameters of p-tyrosol upon intravenous injection in rats. II. Verification of the pharmacokinetics linearity and evaluation of the possible accumulation].
The main pharmacokinetic parameters of p-tyrosol after single (in 3 doses) and repeated intravenous injection were studied in rats. The content ofp-tyrosol in the blood plasma was determined by spectrofluorimetric method. The pharmacokinetic parameters of p-tyrosol are linear in the dose range from 50 to 200 mg/kg. Repeated administration leads to accelerated metabolic elimination of p-tyrosol.
Animals↗
[Polyethox corrects hemodynamic and hemorrheological disturbances after infusion-transfusion therapy of massive hemorrhage].
Inclusion of polyethox, a medicinal form of high-molecular (4,5 x 10(6) Da) poly(ethylene oxide), into infusion-transfusion therapy of massive hemorrhage (33% of blood volume) in cats leads to an increase in the stroke and cardiac indices, restores antiturbulent and hemorrheological properties of blood, increases systemic oxygen transport, and reduces hypoxic acid-base balance disturbances.
Acid-Base Equilibrium↗
[A method for choosing preparations that alter hemoglobin binding to oxygen].
A simple method for investigating drug effect on hemoglobin oxygen affinity by the estimation of HbO2 (%) in blood with and without drugs after gas mixture saturation (4% O2, 5% CO2, 91% N2) is proposed.
Animals↗
[Effect of foridon on the blood supply of the cat brain in health and in intracerebral hemorrhage].
In experiments on anesthetized cats, foridone (1 and 3 micrograms/kg/min intravenously) was found to increase cerebral blood flow by 6-26% with a moderate decrease of systemic arterial blood pressure indicating that the drug possessed properties with respect to a selective cerebral vasodilatator. Phenygidine (0.3-3 micrograms/kg/min) did not exhibit such a property. Intravenous administration of foridone (1 microgram/kg/min) to cats one day after intracerebral hemorrhage produced a significant improvement of blood supply to the brain, glucose utilization by the brain, a moderate increase of oxygen consumption.
Acid-Base Equilibrium↗