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Biomedical subjects

M D Gaevyĭ

Publications and source records attributed to M D Gaevyĭ.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

[The anti-ischemic effects of 3-hydroxypyridine derivatives in cerebrovascular pathology].

The effect of the antioxidant mexidol and two new derivatives of 3-oxypyridine, namely LBK-10 and LBK-39 on the circulation of blood and metabolism of the brain in the postischemic period was studied in acute experiments on narcotized cats under conditions of autohemoperfusion of the cerebral vessels with a stable volume of blood. Therapeutic injection of mexidol and LBK in a dose of 20 mg/kg inhibited the development of the no-flow phenomenon and restored the ischemia damaged metabolism in the brain tissues. LBK-10 reduced the lactate content in the blood flowing from the brain and contributed to constriction of the cerebral vessels.

Animals↗
PubMedDate not supplied

[The action of emoxipin, lithium oxybutyrate and pikamilon on the blood circulation of the ischemic brain].

Acute experiments were conducted on rats under nembutal anesthesia to compare the efficacy of emoxipin with that of lithium oxybutyrate and picamilon in the postischemic period after preventive and therapeutic injections in various doses. Emoxipin proved to be most effective in prevention of postischemic non-restoration of the flow of blood in the brain and in preservation of the autoregulation responses of the cerebral vessels. The possible mechanisms of the effect of the drug are discussed.

Acute Disease↗
PubMedDate not supplied

[Brain ischemia induced by gravitational overload].

It is suggested that radial gravitational overloads in craniocaudal direction, during which the pressure in meningeal arteries drops to zero, can be used to model the ischemic state. The post-ischemic period is characterized by increasing content of lipid peroxidation products in the venous blood and by violation of the neurological state in rats. This ischemia model, requiring no anaesthesia for the experimental animals, can be used in the directed search for new neuroprotectors and their characterization.

Animals↗
PubMedDate not supplied

[Effect of sodium salicylate on the cerebral blood circulation (an experimental and clinical study)].

The effect of sodium salicylate (100 mg/kg intravenously) on the circulation rate of the cerebral blood flow, total arterial pressure, oxygen tension in the cerebral tissue (by the polarographic method) and on the pressure in the brain venous vessels was studied on anesthetized cats with controlled respiration. In rheumatic patients the action of the drug (10 ml of a 10% solution, intravenously) on the rheoencephalographic findings and the total arterial pressure was investigated. Sodium salicylate was shown to raise the tonicity of the intra- and extracranial vessels, to lower the amplitude of the pulse fluctuations and to highten the total arterial pressure. The cerebral circulation depends upon changes in the tonicity of the cerebral vessels and on the total arterial pressure, i. e. with a significant rise of the latter it increases in spite of a greater vascular resistance. Changes in the blood flow are followed by corresponding variations in the PO2 of the brain tissue. No significant changes of the pressure in the venous system of the brain could be established.

Adult↗
PubMedDate not supplied

[Effect of ketamine on cerebral circulation of intact and ischemic animals].

The influence of ketamine on the local cerebral circulation was studied in intact rats and under the conditions of global brain ischemia. The drug increased the local blood flow in intact rats. Despite pronounced hypotension accompanying the global brain ischemia, ketamine helped maintenance of the cerebral circulation.

Animals↗
PubMedDate not supplied

[Effect of dopamine on the blood circulation and metabolism in the brain during ischemia].

In acute experiments on anesthetized cats under blood autoperfusion of cerebral and peripheral vessels with a stable volume of blood during cerebral ischemia there was revealed the vascular and metabolic effects of dopamine on cerebral circulation. Administration of dopamine by perfusion in a dose of 100 micrograms/kg/min for 35 min after ischemia inhibited the development of postischemic hypoperfusion of the brain and also eliminated postischemic hypotension. A significant effect of dopamine on oxidative metabolism of the brain was observed.

Animals↗
PubMedDate not supplied

[Effect of komplamin and nikoshpan on brain circulation and metabolism in the postischemic period].

Intravenous administration of komplamin to anesthetized cats before the brain ischemia or in the early period following ischemia prevents the development of the postischemic phenomenon of the cerebral blood flow nonrecovery and beneficially influences the cerebral metabolism: restores oxygen and glucose consumption by the brain, decreases pyruvic acid level in the arterial and venous blood, attenuates the phenomenon of acidosis. Nikoshpan improves the blood supply to the brain, restores oxygen and glucose consumption by the brain in the postischemic period only if administered before the brain ischemia.

Animals↗
PubMedDate not supplied

[Effect of euphylline and no-shpa on cerebrovascular resistance and the survivability of animals after cerebral ischemia].

In acute experiments on anesthetized cats with total ischemia of the brain (15-minute arrest of blood autoperfusion of the cerebral vessels by a stable blood volume) it was shown that euphylline and no-shpa administered before ischemia or in the early period after ischemia inhibit or prevent the development of the postischemic phenomenon of non-recovery of the cerebral blood flow. The two drugs contributed to survival of albino rats following the brain ischemia produced by ligation of both carotid arteries.

Aminophylline↗
PubMedDate not supplied

[Use of gravitational loads as a screening method in research on new biologically active substances].

The application of longitudinal gravitational overloads in white rats in craniocaudal and caudo-cranial directions modelled on a centrifuge is suggested for the screening of bioactive agents. The time and value of the overload are selected in such a way, as to kill 50% of animals in the control experiments. The same overload is given to animals that have previously received the tested agents. The difference in the survival rate of these animals and the control ones serves as the indicator of activity of the new compounds. This method reflects mainly the functional stability of the system of cerebral circulation.

Acceleration↗
PubMedDate not supplied

[Effect of dibasol and several of its imidazo-analogs on the resistance of animals to gravitational overloading and the dynamics of the development of post-ischemic cerebrovascular phenomena].

Anesthetized and nonanesthetized animals (white rats and cats) were used to study the effect of dibasol and its new imidazo analogs (designated AKS-67 and AKS-87) on animal tolerance to gravitational effects and cerebral ischemia (ligation of both carotid arteries) as well as on systemic arterial pressure and tone of cerebral and peripheral vessels (resistographically) in the postischemic period. The drugs were administered 30-90 min before exposure. It was found that in nonanesthetized rats dibasol and AKS-87 increased tolerance to cranio-caudal acceleration and decreased it to caudo-cranial acceleration, whereas AKS-67 produced a distinct protective effect regardless of the vector. In anesthetized rats (bilateral carotid ligation) AKS-67 and AKS-87 increased acceleration tolerance and dibasol produced no protective effect. Dibasol enhanced postischemic hypotension while AKS-67 and AKS-87 delayed or completely arrested it. For aerospace medicine the drug AKS-67 is of particular importance because it increases significantly animal tolerance to acceleration and stabilizes arterial pressure in the postischemic period.

Animals↗
PubMedDate not supplied

[Effect of complamine and nicospan on the cerebral blood flow and its regulation in changes in blood pressure].

Acute experiments on anesthetized cats under the conditions of artificial respiration were made to study the action of intravenous injection of complamine (75 mg/kg) and nicospan (0.5 ml/kg) on the cerebral blood flow (CBF), arterial blood pressure in venous vessels of the head (VP) and autoregulatory reactions (AR) of cerebral vessels at different levels of arterial blood pressure. The results of experiments indicate that both drugs provoke phasic (dilatation-constriction) responses of cerebral vessels, reduction of the CBF and a decrease in BP and VP. Unlike complamine, nicospan often caused at first a short-term increase in the CBF and VP followed by their lowering as compared with the initial values. Both the drugs brought about alterations in AR of cerebral vessels toward lower levels of BP.

Animals↗