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Biomedical subjects

M Gerard

Publications and source records attributed to M Gerard.

At least 73 records · Page 4Linked to original sources

[Therapeutic embolization in ORL pathology. Indications and results].

The progress of therapeutical embolization in otolaryngology was made possible by the arrival of new techniques which allowed the embolization of the different ramifications of the arteria carotis externa. The embolization technique is based on two principles: 1. The embolus is to be injected in a super-selective way, after catheterization of the pathological blood vessels. 2. The mass of the embolus has to be big enough to be able to obstruct the pathological vessel. Therefore the femoral way is mostly used. The aim of embolization is to create a spontaneous thrombosis around the used particles. The thrombosis thus succeeds in completing the embolization. The principal counter-indications against embolization are due to facts of a technical and a geographical order. Incidents and accidents are often related either to the catheterization, or to the contrast-media, or also to the anastomoses which become functional after the embolization. The major complications are hemiplegiae, aphasiae and eyesight troubles, all problems brought about by ischaemia are: --the indications for isolated embolization, amongst which have to be pointed out the surgical counter-indications, severe epistaxis, vessel malformations, important cranio-facial angiomatosis, the telangiectasical family angiomatosis of Rendu-Osler, and the antalgic effect of embolization, in particular in cancer treatment; -- an excellent indication for embolization is the prevention of massive hemorrhages and the simplification of the surgical act, in particular in hypervascularized ORL tumours, either benign or malignant, for instance the naso-pharyngeal fibrome and the whole of the malignant tumours and of the metastases of the ORL sphere. To conclude, we may say, that, within skilled hands and when taking the usual precautions, accidents in embolization are exceptional, and that embolization remains a therapeutical process with great prospects.

Adult↗

[Labio-palatal cleft and hearing disorders. Study of 72 cases].

The authors propose a systematic surveillance plan in otolaryngology for patients having velopalatal insufficiency. This study was based on 72 children operated for palatoschisis. They described the pharyngo-sinusal consequences secondary to defective nostril permeability and its rapport with auditory problems. They demonstrated the primordial importance of adequate microscopic examination of the ears and impedance measurements in evaluating otological lesions. In addition, they study the results of the treatments wokgone by these patients and their complications. Other than functional reparatory surgery of malformations, primary ENT care and follow-up, eradication of infections and drainage of secretions one must rehabilitate the postadenoidectomy patient. In spite of the risks concerning phonation there is considerable amelioration of rhinopharyngeal and otological problems. In addition transtympanic drainage remains important in the symptomatic treatment and prevention of evolution towards chronic mucous otitis.

Acoustic Impedance Tests↗

[Current therapy of juvenile nasopharyngeal angiofibroma].

The nasopharyngeal angiofibrom continues sometimes to challenge the otolaryngologists because of the difficult radical surgery owing to the deep anchorage of the tumor in the base of the skull. In these cases, when possible, the embolization followed by surgery or the radiotherapy are the two better treatments. Without embolization, radiotherapy must be preferred because of the life threatening surgery that cannot eradicate the tumor.

Adolescent↗

Comparison of sisomicin and gentamicin in bacteriuric patients with underlying diseases of the urinary tract.

Sisomicin and gentamicin (2 mg/kg) were administered in a random fashion to patients with bacteriuria superimposed on abnormalities of the urinary tract. Cure was achieved in a similar number of patients in both groups, but superinfection and reinfection with resistant microorganisms was more frequent in patients receiving gentamicin. Untoward side effects were not frequent in this series, especially if the serious underlying urological disease of most patients is taken into consideration. The susceptibility of the causative pathogens to the antibiotic administered and the severity of the underlying disease were the most important factors in the outcome.

Anti-Bacterial Agents↗

Preovulatory and ovulatory mechanisms in oocyte maturation.

Studies of the effect of gonadotrophins on the cumulus and oocyte or on the whole follicle in vitro offer a good tool for understanding the mechanisms of oocyte maturation, the ability of follicles of different sizes to respond to gonadotrophins and the processes of atresia. The birth of normal young from intrafollicular oocytes matured in vitro furnishes proof that in-vitro techniques are valuable as long as follicular integrity is maintained during the whole culture period.

Animals↗