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Biomedical subjects

M Corazza

Publications and source records attributed to M Corazza.

At least 19 recordsLinked to original sources
PubMed2003

Primary cutaneous CD30+ large T-cell lymphoma in a patient with psoriasis treated with cyclosporine.

We report the case of a 61-year-old woman who developed an anaplastic CD30+ cutaneous T-cell lymphoma during oral cyclosporine (CsA) therapy for recalcitrant psoriasis. Two months after CsA discontinuation, clinical and histological resolution of the lymphoma was observed. However, 3 years later extracutaneous involvement of the lymphoma could be detected. The association between CsA administration and the occurrence of the lymphoma may be casual, but a relationship with immunosuppression may also be hypothesized. We have reviewed all relevant data in the literature. To our knowledge, this is the first case of primary cutaneous CD30+ anaplastic large T-cell lymphoma in a patient treated with CsA for psoriasis.

Biomarkers, Tumor↗
PubMed2002

Proliferation activity in oral and cutaneous canine melanocytic tumours: correlation with histological parameters, location, and clinical behaviour.

A total of 62 canine melanocytic tumours (10 melanocytomas and 52 primary malignant melanomas) were investigated to compare the accuracy of prognosis provided by MIB-1 proliferation index (MIB-1-PI) with classical histological criteria and location. MIB-1-PI was assessed by means of quantitative image analysis of sections immunostained with MIB-1 monoclonal antibody. Tumour location, histological cell type, stromal or lymphatic vessel invasion, maximum tumour thickness, and presence of inflammation or necrosis were recorded for each case. Thirty-eight dogs were submitted to a 1-year follow-up and the clinical outcome of the disease determined. MIB-1-PI in melanocytomas differed significantly from that detected in primary malignant melanomas (P=0.0001). A significant difference in MIB-1-PI was revealed between oral and cutaneous malignant melanomas (P=0.015), and between presence and absence of lymphatic vessel invasion (P=0.05). MIB-1-PI was not correlated with the other parameters. In univariate analysis, only tumour location (oral vs cutaneous), presence of lymphatic vessel invasion, and MIB-1-PI were associated with decreased overall survival (P=0.0001,P=0.0144, and P=0.0489, respectively). In conclusion, the results of our study confirm that the assessment of the MIB-1-PI may be of additional prognostic value for dogs with primary malignant melanomas.

Animals↗
PubMed2002

Dermatophytes isolated from symptomatic dogs and cats in Tuscany, Italy during a 15-year-period.

Between January, 1, 1986 and December, 31, 2000, dermatological specimens from 10.678 animals (7.650 cats and 3.028 dogs) were examined for dermatophytes. All the animals presented clinical signs of ringworm. Two thousand-four hundred fifty-six of the 10.678 (23%) examined animals scored positive for dermatophytes, 566 out of 3.028 canine (18.7%) and 1890 out of 7.650 feline specimens (24.7%). Microsporum canis constituted 83% and 97% of the isolated dermatophytes respectively in dogs and cats, M. gypseum represented 13% and 2.6% and T. mentagrophytes 5.5% and 0.2%. A sexual predisposition for mycotic infections was not observed. The animals with less than 1 year of age were more frequently infected. Canine toy breeds showed a significantly higher (P < 0.001) prevalence of infections by M. canis. Microsporum gypseum was mostly recorded from sporting (hunting) breeds [such as T. mentagrophytes (6.7%)]. Microsporum canis was isolated from long-haired cats with a ratio of 2:1 versus short-haired cats, while M. gypseum and T. mentagrophytes were never recovered from Persian cats. The annual distribution of the infections in dogs showed a significantly higher incidence for M. gypseum in summer versus winter and spring, while the recovery rate of M. canis from cats was very significantly higher in fall and winter than in summer and spring. Trichophyton mentagrophytes did not show a similar seasonal distribution.

Animals↗
PubMed2001

Extracellular enzymatic activity of Malassezia spp. isolates.

Extracellular enzymatic activity of different species of Malassezia spp was evaluated. Thirty-three isolates of animal origin (dogs and cats) and stock culture samples were studied. Twenty isolates of M. pachydermatis, 8 of M. furfur, 2 of M. sympodialis and M. globosa and one of M. restricta, M. obtusa and M. slooffiae were examined. The enzymatic activity was investigated using Api Zym system. The enzymatic patterns showed light differences. Esterase lipase, Phosphatase acid and Naphtol-AS-BI-phosphohydrolase were produced in significant amounts from most isolates excepted for M. restricta, confirming the limited enzymatic activity of this species. Data obtained from the other new species described after the revision of the genus, appear to be quite homogeneous. Dixon's broth appeared to be a valid medium for the growth of all Malassezia spp.

Acid Phosphatase↗
PubMed2001

Five cases of livedo-like dermatitis (Nicolau's syndrome) due to bismuth salts and various other non-steroidal anti-inflammatory drugs.

The authors report five cases of Nicolau's syndrome observed over a period of about 25 years. The disease had occurred after intramuscular injections of different drugs (bismuth, diclofenac and ibuprofen). In all the described cases the clinical aspect was characterized by a livedoid pattern followed by a slow necrotizing evolution with scar formation; in some cases surgical debridement and plastic reconstructive surgery were performed. In the past Nicolau's syndrome was described after intramuscular injections of bismuth salts for the treatment of syphilis; now, although still rare, it is described after injections of various aqueous drug solutions. The pathogenesis of Nicolau's dermatitis appears to be more complex than the previous hypothesized embolism caused by oleous drugs.

Adult↗
PubMed2001

Managing vulvar lichen simplex chronicus.

OBJECTIVE: To develop a flow chart indicting which tests to perform with the aim of helping physicians with the diagnosis, management and treatment of lichen simplex chronicus. STUDY DESIGN: We reviewed the data on vulvar lichen simplex chronicus patients to delineate proper management. RESULTS: Patch test should be added to the series of tests performed to ascertain the causes of vulvar lichen simplex chronicus. CONCLUSION: Among the stimuli that may trigger vulvar lichen simplex chronicus, not only infections and irritating factors but also sensitization must be kept in mind, especially in long-lasting disease.

Decision Trees↗
PubMed2000

Airbag dermatitis.

Explore the source record for details and available documents.

Accidents, Traffic↗
PubMed2000

Anaerobic sealants: still a problem today.

Acrylic anaerobic sealants are widely used in engineering and electronic industries. They may induce allergic contact dermatitis of the first three fingers and onycholysis. We report a case of allergic contact dermatitis due to anaerobic sealants and we underline some practical problems connected with the frequency of sensitization, patch-testing and material safety data sheet availability.

Acrylates↗
PubMed2000

Vulvar hidradenoma papilliferum. A review of 10.5 years' experience.

OBJECTIVE: To analyze 10.5 years' experience with hidradenoma papilliferum in Ferrara, Italy. STUDY DESIGN: Review of 8 cases plus 25 from other area clinicians. RESULTS AND CONCLUSION: The clinical aspects of hidradenoma papilliferum are confusing. The tumor is uncommon, so physicians do not gain enough experience to recognize it. Histology is diagnostic and simple excision curative.

Adenoma, Sweat Gland↗
PubMed2000

Serious hematoma of the vulva from a bicycle accident. A case report.

BACKGROUND: Vulvar hematomas may be caused by obstetric, athletic or sexual trauma or by car or bicycle accidents. CASE: A 29-year-old woman presented with a serious vulvar hematoma caused by a straddle bicycle accident. Monitoring of the hematologic parameters showed progressive anemia resulting from silent bleeding, which required surgical evacuation of the hematoma and complete hemostasis. CONCLUSION: The rich vulvar vascular network may be easily damaged by contusive frontal impacts, which crush the vulvar tissues against the osseous planes. Management of vulvar hematomas may range from conservative to surgical. Drainage and incision are advised in more severe cases to reduce infective complications and hospitalization.

Adult↗