Biomedical subjects
Publications and source records attributed to M Mazza.
The Authors, after shortly summarizing the evolution in the treatment of knee post-traumatic stiffness , punctualize its indications, and remember Judet's operative technique. Then they show a casuistry of 26 patients checked again at an average interval of 7 years after operation, from which one can understand the goodness of the results obtained, and, above all, their duration through the time.
Two intradural and two extradural spinal cysts are reported. The authors compare these cases with others reported in the literature. They agree about the dorsal retromedullary site but they disagree about the age and sex. Although the cysts have been opacified only in two cases, the myelographic diagnosis was easy in every case except one. The myelo-CT is'nt necessary for diagnosis but it offers a better visualization of the relation between the lesion and the spinal cord.
A series of amides, esters and thioesters of 2-thiocyanobenzoic acid were synthesised and tested for antifungal activity in vitro and in vivo against various strains of fungus pathological to plants. The phytotoxicity against representative plants was studied in parallel. The substances were prepared by condensation of suitable mercaptobenzamides with cyanogen bromide or of 2-thiocyanobenzoyl chloride with amines, alcohols or mercaptans. This research showed in vitro antifungal activity of some N-monosubstituted amides and in vivo activity of some N-monosubstituted and N,N-disubstituted amides of 2-thiocyanobenzoic acid which have the same protective activity towards P. viticola as Zineb.
The authors showed a method of treatment of the fractures of femur-neck under head, being persuaded of its validity, for the good remote results in the 38 cases shown, the lighter trauma caused to this type of patients, and the lower risk and operative care required.
The authors showed 32 cases of resection of radial capital, inspected 2 years after operation, the results of which, as compared with those obtained through other methods, revealed a good remote validity. This is true in cases where no other important lesions, especially in the periarticular soft parts, were present.
The authors illustrated the principles of dynamic osteosynthesis applied to olecranon, showed the good results obtained in 40 cases, and pointed out the importance of the early mobilization on a stabilized fracture focus.
Some aryl esters of N-benzyldithiocarbamic acid, characterized by the presence on the S-aryl group of hydrophilic or potentially hydrophilic groups were studied for anticryptogamic activity in vitro and in vivo. The substances were prepared by condensation of benzylisothiocyanate with suitable benzenethiols. The results showed the anticryptogamic activity of acylation derivatives of N-monosubstituted thiosalicylamides with the acyl of N-benzylthiocarbamic acid.
Some aryl esters of N-benzyldithiocarbamic acid [substances (I leads to XVI)], in which S aryl substituents were hydrophylic or potentially hydrophylic groups, were tested for in vitro antifungal activity against the following strains: Candida albicans, Saccharomyces cerevisiae and Trichophyton mentagrophytes. The substances were prepared by condensation of benzylisothiocyanate with suitable benzenethiols. The results, given in Table I, show the marked activity as antifungal agents of the N-benzyldithiocarbamic acid aryl esters studied; the antifungal activity, connected with the N-benzyldithiocarbamic group, is only slightly influenced by the nature of the substituents.
Between April 1977 and April 1981, three schedules of prophylactic antibiotic therapy using four different antibiotics -- Cefaloridine, an association of Tobramycin-Lincomycin, and Ribostamycin -- have been employed in the surgical treatment of a series of patients. clinical experiments were carried out administering the dose of chosen antibiotic one hour before and a few hours after surgery, without prior selection of patients and without considering what type of surgery they were to undertake. The clinical series presented was submitted to statistical analysis for the purpose of monitoring the effectiveness of the therapeutic programmes adopted to prevent postoperative infections of the surgical focus and of the skin wound, comparisons also being made of the different types of drug. The high number and variability of the factors affecting this type of experiment are attributed equally to the patient's physiological and metabolic features and to the types of lesions and surgical intervention carried out. The rationality of these therapeutic solutions are assessed by comparison with traditional programmes of antibiotic administration carried out solely in the postoperative period for a prolonged time. Practicality, cost and incidence of side effects (infrequent) and the absence of serious toxic consequences are also discussed.
Some diesters of benzen-1,2-dithiol wit aliphatic and aromatic carboxylic acids were prepared and tested for in vitro antifungal activity. The diacetate and dipropionate of benzen-1,3- and 1,4-dithiol were used as comparison compounds. The substances (Table I; substances I leads to X) were obtained by condensation of benzenedithiols with suitable acylating agents. The fungistatic activity of the products was tested in vitro against the following fungal strains: Candida albicans, Candida tropicalis, Saccharomyces cerevisiae and Trichophyton mentagrophytes. The results show that the diester of benzen-1,2-dithiols with alkanoic acids (Table I) have marked antimycotic activity, much greater than that of clotrimazol. The diaroyl esters of benzen-1,2-dithiol and the diesters of benzen-1,3- and 1,4-dithiols are inactive or only slightly active.
A large number of 1-aryl-3,3-dialkyl triazenes and 1,2-diphenyl triazenes variously substituted in the 3 position with OH and alkyl groups were prepared and studied for acaricide activity against Panonychus ulmi and chemosterilizing and insecticidal activity against Musca domestica. The results highlighted the marked chemosterilizing activity of 1-(2-methoxyphenyl)-3,3-di-n-propyltriazene and the interesting acaricidal activity of 1-(4-benzoylphenyl)-3,3-dimethyltriazene. The examination of such a large number of compounds for insecticidal activity allowed interesting conclusions to be drawn regarding structure/activity relationships.
Some diesters of 2-mercaptobenzenmethanthiol and of 2-(2-nitrophenyl)-1,3-benzodithiyne were prepared and tested for in vitro antifungal activity. The substances [Table I: substances (I leads to VIII)] were obtained by condensation of 2-mercaptobenzenmethanthiol with suitable reagents. The antifungal activity of the products was tested in vitro against the following strains: Candida albicans, Saccharomyces cerevisiae and Trichophyton mentagrophytes. It was found that antimycotic activity is shown by only some of the diesters of 2-mercaptobenzenmethanthiol with acyl alkylthiocarbamic groups (Table I). The diesters with aliphatic, aromatic, alkylcarbamic groups and the 2-(2-nitrophenyl)-1,3-benzodithiyne are inactive or only slightly active.
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The compound 3,3'-diindolyl-2,2'-tetrasulfide was studied for in vitro and in vivo fungistatic activity against various fungi causing human and plant diseases. The compound showed marked activity in vitro especially against dermatophytes and in the agrarian field against Botrytis cinerea. When the low phytotoxicity of the compound is taken into account, it is concluded that the compound has considerable potential as an anticryptogam.
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A series of 1,3-benzodithiols substituted at position 2, obtained by condensation of benzene 1,2-dithiols with aldehydes and ketones, was studied for antifungal activity. The fungistatic activity of the compounds [Table I, II; (I leads to XXV)] was tested in vitro against the four strains: Candida albicans, Candida tropicalis, Saccharomyces cerevisiae and Trichophyton mentagrophytes. The results indicate at the 2-monosubstituted 1,3-benzodithiols are an interesting class of antifungal substances, the 2-phenyl substituted derivative (1) being of particular interest.
It is first stressed that medial fractures of the femur neck pose therapeutic and prognostic problems linked above all to biological factors. After reference to the criteria of classification adopted by Linton and Pauwels, the need to adopt fixed parameters in establishing the surgical indication is then asserted. These parameters are the patient's age, understood not only as number of years but also as general and psychic state, and the obliquity of the fracture line or its degree of decomposition. The Authors conclude by establishing four theorectical groups of patients and indicating the treatment they adopted for each group.
The Authors report on treatment of patients with total prosthesis of the hip, in whom mobilisation of the prosthesis or one or both its components has occurred. In particular, stress is put on the results of the operation of removal of the prosthesis, which finds its major indications in cases of acute or remote, deep sepsis, and in case of aseptic mobilisation when the theoretical presuppositions allowing its substitution do not exist.