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Biomedical subjects

M Grabowska

Publications and source records attributed to M Grabowska.

At least 55 records · Page 3Linked to original sources
PubMedDate not supplied

Influence of apomorphine on brain serotonin turnover rate.

Apomorphine (5.0 mg/kg) accelerated the disappearance of 5-HIAA from the brain of pargylinepretreated rats as well as depletion of brain 5-HT caused by inhibition of its synthesis. The latter effect has been abolished by spiroperidol. The results obtained suggest that apomorphine increases the 5-HT turnover rate, secondary to the stimulation of central dopamine receptors.

Amides↗
PubMedDate not supplied

[Evaluation of treatment and preventive care for recurrent urolithiasis in children].

Among 425 children with urolithiasis treated in the Paediatric Clinical Department of the National Research Institute of Mother and Child in Warsaw between 1976-1997, 50 of them i.e. 11.7% (26 boys and 24 girls) had recurrent urolithiasis. Patients' age was from 10 months to 16 years and 5 months. The number of recurrences of uroliothiasis before treatment in the Institute was from 1 to 8. Most of the children had numerous surgical operations, some of them excreted stones spontaneously. The etiology was determined in all cases. A metabolic cause of urolithiasis was found in 34 cases, i.e. 68% of the analysed group. They were as follows: idiopathic hypercalcuria--24 cases, uric acid urolithiasis--5 cases, cystynuria--4 cases, and incomplete distal renal tubular acidosis--1 case. Other reasons for urolithiasis were: infection--7 cases, idiopathic urolithiasis--8 cases, ren spongiosum--1 case. Prevention of recurrences depending on the etiology was successful. In 45 cases no recurrences were found. Recurrent urolithiasis was observed in 4 cases of cystynuria and in one case of incomplete tubular acidosis. The observation period was from 3-19 years.

Adolescent↗
PubMedDate not supplied

The effect of buthobendin on human erythrocyte membrane ATPases.

The effect of buthobendin (CravitenR) on the ATPase activities/total (Na, K, Mg)-ATPase, and the ouabaine-sensitive (Na, K-ATPase) and insensitive (Mg-ATPase) fractions/from human erythrocyte membrane was examined in the presence or absence of liposomes. The activities of both ATPase fractions increased by 250% in the presence of 10 mmol/l phosphatidylcholine. Buthobendin inhibited both ATPases, but especially Na, K-ATPase. This inhibitory effect was much greater in the hydrophobic milieu of liposomes. The inhibitory effect was proportional to the drug concentration and was stereospecifically related only to the 2S, 2'S isomer. Isomer 2R, 2'R and epinephrine used for comparison did not show any similar inhibitory influence. The decrease in ouabaine-sensitive ATPase activity under the influence of buthobendin might cause changes in cation distribution and cell membrane polarization. An inhibitory effect was also observed in vivo, after single iv administration of buthobendin to patients with ventricular arrhythmias and elevated activities of both erythrocyte membrane ATPases. Complete normalization of cardiac rhythm in about 30% of patients was accompanied - in the sensitive group of patients - with a decrease in Mg-ATPase activity without any changes in elevated Na, K-ATPase activity. In the group of patients resistant to buthobendin therapy both ATPases remained unchanged.

Adenosine Triphosphatases↗
PubMedDate not supplied

Synthesis and pharmacological properties of the products of condensation of tryptamine derivatives with pyridoxal.

Four new derivatives of 1,2,3,4-tetrahydro-beta-carboline 2a--d were synthetized with the pyridoxal moiety in position 1; there were also obtained four Schiff bases 1a--d which are intermediate products in this synthesis. Schiff bases 1a--d revealed a sedative and analgesic action, and compound 1b also had potential antidepressive properties. The derivatives of tetrahydro-beta-carboline 2a--d were inactive in the carried out tests.

Analgesics↗